ROCK‐dependent phosphorylation of NUP62 regulates p63 nuclear transport and squamous cell carcinoma proliferation | EMBO Reports
Inoue T, Stuart J, Leno R, Maki CG (2002) Nuclear import and export signals in control of the p53‐related protein p73. J Biol ... Hoelz A, Glavy JS, Beck M (2016) Toward the atomic structure of the nuclear pore complex: when top down meets bottom up. Nat ... TP63 was marked in purple as positive control for oncogene. Data show mean from two independent experiments (n = 2). ... TPR, SPRR1B, and IVL mRNA in HNSCC was from The Cancer Genome Atlas (TCGA) through Cancer RNA‐Seq Nexus or cBioportal (see URLs ...http://embor.embopress.org/content/19/1/73
List of MeSH codes (D12.776) - Wikipedia
... oncogene protein p65(gag-jun) MeSH D12.776.602.500.500.660 - oncogene protein tpr-met MeSH D12.776.624.664.500.100 - fusion ... oncogene protein p65(gag-jun) MeSH D12.776.624.664.500.660 - oncogene protein tpr-met MeSH D12.776.624.664.520.045 - adenovirus ... oncogene protein v-maf MeSH D12.776.964.700.750.875 - oncogene proteins v-abl MeSH D12.776.964.700.750.882 - oncogene proteins ... oncogene protein v-maf MeSH D12.776.964.775.750.875 - oncogene proteins v-abl MeSH D12.776.964.775.750.882 - oncogene proteins ...https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776)
Tpr-met fusion protein - Wikipedia
Tpr-Met fusion protein is an oncogene fusion protein consisting of TPR and MET. Tpr-Met was generated following a chromosomal ... The resulting 65 kDa cytoplasmic Tpr-Met oncoprotein forms a dimer mediated through the Tpr leucine zipper. The Tpr-Met fusion ... Peschard, P.; Park, M. (2007-02-26). "From Tpr-Met to Met, tumorigenesis and tubes". Oncogene. 26 (9): 1276-1285. doi:10.1038/ ... "Oncogenic activation of the Met receptor tyrosine kinase fusion protein, Tpr-Met, involves exclusion from the endocytic ...https://en.wikipedia.org/wiki/Tpr-met_fusion_protein
Personalized genomic disease risk of volunteers | PNAS
2007) Oncogenic activation of the Met receptor tyrosine kinase fusion protein, Tpr-Met, involves exclusion from the endocytic ... 2012) Structure-based prediction of protein-protein interactions on a genome-wide scale. Nature 490(7421):556-560. ... New technological advances such as structure-based prediction of protein-protein interactions on a genome wide scale (80), 3D ... 2009) Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Nat Protoc 4(7): ...https://www.pnas.org/content/110/42/16957.full
Evolutionary Conservation and Expression of Human RNA-Binding Proteins and Their Role in Human Genetic Disease | SpringerLink
RNA-binding proteins (RBPs) are effectors and regulators of posttranscriptional gene regulation (PTGR). RBPs regulate stability ... Characterization of the TPR-MET oncogene p65 and the MET protooncogene p140 protein-tyrosine kinases. Proc Natl Acad Sci U S A ... Dean M, Park M, Vande Woude GF (1987) Characterization of the rearranged tpr-met oncogene breakpoint. Mol Cell Biol 7:921-924 ... RNA-binding domains, overview RNA-binding proteins, tissue specificity RNA-binding proteins, abundance RNA-binding proteins, ...https://link.springer.com/chapter/10.1007%2F978-1-4939-1221-6_1
TPR Antibody | Bethyl Laboratories, Inc.
Unconjugated Whole IgG Rabbit anti-TPR Antibody, Affinity Purified suitable for WB, IP applications. Visit Bethyl.com for all ... translocated promoter region (to activated MET oncogene) antibody. *translocated promoter region protein antibody ...https://www.bethyl.com/product/A300-825A?referrer=Cancer&target=TPR
c-Met Inhibitor Synergizes with Tumor Necrosis Factor-Related Apoptosis-Induced Ligand to Induce Papillary Thyroid Carcinoma...
Previously we have shown that c-Met is overexpressed in Middle Eastern papillary thyroid carcinoma... ... The Met receptor tyrosine kinase is overexpressed and/or activated in variety of human malignancies. ... 1988) Characterization of the TPR-MET oncogene p65 and the MET protooncogene p140 protein-tyrosine kinases. Proc. Natl. Acad. ... 2000) Met receptor tyrosine kinase: enhanced signaling through adapter proteins. Oncogene. 19:5582-9.CrossRefGoogle Scholar ...https://rd.springer.com/article/10.2119/molmed.2011.00238
Induction of Hepatocyte Growth Factor/Scatter Factor by Fibroblast Clustering Directly Promotes Tumor Cell Invasiveness |...
Characterization of the TPR-MET oncogene p65 and the MET protooncogene p140 protein tyrosine kinases. Proc Natl Acad Sci U S A ... c-Met ( 13, 14). Expression of the c-met proto-oncogene first results in a 190-kDa precursor protein, from which the mature ... The phosphorylated c-Met (p-c-Met) detected corresponded to the c-Met expression pattern as shown in (A). In response to ... The MET oncogene drives a genetic programme linking cancer to haemostasis. Nature 2005; 434: 396-400. ...http://cancerres.aacrjournals.org/content/65/21/9914?ijkey=1fff079ef0a46fed6c741482191f98426182bcb9&keytype2=tf_ipsecsha
Hepatocyte Growth Factor Receptor | SpringerLink
MET; RCCP2 In the mid-1970s, Harold Varmus and Michael Bishop began the hunting for cancer genes in the cell genome. They ... The v-Src was transforming since it encoded for a mutated tyrosine kinase protein. Like v-Src, oncogenes are mutant-activated ... The treatment of a human osteogenic sarcoma cell line with a chemical carcinogen induced a chromosomal translocation of the TPR ... stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET. Oncogene. 1991a;6(4):501-4.PubMed ...https://link.springer.com/referenceworkentry/10.1007%2F978-3-319-67199-4_101684
INDIVIDUALIZED CANCER TREATMENTS - Patent application
... to activated MET oncogene) TPR NM_003292 periplakin PPL NM_002705 H3 histone, family 3B (H3.3B) H3F3B BC001124 zinc finger ... at v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) ETS2 21q22.3,21q22.2 1711_at tumor protein p53 binding protein, ... to activated TPR BF110993 MET oncogene) PERP, TP53 apoptosis effector PERP NM_022121 importin 13 IPO13 NM_014652 pleckstrin ... at death-associated protein kinase 3 DAPK3 19p13.3 34319_at S100 calcium binding protein P S100P 4p16 34347_at nuclear protein ...http://www.patentsencyclopedia.com/app/20100305058
TPR | CTD
... to activated MET oncogene) , translocated promoter region (to activated MET oncogene)-like protein , TREES_T100002255 , tumor ... nuclear pore complex-associated protein TPR , Nucleoprotein TPR , nucleoprotein TPR-like , nucleoprotein TPR-like protein , ... PANDA_014296 , translocated promoter region and nuclear basket protein , translocated promoter region protein , translocated ... translocated promoter region, nuclear basket protein Synonyms AS27_08102 , AS28_01885 , C77892 , CB1_000818015 , D623_10007711 ...http://ctdbase.org/detail.go?type=gene&acc=7175
Thienyl compounds for inhibition of cell proliferative disorders - Patent # 5710173 - PatentGenius
The c-met oncogene is expressed not only in hepatocytes but also in a variety of tissues and over expression of c-met is found ... Thus, HER-2 protein activities include: (1) phosphorylation of HER-2 protein, HER-3 protein or HER-4 protein; (2) ... The TPR/MET oncogenic rearrangement is present and expressed in human gastric carcinoma and precursorlegion, see Soman et al., ... Normal or increased levels of met mRNA and met protein were consistently foundin fresh samples of carcinomas as well as ...http://www.patentgenius.com/patent/5710173.html
Significance of Fusion Genes Resulting from Chromosomal Somatic Mutations in Neoplasia
As noted from the table, fusion genes may involve tumor suppressor genes (EWS/WT1) or proto- oncogenes as in myc/IgH, TPR/MET, ... including protein kinases and receptors make up most of the remaining functions of the known fusion proteins. There is also the ... In this instance the FUS gene codes a nuclear RNA-binding protein, while the chop gene codes a growth arrest gene. Fusion of ... In Table 6.8 is a reasonably complete listing through 1994 of the known fusion genes and the proteins result- ing from specific ...http://fx.damasgate.com/significance-of-fusion-genes-resulting-from-chromosomal-somatic-mutations-in-neoplasia/
Insights into the Shc Family of Adaptor Proteins
Pathways downstream of Shc and Grb2 are required for cell transformation by the tpr-Met oncoprotein. J Biol Chem May 31 1996271 ... Ravichandran, KS (2001). Signaling via Shc family adapter proteins. Oncogene Oct 1 200120(44): 6322-30, DOI: https://doi.org/ ... Shc proteins are post-translationally modified. Shc protein phosphorylation. The phosphorylation of Shc proteins plays a key ... Adaptor proteins facilitate protein-protein interactions, which are responsible for intracellular signal propagation as well as ...https://jmolecularsignaling.com/articles/10.5334/1750-2187-12-2/
TPR (Translocated promoter region)
... , Authors: Brigitte David-Watine. Published in: Atlas Genet Cytogenet Oncol Haematol. ... Characterization of the TPR-MET oncogene p65 and the MET protooncogene p140 protein-tyrosine kinases.. ... TPM3 (1q21.3) / TPR (1q31.1). TPR (1q31.1) / ALK (2p23.2). TPR (1q31.1) / FGFR1 (8p11.23). TPR (1q31.1) / MET (7q31.2). TPR ( ... TPR Mutations. ICGC Data Portal. TPR TCGA Data Portal. TPR Broad Tumor Portal. TPR. OASIS Portal. TPR [ Somatic mutations - ...http://atlasgeneticsoncology.org/Genes/GC_TPR.html
IMP: Integrative Multi-species Prediction
TPR. translocated promoter region (to activated MET oncogene). 0.022. GSK3B. glycogen synthase kinase 3 beta. 0.022. ... protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1. 0.013. ...http://imp.princeton.edu/predictions/process/human-context-global/14542/?gene=7517
Patente WO2011099007A1 - Pharmaceutical compositions and methods for the treatment and prevention of ... - Google Patentes
1999). Methods of protein chemistry are described generally in Protein Methods (Bollag et al., 1996); Guide to Protein ... Oncogenes can alone or in concert with other changes or genes, contribute to a cells tumorigenicity. Examples of oncogenes ... MIR-200 family induces mesenchymal-to-epithelial transition (MET) in ovarian cancer cells. ... TPR, TRAa, TRBa, TRDa, TRIM33, TRIP1 1, TRK, TSC1, TSC2, TSHR, VHL, WAS, WHSC1L1 8, WRN, WT1, XPA, XPC, ZNF145, ZNF198, ZNF278 ...http://www.google.es/patents/WO2011099007A1?cl=en
CHIP functions as an oncogene by promoting colorectal cancer metastasis via activation of MAPK and AKT signaling and...
The expression of ERK, AKT, NF-кB signaling subunits and EMT related proteins were detected by Western blotting. The influence ... Our finding suggested that CHIP functions as an oncogene in the migration and metastasis of CRC, and is a potential unfavorable ... and function of CHIP on the protein expression of CRC cells were also elucidated by liquid chromatography-tandem mass ... The carboxyl terminus of Hsc70-interacting protein (CHIP) is an E3 ubiquitin ligase that plays a controversial role in ...https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-018-1540-5
IMP: Integrative Multi-species Prediction
TPR. translocated promoter region (to activated MET oncogene). 0.362. PRRC2C. proline-rich coiled-coil 2C. 0.357. ... adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1. 0.049. ... solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group). 0.027. ... heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa). 0.173. ...http://imp.princeton.edu/predictions/process/human-context-global/9093/?gene=3364
Anti-Met (c-Met) antibody [SP59] (ab101539) | Abcam
... c-Met) antibody [SP59] validated for IHC and tested in Human. Immunogen corresponding to synthetic peptide ... Note=Activation of MET after rearrangement with the TPR gene produces an oncogenic protein.. Note=Defects in MET may be ... MET proto oncogene, receptor tyrosine kinase antibody. *Met proto-oncogene (hepatocyte growth factor receptor) antibody ... Anti-Met (c-Met) antibody [SP59]. See all Met (c-Met) primary antibodies. ...http://www.abcam.com/met-c-met-antibody-sp59-ab101539.html
Anti-TPR 抗体 (ab84516) | アブカム
Nucleoprotein TPR antibody. *tpr antibody. *TPR_HUMAN antibody. *translocated promoter region (to activated MET oncogene) ... end of the TPR gene to the protein kinase domain of NTRK1 forms the fusion protein TRK-T1. TRK-T1 is a 55 kDa protein reacting ... Anti-TPR antibody. TPR 一次抗体 製品一覧. ... Defects in TPR are a cause of thyroid papillary carcinoma (TPC ... The Universal Protein Resource (UniProt) in 2010. Nucleic Acids Res. 38:D142-D148 (2010) . ...http://www.abcam.co.jp/TPR-antibody-ab84516.html
CDH1 (gene) - Wikipedia
SH3 domain-mediated protein-protein interaction blocking drug". Oncogene. 21 (13): 2037-50. doi:10.1038/sj.onc.1205271. PMID ... 2. E-cadherin in MET: The mesenchymal state cancer cells migrate to new sites and may undergo METs in certain favorable ... "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459- ... protein binding. • ankyrin binding. • gamma-catenin binding. • beta-catenin binding. • GTPase activating protein binding. • ...https://en.wikipedia.org/wiki/CDH1_
Quantitative Proteomics Discloses MET Expression in Mitochondria as a Direct Target of MET Kinase Inhibitor in Cancer Cells |...
... of proteins whose expression was confidently assessed to be perturbed by MET inhibition were mitochondrial proteins. Upon MET ... 2001) Absence of tpr-met and expression of c-met in human gastric mucosa and carcinoma. J. Pathol. 194, 428-435. ... 2008) HER kinase activation confers resistance to MET tyrosine kinase inhibition in MET oncogene-addicted gastric cancer cells ... calmodulin-related proteins comprising hippocalcin-like protein 1 (IPI00219344.4), protein S100-A4 (IPI00032313.1), protein ...https://www.mcponline.org/content/9/12/2629
hypothetical protein MGC5306. 0.0063. 0.9992. Hs.170472. TPR. translocated promoter region (to activated MET oncogene). 0.0064 ... PITSLRE protein kinase alpha; p58/GTA protein kinase; galactosyltransferase associated protein kinase; CDC-related protein ... ring finger protein 13 /// ring finger protein 13. -0.0113. 0.0004. Hs.132994. DKFZP434C171. DKFZP434C171 protein. -0.0110. ... makorin, ring finger protein, 4 /// makorin, ring finger protein, 4 /// makorin, ring finger protein, 4. 0.0061. 0.9991. ...http://cmgm.stanford.edu/~kimlab/aging_muscle/supp_table_2.htm
Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal...
COOH-terminal tails were inserted downstream of a LexA-tpr-met construct, which lacks substrate binding sites of Met (EGFR, ... The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R. Oncogene. 17:1097-1108. ... Dok proteins bind to wild-type c-Ret, which is phosphorylated upon overexpression (Fig. 5 a). The new dok proteins, dok-4 and ... Characterization of ret proto-oncogene mRNAs encoding two isoforms of the protein product in a human neuroblastoma cell line. ...http://jcb.rupress.org/content/154/2/345.long