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*  MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.
The p38 mitogen-activated protein (MAP) kinase signal transduction pathway is activated by proinflammatory cytokines and ... two MAP kinase kinases that phosphorylate and activate p38 MAP kinase. Expression of activated MKK3 and MKK6 in cultured cells ... MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.. ... The detection of p38 MAP kinase in the nucleus of activated cells suggests that p38 MAP kinase can mediate signaling to the ...
http://www.uniprot.org/citations/8622669
*  What does p38 mitogen-activated protein kinases stand for?
Find out what is the full meaning of p38 mitogen-activated protein kinases on Abbreviations.com! 'Protein Kinase C' is one ... Looking for the definition of p38 mitogen-activated protein kinases? ... What does p38 mitogen-activated protein kinases mean?. p38 Mitogen-Activated Protein Kinases. A mitogen-activated protein ... Know what is p38 mitogen-activated protein kinases? Got another good explanation for p38 mitogen-activated protein kinases? ...
http://www.abbreviations.com/serp.php?st=p38%20mitogen-activated%20protein%20kinases&qtype=3
*  Role of p38 Mitogen-Activated Protein Kinases in Preconditioning | Circulation Research
... mitogen-activated protein kinases (c-Jun N-terminal kinases and p38 mitogen-activated protein kinases) in the myocardium. Circ ... induction of p38 mitogen-activated protein kinase activation and Hsp27 phosphorylation via a tyrosine kinase- and protein ... Role of p38 Mitogen-Activated Protein Kinases in Preconditioning. A Detrimental Factor or a Protective Kinase?. Peipei Ping, ... In this context, the p38 mitogen-activated protein kinases (MAPKs), a family of stress-activated MAPKs,2 3 have been examined ...
http://circres.ahajournals.org/content/86/9/921
*  Staurosporine Induces Platelet Apoptosis Through p38 Mitogen-Activated Protein Kinase Signaling Pathway. | Sigma-Aldrich
Furthermore, STS stimulation induced phosphorylation of p38 mitogen-activated protein kinase (MAPK). Inhibition of p38 MAPK ... Staurosporine Induces Platelet Apoptosis Through p38 Mitogen-Activated Protein Kinase Signaling Pathway.. [Lili Zhao, Guoyuan ... These data indicate that STS induces platelet apoptosis via the p38 MAPK signaling pathway. These findings suggest that ...
https://www.sigmaaldrich.com/catalog/papers/26299070
*  Stress-Induced p38 Mitogen-Activated Protein Kinase Activation Mediates κ-Opioid-Dependent Dysphoria | Journal of Neuroscience
Human serotonin transporter variants display altered sensitivity to protein kinase G and p38-mitogen-activated protein kinase. ... 1998) Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric ... Previous reports demonstrated that SB203580 does not inhibit protein kinase A, protein kinase C, or other mitogen-activated ... 2001) The p38 mitogen-activated protein kinase is involved in associative learning in rabbits. J Neurosci 21:5513-5519. ...
http://www.jneurosci.org/content/27/43/11614
*  P38 mitogen-activated protein kinases - Wikipedia
P38 mitogen-activated protein kinases are a class of mitogen-activated protein kinases (MAPKs) that are responsive to stress ... p38 Mitogen-Activated Protein Kinases at the US National Library of Medicine Medical Subject Headings (MeSH) P38mapkPathway p38 ... MKK3 and SEK activate p38 MAP kinase by phosphorylation at Thr-180 and Tyr-182. Activated p38 MAP kinase has been shown to ... a novel p38 mitogen-activated protein kinase inhibitor: preclinical analysis of efficacy and selectivity". J. Pharmacol. Exp. ...
https://en.wikipedia.org/wiki/P38_mitogen-activated_protein_kinases
*  Pharmacological Inhibition of p38 Mitogen-Activated Protein Kinases Affects KC/CXCL1-Induced Intraluminal Crawling,...
P. A. Detmers, D. Zhou, E. Polizzi et al., "Role of stress-activated mitogen-activated protein kinase (p38) in β2- integrin- ... S. Zhang, M. Rahman, S. Zhang et al., "p38 Mitogen-activated protein kinase signaling regulates streptococcal M1 protein- ... kinase, and p38 mitogen-activated protein kinase in Fc receptor-mediated signaling of chicken heterophil degranulation," ... S. L. Pan, K. Y. Tao, J. H. Guh et al., "The p38 mitogen-activated protein kinase pathway plays a critical role in PAR2-induced ...
https://www.hindawi.com/journals/mi/2013/290565/ref/
*  Doxorubicin Attenuates Serotonin-Induced Long-Term Synaptic Facilitation by Phosphorylation of p38 Mitogen-Activated Protein...
2005) Phosphorylation-dependent degradation of p300 by doxorubicin-activated p38 mitogen-activated protein kinase in cardiac ... and p38 mitogen-activated protein kinase (p38 MAPK), two MAPK isoforms important for long-term memory (LTM) formation. ... 2003) A role for COX-2 and p38 mitogen activated protein kinase in long-term depression in the rat dentate gyrus in vitro. ... 2008) A role of p38 mitogen-activated protein kinase in adenosine A(1) receptor-mediated synaptic depotentiation in area CA1 of ...
http://www.jneurosci.org/content/34/40/13289
*  IJMS | Free Full-Text | A Role for Protein Phosphatase 2A in Regulating p38 Mitogen Activated Protein Kinase Activation and...
We previously showed that H5N1/97 hyperinduces tumor necrosis factor (TNF)-alpha through p38 mitogen activated protein kinase ( ... We investigated the roles of protein phosphatases including MAPK phosphatase-1 (MKP-1) and protein phosphatase type 2A (PP2A) ... We demonstrate that H9N2/G1 virus activated p38MAPK and hyperinduced TNF-alpha production in PBMac when compared with H1N1 ... Here we hypothesize that protein phosphatases are involved in the regulation of cytokine expressions during influenza virus ...
http://www.mdpi.com/1422-0067/14/4/7327
*  Molecules | Free Full-Text | The Histone Deacetylase Inhibitors MS-275 and SAHA Suppress the p38 Mitogen-Activated Protein...
... the impact of MS-275 and SAHA on the p38 mitogen-activated protein kinase (MAPK) signaling pathway and chemotaxis was assessed ... Moreover, MS-275 and SAHA suppressed granulocyte chemotactic protein-2 (GCP-2), monocyte chemotactic protein-2 (MCP-2) and ... an endogenous suppressor of p38α in E11 cells. At the same time, the association between p38α and MKP-1 was up-regulated and ... MS-275 and SAHA significantly suppressed the expression of p38α MAPK, but induced the expression of MAPK phosphatase-1 (MKP-1 ...
https://www.mdpi.com/1420-3049/18/11/14085
*  Rit signaling contributes to interferon-γ-induced dendritic retraction via p38 mitogen-activated protein kinase activation
... ... These observations identify Rit as a downstream target of IFNγ and suggest that a novel IFNγ-Rit-p38 signaling pathway ... Silencing of Rit by RNA interference suppressed IFNγ-elicited activation of p38 MAPK in pheochromacytoma cells, and ... pharmacological inhibition of p38 MAPK significantly attenuated the dendrite-inhibiting effects of IFNγ in cultured sympathetic ...
https://insights.ovid.com/jneur/200812050/00005064-200812050-00024
*  PRIME PubMed | [Influence of electroacupuncture on p38-mitogen activated protein kinase in substantia nigra cells of rats with...
Influence of electroacupuncture on p38-mitogen activated protein kinase in substantia nigra cells of rats with Parkinson ... To explore the role of inflammatory reaction mediated by p38-mitogen activated protein kinase (p38-MAPK) signal path on ... To explore the role of inflammatory reaction mediated by p38-mitogen activated protein kinase (p38-MAPK) signal path on ... p38 Mitogen-Activated Protein Kinases. Pub Type(s). English Abstract. Journal Article. Research Support, Non-U.S. Gov't. ...
https://www.unboundmedicine.com/medline/citation/23819239/
*  Effect of a p38 Mitogen-Activated Protein Kinase Inhibitor on Corneal Endothelial Cell Proliferation | IOVS | ARVO Journals
... and p38 MAPK.35 The p38 MAPK group consists of four isoforms: p38α, p38β, p38γ, and p38δ, with p38α and p38β expressed ... Hongo A, Okumura N, Nakahara M, Kay EP, Koizumi N. The effect of a p38 Mitogen-activated protein kinase inhibitor on cellular ... Iwasa H, Han J, Ishikawa F. Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway. Genes Cells ... Effect of a p38 Mitogen-Activated Protein Kinase Inhibitor on Corneal Endothelial Cell Proliferation ...
https://iovs.arvojournals.org/article.aspx?articleid=2697869
*  Cutting Edge: Activation of the p38 Mitogen-Activated Protein Kinase Signaling Pathway Mediates Cytokine-Induced Hemopoietic...
In recent studies, we have shown that type I IFNs (IFN-α and IFN-β) activate the p38 mitogen-activated protein (Map) kinase ... Activation of the p38 mitogen activated protein kinase by type I IFNs. J. Biol. Chem. 274: 30127. ... Activation of the p38 mitogen activated protein kinase mediates the suppressive effects of type I interferons and transforming ... The Rac1/p38 mitogen-activated protein kinase pathway is required for interferon α-dependent transcriptional activation but not ...
http://www.jimmunol.org/content/168/12/5984?ijkey=20b087f7171ddb99d471e1fdde991d37517bcf85&keytype2=tf_ipsecsha
*  The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced...
The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced ... i ,p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or ... European Bioinformatics InstituteProtein Information ResourceSIB Swiss Institute of Bioinformatics. ... an orthologous protein, a record from another database, etc.,/p> ,p>,a href="/manual/evidences">More…,/a>,/p> Skip Header ...
http://www.uniprot.org/citations/11727828
*  p38 Mitogen-Activated Protein Kinase Regulates Nuclear Receptor CAR that Activates the CYP2B6 Gene | Drug Metabolism &...
mitogen activated protein kinase. MAPKAPK2. MAPK activated protein kinase 2. PCR. polymerase chain reaction. TCPOBOP. 1,4-Bis-[ ... p38 Mitogen-Activated Protein Kinase Regulates Nuclear Receptor CAR that Activates the CYP2B6 Gene. Kosuke Saito, Rick Moore ... p38 Mitogen-activated protein kinase (MAPK), a member of the family of MAPKs, is activated by a number of cellular stresses ... p38 Mitogen-activated protein kinase (MAPK) is highly activated in human primary hepatocytes but barely in human hepatoma cell ...
http://dmd.aspetjournals.org/content/41/6/1170
*  Anti-Inflammatory Properties of a Novel N-Phenyl Pyridinone Inhibitor of p38 Mitogen-Activated Protein Kinase: Preclinical-to...
Kinase Activation.. The activation of p38α kinase by mitogen-activated protein kinase kinase (MKK) 6 was carried out in the ... mitogen-activated protein kinase-activated protein kinase 2. PG. prostaglandin. ELISA. enzyme-linked immunosorbent assay. M-CSF ... extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue ... mitogen-activated protein. ERK. extracellular signal-regulated kinase. JNK. c-Jun NH2-terminal kinase. PH-797804. benzamide, 3 ...
http://jpet.aspetjournals.org/content/331/3/882?ijkey=800c9c63494f426ccaff1365001baa4331f65636&keytype2=tf_ipsecsha
*  4-Hydroxy-2-Nonenal Enhances Tissue Factor Activity in Human Monocytic Cells via p38 Mitogen-Activated Protein Kinase...
HNE treatment generated reactive oxygen species, activated p38 mitogen-activated protein kinase, and increased the exposure of ... Blockade of p38 mitogen-activated protein kinase activation inhibited HNE-induced phosphatidylserine exposure and increased TF ... 4-Hydroxy-2-Nonenal Enhances Tissue Factor Activity in Human Monocytic Cells via p38 Mitogen-Activated Protein Kinase ... 4-Hydroxy-2-Nonenal Enhances Tissue Factor Activity in Human Monocytic Cells via p38 Mitogen-Activated Protein Kinase ...
http://atvb.ahajournals.org/content/early/2013/05/02/ATVBAHA.113.300972
*  Oxidative Stress Induces Premature Senescence by Stimulating Caveolin-1 Gene Transcription through p38 Mitogen-Activated...
In addition, signaling studies show p38 mitogen-activated protein kinase (MAPK) as the upstream regulator of Sp1-mediated ... activation of p38 mitogen-activated protein kinase (MAPK) → Sp1-mediated activation of GC-rich caveolin-1 promoter elements → ... such as G-protein α subunit, Ras, nitric oxide synthase, protein kinase C, and protein kinase A ( 2, 7, 10, 16- 25). However, ... Stress Induces Premature Senescence by Stimulating Caveolin-1 Gene Transcription through p38 Mitogen-Activated Protein Kinase/ ...
http://cancerres.aacrjournals.org/content/66/22/10805
*  Trafficking-Dependent and -Independent Pathways of Neurotransmitter Transporter Regulation Differentially Involving p38 Mitogen...
protein kinase B. p38 MAPK. p38 mitogen-activated protein kinase. KRH. Krebs-Ringer-HEPES. PBS. phosphate-buffered saline. RIPA ... 2000) Phosphatidylinositol 3-kinase stimulates muscle differentiation by activating p38 mitogen-activated protein kinase. ... 2001) p38 Mitogen-activated protein kinase-dependent activation of protein phosphatases 1 and 2A inhibits MEK1 and MEK2 ... PI3K activation was found to support phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK). However, basal and ...
http://jpet.aspetjournals.org/content/299/2/666
*  Mechanism of Action of Sulforaphane: Inhibition of p38 Mitogen-Activated Protein Kinase Isoforms Contributing to the Induction...
Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for activation of p38α and p38δ MAPK isoforms by TGF-β1 in ... Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6. J Biol ... Although MKK6 activates all the p38 MAPK isoforms, MKK3 activates p38α, p38γ, and p38δ, but not p38β ( 35). Enslen et al. ( 36 ... which include p38 mitogen-activated protein kinase (p38 MAPK), extracellular signal-regulated kinase (ERK), c-jun NH2-terminal ...
http://cancerres.aacrjournals.org/content/66/17/8804
*  Differential influence of p38 mitogen activated protein kinase (MAPK) inhibition on acute phase protein synthesis in human...
Differential influence of p38 mitogen activated protein kinase (MAPK) inhibition on acute phase protein synthesis in human ... Differential influence of p38 mitogen activated protein kinase (MAPK) inhibition on acute phase protein synthesis in human ... Objective: To investigate the influence of p38 MAPK inhibition on acute phase protein (APP) production, which is dependent on ... were significantly inhibited by p38 MAPK specific inhibitor in hepatoma cell lines. For p38 MAPK inhibitor treatment in RA SAA ...
http://ard.bmj.com/content/65/7/929
*  Duration of streptozotocin-induced diabetes differentially affects p38-mitogen-activated protein kinase (MAPK) phosphorylation...
... would produce renal and vascular dysfunction that correlate with altered p38- mitogen-activated protein kinase (p38-MAPK) ... Home » Duration of streptozotocin-induced diabetes differentially affects p38-mitogen-activated protein kinase (MAPK) ... Duration of streptozotocin-induced diabetes differentially affects p38-mitogen-activated protein kinase (MAPK) phosphorylation ... and phosphorylated p38-MAPK in thoracic aorta and kidney cortex but not in kidney medulla in 28-days diabetes group. Conclusion ...
http://connection.ebscohost.com/c/articles/28682787/duration-streptozotocin-induced-diabetes-differentially-affects-p38-mitogen-activated-protein-kinase-mapk-phosphorylation-renal-vascular-dysfunction
*  Nerve Growth Factor Activates Extracellular Signal-Regulated Kinase and p38 Mitogen-Activated Protein Kinase Pathways To...
Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase. ... Nerve Growth Factor Activates Extracellular Signal-Regulated Kinase and p38 Mitogen-Activated Protein Kinase Pathways To ... Nerve Growth Factor Activates Extracellular Signal-Regulated Kinase and p38 Mitogen-Activated Protein Kinase Pathways To ... Nerve Growth Factor Activates Extracellular Signal-Regulated Kinase and p38 Mitogen-Activated Protein Kinase Pathways To ...
https://mcb.asm.org/content/18/4/1946?ijkey=bd6ec37fabbd856453ad8036367896becf5298f4&keytype2=tf_ipsecsha
*  p38 Mitogen-Activated Protein Kinase Activates eNOS in Endothelial Cells by an Estrogen Receptor α-Dependent Pathway in...
... activated) form of the p38 MAPK downstream target, mitogen-activated protein kinase activated protein kinase-2 (MAPKAPK-2). B, ... p38 Mitogen-Activated Protein Kinase Activates eNOS in Endothelial Cells by an Estrogen Receptor α-Dependent Pathway in ... p38 Mitogen-Activated Protein Kinase Activates eNOS in Endothelial Cells by an Estrogen Receptor α-Dependent Pathway in ... p38 Mitogen-Activated Protein Kinase Activates eNOS in Endothelial Cells by an Estrogen Receptor α-Dependent Pathway in ...
http://circres.ahajournals.org/content/96/10/1072