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*  ABL1(Q252H)-phosphorylated
ABL; Abelson tyrosine-protein kinase 1; JTK7; bcr/abl; bcr/c-abl oncogene protein; c-ABL; c-abl oncogene 1, non-receptor ... proto-oncogene c-Abl; proto-oncogene tyrosine-protein kinase ABL1; tyrosine-protein kinase ABL1; v-abl; v-abl Abelson murine ... Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene ... c-abl oncogene 1, receptor tyrosine kinase (ABL1(Q252H)-phosphorylated). Target Class. Kinase. Family. TK. Official Symbol. ...
https://www.discoverx.com/target-data-sheets/kinase/abl1
*  Corneal angiogenesis assay of wt and c-abl-deficient | Open-i
Corneal angiogenesis assay of wt and c-abl-deficient mice. VEGF-saturated or PBS sham Hydron pellets were implanted in corneas ... Proto-Oncogene Proteins c-abl/genetics/physiology*. *Retinopathy of Prematurity/etiology*/metabolism/pathology ... These observations demonstrate that c-abl activity is not required for VEGF-induced signal transduction and that the c-abl−/− ... These observations demonstrate that c-abl activity is not required for VEGF-induced signal transduction and that the c-abl−/− ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2193304_JEM001496.f5&req=4
*  RCSB PDB - 1IEP: CRYSTAL STRUCTURE OF THE C-ABL KINASE DOMAIN IN COMPLEX WITH STI-571. Macromolecule Annotations Page
Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571) ... PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL (1IEP:A,B) * Protein Kinase Activity ... Protein kinase-like (PK-like) Protein kinase-like (PK-like) Protein kinases, catalytic subunit Abelsone tyrosine kinase (abl) ... Protein kinase-like (PK-like) Protein kinase-like (PK-like) Protein kinases, catalytic subunit Abelsone tyrosine kinase (abl) ...
http://www.rcsb.org/pdb/explore/derivedData.do?structureId=1IEP&bionumber=1
*  ABL Exon 6 Primer Set (A) - FemtoPath | HongJing弘晉
ABL; ABL1; JTK7; Proto-oncogene tyrosine-protein kinase ABL1; c-ABL; p150; c-abl oncogene 1, non-receptor tyrosine kinase ... ABL. BCR/ABL1 Dual Color Dual Fusion FISH ProbeABL Mutation Screen KitABL Exon 4 Primer Set (A)ABL Exon 4 Primer Set (B)ABL ... ABL Exon 6 Primer Set (A). The ABL proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been ... ABL exon 6 primer set have the function to enrich mutation type of ABL gene and allows to detect target codons T315 on DNA ...
http://femtopath.com/product/abl-exon-6-primer-set/
*  CRKL - Wikipedia
"The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins". Leukemia. 11 (3): 376-85 ... "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene". ... "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene". ... "The SH2-containing adapter protein GRB10 interacts with BCR-ABL". Oncogene. 17 (8): 941-8. doi:10.1038/sj.onc.1202024. PMID ...
https://en.wikipedia.org/wiki/CRKL
*  STRUCTURE AND DYNAMIC REGULATION OF ABL KINASES* - PDF
Published on January 11, 2013 as Manuscript R The latest version is at STRUCTURE AND DYNAMIC REGULATION OF ABL KINASES* ... hydrogen exchange mass spectrometry SUMMARY The c-abl proto-oncogene encodes a unique protein-tyrosine kinase (Abl) distinct ... Lecture 20: Protein-Protein Interaction Lecture 20: Protein-Protein Interaction Proteins are responsible for several functions ... Lecture 2. Protein conformation. Proteins. 8 types of protein function 10/21/10. Proteins.. > 50% dry weight of a cell Lecture ...
http://docplayer.net/425346-Structure-and-dynamic-regulation-of-abl-kinases.html
*  Abl - Tyrosine-protein kinase Abl - Drosophila melanogaster (Fruit fly) - Abl gene & protein
Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis; critical for embryonic ... interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both Slit/robo and Abl- ... "DNA sequence, structure, and tyrosine kinase activity of the Drosophila melanogaster Abelson proto-oncogene homolog.". ... View protein in PROSITE. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 ...
http://www.uniprot.org/uniprot/P00522
*  Ponatinib - DrugBank
Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the ... Details4. Proto-oncogene tyrosine-protein kinase receptor Ret. Kind. Protein. Organism. Human. Pharmacological action. Unknown ... This protein arises from the fused Bcr and Abl gene- what is commonly known as the Philadelphia chromosome. Ponatinib is unique ... Protein binding. , 99% bound to plasma proteins. Metabolism. At least 64% of a ponatinib dose undergoes phase I and phase II ...
https://www.drugbank.ca/drugs/DB08901
*  The c-Abl-MST1 Signaling Pathway Mediates Oxidative Stress-Induced Neuronal Cell Death | Journal of Neuroscience
1B, inset). We next used c-Abl RNAi in primary culture of neurons to knock down endogenous c-Abl protein, and found that c-Abl ... c-Abl stabilized the protein level of WT-MST1 but not that of Y433F-MST1. D, Neuro2A cells were transfected with c-Abl RNAi or ... c-Abl-mediated phosphorylation stabilizes MST1 protein. A, Neuro2A cells were transfected with c-Abl RNAi or control vector. At ... c-Abl-mediated phosphorylation of MST1 stabilizes its protein level. Interestingly, we observed that the MST1 protein level was ...
http://www.jneurosci.org/content/31/26/9611
*  How to trace exon number in genome sequence? - Molecular Biology - BioForum
I am working on a fusion oncogene (BCR-ABL) causing blood cancer. The problem is that I dont exactly know the product size of ... my pcr product (amplifying the fusion-oncogene). I know the exons of both genes involved (e13 & 14 of BCR) and (a2 of ABL1) in ... Presuming that you are looking for the p210bcr-abl fusion protein and that you are looking for the full lenght, you will have a ... I am working on a fusion oncogene (BCR-ABL) causing blood cancer. The problem is that I don't exactly know the product size of ...
http://www.protocol-online.org/forums/topic/24767-how-to-trace-exon-number-in-genome-sequence/
*  ALK in lung cancer: Past, present, and future - ppt download
ALK 40-60 5-8X ROS 60 7X RON 80 10X Axl 294 34X 322 37X Tie-2 448 52X Trk A 580 67X Trk B 399 46X Abl 1,159 166X IRK 2,887 334X ... Glioblastoma ALK protein expression Growth factor PTN protein, mRNA expression - Murugan et al., Cancer Res 2011; 71:4403-4411 ... 9 Evidence for EML4-ALK as a Lung Cancer Oncogene. Insertion of EML4-ALK into NIH 3T3 fibroblasts was tumorigenic when ... like T790M in EGFR and T315I in BCR-ABL) Alternative signaling pathways (bypass tracks) can be activated in resistant cells, ...
http://slideplayer.com/slide/4315316/
*  adult acute non lymphocytic leukemia in remission 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Oncogene Proteins v-abl / antagonists & inhibitors. Proto-Oncogene Proteins c-bcr / antagonists & inhibitors ... Oncogene Proteins v-abl; EC 2.7.11.1 / Proto-Oncogene Proteins c-bcr ... DNA-Binding Proteins; 0 / Nuclear Proteins; 0 / Tumor Suppressor Proteins; 0 / tumor suppressor protein p73 ... Tumor Suppressor Protein p53 / antagonists & inhibitors. Tumor Suppressor Protein p53 / genetics. Tumor Suppressor Protein p53 ...
http://www.bmlsearch.com/?kwr=adult+acute+non+lymphocytic+leukemia+in+remission+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
*  SH2 protein microarray assays of HA4 specificity(a) Flu | Open-i
SH2 protein microarray assays of HA4 specificity(a) Fluorescence images of SH2 chips following incubation with fluorophore- ... Abl) kinase SH2 domain with low nanomolar affinity. SH2 protein microarray analysis and MS of intracellular HA4 interactors ... Abl) kinase SH2 domain with low nanomolar affinity. SH2 protein microarray analysis and MS of intracellular HA4 interactors ... Because the Abl and Abl2 SH2 domains share ,90% sequence identity, this cross reactivity was expected. At higher concentrations ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2926940_nihms223170f2&req=4
*  2G1T: A Src-Like Inactive Conformation In The Abl Tyrosine Kinase Domain
ATP-PEPTIDE CONJUGATEPROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1Magnesium IonThiophosphoric Acid O-((Adenosyl-Phospho)phospho)- ... Proteins (2 molecules). A. 1. Proto-oncogene Tyrosine-protein Kinase Abl1(Gene symbol: ABL1) ... 2G1T: A Src-Like Inactive Conformation In The Abl Tyrosine Kinase Domain. ...
https://www.ncbi.nlm.nih.gov/Structure/pdb/2G1T
*  Buy Sheep ELISA Kits | Sheep ELISA Kits
Sheep Oncogene protein p190/bcr-abl ELISA Kit. Sheep Oncogene protein p190/bcr-abl 96T. $495. Add to Cart ... Re-engineering Insoluble Proteins. Insoluble Proteins Become Soluble. Little Change in pI, MW; Keep the Same Structure. ...
https://neobiolab.com/index.php?m=Product&a=index&id=392&alphabetical=O&s1=
*  List of MeSH codes (D12.776) - Wikipedia
... oncogene protein v-maf MeSH D12.776.964.700.750.875 - oncogene proteins v-abl MeSH D12.776.964.700.750.882 - oncogene proteins ... oncogene protein v-maf MeSH D12.776.964.775.750.875 - oncogene proteins v-abl MeSH D12.776.964.775.750.882 - oncogene proteins ... oncogene protein v-maf MeSH D12.776.624.664.520.750.875 - oncogene proteins v-abl MeSH D12.776.624.664.520.750.882 - oncogene ... oncogene proteins v-fos MeSH D12.776.964.700.750.900 - oncogene proteins v-mos MeSH D12.776.964.700.750.903 - oncogene proteins ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776)
*  CRK CRK proto-oncogene, adaptor protein [Homo sapiens (human)] - Gene - NCBI
Reciprocal regulation of Abl kinase by Crk Y251 and Abi1 controls invasive phenotypes in glioblastoma. Kumar S, et al. ... proto-oncogene c-Crk. v-crk avian sarcoma virus CT10 oncogene homolog. v-crk sarcoma virus CT10 oncogene-like protein. ... CRK CRK proto-oncogene, adaptor protein [Homo sapiens] CRK CRK proto-oncogene, adaptor protein [Homo sapiens]. Gene ID:1398 ... CRK proto-oncogene, adaptor proteinprovided by HGNC. Primary source. HGNC:HGNC:2362 See related. Ensembl:ENSG00000167193 MIM: ...
https://www.ncbi.nlm.nih.gov/gene/1398
*  Proto-oncogene tyrosine-protein kinase Src - Wikipedia
Musumeci F, Schenone S, Brullo C, Botta M (April 2012). "An update on dual Src/Abl inhibitors". Future Med Chem. 4 (6): 799-822 ... Proto-oncogene tyrosine-protein kinase Src, also known as proto-oncogene c-Src or simply c-Src , is a non-receptor tyrosine ... This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this ... This protein phosphorylates specific tyrosine residues in other proteins. An elevated level of activity of c-Src tyrosine ...
https://en.wikipedia.org/wiki/Proto-oncogene_tyrosine-protein_kinase_Src
*  anti-ABL1 antibody | Rabbit anti-Mouse Abl1 Polyclonal Antibody-AAA88012.1
tyrosine-protein kinase ABL1; proto-oncogene c-Abl; bcr/c-abl oncogene protein; Abelson tyrosine-protein kinase 1; c-abl ... ABL; JTK7; p150; c-ABL; v-abl; bcr/abl. [Similar Products] NCBI Protein Information ... UniProt Protein Name Tyrosine-protein kinase ABL1 UniProt Synonym Protein Names Abelson murine leukemia viral oncogene homolog ... Abl1, ID (Abl1, Abl, Tyrosine-protein kinase ABL1, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein ...
https://www.mybiosource.com/prods/Antibody/Polyclonal/Abl1/datasheet.php?products_id=6005021
*  anti-ABL1 antibody | Rabbit ABL1 (Phospho-Thr735) Antibody-NP 005148.2
tyrosine-protein kinase ABL1; proto-oncogene c-Abl; bcr/c-abl oncogene protein; Abelson tyrosine-protein kinase 1; c-abl ... Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Proto-oncogene c-Abl; p150 ... oncogene 1, receptor tyrosine kinase; proto-oncogene tyrosine-protein kinase ABL1; v-abl Abelson murine leukemia viral oncogene ... Protein type: Kinase, protein; Oncoprotein; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; TK group ...
https://www.mybiosource.com/abl1-human-mouse-rat-antibody/abl1-phospho-thr735/1897
*  VII - Topnotch Pharma Flash Cards - Chemotherapeutic Drugs Flashcards by | Brainscape
Tyrosine kinase inhibitor of the protein product of bcr-abl oncogene in CML ; For CML, GIST ... cleaves precursor polyprotein to form the final structural protein of the mature virion core, inhibits viral protein processing ... Inhibits neuraminidase which cleaves sialic acid residues from viral proteins and surface proteins of infected cells , decrease ... recognizes a surface protein in breast CA cells that overexpress Her-2-Neu receptors for epidermal growth factor ...
https://www.brainscape.com/flashcards/vii-topnotch-pharma-flash-cards-chemother-4055787/packs/6005684
*  Scientists Use Abnormal DNA Repair to Selectively Target Cancer Cells - - UNM Comprehensive Cancer Center - UNM Comprehensive...
Tomkinson explains, "Chronic myeloid leukemia is driven by an oncogene called BCR-ABL. We wanted a form of cancer where we knew ... a chemotherapy drug called Gleevec targets the protein this oncogene produces. But the cancer can become resistant to Gleevec. ... Tomkinson is an expert in DNA ligases, one of the proteins a cell uses to repair its DNA. He and the team recently published a ... While every cell has the ability to repair its own DNA-the cell must repair DNA prior to dividing or making proteins-the ...
http://cancer.unm.edu/newsroom/scientists-use-abnormal-dna-repair-to-selectively-target-cancer-cells/
*  øc-Abl ?? hz-8440R / ۸ - ?? ???? ??????? ?? øc-Abl ?? HZbscience- ?? ??ʵҵ???? ˾-???????? Lab-on-Web
Abl 1; ABL; Abl protein; Abl1; Bcr/c abl oncogene protein; JTK 7; JTK7; p150 ; Proto oncogene tyrosine protein kinase ABL1; ... Transformation gene oncogene ABL; v abl Abelson murine leukemia viral oncogene homolog 1; v abl; ABL1_HUMAN. ... Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily. Contains 1 protein kinase domain. Contains ... Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene ...
http://www.bioon.com.cn/antibody/Show_product.asp?id=3458099
*  "Senescence induction in human fibroblasts and hematopoietic progenitor" by Narendra Wajapeyee, Shu-Zong Wang et al.
Here we show that 3 leukemogenic fusion proteins, BCR-ABL, CBFB-MYH11, and RUNX1-ETO, can induce senescence in primary ... Previous studies have shown that certain oncogenes that promote solid tumors, such as RAS and BRAF, can induce senescence in ... All 3 fusion proteins activate the p38 MAPK pathway, which is required for senescence induction. Our results reveal diverse ... In these cases, the activated oncogene elicits a DNA damage response (DDR), which is essential for the senescence program. ...
http://escholarship.umassmed.edu/gsbs_sp/1649/
*  PPT - Cancer Development and Causes of Cancer Tumor Viruses Oncogenes/Tumor Suppressor Genes Molecular Approaches to Cancer...
Oncogenes in Human Cancer*The abl proto-oncogene encodes a protein-tyrosine kinase and is activated by chromosome translocation ... Ras is a Frequently mutated Proto-oncogene. 25. Functions of Oncogene Products*The function of oncogene proteins in regulation ... converted into oncogenes. *Oncogenes frequently encode proteins that differ in structure and function from those encoded by ... receptors, most of which are protein-tyrosine kinases.. 26. Functions of Oncogene Products*The failure of cancer cells to ...
https://www.powershow.com/view2a/419081-ZjI1N/Cancer_Development_and_Causes_of_Cancer_Tumor_Viruses_Oncogenes_Tumor_Suppressor_Genes_Molecular_Approaches_to_Cancer_Treatment_powerpoint_ppt_presentation