JCI - Insulin sensitivity: modulation by nutrients and inflammation
Accordingly, the expression of osteopontin is elevated in obese adipose tissue (124) and osteopontin-KO mice have reduced ATM ... Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice. J. Clin. Invest. ... The cytokine osteopontin is a chemoattractant that is secreted by macrophages in order to facilitate immune cell recruitment, ...
JCI Insight -
Inhibition of the renin-angiotensin system causes concentric hypertrophy of renal arterioles in mice and humans
51). ELISA for osteopontin was performed with Mouse/Rat Osteopontin (OPN) Quantikine ELISA Kit (R&D Systems). ... the plasma osteopontin was significantly higher in Ren1c-KO mice, suggesting that osteopontin could be used as a predictive ... ELISA of plasma samples at several ages showed increased levels of osteopontin at every time point of Ren1c-KO mice compared ... B) ELISA for osteopontin during disease development (n = 4, Students t test). All data are reported as means ± standard ...
JCI - Age- and gender-related changes in the distribution of osteocalcin in the extracellular matrix of normal male and female...
Sections of bone immunostained for osteopontin (SPP-I), osteonectin, and decorin did not reveal multiple patterns or ...
JCI - Volume 93, Issue 5
... expression of osteopontin and osteonectin (SPARC), and production of bone-specific osteocalcin and hydroxyapatite. Cultures of ...
JCI - Osteopontin mediates glioblastoma-associated macrophage infiltration and is a potential therapeutic target
The role of osteopontin in tumor metastasis. J Surg Res. 2004;121(2):228-241.. View this article via: PubMed CrossRef Google ... Osteopontin: role in cell signaling and cancer progression. Trends Cell Biol. 2006;16(2):79-87.. View this article via: PubMed ... Osteopontin is a marker for cancer aggressiveness and patient survival. Br J Cancer. 2010;103(6):861-869.. View this article ... Osteopontin mediates glioblastoma-associated macrophage infiltration and is a potential therapeutic target. Jun Wei,1 Anantha ...