Loading...
*  HGF | Cancer Genetics Web
Proto-Oncogene Proteins c-myc. *Cell Movement. *Lung Cancer. *Proto-Oncogene Proteins pp60(c-src) ... To identify proteins modulated by a low concentration of SF, we treated HT29 colon cancer cells with 2.5 μM SF. Protein ... Subsets of proteins enriched in each subcellular compartment led to a complementary list of 4289 proteins identified with high ... This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a ...
http://www.cancerindex.org/geneweb/HGF.htm
*  Cloning of a novel inhibitory adaptor, SLAP-2. (A) Huma | Open-i
Proto-Oncogene Proteins pp60(c-src)/genetics*/immunology*. *Receptors, Antigen, B-Cell/immunology* ... The SLAP-2 protein contains an NH2-terminal myristoylation consensus sequence and SH3 and SH2 Src homology domains, but lacks a ... The SLAP-2 protein contains an NH2-terminal myristoylation consensus sequence and SH3 and SH2 Src homology domains, but lacks a ... Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling. ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2195979_010067f2b&req=4
*  Confocal images of COS-7 cells expressing mutant Tiam1 | Open-i
Confocal images of COS-7 cells expressing mutant Tiam1 proteins. Confocal laser scanning microscopic images of COS-7 cells ... JNK Mitogen-Activated Protein Kinases. *Mice. *Proto-Oncogene Proteins pp60(c-src)/genetics ... 6 E, inset). A fusion protein containing the NH2-terminal Src domain in front of the C1199-ΔPHn Tiam1 protein was also able to ... 6 E, inset). A fusion protein containing the NH2-terminal Src domain in front of the C1199-ΔPHn Tiam1 protein was also able to ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2139766_JCB.michiels6m&req=4
*  List of MeSH codes (D12.776) - Wikipedia
... oncogene protein p55(v-myc) MeSH D12.776.964.700.750.760 - oncogene protein pp60(v-src) MeSH D12.776.964.700.750.817 - oncogene ... oncogene protein p55(v-myc) MeSH D12.776.964.775.750.760 - oncogene protein pp60(v-src) MeSH D12.776.964.775.750.817 - oncogene ... oncogene protein p55(v-myc) MeSH D12.776.624.664.520.750.760 - oncogene protein pp60(v-src) MeSH D12.776.624.664.520.750.788 - ... proto-oncogene proteins p21(ras) MeSH D12.776.624.664.700.202 - proto-oncogene proteins pp60(c-src) MeSH D12.776.624.664. ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776)
*  Restricted expression of Slap-1 in the rodent cerebral cortex. - Oxford Neuroscience
One of the genes we isolated was the rat homologue of the mouse Slap-1. SLAP-1 is an adaptor protein containing SH2-SH3 domains ... Proto-Oncogene Proteins pp60(c-src), RNA, Messenger, Rats, Rats, Sprague-Dawley, Receptor Protein-Tyrosine Kinases, src ... One of the genes we isolated was the rat homologue of the mouse Slap-1. SLAP-1 is an adaptor protein containing SH2-SH3 domains ... Adaptor Proteins, Signal Transducing, Animals, Animals, Newborn, Cell Differentiation, Cerebral Cortex, DNA, Complementary, ...
https://www.neuroscience.ox.ac.uk/publications/114575
*  NAVER Academic | Malignant Osteopetrosis: c-src kinase is not reduced in fibroblasts
... congenital osteopetrosis for the expression of c-src at the protein level. No differences could be detected in c-src protein ... Thus, impairment of c-src function as an etiological factor in human osteopetrosis appears unlikely in the individuals ... As the c-src gene is expressed in all tissues and cells tested, we have analyzed fibroblasts from three individuals with ... and c-src kinase activity levels between fbroblasts from healthy controls and affected individuals. ...
https://academic.naver.com/article.naver?doc_id=139579223
*  Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and...
Molecular Molecular Sequence Data Mutation Oncogene Protein pp60(v-src)/metabolism Phenotype Protein Binding Protein ... Drug Escherichia coli Proteins/metabolism Fungal Proteins/chemistry HSP90 Heat-Shock Proteins/*chemistry/*metabolism Hydrolysis ... Activation of client proteins by the Hsp90 molecular chaperone is dependent on binding and hydrolysis of ATP, which drives a ... Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and ...
http://sro.sussex.ac.uk/44340/
*  Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides. -...
Oncogene Protein pp60(v-src)/metabolism. *Oncogene Protein pp60(v-src)/ultrastructure* ... Three-dimensional structures of complexes of the SH2 domain of the v-src oncogene product with two phosphotyrosyl peptides have ... Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides.. ...
https://www.ncbi.nlm.nih.gov/pubmed/0001379696
*  Substrate specificity of protein kinases - Patent # 5532167 - PatentGenius
The invention also provides peptide substrates for protein kinase A, cell cycle control kinases, src family kinases, the EGF ... motif for a phosphorylation site of a protein kinase. In the method of the invention, a protein kinase is contacted with an ... wherein the member of the src family of protein kinases is selected from the group consisting of pp60.sup.c-src, pp60.sup.v-src ... al, (1987) Oncogene Res. 1:441- 458). In the case of PKA, the reaction was done insolution and the peptides were separated from ...
http://www.patentgenius.com/patent/5532167.html
*  Phospho-SRC (Tyr527) Antibody
Phospho-SRC (Tyr527) Polyclonal Antibody from Invitrogen for Western Blot and Immunohistochemistry (Paraffin) applications. ... tyrosine protein kinase pp60-c-src; tyrosine-protein kinase SRC-1; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene ... p60-Src; pp60c-src; Proto-oncogene c-Src; Proto-oncogene tyrosine-protein kinase Src; protooncogene SRC, Rous sarcoma; Rous ... Protein Aliases: c-Src; Neuronal proto-oncogene tyrosine-protein kinase Src; non-tyrosine protein kinase; OTTHUMP00000174476; ...
https://www.thermofisher.com/antibody/product/Phospho-Src-pTyr527-Antibody-Polyclonal/PA5-17781
*  Identification of p130(cas) as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST.
Mayer BJ, Hanafusa H. Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase ... The SH2 and SH3 domains of pp60src direct stable association with tyrosine phosphorylated proteins p130 and p110. EMBO J. 1991 ... Stimulation by phospholipids of a protein-tyrosine-phosphatase containing two src homology 2 domains. Proc Natl Acad Sci U S A ... Stable association of activated pp60src with two tyrosine-phosphorylated cellular proteins. Mol Cell Biol. 1989 Sep;9(9):3951- ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC231642/?lang=en-ca
*  Muscle ring finger protein-1 inhibits PKCε activation and prevents cardiomyocyte hypertrophy | JCB
Role of c-Src tyrosine kinase in G protein-coupled receptor and Gβγ subunit-mediated activation of mitogen-activated protein ... Adaptor proteins in protein kinase C-mediated signal transduction. Oncogene. 20:6339-6347. ... Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src. Mol. Cell. Biol. 14:1680- ... RACK1, a protein kinase C anchoring protein, coordinates the binding of activated protein kinase C and select pleckstrin ...
http://jcb.rupress.org/content/167/6/1147
*  Proto-Oncogene Proteins c-bcl-2 | Profiles RNS
Proto-Oncogene Proteins c-yes. *Proto-Oncogene Proteins p21(ras). *Proto-Oncogene Proteins pp60(c-src) ... Proto-Oncogene Proteins c-bcl-2*Proto-Oncogene Proteins c-bcl-2 ... Proto-Oncogene Proteins c-akt. *Proto-Oncogene Proteins c-bcl-2 ... "Proto-Oncogene Proteins c-bcl-2" by people in this website by year, and whether "Proto-Oncogene Proteins c-bcl-2" was a major ... "Proto-Oncogene Proteins c-bcl-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH ( ...
https://profiles.rush.edu/display/10326
*  Geldanamycin: the prototype of a class of antitumor drugs targeting the heat shock protein 90 family of molecular chaperones
Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for ... Oncogene. 1995;11:933-939. [PubMed]. *Bose S, Weikl T, Bügl H, Buchner J. Chaperone function of Hsp90-associated proteins. ... The neu oncogene encodes an epidermal growth factor receptor-related protein. Nature. 1986;319:226-230. [PubMed] ... phosphorylation in the regulation of the heteroprotein complex between the Hsp90 stress protein and the pp60v-src tyrosine ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC434387/?lang=en-ca
*  Proteogenomic characterization of human colon and rectal cancer. | Broad Institute
Neoplasm Proteins, Point Mutation, Proteome, Proteomics, Proto-Oncogene Proteins pp60(c-src), Rectal Neoplasms, RNA, Messenger ... and SRC (SRC proto-oncogene, non-receptor tyrosine kinase). Integrated proteogenomic analysis provides functional context to ... The chromosome 20q amplicon was associated with the largest global changes at both mRNA and protein levels; proteomics data ... Somatic variants displayed reduced protein abundance compared to germline variants. Messenger RNA transcript abundance did not ...
https://www.broadinstitute.org/publications/broad5917
*  src-Family Kinases | REACH
A PROTEIN-TYROSINE KINASE family that was originally identified by homology to the Rous sarcoma virus ONCOGENE PROTEIN PP60(V- ... Oncogenic forms of src-family kinases can occur through altered regulation or expression of the endogenous protein and by ... The Haemophilus ducreyi LspA1 protein inhibits phagocytosis by using a new mechanism involving activation of C-terminal Src ... Bunda S, Kang MW, Sybingco SS, Weng J, Favre H, Shin DH, Irwin MS, Loh ML, Ohh M. Inhibition of SRC corrects GM-CSF ...
https://reach.sickkids.ca/display/16809
*  ScholarSpace at University of Hawaii at Manoa: pp60src-mediated phosphorylation of connexin43, a gap junction protein
Several laboratories have demonstrated a decrease in gap junctional communication in cells transformed by the src oncogene of ... pp60src-mediated phosphorylation of connexin43, a gap junction protein. File. Description. Size. Format. ... pp60v-src, and Cx43. Confocal microscopy data indicates that the two proteins are within physical proximity allowing for a ... Previous biochemical studies have been limited by the low levels of Cx43 protein in fibroblast cell lines. To obtain larger ...
http://scholarspace.manoa.hawaii.edu/handle/10125/9407
*  Angiotensin II Signal Transduction in Vascular Smooth Muscle | Circulation Research
c-Src, v-Src. =. pp60c-src kinase, pp60v-src kinase. ... proto-oncogene expression, and protein synthesis, on the basis ... This protein was originally isolated from v-Src-transformed chicken embryo fibroblasts by Kanner et al.62 FAK exhibits protein ... Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gβy subunit-mediated activation of mitogen-activated protein ... As such, Pyk2 is a candidate both to regulate c-Src and to link G protein-coupled vasoconstrictor receptors with protein ...
http://circres.ahajournals.org/content/80/5/607
*  Oncogenic fusion proteins adopt the insulin-like growth factor signaling pathway | Molecular Cancer | Full Text
In this review article we provide evidence that the mechanism of action of oncogenic fusion proteins associated with both ... Combined targeting of oncogenic fusion proteins along with the IGF1R may constitute a promising therapeutic approach. ... Thus, transformation by pp60src, the protein encoded by the src oncogene of Rous sarcoma virus, results in the constitutive ... Oncogene. 1995;11:545-52.PubMedGoogle Scholar. *. Kempf BE, Vogt PK. A genetic analysis of PAX3-FKHR, the oncogene of alveolar ...
https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-018-0807-z
*  Mouse disabled (mDab1): a Src binding protein implicated in neuronal development | The EMBO Journal
Stable association of pp60src and pp59fyn with the focal adhesion‐associated protein tyrosine kinase, pp125fak. Mol Cell Biol, ... Soriano P, Montgomery C, Geske R and Bradley A (1991) Targeted disruption of the c‐src proto‐oncogene leads to osteopetrosis in ... LexA-Src(wt), LexA-Src(FF), LexA-Src(ΔSH3), LexA-Src(SH2′) and LexA-Src(295R) (Table I). Total DNA was purified from selected ... Several labeled proteins including Src and proteins of ∼60 and 80 kDa were observed (Figure 6). To test whether mDab1 proteins ...
http://emboj.embopress.org/content/16/1/121
*  Anti-phospho-Src family (Tyr416) Antibody, clone 2N8, rabbit monoclonal | 04-857
... clone 2N8 is an antibody against phospho-Src family (Tyr416) for use in WB. Find MSDS or SDS, a COA, data sheets and more ... v-Src (a viral protein) is encoded by the chicken oncogene of Rous sarcoma virus, and Src (the cellular homologue) is encoded ... Src (also known as pp60src) is a non receptor Tyrosine Kinase involved in signal transduction in many biological systems and ... Gene Symbol: pp60c-src, ASV, c-SRC, SRC1, p60-Src, c-src, SRC UniProt Number: P12931 Research Sub-Category: Cytoskeletal ...
http://www.merckmillipore.com/INTL/en/product/Anti-phospho-Src-family-Tyr416-Antibody-clone-2N8-rabbit-monoclonal,MM_NF-04-857
*  Interactive Fly, Drosophila
Transformation of cells by the src oncogene results in elevated tyrosine phosphorylation of two related proteins, p80 and p85 ( ... Cortactin, a prominent substrate for pp60(c-src), is a filamentous actin (F-actin) binding protein. Cortactin can promote ... This identified several proteins, including CD2-associated protein (CD2AP), as targets for the cortactin Src homology 3 domain ... Cortactin, a filamentous actin cross-linking protein and a substrate of Src protein tyrosine kinase, is phosphorylated at ...
http://www.sdbonline.org/sites/fly/cytoskel/cortactin2.htm
*  List of MeSH codes (D08) - Wikipedia
... oncogene protein pp60(v-src) MeSH D08.811.913.696.620.682.725.800.551 --- proto-oncogene proteins c-fyn MeSH D08.811.913.696. ... proto-oncogene proteins c-yes MeSH D08.811.913.696.620.682.725.800.630 --- proto-oncogene proteins pp60(c-src) MeSH D08.811. ... proto-oncogene proteins c-bcr MeSH D08.811.913.696.620.682.700.776 --- proto-oncogene proteins c-pim-1 MeSH D08.811.913.696. ... proto-oncogene proteins c-kit MeSH D08.811.913.696.620.682.725.400.075 --- proto-oncogene proteins c-met MeSH D08.811.913.696. ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D08)
*  Sequence Similarity - 1O4L: CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH FRAGMENT2. Sequence Similarity Report Page
Src are identical to those for high affinity binding of full length inhibitors. ... V-SRC SH2 DOMAIN 11886 2.7.10.2 , Details 5 1O48 1 A PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC SH2 DOMAIN 9606 2.7.10.2 , ... C-SRC TYROSINE KINASE SH2 DOMAIN 9606 2.7.10.2 , Details 38 1SKJ 1 A PP60 V-SRC TYROSINE KINASE TRANSFORMING PROTEIN SH2 DOMAIN ... V-SRC SH2 DOMAIN 11886 2.7.10.2 , Details 33 1O46 1 A PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC SH2 DOMAIN 9606 2.7.10.2 , ...
http://www.rcsb.org/pdb/explore/sequenceCluster.do?structureId=1O4L&entity=1&seqid=95