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*  Navitoclax augments the activity of carboplatin and paclitaxel combinations in ovarian cancer cells | Read by QxMD
A phase I safety and pharmacokinetic study of ABT-263 in combination with carboplatin/paclitaxel in the treatment of patients ... Navitoclax enhanced the activation of caspase 3/7 induced by carboplatin and/or paclitaxel in Igrov-1 cells. Combinations of ... Antagonism between carboplatin and paclitaxel was evident in Ovcar-4, Ovcar-8 and Skov-3 cells. Drug combinations including ... Navitoclax augments the activity of carboplatin and paclitaxel combinations in ovarian cancer cells. Vasileios A Stamelos, ...
https://www.readbyqxmd.com/read/23168176/navitoclax-augments-the-activity-of-carboplatin-and-paclitaxel-combinations-in-ovarian-cancer-cells
*  The role of p27(Kip1) in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian cancer cells. - Nuffield Department of...
... paclitaxel vs paclitaxel: 0.28 vs. 0.81 cm3, difference = 0.53 cm3, 95% confidence interval [CI] = 0.44 to 0.62 cm3, P = .014 ... The roles of p27(Kip1), Bcl-2, and Cdk1 in apoptosis induced by dasatinib and paclitaxel were assessed using a terminal ... The effect of dasatinib, an inhibitor of Src and Abl kinases, on paclitaxel sensitivity was measured in ovarian cancer cells ... The siRNA knockdown of Src, Fyn, or Abl1 enhanced paclitaxel-mediated growth inhibition in ovarian cancer cells compared with a ...
https://www.wrh.ox.ac.uk/publications/248407
*  Paclitaxel | SpringerLink
A Case of Albumin-Bound Paclitaxel-Induced Peripheral Neuropathy without Exacerbation]. Gan to Kagaku Ryoho 44: 517-519, No. 6 ...
https://link.springer.com/article/10.1007/s40278-017-37379-4
*  paclitaxel (CHEBI:45863)
... has role human metabolite (CHEBI:77746) paclitaxel (CHEBI:45863) has role metabolite (CHEBI:25212) ... paclitaxel (CHEBI:45863) is a taxane diterpenoid (CHEBI:50367) paclitaxel (CHEBI:45863) is a tetracyclic diterpenoid (CHEBI: ... paclitaxel (CHEBI:45863) has functional parent baccatin III (CHEBI:32898) paclitaxel (CHEBI:45863) has role antineoplastic ... CHEBI:45863 - paclitaxel. Main. ChEBI Ontology. Automatic Xrefs. Reactions. Pathways. Models. .gridLayoutCellStructure { min- ...
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:45862
*  Paclitaxel total synthesis - Wikipedia
Paclitaxel total synthesis in organic chemistry is a major ongoing research effort in the total synthesis of paclitaxel (Taxol ... "Synthesis of Paclitaxel. 1. Synthesis of the ABC Ring of Paclitaxel by SmI2-Mediated Cyclization" Organic Letters 17 (11), 2570 ... but it also opens the way to paclitaxel derivatives not found in nature but with greater potential. The paclitaxel molecule ... Paclitaxel Total Syntheses @ SynArchive.com Taxolog for Taxol research, founded by Holto The complete Taxol story from Chemical ...
https://en.wikipedia.org/wiki/Paclitaxel_total_synthesis
*  Cipla-Paclitaxel - Drugs.com
A list of US medications equivalent to Cipla-Paclitaxel is available on the Drugs.com website. ... Cipla-Paclitaxel is a medicine available in a number of countries worldwide. ... Ingredient matches for Cipla-Paclitaxel. Paclitaxel. Paclitaxel is reported as an ingredient of Cipla-Paclitaxel in the ... Cipla-Paclitaxel. Cipla-Paclitaxel may be available in the countries listed below. ...
https://www.drugs.com/international/cipla-paclitaxel.html
*  Paclitaxel (taxol) - PubMed - NCBI
Paclitaxel (taxol). Rowinsky EK1, Donehower RC.. Author information. 1. Division of Pharmacology and Experimental Therapeutics ...
https://www.ncbi.nlm.nih.gov/pubmed/7885406
*  paclitaxel protein-bound
... is used to treat cancer of the breast, lung, or pancreas. Paclitaxel protein-bound is sometimes given ... Paclitaxel protein-bound may also be used for... ... Paclitaxel protein-bound is a cancer medicine that interferes ... What is paclitaxel protein-bound?. Paclitaxel protein-bound is a cancer medicine that interferes with the growth and spread of ... How is paclitaxel protein-bound given?. Paclitaxel protein-bound is given as an infusion into a vein. A healthcare provider ...
https://www.rexhealth.com/rh/health-library/document-viewer/?id=d05427a1
*  paclitaxel (thing) by BioTech - Everything2.com
Paclitaxel is a taxoid chemotherapy drug originally extracted from the bark of the Pacific yew. It is sold under the trade name ... paclitaxel (thing). See all of paclitaxel, no other writeups in this node. ... Paclitaxel is a taxoid chemotherapy drug originally extracted from the bark of the Pacific yew. It is sold under the trade name ... Paclitaxel is given intravenously (it irritates skin and mucous membranes on contact), and is most effective against ovarian ...
https://everything2.com/user/BioTech/writeups/paclitaxel
*  Paclitaxel
... paclitaxel) Injection should be administered under the supervision of a physician experienced in the use of cancer ... Paclitaxel is a white to off- white crystalline powder with the empirical formula C47H51NO14 and a molecular weight of 853.9. ... Paclitaxel is a natural product with antitumor activity. TAXOL is obtained via a semi-synthetic process from Taxus baccata. The ... TAXOL® (paclitaxel) Injection should be administered under the supervision of a physician experienced in the use of cancer ...
http://www.egeneralmedical.com/rxlist00000073.html
*  Paclitaxel (Taxol, Onxal) Chemotherapy Drug Information
Paclitaxel (Taxol, Onxal) chemotherapy side effects, how it's given, how it works, precautions and self care tips for treatment ... Do not breast feed while taking Paclitaxel.. Self-Care Tips:. *Paclitaxel, or the medications that you take with Paclitaxel may ... How Paclitaxel Is Given:. *Paclitaxel is given as an injection or infusion into the vein (intravenous, IV). ... There is no pill form of Paclitaxel. *The amount of Paclitaxel and the schedule that it is given will receive depend on many ...
http://www.chemocare.com/chemotherapy/drug-info/paclitaxel.aspx
*  Paclitaxel Protein-Bound - Chemotherapy Drugs - Chemocare
Paclitaxel Protein-bound (Abraxane) chemotherapy side effects, how it's given, how it works, precautions and self care tips for ... Paclitaxel belongs to a group of plant alkaloids known as taxanes, along with paclitaxel. Paclitaxel (protein bound) differs ... How Paclitaxel (Protein Bound) Is Given. *Paclitaxel (protein bound) is administered into a vein by intravenous (IV) injection ... Paclitaxel (protein bound) is generally given over 30 minutes.. *Paclitaxel (protein bound) is an irritant. An irritant is a ...
http://chemocare.com/chemotherapy/drug-info/Paclitaxel-Proteinbound.aspx
*  Abitaxel (Paclitaxel) Teva
Abitaxel information about active ingredients, pharmaceutical forms and doses by Teva, Abitaxel indications, usages and related health products lists
http://drugs-about.com/drugs-a/abitaxel.html
*  Controversy Deepens Over Paclitaxel-based Devices in PAD
FDA Investigating Late Risk With Paclitaxel Balloons, Stents in PAD * Greater Risks With Post-TAVR Rivaroxaban Halt GALILEO ... PCR Stands Firm Behind Paclitaxel-Coated Devices in PAD * Peripheral Artery Disease in HIV-Infected Older Adults on ... It showed a 19% absolute risk reduction in TLR with the use of paclitaxel-coated devices, compared with noncoated devices, and ... A second review, published just days earlier, also showed no excess mortality risk with paclitaxel-coated stents and balloons ...
https://www.medscape.com/viewarticle/910008?nlid=128442_4961&src=WNL_mdplsnews_190308_mscpedit_card&uac=70121MT&spon=2&impID=1902689&faf=1
*  paclitaxel | UW Health | Madison, WI
Paclitaxel is used to treat breast cancer, ovarian cancer, and lung cancer. It is also used to treat AIDS-related Kaposi's ... Paclitaxel may also be used for purposes not listed in this medication guide. ... Paclitaxel is a cancer medication that interferes with the growth and spread of cancer cells in the body. ... What is paclitaxel?. Paclitaxel is a cancer medication that interferes with the growth and spread of cancer cells in the body. ...
https://www.uwhealth.org/health/topic/multum/onxol/d01376a1.html
*  Patent US5473055 - Polymer-bound paclitaxel derivatives - Google Patents
... are endowed with antitumor activity and show improved water solubility and decreased toxicity in comparison with paclitaxel or ... of units containing the paclitaxel and paclitaxel derivatives is from 0.5 to 2, more preferably, the content of paclitaxel in ... The paclitaxel content was 4% w/w%.. EXAMPLE 7. 2',7-di(carbobenzyloxy-β-alanyl)paclitaxel. To a solution of 200 mg of ... Water soluble paclitaxel prodrugs. US20080153865 *. Oct 29, 2007. Jun 26, 2008. Pg-Txl Company, L.P.. Water soluble paclitaxel ...
http://www.google.com/patents/US5473055?dq=6,081,786
*  Paclitaxel - Paclitaxel Manufacturer, Supplier & Exporter
... paclitaxel dealers, suppliers, traders & exporters. Listed manufacturing companies are offering wide range of paclitaxel with ... Paclitaxel Paclitaxel is a used in . It was discovered in a program at the in 1967 when and isolated it from the bark of the ... Paclitaxel Paclitaxel, a potent disruptor of microtubules derived from the bark of the Pacific yew tree, is widely used as a ... Paclitaxel Paclitaxel is now used to treat patients with lung, ovarian, breast, head and neck cancer, and advanced forms of ...
https://www.tradeindia.com/manufacturers/paclitaxel.html
*  Paclitaxel docosahexaenoic acid - DrugBank
... and paclitaxel (an anticancer drug) being studied in the treatment of cancer. It is a type of mitotic inhibitor. ... Because tumor cells take up DHA, DHA-paclitaxel is delivered directly to tumor tissue, where the paclitaxel moiety binds to ... DHA-paclitaxel. Clinical Trials. Clinical Trials Phase. Status. Purpose. Conditions. Count. 2. Unknown Status. Treatment. ... DHA-paclitaxel exhibits improved pharmacokinetic and toxicity profiles when compared to conventional paclitaxel and has ...
https://www.drugbank.ca/drugs/DB05297
*  Paclitaxel & carboplatin - Information and support - Macmillan Cancer Support
If you or someone close to you has been diagnosed with cancer, you're not alone. Find out what to expect, get information, practical advice and support, hear from experts and read about other people's experiences.
https://www.macmillan.org.uk/information-and-support/lung-cancer/small-cell-lung-cancer/treating/chemotherapy/drugs-and-combination-regimens/combination-chemotherapy/paclitaxel-and-carboplatin.html
*  Abraxane: A Better Delivery System for Paclitaxel? | HealthCentral
... paclitaxel) as part of my chemo. Both Taxol and its cousin Taxotere (docetaxel) need to be dissolved in a solvent before they ... Abraxane (nab-paclitaxel) is the same active ingredient as Taxol, but scientists have found a new way to deliver it. The 'nab' ... Like many other people, I had Taxol (paclitaxel) as part of my chemo. Both Taxol and its cousin Taxotere (docetaxel) need to be ... to mix the paclitaxel has proved to be a safe and less toxic way to deliver the drug. ...
https://www.healthcentral.com/article/abraxane-a-better-delivery-system-for-paclitaxel
*  Phase I Study of Weekly LOC-paclitaxel Injection
The goal of this clinical research study is to find the highest tolerable dose of LOC-paclitaxel when given to patients with ... 3. To measure the plasma pharmacokinetics of LOC-paclitaxel and paclitaxel derived from LOC-paclitaxel in patients receiving ... The goal of this clinical research study is to find the highest tolerable dose of LOC-paclitaxel when given to patients with ... Part I 1. To determine the recommended dose of LOC-paclitaxel as a single agent, given weekly, 5/6 weeks. 2. To determine the ...
https://www.mdanderson.org/patients-family/diagnosis-treatment/clinical-trials/clinical-trials-index/clinical-trials-detail.ID2009-0432.html
*  Is the Paclitaxel Narrative Getting Worse?
Paclitaxel drug-coated balloons and drug-eluting stents received some bad press in January after a meta-analysis showed an ... Paclitaxel drug-coated balloons and drug-eluting stents received some bad press in January after a meta-analysis showed an ... To assess the efficacy and safety of the LEGFLOW OTW drug coated balloon (DCB; coated with paclitaxel) for the treatment of ... Data corrections by Cook Medical and Medtronic aren't helping the paclitaxel narrative, in our view.' Medtronic reported in ...
https://medworm.com/679161369/is-the-paclitaxel-narrative-getting-worse/
*  Paclitaxel - Fresenius Kabi Great Britain
Paclitaxel. Please note that due to the Association of the British Pharmaceutical Industry body information on prescription ...
https://www.fresenius-kabi.com/gb/products/paclitaxel
*  JCI - OATP1B2 deficiency protects against paclitaxel-induced neurotoxicity
Paclitaxel is among the most widely used anticancer drugs and is known to cause a dose-limiting peripheral neurotoxicity, the ... Here, we identified the murine solute carrier organic anion-transporting polypeptide B2 (OATP1B2) as a mediator of paclitaxel- ... Additionally, using established tests to assess acute and chronic paclitaxel-induced neurotoxicity, we found that genetic or ... Collectively, our findings reveal a pathway that explains the fundamental basis of paclitaxel-induced neurotoxicity, with ...
https://www.jci.org/articles/view/96160/pdf