Frontiers | Microglial Corpse Clearance: Lessons From Macrophages
... in the form of dead cells and protein aggregates. To prevent garbage buildup, the brain is equipped with efficient phagocytes: ... in the form of dead cells and protein aggregates. To prevent garbage buildup, the brain is equipped with efficient phagocytes: ... or chromatin proteins such as HMGB1 (high mobility group box 1 protein). These signals are initially recognized by the fluidic ... which fail to develop in the absence of c-Myb (10). c-Myb dependence is therefore a classifying criterion for macrophage ...
Frontiers | Cellular Senescence in Kidney Fibrosis: Pathologic Significance and Therapeutic Strategies
CCAT/enhancer binding protein-β (C/EBP-β), p38 mitogen-activated protein kinase (MAPK) (Flanagan et al., 2018). DNA damage and ... 2018). c-Myb and C/EBPβ regulate OPN and other senescence-associated secretory phenotype factors. Oncotarget 9 (1), 21-36. doi: ... DNA damage, oncogene activation and oxidative stress trigger DNA damage response (DDR) and activates ataxia telangiectasia ... AMP-activated protein kinase (AMPK). AMPK is an evolutionarily conserved protein kinase which regulates energy balance and ...