Biomolecules | Free Full-Text | The Use of Euterpe oleracea Mart. As a New Perspective for Disease Treatment and Prevention
NLRP3: nod-like receptor pyrin containing 3; p38-MAPK: p38 mitogen-activated protein kinase; NF-κB: nuclear factor κB; iNOS: ... 31], using BV-2 murine microglial cells, observed that the p38 mitogen-activated protein kinase (p38-MAPK) and the ... activating the phosphorylated adenosine monophosphate-activated protein kinase pathway and increasing the expression of insulin ... Expressions of phosphorylated adenosine monophosphate activated protein kinase (pAMPK), phosphorylated acetyl-CoA carboxylase ( ...
Biomolecules | Free Full-Text | Endothelial-Cell-Derived Human Secretory Leukocyte Protease Inhibitor (SLPI) Protects...
... and in preconditioned CMs by activation of p38 MAPK and Akt survival kinase. In conclusion, this study showed for the first ... Zhang, Y.; Gu, E.W.; Zhang, J.; Chen, Z.W. Role of p38 mitogen-activated protein kinases in cardioprotection of morphine ... Weinbrenner, C.; Liu, G.-S.; Cohen, M.V.; Downey, J.M. Phosphorylation of Tyrosine 182 of p38 Mitogen-activated Protein Kinase ... such as PI3-kinase and Akt, protein kinase C, and protein kinase A-p38 MAPK [28]. ...
Nutrients | Free Full-Text | Phytomedicine in Joint Disorders
... apoptosis induction via increased production of reactive oxygen species and activation of p38 mitogen-activated protein kinase ... mitogen-activated protein kinase; MCP-1, monocyte chemoattractant protein-1; MIP-1α, monocyte inflammatory protein-1; MMP, ... mitogen-activated protein kinase; MCP-1, monocyte chemoattractant protein-1; MIP-1α, monocyte inflammatory protein-1; MMP, ... arthritis fibroblast-like synoviocytes via reactive oxygen species-dependent activation of p38 mitogen-activated protein kinase ...
IJMS | Free Full-Text | PDE4 Inhibition and Inflammatory Bowel Disease: A Novel Therapeutic Avenue
... p38 mitogen-activated protein kinase, and c-Jun NH2-terminal kinase activation. J. Pharmacol. Exp. Ther. 2005, 315, 1188-1195 ... While UCR1 contains the Protein kinase A (PKA) phosphorylation site, which is important for the regulation of PDE4 catalytic ... Baillie, G.S.; Scott, J.D.; Houslay, M.D. Compartmentalisation of phosphodiesterases and protein kinase A: Opposites attract. ... and histamine are able to bind to G-protein coupled receptors and to activate adenylate cyclase, which consequently increases ...
IJMS | Free Full-Text | Molecular Mechanisms of Nickel Allergy
Several studies have shown that the activation of p38 mitogen-activated protein kinase in dermal DCs is required to trigger a T ... Arrighi, J.F.; Rebsamen, M.; Rousset, F.; Kindler, V.; Hauser, C. A critical role for p38 mitogen-activated protein kinase in ... Some cytokines activate APCs, such as Langerhans cells (LCs) or dendritic cells (DCs). Activated APCs migrate to the draining ... The activated T cells produce inflammatory cytokines and chemokines at the site of exposure that promote an allergic reaction, ...
IJMS | September-1 2019 - Browse Articles
1/p38 mitogen-activated protein kinases signaling. The uMSCs abrogated TGF-β1-induced fibrosis by reducing extracellular matrix ... Among these are phospholipase C, mitogen-activated kinases (MAP kinases) or β-arrestin. The present review focuses on major ... These protein building blocks are robust scaffolds that can be conveniently functionalized with full-length proteins and ... We found that hnRNPA1, a nuclear protein known to control mRNA export and mRNA translation of anti-apoptotic proteins, mediates ...
IJMS | Free Full-Text | Pro-Inflammatory Cytokines: Potential Links between the Endocannabinoid System and the Kynurenine...
Enhanced pro-inflammatory cytokine levels may over-activate the KP, leading to tryptophan depletion and reduced serotonin ... Involvement of p38 Mitogen-Activated Protein Kinase and Nuclear Factor-κB. J. Biochem. 2006, 139, 655-662. [Google Scholar] [ ... both classes uniformly activate the Janus kinase-signal transducers and activators of the transcription (JAK-STAT) pathway [22 ... there are data demonstrating other signaling pathways activated by CBRs, involving cell and G-protein type specificity or G- ...
IJMS | Free Full-Text | Targeting ERK-Hippo Interplay in Cancer Therapy
... is a part of the mitogen-activated protein kinase (MAPK) signaling pathway which allows the transduction of various cellular ... Cross-talk of the MAPK signaling pathway with other proteins and signaling pathways have a crucial impact on clinical outcomes ... Targeted inhibition of individual kinases of the MAPK signaling pathway using synthetic compounds represents a promising way to ... terminal kinase but not p38 mitogen-activated protein kinases is required for RRR-alpha-tocopheryl succinate-induced apoptosis ...
Antioxidants | Free Full-Text | Redox for Repair: Cold Physical Plasmas and Nrf2 Signaling Promoting Wound Healing
... which further influence the activation of all three major mitogen-activated protein (MAP) kinases: p38, the extracellular ... Roux, P.P.; Blenis, J. ERK and p38 MAPK-Activated Protein Kinases: A Family of Protein Kinases with Diverse Biological ... Selective activation of c-Jun kinase mitogen-activated protein kinase by CD40 on human B cells. J. Biol. Chem. 1995, 270, 30823 ... Schaeffer, H.J.; Weber, M.J. Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers. Mol. Cell. Biol. ...
Toxins | Free Full-Text | Tetrodotoxin, a Potential Drug for Neuropathic and Cancer Pain Relief?
... allodynia positively correlates with an increase in activated microglia and increased P-p38 mitogen-activated protein kinase ... Multiple sodium channel isoforms and mitogen-activated protein kinases are present in painful human neuromas. Ann. Neurol. 2008 ... The VGSCs are integral membrane proteins composed of a 260 kDa α-subunit and one or more β-subunits, being the α-subunit ... Jia, Q.; Dong, W.; Zhang, L.; Yang, X. Activating Sirt1 by resveratrol suppresses Nav1.7 expression in DRG through miR-182 and ...
Nutrients | January 2017 - Browse Articles
Moreover, pretreatment of GHP increased the activation of p38 mitogen-activated protein kinase (p38 MAPK) and extracellular ... signal-regulated protein kinase 1/2 (ERK1/2), which were shown to contribute to Nrf2-mediated HO-1 expression. Taken together, ... Very Low-Protein Diet (VLPD) Reduces Metabolic Acidosis in Subjects with Chronic Kidney Disease: The "Nutritional Light Signal ... Of these, 54 patients assumed very low-protein diet (VLPD) and 92 were controls (ratio 1:2). We calculated every three months ...
Bioengineering | Free Full-Text | Application of Metal Nanoparticle-Hydrogel Composites in Tissue Regeneration
... mitogen-activated protein kinases (MAPK), and p38 MAPK pathways, respectively [23]. Besides, functionalized Au NPs such as ... It was highlighted that the effect of Au NPs was comparable to the osteoinductive protein BMP-2. Hence, it might able to act as ... Ding, H.; Yang, D.; Zhao, C.; Song, Z.; Liu, P.; Wang, Y.; Chen, Z.; Shen, J. Protein-Gold Hybrid Nanocubes for Cell Imaging ... Gold nanoparticles promote osteogenic differentiation of mesenchymal stem cells through p38 MAPK pathway. ACS Nano. 2010, 4, ...
IJMS | Free Full-Text | Obesity and the Brain
Neurotrophic Factor-Dependent Synaptic Plasticity Is Suppressed by Interleukin-1 via p38 Mitogen-Activated Protein Kinase. J. ... Effect of Interleukin-1β on Long-Term Potentiation Is Coupled with Increased Activity of Stress-Activated Protein Kinases. J. ... Reduced LTP has been correlated with the activity of stress-activated kinases and ROS in the hippocampal tissue. The potential ... they can directly activate innate immune pathways to affect CNS function. For instance, LPS has been used to activate the ...
IJMS | Free Full-Text | The E3 Ubiquitin-Protein Ligase RNF4 Promotes TNF-α-Induced Cell Death Triggered by RIPK1
... through downregulation of transforming growth factor β-activated kinase 1 (TAK1) activity, indicating the possibility that RNF4 ... In this study, we found that RING finger protein 4 (RNF4), a RING finger E3 ubiquitin ligase, is required for the RIPK1 ... Receptor-interacting protein kinase 1 (RIPK1) is a key component of the tumor necrosis factor (TNF) receptor signaling complex ... and the mitogen-activated protein kinase (MAPK) pathways, such as the c-Jun N-terminal kinase (JNK) and p38 MAPK pathways, that ...
Cells | Free Full-Text | Shared and Divergent Epigenetic Mechanisms in Cachexia and Sarcopenia
... analysis revealed that hsa-miR-34a was significantly enriched in cellular senescence and the mitogen-activated protein kinase ( ... Bernet, J.D.; Doles, J.D.; Hall, J.K.; Kelly Tanaka, K.; Carter, T.A.; Olwin, B.B. p38 MAPK signaling underlies a cell- ... It has been reported that hsa-miR-19a is closely related to the AMP-activated protein kinase (AMPK) signaling pathway, ... Salminen, A.; Kaarniranta, K. AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling ...
Molecules | Free Full-Text | Multiple Targets of 3-Dehydroxyceanothetric Acid 2-Methyl Ester to Protect Against Cisplatin...
Expression of c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), and p38 was markedly suppressed by ... Treatment with 3DC2ME also significantly reduced expression of active caspase-8 and -3, Bcl-2-associated X protein (Bax), and B ... on cisplatin-induced damage to kidney epithelial LLC-PK1 cells via mitogen-activated protein kinase (MAPK) and apoptosis ... mitogen-activated protein kinase (MAPK) [14], and apoptosis [8,14]. Natural products and their compounds may reduce this damage ...
Viruses | Free Full-Text | African Swine Fever Virus Ubiquitin-Conjugating Enzyme Is an Immunomodulator Targeting NF-κB...
Experiments aimed at mapping UBCv1 inhibitory activity indicated that this viral protein acts upstream or at the level step of ... In this work, we have revealed that early viral protein UBCv1, the only known conjugating enzyme encoded by a virus, modulates ... A critical protein in the activation of the mitogen-activated protein kinase (MAPK) pathway and AP-1 is the kinase TAK1, which ... c-Jun N-terminal kinases (JNKs) and p38 MAPKs, which collectively regulate numerous proteins and/or transcription factors ...
Antioxidants | Special Issue : Pharmacological and Clinical Significance of Heme Oxygenase-1 2022
Src kinase inhibitor II (Srci II)), Pyk2 (PF431396), protein kinase C (PKC)α (Gö6976), p38 mitogen-activated protein kinase ( ... However, BVR-A did not affect the KRGE-induced expression of AMP-activated protein kinase α (AMPKα). The KRGE-stimulated BVR-A- ... KPR-mediated NOX/ROS/c-Src/Pyk2/PKCα/p38α MAPK and JNK1/2 activate Nrf2 to bind with ARE on the HO-1 promoter and induce HO-1 ... The transcription of the homx1 gene was enhanced by Nrf2 activated by JNK1/2 and p38α MAPK. The binding activity between Nrf2 ...
IJMS | Special Issue : Signalling Molecules and Signal Transduction in Cells
... cyclin-dependent protein kinase, mitogen-activated protein kinase, Akt protein kinase). A number of studies have demonstrated ... In this review, we focus on ERK, JNK, p38 and ERK5, the major MAPKs, and their interactions with PI3K-Akt, TGFβ/Smad and Wnt/β- ... protein kinase C (PKC) isoforms, the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway, the mitogen-activated ... where many protein kinases contain kinase-activating autophosphorylation sites (e.g., cAMP-dependent protein kinase, Src family ...
Cells | Free Full-Text | MARCKS as a Potential Therapeutic Target in Inflammatory Breast Cancer
The combination of MARCKS-/PTEN+ protein status was associated with longer MFS in IBC patient only (p = 8.7 × 10−3), and ... Associated with the good-prognosis value of the MARCKS-/PTEN+ protein status that mirrors the molecular profile of MPS-treated ... The prognostic relevance of MARCKS and phosphatase and tensin homolog (PTEN) protein expression as a surrogate marker of ... protein was associated with shorter survival in IBC patients. MARCKS has been associated with the PI3K/AKT pathway. MARCKS ...
Antioxidants | Free Full-Text | A Review of the Potential Benefits of Plants Producing Berries in Skin Disorders
These effects were exerted through the inhibition of mitogen-activated protein kinases/activator protein-1 (MAPK/AP-1) and NF- ... The authors observed also inhibition of ERK 1/2, c-Jun-NH2-kinase, and p38 phosphorylation, leading to impaired activation of ... Pomegranate fruit extract modulates UV-B-mediated phosphorylation of mitogen-activated protein kinases and activation of ... Dietary grape seed proanthocyanidins inhibit UVB-induced oxidative stress and activation of mitogen-activated protein kinases ...
Pharmaceutics | Free Full-Text | Anti-Inflammatory Effects of a Polyphenol, Catechin-7,4′-O-Digallate, from Woodfordia uniflora...
The anti-inflammatory effects of CDG were mediated via the inhibition of nuclear factor kappa-light-chain-enhancer of activated ... signaling pathways for LPS-induced activation of inflammatory response in macrophages are mitogen-activated protein kinases ( ... Zhao, W.; Liu, M.; DSilva, N.J.; Kirkwood, K.L. Tristetraprolin regulates interleukin-6 expression through p38 MAPK-dependent ... The prepared protein samples concentrations were measured at 595 nm using Bio-Rad Protein Assay Kit (Bio-Rad Laboratories). ...
Vaccines | Free Full-Text | Dendritic Cell Tumor Vaccination via Fc Gamma Receptor Targeting: Lessons Learned from Pre-Clinical...
PRR engagement activates mitogen-activated protein kinase (MAPK) and nuclear factor kappa-light-chain-enhancer of activated B ... The synergistic effects of combining TLR ligand based adjuvants on the cytokine response are dependent upon p38/JNK signalling ... The fine art of establishing a model that selectively and fully activates DCs without activating other immune cell populations ... They can effectively activate CD8+ T cells, as well as promote CD4+ T-helper type 1 (Th1) cells (3), while cDC2 DCs can be ...
IJMS | Free Full-Text | Curcumin and Weight Loss: Does It Work?
... and constrained mitogen-activated protein kinase (MAPK) phosphorylation, which has been associated with 3T3-L1 differentiation ... Furthermore, curcumin also reduced IL-1β-induced activation of p38 MAPK in IECs. It is, therefore, considered that the IEC and ... inhibition of the activity of protein kinase activated by AMP-activated protein kinase, AMP-AMPK) [33,35] and a hormonal ... This process improves transcription of lipogenic enzyme genes [83]. 5-AMP-activated protein kinase (AMPK) is a valid regulator ...
Molecules | Free Full-Text | Dioscorea spp.: Bioactive Compounds and Potential for the Treatment of Inflammatory and Metabolic...
... and mitogen-activated protein kinase (MAPK)-peroxisome proliferator-activated receptor γ (PPARγ) signaling pathways [81,82]. ... 4-Dimethoxy Phenanthrene Isolated from Dioscorea batatas Decne Partly through Suppressing the P38 MAPK/NF-κB Pathway in BV2 ... AMP-activated protein kinase (AMPK), carnitine palmitoyltransferase (CPT), forkhead box O 1 (FoxO1), and adipose triglyceride ... protein kinase B (Akt) pathway. More importantly, this ameliorated acute lung injury associated with pancreatitis [88]. ...
Cancers | May 2018 - Browse Articles
... extracellular signal-regulated kinases/mitogen-activated protein kinases (ERK-MAPK), PI3-Kinase and tyrosine kinases, but not ... Insights of Crosstalk between p53 Protein and the MKK3/MKK6/p38 MAPK Signaling Pathway in Cancer by Lorenzo Stramucci ... Proline-Rich Protein Tyrosine Kinase 2 in Inflammation and Cancer by Xiangdong Zhu ... Focal adhesion kinase (FAK) and its homologous FAK-related proline-rich tyrosine kinase 2 (Pyk2) contain the same domain, ...
Molecules | Free Full-Text | Effects of Honey and Its Mechanisms of Action on the Development and Progression of Cancer
Two important components of the inflammatory pathway frequently activated in cancers are mitogen-activated protein kinase (MAPK ... Pichichero, E.; Cicconi, R.; Mattei, M.; Canini, A. Chrysin-induced apoptosis is mediated through p38 and Bax activation in B16 ... The regulation of the cell cycle events is under the control of a cascade of protein kinases and checkpoints [78]. In cancer ... induction of p53 and up-regulation of pro-apoptotic proteins-Bax and down-regulation of anti-apoptotic proteins such as Bcl-2. ...
Nutrients | Free Full-Text | Dietary Interventions with Polyphenols in Osteoarthritis: A Systematic Review Directed from the...
TGF-β-activated kinase 1, TAB: TAK1-binding proteins, MKK: mitogen-activated protein kinase kinase, JNK: c-Jun N-terminal ... IL-1β induced phosphorylation of NF-κB p65 and p38 MAPK. ... mitogen-activated protein kinase kinase, JNK: c-Jun N-terminal ... Protein kinase A, LKB1: Liver kinase B1, AMPK: AMP-activated protein kinase, TSC: Tuberous sclerosis complex, mTOR: Mammalian ... Protein kinase A, LKB1: Liver kinase B1, AMPK: AMP-activated protein kinase, TSC: Tuberous sclerosis complex, mTOR: Mammalian ...
IJMS | Free Full-Text | Mechanical and Immunological Regulation in Wound Healing and Skin Reconstruction
... mitogen-activated protein kinases (MAPK), extracellular-related kinase (ERK), and monocyte chemoattractant protein-1 (MCP-1, ... Tsukada, S.; Westwick, J.K.; Ikejima, K.; Sato, N.; Rippe, R.A. SMAD and p38 MAPK signaling pathways independently regulate ... extracellular signal-regulated kinase (ERK)-monocyte chemotactic protein 1 (MCP-1) pathway was activated and the number of ... Ding, Q.; Gladson, C.L.; Wu, H.; Hayasaka, H.; Olman, M.A. Focal adhesion kinase (FAK)-related non-kinase inhibits ...
Antioxidants | Free Full-Text | Neuro-Nutraceutical Polyphenols: How Far Are We?
... mitogen-activated protein kinase). These bind tyrosine receptor kinases (Trk), activating protein kinase cascades and cAMP (3′, ... Staurosporine prevented the toxic effects of myricetin, while inhibitors of the p53, p38, and PI3K/Akt pathways were without ... The inhibitors of PARP-1, ERK1/2, JNK, protein kinase (PKA), and voltage-gated calcium channels again promoted the toxic ... properties of resveratrol against beta-amyloid-induced neurodegeneration by modulating AMP-activated protein kinase pathways. J ...