*  AID 179614 - Antiallergic activity in rat reaginic passive cutaneous anaphylaxis (PCA) test upon intravenous administration -...
BioAssay record AID 179614 submitted by ChEMBL: Antiallergic activity in rat reaginic passive cutaneous anaphylaxis (PCA) test upon intravenous administration.
*  Cutaneous anaphylaxis | Article about cutaneous anaphylaxis by The Free Dictionary
Looking for cutaneous anaphylaxis? Find out information about cutaneous anaphylaxis. Hypersensitivity that is marked by an intense skin reaction following parenteral contact with a sensitizing agent Explanation of cutaneous anaphylaxis
*  AID 179635 - Antianaphylactic activity was measured by its ability to inhibit the passive cutaneous anaphylaxis (PCA) by 50% in...
BioAssay record AID 179635 submitted by ChEMBL: Antianaphylactic activity was measured by its ability to inhibit the passive cutaneous anaphylaxis (PCA) by 50% in rats when administered intravenously; Not tested.
*  AID 183478 - Inhibition of passive cutaneous anaphylaxis following 3 mg/kg p.o. administration. - PubChem
BioAssay record AID 183478 submitted by ChEMBL: Inhibition of passive cutaneous anaphylaxis following 3 mg/kg p.o. administration..
*  Passive cutaneous anaphylaxis definition | Drugs.com
Definition of passive cutaneous anaphylaxis. Provided by Stedman's medical dictionary and Drugs.com. Includes medical terms and definitions.
*  Filodulcina - Wikipedia
Filodulcina es una dihydroisocumarina encontrada en Hydrangea macrophylla[2]​ y Hydrangea serrata.[3]​ Es un edulcorante 400-800 más dulce que el azúcar.[4]​ Amacha Número CAS Effects of phyllodulcin, hydrangenol, and their 8-O-glucosides, and Thunberginols A and F from Hydrangea macrophylla SERINGE var. thunbergii MAKINO on passive cutaneous anaphylaxis reaction in rats. Matsuda H., Shimoda H., Yamahara J. and Yoshikawa M., Biological & pharmaceutical bulletin, 1999, vol. 22, no8, pp. 870-872, INIST-1959604 Accumulation of phyllodulcin in sweet-leaf plants of Hydrangea serrata and its neutrality in the defence against a specialist leafmining herbivore. Mami Ujihara, Masateru Shinozaki and Makoto Kato, Researches on population ecology, Volume 37, Number 2, pp. 249-257, doi 10.1007/BF02515827 Chemical and Functional Properties of Food Saccharides. P. Tomasik, CRC Press, Boca Raton, 2003, isbn: 978-0-8493-1486-5 Esta obra contiene una traducción derivada de ...
*  Filodulcina - Wikipedia
Filodulcina, conhecida também pela designação phyllodulcin, é uma dihidroisocumarina que ocorre naturalmente em algumas espécies do género Hydrangea, nomeadamente em Hydrangea macrophylla e Hydrangea serrata. O composto apresenta forte actividade edulcorante, sendo 400-800 vezes mais adoçante que o açucar de mesa. Amacha Effects of phyllodulcin, hydrangenol, and their 8-O-glucosides, and Thunberginols A and F from Hydrangea macrophylla SERINGE var. thunbergii MAKINO on passive cutaneous anaphylaxis reaction in rats. Matsuda H., Shimoda H., Yamahara J. and Yoshikawa M., Biological & pharmaceutical bulletin, 1999, vol. 22, no8, pp. 870-872, INIST:1959604 Accumulation of phyllodulcin in sweet-leaf plants of Hydrangea serrata and its neutrality in the defence against a specialist leafmining herbivore. Mami Ujihara, Masateru Shinozaki and Makoto Kato, Researches on population ecology, Volume 37, Number 2, pp. 249-257, doi:10.1007/BF02515827 Chemical and ...
*  Thunberginol A - Wikipedia
Thunberginol A es una isocumarina que se encuentra en Hydrangea macrophylla[2]​ y en su forma de hojas procesadas (Hydrangeae dulcis folium).[3]​[4]​ Número CAS Matsuda, H.; Shimoda, H.; Yamahara, J.; Yoshikawa, M. (1999). "Effects of phyllodulcin, hydrangenol, and their 8-O-glucosides, and thunberginols a and F from Hydrangea macrophylla SERINGE var. Thunbergii MAKINO on passive cutaneous anaphylaxis reaction in rats". Biological & Pharmaceutical Bulletin 22 (8): 870-872. doi:10.1248/bpb.22.870. PMID 10480329. INIST:1959604. Yamahara, J.; Matsuda, H.; Shimoda, H.; Wariishi, N.; Yagi, N.; Murakami, N.; Yoshikawa, M. (1995). "Efectos de la thunberginol un contenidas en Hydrangeae dulcis forium sobre tipos alergias I-IV". Nihon yakurigaku zasshi. Folia Pharmacologica japónica (en japonés) 105 (5):. 365-379 PMID 7628785 Matsuda, H.; Shimoda, H.; Yamahara, J.; Yoshikawa, M. (1998). "Immunomodulatory activity of thunberginol a and related compounds isolated from ...
*  Hidrangenol - Wikipedia
Hydrangenol é um composto orgânico natural da família das di-hidro-isocumarinas, abundante nas folhas e talos da espécie Hydrangea macrophylla (hortênsia), onde ocorre em conjunto com o seu 8-O-glicosídeo, (-)-hidrangenol 4'-O-glicosídeo e (+)-hidrangenol 4'-O-glicosídeo. Uma elevada concentração destes compostos está presente no preparado comercializado sob o nome de Hydrangeae Dulcis Folium, as folhas processadas da variedade H. macrophylla var. thunbergii. Matsuda, Hisashi; Simoda, Hiroshi; Yamahara, Johji; Yoshikawa, Masayuki (1999). «Effects of phyllodulcin, hydrangenol, and their 8-O-glucosides, and Thunberginols A and F from Hydrangea macrophylla SERINGE var. thunbergii MAKINO on passive cutaneous anaphylaxis reaction in rats». Biological & Pharmaceutical Bulletin. 22 (8): 870-872. PMID 10480329. doi:10.1248/bpb.22.870. INIST:1959604 Yoshikawa, M; Uchida, E; Chatani, N; Kobayashi, H; Naitoh, Y; Okuno, Y; Matsuda, H; Yamahara, J; Murakami, N (1992). ...
*  Hypersensitivity to Ascaris Antigens | The Journal of Immunology
Rats were immunized with crude Ascaris extracts together with Bordetella pertussis organisms and the homocytotropic antibody titers were estimated by homologous PCA. Rats injected with 1 mg of crude extract produced homocytotropic antibodies giving and average PCA titer of 1:80. A second injection of 100 µg of the extract given 6 days later, without B. pertussis vaccine, caused a considerable increase in the PCA titer. The crude extract was fractionated by DEAE-cellulose chromatography and the fractions were tested in P-K type reactions. The homocytotropic antibodies produced in rats immunized with the crude extract demonstrated a tendency to react with the fractions displaying a negative charge at pH 8.. The capacity of rats to produce Hc antibodies to part of the antigenic components present in the crude extract but not against others was demonstrated when rats were immunized separately with isolated fractions.. ...
2) Ukrainian Anti-Cancer Institute, 1040 Vienna, Austria.. * Address for correspondence: Janina Wyczółkowska, Department of Biogenic Amines, Polish Academy of Sciences, Tylna 3, 90-950 Łódź, P.O. Box 225, Poland.. Summary: The ability of the Chelidonium majus L alkaloid derivative Ukrain (UK) to inhibit ovalbumininduced sensitization was tested in BALB/c and F1(BALB/c x C57BL/6J) mice. UK introduced into the mice in the mixture with antigen (ovalbumin) and adjuvant (alum) inhibited the sensitization of mice, reflected in lower anti-OA IgE antibody response and decreased antigen-induced histamine release from mast cells isolated from peritoneal cavities of sensitized mice. The effect of UK on the antigenicity of ovalbumin (OA) in anaphylaxis was tested in heterologous passive cutaneous anaphylactic (PCA) reaction on rats. The results show that the OA prepared in the mixture with UK had a decreased ability to react with anti-OA IgE antibodies raised against ...
*  Immediate hypersensitivity reaction legal definition of immediate hypersensitivity reaction
Definition of immediate hypersensitivity reaction in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is immediate hypersensitivity reaction? Meaning of immediate hypersensitivity reaction as a legal term. What does immediate hypersensitivity reaction mean in law?
*  Cutaneous drug reactions | University of Maryland Medical Center
Ahmed AM, Pritchard S, Reichenberg J. A review of cutaneous drug eruptions. Clin Geriatr Med. 2013;29(2):527-45.. Bae EA, Han MJ, Shin YW, et al. Inhibitory effects of Korean red ginseng and its genuine constituents ginsenosides Rg3, Rf, and Rh2 in mouse passive cutaneous anaphylaxis reaction and contact dermatitis models. Biol Pharm Bull. 2006 Sep;29(9):1862-7.. Brinkhaus B, Lindner M, Schuppan D, et al. Chemical, pharmacological and clinical profile of the east Asian medical plant Centella asiatica. Phytomedicine. 2000;7:427-48.. Chularojanamontri L, Jiamton S, Manapajon A, et al. Cutaneous reactions to proton pump inhibitors: a case-control study. J Drugs Dermatol. 2012;11(10):e43-7.. Feliciano C, Verrotti A, Coscione G, et al. Skin reactions due to anti-epileptic drugs: several case-reports with long-term follow-up. Int J Immunopathol Pharmacol. 2003;16(1):89-93.. Habif. Clinical Dermatology. 5th ed. Philadelphia, PA: ...
*  Thymus Dependence of Reaginic Antibody Formation in Mice | The Journal of Immunology
Formation of reaginic antibodies in mice has been demonstrated by numerous investigators (1-4). These antibodies were shown to be fixed to homologous skin, being retained there for several days. They were also shown to be heat and mercaptoethanol sensitive. Thus in many of their biologic activities mouse reaginic antibodies resemble human IgE antibodies (5). Availability of genetically thymusless nude mice provided an opportunity to examine the dependence of mouse reaginic antibody formation on the presence of thymus cells. Nude mice (nu/nu) were shown to respond poorly to sheep erythrocytes in respect to formation of IgM and IgG antibodies (6-8). The immune response to sheep erythrocytes was at least partially restored by normal thymus grafts or by injection of normal thymus cells (9). Nude mice (nu/nu) and heterozygous (nu/-) derived from back-crosses to the BALB/c strain (3 to 5 generations) were obtained from Bomholtgaard, Ltd., Ry. Denmark. BALB/c mice (+/+) originated from Jackson ...
*  Frontiers | RhoA/ROCK Signaling Pathway Mediates Shuanghuanglian Injection-Induced Pseudo-allergic Reactions | Pharmacology
Background: Shuanghuanglian injection (SHLI) is a famous Chinese medicine used as an intravenous preparation for the treatment of acute respiratory tract infections. In the recent years, the immediate hypersensitivity reactions induced by SHLI have attracted broad attention. However, the mechanism involved in these reactions has not yet been elucidated. The present study aims to explore the characteristics of the immediate hypersensitivity reactions induced by SHLI and deciphers the role of the RhoA/ROCK signaling pathway in these reactions.Methods: SHLI-immunized mice or naive mice were intravenously injected (iv) with SHLI (600 mg/kg) once, and vascular leakage in the ears was evaluated. Passive cutaneous anaphylaxis test was conducted using sera collected from SHLI-immunized mice. Naive mice were administered (iv) with a single dose of 150, 300, or 600 mg/kg of SHLI, and vascular leakage, histamine release, and histopathological alterations in the ears, ...
*  Molecules | Free Full-Text | The Herbal Medicine KIOM-MA128 Inhibits the Antigen/IgE-Mediated Allergic Response in Vitro and in...
KIOM-MA128, a novel herbal medicine, has been reported to exert some beneficial effects on various biological events, such as atopic dermatitis, inflammation and cancer. The aim of this study is to investigate how KIOM-MA128 regulates the allergic response. We measured the activity of β-hexosaminidase and the levels of allergic mediators in the conditioned media of antigen/IgE (Ag/IgE)-activated RBL-2H3 mast cells. We examined the levels of proteins associated with both the FcεRI and arachidonate cascades. Finally, we established the passive cutaneous anaphylaxis (PCA) model in mice to confirm the anti-allergic effects of KIOM-MA128 in vivo. KIOM-MA128 dose-dependently inhibited degranulation and the production of the allergic mediators described above, with no significant cytotoxicity. In the arachidonate cascade, KIOM-MA128 significantly reduced both cytosolic phospholipase A2 (cPLA2) phosphorylation and cyclooxygenase-2 (COX-2) expression. Moreover, in ...
*  Mouse IgE and Anti-Mouse IgE Monoclonal Antibodies | Yeda Research and Development Company Ltd.
Description: Rat monoclonal anti-IgE antibodies that was generated by fusion of plasmacytoma (84.1C) or myeloma (EM953) cells with splenocytes of rat immunized with purified murine IgE mAb. The antibodies react with various IgE mAb of different specificities and not with immunoglobulins of other classes, and recognize an epitope on the murine Fc epsilon region. Were shown to block IgE-Fc?R interactions and inhibit passive cutaneous anaphylaxis. Clone 84.1c recognizes a site on IgE, which is identical or very close to the Fc?R binding site. May be used for detection and manipulation of the IgE response in mice. Reference: Schwarzbaum S, Nissim A, Alkalay I, Ghozi MC, Schindler DG, Bergman Y, Eshhar Z. 1989. Mapping of murine IgE epitopes involved in IgE-Fc epsilon receptor interactions. Eur J Immunol 19(6):1015-23. M182, M185, M186. ...
*  Regulation of Antibody Response in Different Immunoglobulin Classes | The Journal of Immunology
Selective suppression of IgE antibody response was demonstrated. Preadministration of DNP-coupled mycobacterium (DNP-Tbc) inhibited the formation of anti-DNP IgE antibody induced by DNP-OA without any suppressive effect on anti-DNP IgG antibody response. Secondary anti-DNP IgE antibody response by DNP-OA was also significantly depressed by the preadministration of DNP-Tbc. Anti-OA IgE antibody response induced by DNP-OA was also depressed by DNP-Tbc, whereas anti-OA IgE antibody response induced by PAB-OA was not affected by the preadministration of DNP-Tbc. Preimmunization with DNP-MGG induced much higher anti-DNP IgG antibody response than DNP-Tbc, but DNP-MGG did not suppress the induction of anti-DNP IgE antibody. The transfer of DNP-Tbc-primed spleen cells into normal mice depressed anti-DNP IgE antibody response. B cell-depleted cell populations also showed a comparable inhibitory effect to that of unfractionated DNP-Tbc primed cells. In the adoptive cell transfer experiment, ...
*  JoVE Author Search: Iinuma M
Anaphylaxis, Antigen, Cells, Concentration, Eupatorium, Histamine, Histamine Release, Ige, Lactones, Leukemia, Mice, Passive Cutaneous Anaphylaxis, Pca, Rat, Treatment, Fibroblasts, Human, Interleukin, Interleukin-1, Matrix Metalloproteinase-1
*  MGI - Inbred Strains: SJL
Susceptible to induction of experimental allergic encephalomyelitis (EAE) (1/18) (Levine and Sowinski, 1973). High susceptibility to induction of EAE (1/10) but moderate mortality (Lindsey, 1996). Low lymphocyte phytohaemagglutinin response (29/43) (Heiniger et al., 1975., 1975). Poor immune response to small doses of bovine gamma-globulin (cf. 4/8) (Levine and Vaz, 1970). Poor immune response to DNP-keyhole-limpet haemocyanin (11/11) (Borel and Kilham, 1974). No immune response to GAT (random terpolymer of Glu60, Ala30, Tyr10) (10/10) (Dorf et al., 1974., 1974). Discriminator between `H' and `L' sheep erythrocytes (cf. 12/18) (McCarthy and Dutton, 1975). Very sensitive to anaphylactic shock (Treadwell, 1969). Resistant to induction of immunological tolerance (1/14) (Fujiwara and Cinader, 1974). Poor immune response to (Pro66, Gly34)n (7/7) (Fuchs et al., 1974., 1974). High (3/12) susceptibility to IgE- and IgG1-mediated passive cutaneous anaphylaxis (De ...
*  The American Journal of Tropical Medicine and Hygiene | Reactivity of Human Immunoglobulins in Echinococcosis and Trichinosis
Summary Immunoglobulins (IgG, IgA, and IgM) were separated from the serum of a person infected with Trichinella spiralis (Serum T) and another infected with Echinococcus granulosus (Serum E) by Sephadex G-200 and DEAE cellulose column chromatography and sucrose-density gradient ultracentrifugation. The composition of fractions was assayed by the Ouchterlony technique and by immunoelectrophoresis. Whole serum and serum fractions were tested by serodiagnostic methods and by passive cutaneous anaphylaxis (PCA) in the guinea pig and monkey. The IgG fractions of Serum E were reactive in serologic tests and in the skin of guinea pigs. Reactivity in the skin of monkeys appeared to be associated with the IgA fraction from a Sephadex G-200 column and the IgG fraction from a DEAE cellulose column. The IgM fraction from serum T showed the greatest reactivity in serologic tests. The IgG fraction was reactive in serologic tests and in the skin of guinea pigs. Neither ...
*  Anaphylaxis reactions? - Celiac Disease - HealingWell.com Forum
I should mention that I eliminated gluten from my diet 10 days ago (because of a severe anaphylactic episode) and for the first time -- possibly ever -- I do not have a headache. It is actually kinda strange because until it went away I wasn't really even aware of what NOT having a headache really feels like. I do now. I also found I can hear things clearly, most likely because my lymph-nodes have almost disappeared and there is no pressure around my ears any more. I have been taking allergy meds for years and will have to get retested after a few months, but I am beginning to wonder if my allergies are also gluten related? I also have no stomach upset of any kind -- again something I have had virtually my entire life. I am gradually becoming aware that I feel fantastic and am kinda freaked out really ...
*  IgE knock-in mice suggest a role for high levels of IgE in basophil-mediated active systemic anaphylaxis.
Immunoglobulin E (IgE) production is tightly regulated at the cellular and genetic levels and is believed to be central to allergy development. At least two cellular pathways exist that lead to systemic anaphylaxis reactions in vivo: IgE-sensitized m
*  Members of Parliament pass Anaphylaxis Awareness Motion - May 22, 2013 | Canadian Anaphylaxis Initiative
Members of Parliament pass Anaphylaxis Awareness Motion. Canadian Anaphylaxis Initiative pleased with "step in right direction". May 23, 2013 - OTTAWA - MPs' votes in the House of Commons last night included the passing of Motion 230, a motion to raise awareness of anaphylaxis, a life-threatening medical condition brought on by severe allergies. This is welcomed news for family members of the Canadian Anaphylaxis Initiative (CAI), a volunteer network of concerned families who have been working with MPs to raise awareness of severe allergies in Ottawa.. The anaphylaxis motion passed with unanimous, all-Party support. Niagara West-Glanbrook MP Dean Allison initiated the debate in the House of Commons, moving: That in the opinion of the House, anaphylaxis is a serious concern for an increasing number of Canadians and the government should take the appropriate measures necessary to ensure these Canadians are ...