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Roth M, Obaidat A, Hagenbuch B. OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene ... Tumor-specific expression of organic anion-transporting polypeptides: transporters as novel targets for cancer therapy. Journal ... Obaidat A, Roth M, Hagenbuch B. The expression and function of organic anion transporting polypeptides in normal tissues and in ... organic anion-transporting polypeptide (OATP) signaling [7, 13]. However, whether these dyes possess the potential to bind ...
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Interactions of organic anion transporters and organic cation transporters with mycotoxins. Journal of Pharmacological Sciences ... Oxford, G.S.; Yeh, J.Z. 1985: Interactions of monovalent cations with sodium channels in squid axon. I. Modification of ... Yeh, J.Z.; Oxford, G.S. 1985: Interactions of monovalent cations with sodium channels in squid axon. II. Modification of ... Yamamoto, D.; Yeh, J.Z.; Narahashi, T. 1985: Interactions of permeant cations with sodium channels of squid axon membranes. ...
BESPONSA™ (inotuzumab ozogamicin) Warnings and Precautions | Pfizer Medical Information - US
... organic anion transporter (OAT)1 and OAT3, organic cation transporter (OCT)2, and organic anion transporting polypeptide (OATP) ... Effect of Metabolic Pathways and Transporter Systems on BESPONSA N-acetyl-gamma-calicheamicin dimethylhydrazide is a substrate ... Effect of BESPONSA on Metabolic Pathways and Transporter Systems. At clinically relevant concentrations, N-acetyl-gamma- ... Inhibit Drug Transporters: P-gp, breast cancer resistance protein (BCRP), ...
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YRC Public Data Repository - Protein Overview - SPCC576.17c
cation transmembrane transporter activity. 1.79369588808394. bayes_pls_golite062009. *active transmembrane transporter activity ... organic acid transmembrane transporter activity. 1.24937104052238. bayes_pls_golite062009. *secondary active transmembrane ... pyridoxamine transmembrane transporter activity [ISS. ] pyridoxine transmembrane transporter activity [ISS. ] pyridoxal ...
Kratom Alkaloids: The Building Blocks Of Botanical Magic - Puffs & Potions
... interact with organic anion transporter polypeptides (OATPs), organic cation transporters (OCTs), and P-glycoprotein (P-gp). ... Moreover, drug transporters such as P-glycoprotein (P-gp), organic anion-transporting polypeptide (OATP), and other proteins ... Involvement of membrane transporters. The Kratom alkaloids interact with membrane transporters, which play a crucial role in ... In addition to enzymes, membrane transporters such as P-glycoprotein (P-gp) have been found to play significant roles in the ...
Three soluble lysosomal proteins were detected in significantly elevated amounts in Cln7 ko MEFs compared with wild-type...
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... organic acid metabolic process;0.00162791469100455!GO:0022890;inorganic cation transmembrane transporter activity; ... monovalent inorganic cation transmembrane transporter activity;4.05742113092156e-07!GO:0016591;DNA-directed RNA polymerase II, ... cation-transporting ATPase activity;5.9928221964589e-08!GO:0016876;ligase activity, forming aminoacyl-tRNA and related ... protein transporter activity;3.59754767542358e-09!GO:0051169;nuclear transport;4.11175763405101e-09!GO:0006399;tRNA metabolic ...
BOSULIF® Clinical Pharmacology (bosutinib) | Pfizer Medical Information - US
... organic anion transporter (OAT)1, OAT3, organic cation transporter (OCT)1, and OCT2 at clinically relevant concentrations. ... Bosutinib Effect on Transporters. Bosutinib may have the potential to inhibit breast cancer resistance protein (BCRP) in the ... gastrointestinal tract but has a low potential to inhibit BCRP, systemically, or organic anion transporting polypeptide (OATP) ...
These off-target ramifications of proton pump inhibitors have already been successfully validated by retrospective analysis of...
GO:1903352 L-ornithine transmembrane transport AnnotationPropagation P GO:0000064 L-ornithine transmembrane transporter...
0015101 organic cation transmembrane transporter activity IBA GO:0015695 organic cation transport AnnotationPropagation P GO: ... 0015101 organic cation transmembrane transporter activity IBA GO:0015695 organic cation transport AnnotationPropagation P GO: ... 0015101 organic cation transmembrane transporter activity IBA GO:0001580 detection of chemical stimulus involved in sensory ... 0015101 organic cation transmembrane transporter activity IBA GO:1902600 proton transmembrane transport AnnotationPropagation P ...
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... along with upregulation of mRNA and protein levels of organic anion transporter 1 and organic cation/carnitine transporters in ... There was a significant downregulation of mRNA and protein levels of mouse glucose transporter 9 and urate transporter 1, ... renal organic ion transporter involvement. Am. J. Physiol. Renal Physiol. 2009;297(4):F1080-F1091. [PubMed] ... along with reversal of dysregulation of renal transporters (Hu et al., 2009). Inhibition of inducible nitric oxide synthase ...
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Gene Knockout and Metabolome Analysis of Carnitine/Organic Cation Transporter OCTN1 Y Kato, Y Kubo, D Iwata, S Kato, T Sudo, T ... Effects of pravastatin on the expression of ATP-binding cassette transporter A1. 311巻 1号 420-425頁 2004 原著論文 ... The uptake transporter OATP8 expression decreases during multistep hepatocarcinogenesis: correlation with gadoxetic acid ... Hepatocellular Carcinoma: Signal Intensity at Gadoxetic Acid-enhanced MR Imaging--Correlation with Molecular Transporters and ...
Blocking hormone uptake burns more fat: New regulatory mechanism highlights importance of 'beige fat' tissue - amis...
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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM - Terms starting with 'E' - MEDINDEX.AM
Organic Cation Transporter-Like 2 Protein) is a polyspecific organic-cation transporter, containing 10 transmembrane segments, ... UMLS (NCI) C0701075) =Organic Chemical; Pharmacologic Substance; Vitamin 194. Behavioral Health & Social Service; Psychologist ... Expressed predominantly in fetal and adult liver and kidney by human SLC22A1L Gene (Polyspecific Transporter/MDR Family), 424- ...
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IJMS | Free Full-Text | Structure, Function, and Applications of Soybean Calcium Transporters
Now, eight transporters were found to control the uptake and efflux of calcium. Though these calcium transporters have been ... Therefore, in this study, we summarized the current knowledge of soybean calcium transporters in structural features, ... a counter-cation for inorganic and organic anions in the vacuole, and an activator of an enzyme [2,3,4]. Mostly, they are ... including two efflux transporters (Ca2+-ATPase, and Ca2+/cation antiporter (CaCA)), and six influx transporters (cyclic ...
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... creatinine clearance due to inhibition of active tubular secretion of creatinine via blockade of the organic cation transporter ... 2 . In the kidney, OCT2 is an uptake transporter located on the basolateral membrane of renal proximal tubular cells, and it ...
Herald of Medicine
... the prototypical substrates or inhibitors of well-characterized organic cation transporter (OCTs), organic cation/carnitine ... Conclusion Toxic alkaloids of Fuzi are mainly actively transported into liver cells, and the novel organic cation/proton ... transporters (OCTNs), multidrug and toxin extrusion transporters (MATEs) and plasma membrane monoamine transporter (PMAT) ... The mRNA expression of PXR, CAR and CYP2C8, CYP3A4, CYP3A5, transporter P-gp were detected by RT-PCR. The protein expression of ...