Receptor Tyrosine Protein Kinase ERBB 4 (Tyrosine Kinase Type Cell Surface Receptor HER4 or Proto Oncogene Like Protein c ErbB...
Tyrosine Kinase Type Cell Surface Receptor HER4 or Proto Oncogene Like Protein c ErbB 4 or p180erbB4 or HER4 or ERBB4 or EC 2.7 ... Global Markets Direct's, 'Receptor Tyrosine Protein Kinase ERBB 4 (... ... 111 Pages Report] Check for Discount on Receptor Tyrosine Protein Kinase ERBB 4 ( ... Receptor Tyrosine Protein Kinase ERBB 4 (Tyrosine Kinase Type Cell Surface Receptor HER4 or Proto Oncogene Like Protein c ErbB ...http://www.reportsnreports.com/reports/628278-receptor-tyrosine-protein-kinase-erbb-4-tyrosine-kinase-type-cell-surface-receptor-her4-or-proto-oncogene-like-protein-c-erbb-4-or-p180erbb4-or-her4-or-erbb4-or-ec-27101-pipeline-review-h1-2016.html
Epistatic and functional interactions of catechol-o-methyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell...
... functional interactions between COMT and AKT1 and may provide novel insights into pathogenesis of schizophrenia and other ErbB- ... ErbB signaling has been implicated in the pathogenesis of cancer and schizophrenia. We have previously reported that NRG1- ... Protein Transport, Proto-Oncogene Proteins c-akt, Receptor, Epidermal Growth Factor, Signal Transduction, Transfection ... BACKGROUND: Neuregulin1 (NRG1)-ErbB signaling has been implicated in the pathogenesis of cancer and schizophrenia. We have ...https://www.psych.ox.ac.uk/publications/139577
MYC | SelfDecode | Genome Analysis
hypothetical protein, transcription factor protein, A306_09622, anon-WO03040301.171, avian myelocytomatosis viral oncogene ... class E basic helix-loop-helix protein 39, cmyc, c-MYC, c-myc20, c-Myc-a, c-Myc-b, c-myc-like protein, c-myc proto-oncogene, ... v-myc myelocytomatosis viral oncogene-like protein, v-myc myelocytomatosis viral oncoprotein-like protein, Xcmyc, X-cmyc, Y1Q_ ... myc proto-oncogene protein, myc-related translation/localization regulatory factor, myelocytomatosis oncogene, myelocytomatosis ...https://www.selfdecode.com/gene/myc/
Staff List - NUI Galway
Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer. Switzer, CH,Glynn ... "An investigation of the role of the ErbB receptor family in chemotherapeutic drug resistance and invasion in human breast ... Oncogene, 32 (35):4139-4147 [Details] ... Nitric oxide and protein phosphatase 2A provide novel ... Switzer, C.H., Glynn, S.A., Ridnour, L.A., Cheng, R.Y.-S., Vitek, M.P., Ambs, S., Wink, D.A. (2011) 'Nitric oxide and protein ...http://www.nuigalway.ie/medicine-nursing-and-health-sciences/medicine/disciplines/medicine/stafflist/sharonglynn/
Komuro, A., Nagai, M., Navin, N. E. and Sudol, M. (2003). WW domain-containing protein YAP associates with ErbB-4 and acts as a ... is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product, Oncogene 9: 2145-2152. 8035999 ... Protein-protein interactions among these factors have been documented in vitro and/or in vivo, leading to the proposal that two ... 2005). WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional ...http://www.sdbonline.org/sites/fly/polycomb/yorkie4.htm
KAKEN - Research Projects | Study of mechanisms of development and growth in hormone (especially estrogen) dependent uterine...
Preliminary study of oncogene expressions in endometrial cancers-aberrant estrogen receptor gene and erbB-2-' Eur J Gynecol. ( ... Publications] Fujimoto J,et al.: 'Estrogen induces expression of c-fos and c-jun via activation of protein kinase C in an ... Publications] Fujimoto J,et al.: 'Estrogen Induces Expression of c-fos and c-jun via Activation of Protein Kinase C in an ... Publications] Fujimoto J.,et al.: 'Estrogen induces expression of c-fos and c-jun via activation of protein kinase C in an ...https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06671638/
Lung cancer - Unionpedia, the concept map
Receptor tyrosine-protein kinase erbB-2, also known as CD340 (cluster of differentiation 340), proto-oncogene Neu, Erbb2 ( ... Protein kinase B. Protein kinase B (PKB), also known as Akt, is a serine/threonine-specific protein kinase that plays a key ... Programmed cell death protein 1, Prophylactic cranial irradiation, Protein, Protein kinase B, Pulmonary function testing, ... The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members ...https://en.unionpedia.org/Lung_cancer
Molecular network profiling of U373MG human glioblastoma cells following induction of apoptosis by novel marine-derived anti...
... alternatively named protein tyrosine kinase 2 (PTK2), v-akt murine thymoma viral oncogene homolog (AKT)/protein kinase B (PKB ... We identified the ErbB (EGFR) signaling pathway as one of the common pathways enriched in the set of downregulated genes, ... Louis, MO, USA). The protein extract was centrifuged at 12,000 rpm for 5 min at room temperature (RT). The protein ... heat shock protein HSP60, an internal control of protein loading. The lanes (1-16) represent the cells (1, 7) untreated or ...https://cancerci.biomedcentral.com/articles/10.1186/1475-2867-12-14
IJMS | Free Full-Text | Aptamers and Their Potential to Selectively Target Aspects of EGF, Wnt/β-Catenin and TGFβ-Smad Family...
We propose that peptide aptamers can provide a very useful and new alternative for interfering with protein-protein ... their high specificity and affinity for individual target proteins, and their use in high-throughput screening protocols. ... cytoplasmic and nuclear effector proteins, remain important challenges in biomedical research. ... binding a larger set of phospho-Tyr binding proteins than the other ErbB receptors, and its over-activity directly correlates ...http://mdpi.com/1422-0067/14/4/6690/htm
Prof Richard Epstein | Garvan Institute of Medical Research
... where he patented a technique for creating antibodies that detect different activation states of cancer proteins. ... Synthetic phosphopeptide immunogens yield activation-specific antibodies to the c-erbB-2 receptor. Proc Natl Acad Sci U S A. ... Proxy activation of protein ErbB2 by heterologous ligands implies a heterotetrameric mode of receptor tyrosine kinase ... Oncogene. 2002; 21(32):4921-31 ... that detect different activation states of cancer proteins.. He ...https://www.garvan.org.au/people/riceps
1984 The erbB oncogene product is discovered to be a truncated version of a protein (the epidermal growth factor receptor) that ... This discovery showed how a mutation in an oncogene can disrupt the normal function of the protein product. (The mutated ErbB ... 1983 The sis oncogene product is found to be a mutant form of a known protein, the platelet-derived growth factor (PDGF). This ... This was the first clue to the function of an oncogene. Although the exact function of the src protein was not known, this ...http://kwing.christiansonnet.org/news-scrap/science_medical-advances.htm
Correlation of WWOX, RUNX2 and VEGFA protein expression in human osteosarcoma | BMC Medical Genomics | Full Text
Protein expression of WWOX, RUNX2 and VEGFA were examined in 54 FFPE OS samples by immunohistochemistry (IHC). Analysis of ... Compared with positive expression of WWOX in 38.9% of the OS samples, positive expression of RUNX2 and VEGFA protein was found ... Our data show increased RUNX2 and VEGFA gene copy numbers and elevation of their respective proteins in human OS. Positive ... Although there was no significant association between gene copy number aberration and protein expression for WWOX and RUNX2, ...https://bmcmedgenomics.biomedcentral.com/articles/10.1186/1755-8794-6-56
Apoptosis and survival Role of CDK5 in neuronal death and survival
... v-raf-1 murine leukemia viral oncogene homolog 1 ( c-Raf-1 )/ Mitogen-activated protein kinase kinase 1 ( MEK1 )/ Mitogen ... ErbB ). In this case, Neuregulin-1- stimulated ErbB2 and ErbB3 are activated by CDK5R1(p35)/ CDK5 phosphorylation in their ... It is possible, that signal from damaged DNA is transited via Protein kinase C, delta ( PKC-delta )/ Shc/ Sos/ H-Ras/ c-Raf-1/ ... Then CDK5R1(p35)/ CDK5 phosphorylates p53 tumor suppressor, which activates transcription of BCL2-associated X protein ( BAX ) ...http://pathwaymaps.com/maps/2374/
Genetic and Biochemical Alterations in Non-Small Cell Lung Cancer
These mutant accumulated proteins are retained in distant metastasis and also shown to be capable of cooperating with oncogenes ... M. A. Olayioye, D. Graus-Porta, R. R. Beerli, J. Rohrer, B. Gay, and N. E. Hynes, "ErbB-1 and ErbB-2 acquire distinct signaling ... Nearly a decade after the discovery of RAS as a human oncogene, the first critical effector protein was identified-RAF-1 serine ... D. Graus-Porta, R. R. Beerli, J. M. Daly, and N. E. Hynes, "ErbB-2, the preferred heterodimerization partner of all ErbB ...https://www.hindawi.com/journals/bri/2012/940405/
EGFR-dependent migration of glial cells is mediated by reorganisation of N-cadherin | Journal of Cell Science
Messerle, K., Schlegel, J., Hynes, N. E. and Groner, B. (1994). NIH/3T3 cells transformed with the activated erbB-2 oncogene ... Dietzmann, K. and von Bossanyi, P. (1994). Coexpression of epidermal growth factor receptor protein and c-erbB-2 oncoprotein in ... The Akt/protein kinase B-dependent anti-apoptotic pathway and the mitogen-activated protein kinase cascade are alternatively ... Holbro, T., Civenni, G. and Hynes, N. E. (2003). The ErbB receptors and their role in cancer progression. Exp. Cell Res. 284, ...http://jcs.biologists.org/content/121/24/4089
Publications - FeiginLab
Dysregulation of cell polarity proteins synergize with oncogenes or the microenvironment to induce invasive behavior in ... ErbB receptors and cell polarity: New pathways and paradigms forunderstanding cell migration and invasion (Review). Exp Cell ... p38 mitogen activated protein kinase regulates canonical Wnt/β-catenin signaling by inactivation of GSK3β. J Cell Sci. 121(21 ... Polarity proteins regulate mammalian cell-cell junctions and cancer pathogenesis (Review). Curr Opin Cell Bio. 21(5), 694-700, ...https://www.feiginlab.org/publications/
ERBB3 Antibody 10369-1-AP | Proteintech
V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (ErbB-3, HER3) is a member of the EGF receptor tyrosine kinase family ... ERBB3 fusion protein Ag0215 Full name: v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) ... ErbB-3 binds and is activated by neuregulins and NTAK. It forms a heterodimer with each of the other ErbB receptors. ErbB-3 is ... c erbB 3, c erbB3, ErbB 3, ERBB3, erbB3 S, HER3, LCCS2, MDA BF 1, p180 ErbB3, p45 sErbB3, p85 sErbB3 ...https://www.ptglab.com/Products/ERBB3-Antibody-10369-1-AP.htm
DiVA - Search result
Surface EPO-R protein was not detected. Intracellular EPO-R staining with anti-EPO-R antibodies was unspecific. No tumor- ... ErbB ligands are suggested to mediate the effects of TAZ on lung cancer progression. Our findings emphasize the tumorigenic ... Purpose: TAZ, also known as WWTR1, has recently been suggested as an oncogene in non-small cell lung cancer (n =SCLC). We ... Protein and RNA levels were examined in paraffin embedded tissue of 330 breast cancer patients. The cell types were identified ...http://uu.diva-portal.org/smash/resultList.jsf?af=%5B%5D&aq=%5B%5B%7B%22journalId%22%3A%229290%22%7D%5D%5D&aqe=%5B%5D&aq2=%5B%5B%5D%5D&language=en&query=
A phase I open-label dose-escalation study of the anti-HER3 monoclonal antibody LJM716 in patients with advanced squamous cell...
The receptor tyrosine-protein kinase (RTK) of the v-erb-b2 erythroblastic leukemia viral oncogene homolog (ErbB) receptor ... Footnote: ERRB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3, ESCC esophageal squamous cell carcinoma, NRG1 ... The HER3 protein lacks significant kinase activity and is activated through heterodimerization with other RTKs such as ... tyrosine kinase family, ErbB-3 or human epidermal growth factor receptor 3 (HER3), is implicated in tumor growth, proliferation ...https://0-bmccancer-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/s12885-017-3641-6
SMART: ETS domain annotation
The v-ets oncogene was originally discovered as part of a fusion protein expressed by a transforming retrovirus (avian E26), ... ErbB signaling pathway. 7.32. map05213. Endometrial cancer. 7.32. map04912. GnRH signaling pathway. ... About 30 related proteins have now been found in species ranging from flies to humans, that resemble the vEts protein in the so ... Click on the protein counts, or double click on taxonomic names to display all proteins containing ETS domain in the selected ...http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00413
Oncogene - Biological reprogramming in acquired resistance to endocrine therapy of breast cancer
It is published weekly and covers all aspects of the structure and function of Oncogenes. ... Oncogene is one of the world's leading cancer journals. ... ERBB/AKT and a switch from phospho-Ser118 (pS118)- to pS167-ERα ... 2005). Pocket protein complexes are recruited to distinct targets in quiescent and proliferating cells. Mol Cell Biol 25: 8166- ... Oncogene 23: 8743-8755. , Article , PubMed , ISI , ChemPort ,. *. Brown LA, Hoog J, Chin SF, Tao Y, Zayed AA, Chin K et al. ( ...http://www.nature.com/onc/journal/v29/n45/full/onc2010333a.html?foxtrotcallback=true&error=cookies_not_supported&code=4e4de2b9-362c-43f6-b1eb-2244ff9569fc
Screening for Anti‐cancer Drugs in Drosophila
2004) Expression of leukemic MLL fusion proteins in Drosophila affects cell cycle control and chromosome morphology. Oncogene ... 2003) Genetic identification of effectors downstream of Neu (ErbB‐2) autophosphorylation sites in a Drosophila model. Oncogene ... Oncogene 29: 313-324.. Denton JE, Lui MS, Aoki T, Sebolt J and Weber G (1982) Rapid in vivo inactivation by acivicin of CTP ... Oncogene 20: 6871-6880.. Bier E (2005) Drosophila, the golden bug, emerges as a tool for human genetics. Nature Reviews ...http://www.els.net/WileyCDA/ElsArticle/refId-a0022535.html
2016-2020 Canada Cancer Diagnostics Market: Emerging Cancer Diagnostics, Oncogenes, Biochemical Markers, Lymphokines, GFs, CSFs...
535 Pages Report] Check for Discount on 2016-2020 Canada Cancer Diagnostics Market: Emerging Cancer Diagnostics, Oncogenes, ... Oncogenes. - Abl/abl-bcr. - AIB1. - BCL-2. - BRCA1. - CD44. - C-fos. - C-myb. - C-myc. - CYP-17. - Erb-B. - HPC1. - N-myc. - ... S-100 Protein Test Volume and Diagnostics Sales Forecast. Serotonin Test Volume and Diagnostics Sales Forecast. Sialic Acid ... Oncogenes Potential Applications in Cancer Diagnosis. Major Companies Developing or Marketing Oncogene Tests. Growth Factors ...http://www.reportsnreports.com/reports/540625-2016-2020-canada-cancer-diagnostics-market-emerging-cancer-diagnostics-oncogenes-biochemical-markers-lymphokines-gfs-csfs-hormones-immunohistochemical-stains-test-volume-and-sales-forecasts-competitive-strategies-opportunities-for.html
Protoanemonin | definition of protoanemonin by Medical dictionary
Proto-oncogene-like protein c-ErbB-3. *Proto-oncogene-like protein c-ErbB-4 ... proto-oncogene tyrosine-protein kinase receptor Ret. *proto-oncogene tyrosine-protein kinase receptor Ret ... proto-oncogene tyrosine-protein kinase receptor Ret. *proto-oncogene tyrosine-protein kinase receptor Ret ... proto-oncogene tyrosine-protein kinase ABL1. *proto-oncogene tyrosine-protein kinase LCK ...http://medical-dictionary.thefreedictionary.com/protoanemonin
C erba proto oncogene Dictionary Definition and More from Dictionary.net
previousC erba proteins next C erba proto oncogenes C erba proto oncogene. ... erbB gene and eliminates growth requirements of transformed erythroblasts. ... oncogenes have been identified, erbA- alpha and erbA- beta, each giving rise to at least two proteins. erbA- alpha is located ... The c- erbA proto- oncogene encodes the thyroid hormone receptors ( RECEPTORS, THYROID HORMONE). Two distinct c- erbA proto- ...http://www.dictionary.net/c%20erba%20proto%20oncogene