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*  anti-CrkL antibody | GeneTex
... v-crk avian sarcoma virus CT10 oncogene homolog-like) for IHC-P, WB. Anti-CrkL pAb (GTX32539) is tested in Human, Mouse, Rat ... v-crk avian sarcoma virus CT10 oncogene homolog-like. Background. This gene encodes a protein kinase containing SH2 and SH3 ( ... Primary Antibodies Secondary Antibodies Proteins & Peptides Lysates & Slides Serum & Reagents Research Kits Isotype Controls ... CRKL Antibody , v-crk avian sarcoma virus CT10 oncogene homolog-like Antibody. ...
http://www.genetex.com/CrkL-antibody-GTX32539.html
*  EGFR ligands differentially affect EGFR endocytosis and | Open-i
Lysosomal-Associated Membrane Protein 1/metabolism. *Phosphorylation. *Proto-Oncogene Proteins c-cbl/metabolism ... The Cbl ubiquitin ligases, especially c-Cbl, are responsible for EGFR ubiquitination after stimulation with all ligands, and ... The Cbl ubiquitin ligases, especially c-Cbl, are responsible for EGFR ubiquitination after stimulation with all ligands, and ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2723868_tra0010-1115-f1&req=4
*  ZFIN Publication: Peng et al., 2015
Protein Structure, Tertiary; Proto-Oncogene Proteins c-cbl/chemistry; Proto-Oncogene Proteins c-cbl/genetics*; Zebrafish ... The causal mutation was located by positional cloning in the c-cbl gene, of which the human ortholog, c-CBL, is found ... A point mutation of zebrafish c-cbl gene in the ring finger domain produces a phenotype mimicking human myeloproliferative ... A point mutation of zebrafish c-cbl gene in the ring finger domain produces a phenotype mimicking human myeloproliferative ...
http://zfin.org/ZDB-PUB-150625-8
*  Genetics of RAS Signaling in Drosophila | SpringerLink
RAS proteins play a key role in the signaling pathways that regulate cell growth and differentiation in Drosophila. Although ... The cbl oncogene-a novel substrate of protein tyrosine kinases. Australian & New Zealand Journal of Medicine 1995; 25:859-864. ... The protein product of the c-cbl oncogene rapidly complexes with the egf receptor and is tyrosine phosphorylated following egf ... Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (egf) ...
https://link.springer.com/chapter/10.1007/978-1-4613-1183-6_1
*  UniGene Links for PubMed (Select 19571318) - UniGene - NCBI
Cbl proto-oncogene, E3 ubiquitin protein ligase. CBL, Homo sapiens. Hs.504096: 294 sequences. ...
https://www.ncbi.nlm.nih.gov/unigene?LinkName=pubmed_unigene&from_uid=19571318
*  RAS Pathway v2.0 - National Cancer Institute
Cbl proto-oncogene B, E3 ubiquitin protein ligase. Cbl-b, RNF56. CBLC. Cbl proto-oncogene C, E3 ubiquitin protein ligase. CBL-3 ... CBL. Cbl proto-oncogene, E3 ubiquitin protein ligase. C-CBL, CBL2, FRA11B, NSLL, RNF55. ... MDM2 proto-oncogene, E3 ubiquitin protein ligase. ACTFS, HDMX, hdm2. MET. MET proto-oncogene, receptor tyrosine kinase; ... ELK1, member of ETS oncogene family. [none]. ERBB2. receptor tyrosine-protein kinase erbB-2. CD340, HER-2, HER-2/neu, HER2, MLN ...
https://www.cancer.gov/research/key-initiatives/ras/ras-central/blog/2015/ras-pathway-v2
*  CBL Gene - GeneCards | CBL Protein | CBL Antibody
Protein Coding), Cbl Proto-Oncogene, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards ... GeneCards Summary for CBL Gene CBL (Cbl Proto-Oncogene) is a Protein Coding gene. Diseases associated with CBL include Noonan ... Protein Symbol:. P22681-CBL_HUMAN. Recommended name:. E3 ubiquitin-protein ligase CBL Protein Accession:. P22681. Secondary ... Aliases for CBL Gene Aliases for CBL Gene. * Cbl Proto-Oncogene 2 3 5 ...
http://www.genecards.org/cgi-bin/carddisp.pl?id_type=entrezgene&id=867
*  GO Gene List
Cbl proto-oncogene, E3 ubiquitin protein ligase. NM_005188. Gene Info. CBLL1. Cbl proto-oncogene, E3 ubiquitin protein ligase- ... Mannose-binding lectin (protein C) 2, soluble. NM_000242. Gene Info. MERTK. C-mer proto-oncogene tyrosine kinase. NM_006343. ... Mindbomb E3 ubiquitin protein ligase 1. NM_020774. Gene Info. MIB1. Mindbomb E3 ubiquitin protein ligase 1. BX648566. Gene Info ... RAB26, member RAS oncogene family. NM_014353. Gene Info. RAB27A. RAB27A, member RAS oncogene family. NM_004580. NM_183235. NM_ ...
https://cgap.nci.nih.gov/Genes/GoGeneQuery?PAGE=1&ORG=Hs&GOID=0060627
*  anti-CBL antibody | GeneTex
Cbl proto-oncogene, E3 ubiquitin protein ligase) for ELISA, IHC-P, WB. Anti-CBL pAb (GTX31301) is tested in Human, Mouse, Rat ... Cbl proto-oncogene, E3 ubiquitin protein ligase. Background. This gene is a proto-oncogene that encodes a RING finger E3 ... CBL2 Antibody , C-CBL Antibody , NSLL Antibody , RNF55 Antibody , Cbl proto-oncogene, E3 ubiquitin protein ligase Antibody , ... Cbl antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human cbl.The immunogen is ...
http://www.genetex.com/CBL-antibody-GTX31301.html
*  Epileptic Encephalopathies, Early Infantile, 72 Gene Panel - UK Genetic Testing Network
CBL proto-oncogene, E3 ubiquitin protein ligase. *oncogene CBL. *oncogene CBL2. * CBL *C-CBL ... methyl-CpG binding protein 2 *encephalopathy, nonprogressive, neonatal-onset, included. *methyl-CpG binding protein 2 (rett ... GTPase-activating protein, RAS, synaptic, 135-KD, rat, homolog of. *RAS-GTPase-activating protein, synaptic, 135-KD, rat, ...
https://ukgtn.nhs.uk/find-a-test/search-by-disorder-gene/epileptic-encephalopathies-early-infantile-72-gene-panel-670/
*  List of MeSH codes (D12.776) - Wikipedia
... oncogene protein v-akt MeSH D12.776.624.664.520.750.817 - oncogene protein v-cbl MeSH D12.776.624.664.520.750.846 - oncogene ... oncogene protein v-maf MeSH D12.776.964.700.750.875 - oncogene proteins v-abl MeSH D12.776.964.700.750.882 - oncogene proteins ... oncogene protein v-maf MeSH D12.776.964.775.750.875 - oncogene proteins v-abl MeSH D12.776.964.775.750.882 - oncogene proteins ... oncogene proteins v-fos MeSH D12.776.964.700.750.900 - oncogene proteins v-mos MeSH D12.776.964.700.750.903 - oncogene proteins ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776)
*  GO Gene List
CBL. Cbl proto-oncogene, E3 ubiquitin protein ligase. NM_005188. Gene Info. ... BCL2/adenovirus E1B 19kDa interacting protein 2. NM_004330. Gene Info. BRAF. V-raf murine sarcoma viral oncogene homolog B1. NM ... Ajuba LIM protein. NM_032876. NM_198086. Gene Info. AKAP12. A kinase (PRKA) anchor protein 12. NM_005100. NM_144497. Gene Info ... Bone morphogenetic protein 2. NM_001200. Gene Info. BMP4. Bone morphogenetic protein 4. NM_001202. NM_130851. NM_130850. Gene ...
https://cgap.nci.nih.gov/Genes/GoGeneQuery?PAGE=1&ORG=Hs&GOID=0023056
*  miR-124-3p functions as a tumor suppressor in breast cancer by targeting CBL | BMC Cancer | Full Text
Cbl proto-oncogene, E3 ubiquitin protein ligase) as a direct target gene of miR-124-3p. Moreover, we found that ectopic ... Quantitative RT-PCR and western blotting assays were used to measure miR-124-3p and CBL expression levels in breast cancer ... This study identified a new regulatory axis in which miR-124-3p and CBL regulate the proliferation and invasion of breast ... Luciferase reporter assay was employed to validate the direct targeting of CBL by miR-124-3p. Cell proliferation and invasion ...
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-016-2862-4
*  CBLB (Cas-Br-M (murine) ecotropic retroviral transforming sequence b)
Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene.. ... Adaptor_Cbl Adaptor_Cbl_EF_hand-like Adaptor_Cbl_N_dom_sf Adaptor_Cbl_N_hlx Adaptor_Cbl_SH2-like Cbl_PTB EF-hand-dom_pair SH2_ ... Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation.. ... Protein. Description. 982 amino acids; 120 kDa; the overall structure of CBLb is very close to the sructure of CBL: the ...
http://atlasgeneticsoncology.org/Genes/GC_CBLB.html
*  "Coupling of the proto-oncogene product c-Cbl to the epidermal growth f" by Herman Meisner and Michael P. Czech
Cbl, is a 120-kDa protein present in lymphocytes that contains numerous PXXP motifs in its COOH-terminal region and ... which is complexed through its SH3 domain with proline-rich regions of Cbl. Such recruitment of Cbl to EGF receptors may ... Immunoprecipitates of Cbl from lysates of these cells contain Grb2 in the basal state, while EGF stimulation causes co- ... Both Grb2 and EGF receptors are released from Cbl in the presence of a proline-rich peptide that binds the NH2-terminal SH3 ...
https://escholarship.umassmed.edu/oapubs/805/
*  Anti-CBL Rabbit Polyclonal Antibody (Cy5.5®) | VWR
CBL. Antigen Name. Cbl proto-oncogene, E3 Ubiquitin Protein Ligase. Reactivity. Human, Mouse, Rat. ... SH3-binding protein CBL-C, CBLC, Signal transduction protein CBL-C, RING finger protein 57, CBL-3, RNF57. ... The proto oncogene c CBL was initially identified as the cellular homologue of v CBL oncogene that induces pre B cell lymphomas ... Targets of CBL include activated protein tyrosine kinases belonging to the Src and Syk/Zap 70 families. An additional mechanism ...
https://us.vwr.com/store/product/17122199/anti-cbl-rabbit-polyclonal-antibody-cy5-5
*  Anti-CBL Rabbit Polyclonal Antibody (Alexa Fluor® 350) | VWR
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes ... Signal transduction protein CBL-C, CBLC, RING finger protein 57, SH3-binding protein CBL-C, CBL-3, RNF57. ... Anti-CBL Rabbit Polyclonal Antibody (Alexa Fluor® 350). Anti-CBL Rabbit Polyclonal Antibody (Alexa Fluor® 350). Supplier: Bioss ... This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein ...
https://us.vwr.com/store/product/17122204/anti-cbl-rabbit-polyclonal-antibody-alexa-fluor-350
*  KAKEN - Research Projects | Analysis of transcription factor abnormality in the progression of preleukemic state. (KAKENHI...
TPO/c-MPL ligand induces tyrosine phosphorylation multiple cellular proteins including proto-oncogene produckts,VAV and c-CBL, ... Publications] Ueno, H.: 'Antisense repression of proto-on-cogene c-CBL enhances activation of the JAK-STAT pathway but not the ... Publications] Ueno H: 'Antisense repression of proto-oncogene c-CBL enhances activation of the JAK-STAT pathway but not the Ras ... The MIL/MEN fusion protein contains the amino-terminal half of MLL including AT hook motifs which is fused to the MEN protein ...
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08671215/
*  Recombinant Human CBLC cell lysate CBLC-001HCL - Creative BioMart
Cbl-c derived in Baculovirus-Insect cells. The whole cell lysate is provided in 1X Sample Buffer.Browse all transfected cell ... CBLC; Cbl proto-oncogene, E3 ubiquitin protein ligase C; Cas Br M (murine) ecotropic retroviral transforming sequence c , Cas ... signal transduction protein CBL-C; CBL 3; CBL SL; RNF57; RING finger protein 57; SH3-binding protein CBL-3; SH3-binding protein ... Human CBLC / Cbl-c derived in Baculovirus-Insect cells. The whole cell lysate is provided in 1X Sample Buffer.Browse all ...
https://www.creativebiomart.net/description_398052_318.htm
*  Erythropoietin, Thrombopoietin and Leptin Receptors | SpringerLink
1996 Discrete protein interactions with the Grb2/c-Cbl complex in SCF- and TPOmediated myeloid cell proliferation. Oncogene 13 ... Hanazono, Y., Odai, H., Sasaki, K., Iwamatsu, A., Yazaki, Y. and Hirai, H 1996 Proto-oncogene products Vav and c-Cbl are ... 1995 TPO/c-mpl ligand induces tyrosine phosphorylation of multiple cellular proteins including proto-oncogene products, Vav and ... 1998 Thrombopoietin potentiates the protein-kinase-C-mediated activation of mitogen-activated protein kinase/ERK kinases and ...
https://link.springer.com/chapter/10.1007/978-1-4757-3600-7_8
*  List of MeSH codes (D08) - Wikipedia
... proto-oncogene proteins c-cbl MeSH D08.811.464.938.750.562 --- proto-oncogene proteins c-mdm2 MeSH D08.811.464.938.750.750 --- ... proto-oncogene proteins c-bcr MeSH D08.811.913.696.620.682.700.776 --- proto-oncogene proteins c-pim-1 MeSH D08.811.913.696. ... proto-oncogene proteins c-kit MeSH D08.811.913.696.620.682.725.400.075 --- proto-oncogene proteins c-met MeSH D08.811.913.696. ... oncogene protein pp60(v-src) MeSH D08.811.913.696.620.682.725.800.551 --- proto-oncogene proteins c-fyn MeSH D08.811.913.696. ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D08)
*  Nef-mediated lipid raft exclusion of UbcH7 inhibits Cbl activity in T cells to positively regulate signaling. - Oxford...
... lipid raft Cdc42 is activated and forms a ternary complex between the c-Cbl-interacting protein p85Cool-1/betaPix and c-Cbl, ... Here, the E2 ubiquitin-conjugating enzyme UbcH7, which acts in conjunction with c-Cbl, is absent from lipid rafts. This Nef- ... Proto-Oncogene Proteins c-cbl, RNA, Small Interfering, Rho Guanine Nucleotide Exchange Factors, Signal Transduction, Ubiquitin- ... lipid raft Cdc42 is activated and forms a ternary complex between the c-Cbl-interacting protein p85Cool-1/betaPix and c-Cbl, ...
https://www.neuroscience.ox.ac.uk/publications/33330
*  NAVER Academic | A dynamic constitutive and inducible binding of c-Cbl by PLCgamma1 SH3 and SH2 domains (negatively) regulates...
Protein Binding, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-cbl, Receptors, Antigen, Transcription Factors, ... A dynamic constitutive and inducible binding of c-Cbl by PLCgamma1 SH3 and SH2 domains (negatively) regulates antigen receptor- ... Animals, Binding Sites, immunology, DNA-Binding Proteins, metabolism, Down-Regulation, Feedback, Physiological, Humans, Jurkat ... Transcriptional Activation, Type C Phospholipases, Tyrosine, Ubiquitin-Protein Ligases, src Homology Domains. ...
https://academic.naver.com/article.naver?doc_id=143383073
*  CD43 regulates the threshold for T cell activation by targeting Cbl functions. - Department of Paediatrics
... tyrosine phosphorylation and delayed degradation of ZAP-70 and of the ζ chain lead to enhanced mitogen-activated protein kinase ... These data indicates that CD43-mediated signals lower the threshold for TC activation by restricting the c-Cbl and Cbl-b ... c-Cbl interaction with the adapter molecule Crk-L and promotes Cbl-b degradation in a PKCθ-dependent manner. Consequently, the ... The Cbl family members prevent undesired activation of T cells by regulating TCR signals. In this report, we show that TC ...
https://www.paediatrics.ox.ac.uk/publications/309056
*  Clinical whole-genome sequencing in severe early-onset epilepsy reveals new genes and improves molecular diagnosis. - Oxford...
The two patients with NSEOE had likely pathogenic de novo mutations in CBL and CSNK1G1, respectively. Mutations in these genes ... Membrane Proteins, Nerve Tissue Proteins, Mutation, Child, Child, Preschool, Male, Proto-Oncogene Proteins c-cbl, KCNQ2 ... The two patients with NSEOE had likely pathogenic de novo mutations in CBL and CSNK1G1, respectively. Mutations in these genes ...
https://www.bdi.ox.ac.uk/publications/447735