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*  Atypical Optic Neuritis : Journal of Neuro-Ophthalmology
Optic neuritis of adulthood is most commonly seen in younger individuals, aged 15-45 years. Pediatric optic neuritis has a different clinical presentation and prognosis and will not be discussed here. The ONTT (Optic Neuritis Treatment Trial) demonstrated that patients with typical optic neuritis present with subacute unilateral loss of visual acuity, acquired dyschromatopsia and visual field loss. Optic neuritis is associated with pain in approximately 90% of patients, with pain preceding the visual loss in approximately 40% of cases. Patients often experience pain with eye movements. Clinical examination shows a relative afferent pupillary defect in the affected eye unless there has been prior damage to the contralateral optic nerve for any reason. Funduscopic evaluation reveals a normal optic disc, ...
http://journals.lww.com/jneuro-ophthalmology/Fulltext/2014/12000/Atypical_Optic_Neuritis.28.aspx?WT.mc_id=HPxADx20100319xMP
*  Optic neuritis - Symptoms, Treatments and Resources for Optic neuritis
Optic neuritis - MedHelp's Optic neuritis Center for Information, Symptoms, Resources, Treatments and Tools for Optic neuritis. Find Optic neuritis information, treatments for Optic neuritis and Optic neuritis symptoms.
http://www.medhelp.org/tags/show/16813/Optic-neuritis
*  Optic Neuritis Symptoms, Treatments, Causes & Diagnosis Patient Comments: Optic Neuritis - Treatments - Viewers Share Their...
View messages from patients providing insights into their medical experiences with Optic Neuritis - Treatments. Share in the message dialogue to help others and address questions on symptoms, diagnosis, and treatments, from MedicineNet's doctors.
http://www.medicinenet.com/optic_neuritis/patient-comments-809.htm
*  A comparison of optic neuritis and NAION with OCT and OCT angiography | IOVS | ARVO Journals
Purpose : Nonarteritic anterior ischemic optic neuropathy (NAION) and optic neuritis are the two most common acute optic neuropathies. OCT angiography is a new tool that can evaluate the density of the radial peripapillary capillary network, which has been shown to be decreased in various chronic optic neuropathies. The goal of this study was to evaluate OCT and OCT angiography's ability to differentiate optic neuritis and NAION, and predict visual outcomes. Methods : We performed a cross-sectional, observational study of patients with unilateral optic neuritis or NAION who presented between 2015 and 2016. Patients were included if they had unilateral optic neuritis or NAION and had OCT (Cirrus) and OCT angiography (Optovue) done at least 3 months after onset. Because a normative database for OCT angiography has not been ...
http://iovs.arvojournals.org/article.aspx?articleid=2642427
*  Pediatric optic neuritis: brain MRI abnormalities and risk of multiple sclerosis
Optic neuritis is often the initial presentation of multiple sclerosis (MS). As established by the Optic Neuritis Treatment Trial, an abnormal baseline brain MRI is a strong predic..
https://www.omicsonline.org/references/pediatric-optic-neuritis-brain-mri-abnormalities-and-risk-of-multiple-sclerosis-504063.html
*  Corticosteroids do not prevent optic nerve atrophy following optic neuritis | Journal of Neurology, Neurosurgery & Psychiatry
The design, conduct and clinical results of the trial have been reported previously.7 Briefly, 66 patients with a first episode of acute unilateral optic neuritis within 30 days of onset were enrolled into the study. The median duration of symptoms before randomisation was eight days (range 1-30). Six of the patients had clinically definite MS, another 14 had clinically probable MS, and the rest had clinically isolated optic neuritis. Their optic nerves were imaged with a short tau inversion recovery (STIR) sequence (TR 2500 ms, TE 40 ms, TI 175 ms, matrix 256×128, field of view 16 cm × 16 cm, 2 excitations, 5 mm contiguous slices) and were then randomised to receive either 1 g/day IVMP for three days or intravenous saline. Reimaging was performed six months later. In addition, at six months, a detailed clinical assessment was performed including Snellen visual acuity, contrast sensitivity using the Pelli-Robson chart, 30-2 ...
http://jnnp.bmj.com/content/74/8/1139
*  Autoimmune optic neuropathy - Wikipedia
Autoimmune optic neuropathy (AON), sometimes called autoimmune optic neuritis, may be a forme fruste of systemic lupus erythematosus (SLE) associated optic neuropathy. AON is more than the presence of any optic neuritis in a patient with an autoimmune process, as it describes a relatively specific clinical syndrome. AON is characterized by chronically progressive or recurrent vision loss associated with serological evidence of autoimmunity. Specifically, this term has been suggested for cases of optic neuritis with serological evidence of vasculitis by positive ANA, despite the lack of meeting criteria for SLE. The clinical manifestations include progressive vision loss that tends to be steroid-responsive and steroid dependent. Patients with defined SLE that go on to develop optic neuritis should be better identified as lupus ...
https://en.wikipedia.org/wiki/Autoimmune_optic_neuropathy
*  Optic neuritis - Treatment - Mayo Clinic
Optic neuritis - Learn more about symptoms, causes, treatment of this painful eye disorder that affects adults under 40. Often improves without treatment.
http://www.mayoclinic.org/diseases-conditions/optic-neuritis/diagnosis-treatment/treatment/txc-20263661
*  Biogen Idec Reports Positive Top-Line Results from Phase 2 Anti-LINGO-1 Trial in People with Acute Optic Neuritis | Biogen Media
CAMBRIDGE, Mass.--(BUSINESS WIRE)--Biogen Idec (NASDAQ: BIIB) today announced top-line results from the Phase 2 acute optic neuritis (AON) RENEW trial in which treatment with anti-LINGO-1 showed evidence of biological repair of the visual system. Anti-LINGO-1 demonstrated an improvement in the study's primary endpoint, recovery of optic nerve latency (time for a signal to travel from the retina to the visual cortex), as measured by full field visual evoked potential (FF-VEP), relative to placebo.
http://newsroom.biogen.com/press-release/corporate/biogen-idec-reports-positive-top-line-results-phase-2-anti-lingo-1-trial-peo
*  Optic Neuritis: Evaluation
Another name for Optic Neuritis is Optic Neuritis. The evaluation of optic neuritis begins with a history and physical exam, including an eye exam. Physical ...
http://www.freemd.com/optic-neuritis/evaluation.htm
*  Best Optic Neuritis Doctor in Bangalore, Optic Neuritis Doctors | Credihealth
Find the best optic neuritis doctors in Bangalore. Get guidance from medical experts to select optic neuritis specialist in Bangalore from trusted hospitals - credihealth.com
https://www.credihealth.com/doctors/bangalore/optic-neuritis
*  Visual Reconstitution Therapy After Optic Neuritis - Full Text View - ClinicalTrials.gov
Patients with an acute optic neuritis (between 60 and 180 days before screening) or with residual visual deficits after a past optic neuritis are randomized in two treatment groups. Group A is instructed to perform software-based visual reconstitution therapy on a home PC daily and regularly for 30 minutes over a period of six month. Group B will perform a similarly, also software-based training program, developed to improve saccadic eye movements rather than visual fields. Patients are blinded to the respective treatment ...
https://clinicaltrials.gov/ct2/show/NCT01274702
*  Adventures in Autism: H1N1 Vaccine, Optic Neuritis and Disseminated Encephalomyelitis
When a neurologic condition develops after vaccination of a patient, the causal relationship is difficult to determine. We report an unusual case in which neurologic signs occurred in a previously healthy child after both doses of H1N1 2009 influenza vaccine, culminating in bilateral optic neuritis and disseminated encephalomyelitis. A causal association is more likely with repeated injury following influenza vaccination ...
http://adventuresinautism.blogspot.com/2010/08/h1n1-vaccine-optic-nuritis-and.html
*  Perimetric results in patients with Multiple Sclerosis without optic neuritis | IOVS | ARVO Journals
Purpose: Aim of the study was to investigate the perimetric results in patients with Multiple Sclerosis without optic neuritis.. Methods: All patients and controls underwent ophthalmologic examinations (visual acuity, refraction, slit lamp and fundus examination, intraocular pressure) and were examined with the achromatic perimetry (Octopus 311, G1, Haag-Streit), frequency doubling perimetry (Matrix, 30-2, Zeiss Meditec) and flimmer perimetry (Pulsar, TOP/CP-T30W, Haag-Streit). The statistic analysis took place with the Wilcoxon - test (side comparison) and Mann- Whitney- U- test (group comparison).. Results: 26 patients with Multiple Sclerosis without optic neuritis (m : f=11 : 15, average age 43.8 ± 9.4 years) were included into the study and compared with age-corresponding controls (n=26, m:f=6:20, average age 40.0 ± 10.3years). The ophthalmologic examinations in all patients and controls showed no statistical differences. Regarding the ...
http://iovs.arvojournals.org/article.aspx?articleid=2147032
*  PRIME® Clinical Case Study: Does Optic Neuritis Equal Multiple Sclerosis?
Optic neuritis is often the first sign of multiple sclerosis. While other conditions can cause optic neuritis, MS must be high in the differential diagnosis, so that early treatment can be initiated.
http://primeinc.org/casestudies/physician/study/790/Does_Optic_Neuritis_Equal_Multiple_Sclerosis
*  Optic Neuritis - AAPOS
The first symptom of optic neuritis in a child is most commonly a rapid, often profound decrease in vision (visual acuity less than 20/400). It can occur in both eyes and it may be worse in one eye than another. Patients may also have headaches and pain with eye movement. Many children with optic neuritis have a history of a fever, flu-like illness, or immunizations 1-2 weeks prior to the onset of the decreased vision.. ...
https://aapos.org/terms/conditions/84
*  I Had Optic Neuritis
Have You Had Optic Neuritis? Join friendly people sharing true stories in the I Had Optic Neuritis group. Find support forums, advice and chat with groups who share this life experience.
http://www.experienceproject.com/groups/Had-Optic-Neuritis/33674
*  Unilateral Optic Neuritis: A Rare Complication after Measles-Mumps-Rubella Vaccination in a 30-Year-Old Woman
Case Reports in Ophthalmological Medicine is a peer-reviewed, Open Access journal that publishes case reports related to the anatomy, physiology and diseases of the eye.
https://www.hindawi.com/journals/criopm/2016/8740264/abs/
*  ReCOVER trial | The Green Lab
A Randomized, Double-Blind, Parallel-Group, Placebo Controlled Trial to Assess the Efficacy, Safety, Tolerability, and Pharmacokinetics of Clemastine Fumarate as a Remyelinating Agent in Acute Optic Neuritis. This Phase II clinical trial will assess the efficacy, safety, and tolerability of an identified compound in the promotion of remyelination in patients experiencing acute optic neuritis. This investigational drug was approved for the treatment of allergic rhinitis by the Food and Drug Administration (FDA) in 1977. Since then, the medication has been identified at UCSF as a compound that potentially enhances oligodendrocyte differentiation and remyelination. However, it is not approved as a therapy for optic neuritis.. Study participants will be asked to come to the UCSF Multiple Sclerosis Center at least 5 times over approximately 9 months. Participation will include an initial screening visit to ...
http://greenlab.ucsf.edu/recover-trial
*  Multiple Sclerosis Research: The eye as a predictor of brain activity
METHODS: In this multicentre, cohort study, we collected data about patients (age ≥16 years old) with clinically isolated syndrome, relapsing-remitting multiple sclerosis, and progressive multiple sclerosis. Patients were recruited from centres in Spain, Italy, France, Germany, Czech Republic, Netherlands, Canada, and the USA, with the first cohort starting in 2008 and the latest cohort starting in 2013. We assessed disability worsening using the Expanded Disability Status Scale (EDSS). The pRNFL thickness and macular volume were assessed once at study entry (baseline) by optical coherence tomography (OCT) and was calculated as the mean value of both eyes without optic neuritis for patients without a history of optic neuritis or the value of the non-optic neuritis eye for patients with previous unilateral optic neuritis. Researchers who did the OCT at ...
http://multiple-sclerosis-research.blogspot.com/2016/03/the-eye-as-predictor-of-brain-activity.html
*  Optic Neuritis Recovery After Oral or IV Corticosteroids - Full Text View - ClinicalTrials.gov
Patients aged 18-65 with acute demyelinating optic neuritis where treatment with high dose corticosteroids are already been chosen by the patient and the diagnosing physician will be contacted for screening and enrollment. Patients will then be randomized to receive equivalent doses of either intravenous (IV) or oral corticosteroid treatment. Optic nerve function assessments will be compared at baseline, prior to treatment, one and six months post corticosteroid treatment. This will allow for a comparison on whether the route of medication plays a role in the effectiveness of treatment with high dose corticosteroids ...
https://clinicaltrials.gov/ct2/show/NCT01524250
*  Early pericalcarine atrophy in acute optic neuritis is associated with conversion to multiple sclerosis | Journal of Neurology,...
Funding Part of this work was undertaken at UCLH/UCL which received a proportion of funding from the Department of Health's NIHR Biomedical Research Centres Funding Scheme. ATT is supported by the Higher Education Funding Council for England. OC is a Wellcome Trust Advanced Clinical Research Fellow. The MS Society of Great Britain and Northern Ireland provided a charity research grant which was used to fund this study (TMJ, grant 815/04). NMR Unit also supported the study, including a recent programme grant which funded a new scanner. ...
http://jnnp.bmj.com/content/early/2011/02/04/jnnp.2010.239715
*  Repositorio da Producao Cientifica e Intelectual da Unicamp: Visual Pathway Abnormalities Were Found In Most Multiple Sclerosis...
It was to investigate visual field (VF) abnormalities in a group of multiple sclerosis (MS) patients in the remission phase and the presence of magnetic resonance imaging (MRI) lesions in the optic radiations. VF was assessed in 60 participants (age range 20-51 years): 35 relapsing-remitting MS patients [20 optic neuritis (+), 15 optic neuritis (-)] and 25 controls. MRI (3-Tesla) was obtained in all patients. Visual parameters were abnormal in MS patients as compared to controls. The majority of VF defects were diffuse. All patients except one had posterior visual pathways lesions. No significant difference in lesion number, length and distribution was noted between patients with and without history of optic neuritis. One patient presented homonymous hemianopsia. Posterior visual pathway abnormalities were found in most MS patients despite history of previous optic ...
http://repositorio.unicamp.br/jspui/handle/REPOSIP/200732
*  Epilepsy Drug May Preserve Eyesight for People with MS - Healthcanal.com : Healthcanal.com
About half of people with MS experience at some point in their life a condition called acute optic neuritis, in which the nerve carrying vision from the eye to the brain gets inflamed," said study author Raj Kapoor, MD, with the National Hospital for Neurology and Neurosurgery in London, England. "The condition can cause sudden total or partial blindness, foggy or blackened vision and pain. Even though eyesight can recover eventually, each attack still damages the nerve and the eye.". For the study, the researchers randomly selected 86 people with acute optic neuritis within two weeks of having symptoms to receive either the epilepsy drug phenytoin or a placebo for three months. The researchers then used medical imaging to measure the thickness of the retina, the light sensitive nerve layer at the back of the eye at the beginning of the study and then six months later. Each patient's eyesight (including sharpness and color perception) was ...
https://www.healthcanal.com/eyes-vision/62463-epilepsy-drug-may-preserve-eyesight-for-people-with-ms.html
*  Simvastatin Treatment of Patients With Acute Optic Neuritis - No Study Results Posted - ClinicalTrials.gov
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... ...
https://clinicaltrials.gov/ct2/show/results/NCT00261326