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*  The Heat Shock Protein 90 Inhibitor Geldanamycin and the ErbB Inhibitor ZD1839 Promote Rapid PP1 Phosphatase-Dependent...
Mouse monoclonal anti-ErbB2 (Ab-3) and monoclonal anti-tubulin (Ab-1) were purchased from Oncogene Research Products. ... which mediates lipid-protein and/or protein-protein interactions (9 , 10) , whereas the COOH-terminus of AKT contains a ... The Heat Shock Protein 90 Inhibitor Geldanamycin and the ErbB Inhibitor ZD1839 Promote Rapid PP1 Phosphatase-Dependent ... The Heat Shock Protein 90 Inhibitor Geldanamycin and the ErbB Inhibitor ZD1839 Promote Rapid PP1 Phosphatase-Dependent ...
http://cancerres.aacrjournals.org/content/63/22/7777
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Porter P. L., Garcia R., Moe R., Corwin D. J., Gown A. M. C-erbB-2 oncogene protein in in situ and invasive lobular breast ... 1) ⇓ . This cluster included genes such as cyclin E1, cdc6, PCNA, B-myb, histones and histone related centromeric proteins ( ... Decary S., Decesse J. T., Ogryzko V., Reed J. C., Naguibneva I., Harel-Bellan A., Cremisi C. E. The retinoblastoma protein ... Soomro S., Shousha S., Taylor P., Shepard H. M., Feldmann M. c-erbB-2 expression in different histological types of invasive ...
http://cancerres.aacrjournals.org/content/63/21/7167
*  The Characterization of Novel, Dual ErbB-2/EGFR, Tyrosine Kinase Inhibitors | Cancer Research
Amplification of the erbB-2 oncogene or overexpression of ErbB-2 protein is documented in a variety of other neoplastic tissues ... 2 ErbB-2, ErbB-3, and ErbB-4. EGFR and ErbB-2 have been investigated as potential targets for cancer therapy because of their ... ErbB family proteins have functional tyrosine kinase catalytic domains, with the exception of ErbB-3, which acts as a ... The expression of ErbB-2 protein was unaffected by treatment. B, inhibition of EGFR tyrosine phosphorylation was seen in ...
http://cancerres.aacrjournals.org/content/61/19/7196?ijkey=58d6033582f73a7f7f1f9b9a653b7b2ce69e20b9&keytype2=tf_ipsecsha
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New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades. Oncogene 2001; 20: 1532-9. ... Anti-erbB-2 antibody trastuzumab in the treatment of HER2-amplified breast cancer. Invest New Drugs 2005; 23: 391-409. ... along with the activation of transcription factors activator protein-1 (AP-1) and cAMP-responsive element-binding protein and ... G-protein-coupled receptors and signaling networks: emerging paradigms. Trends Pharmacol Sci 2001; 22: 368-76. ...
http://cancerres.aacrjournals.org/content/66/12/6243
*  Epidermal Growth Factor Receptor (HER1) Tyrosine Kinase Inhibitor ZD1839 (Iressa) Inhibits HER2/neu (erbB2)-overexpressing...
... but not phospholipase Cγ or GTPase-activating protein, distinguishes ErbB-3 signaling from that of other ErbB/EGFR family ... Kraus M. H., Popescu N. C., Amsbaugh S. C., King C. R. Overexpression of the EGF receptor-related proto-oncogene erbB-2 in ... Graus-Porta D., Beerli R. R., Daly J. M., Hynes N. E. ErbB-2, the preferred heterodimerization partner of all ErbB receptors, ... Goldman R., Levy R. B., Peles E., Yarden Y. Heterodimerization of the erbB-1 and erbB-2 receptors in human breast carcinoma ...
http://cancerres.aacrjournals.org/content/61/24/8887?ijkey=c4508afcdff8886694fcf88d360660c78d2a5617&keytype2=tf_ipsecsha
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A soluble protein related to the HER-2 proto-oncogene product is released from human breast carcinoma cells. Oncogene, 6: 639- ... Di Fiore P. P., Pierce J. H., Kraus M. H., Segatto O., King C. R., Aaronson S. A. erbB-2 is a potent oncogene when ... protein concentration in cell lysates was determined by Lowry assay (DC Protein assay, Bio-Rad, Hercules, CA). In some cases, ... protein concentration in cell lysates was determined by Lowry assay. Lysate samples containing 5 μg of protein were then added ...
http://cancerres.aacrjournals.org/content/61/12/4744
*  Activation of Akt-1 (PKB-α) Can Accelerate ErbB-2-Mediated Mammary Tumorigenesis but Suppresses Tumor Invasion | Cancer Research
4A) ⇓ . The differences in the levels of HA-AktDD, ErbB-2, and ErbB-3 were not caused by protein loading, because all tissues ... ErbB-2 was detected by a mouse monoclonal antibody (AB-3; Oncogene Research Products). ErbB-3 (C-17, 1:500) and Grb2 (C-23, 1: ... ErbB-2 (Neu and HER-2); (c) ErbB-3 (HER-3); and (d) ErbB-4 (HER-4; Ref. 1 ). The importance of ErbB-2 in primary human breast ... we have demonstrated an identical pattern of ErbB-2 and ErbB-3 expression, with 50% of samples showing elevated ErbB-2 and ErbB ...
http://cancerres.aacrjournals.org/content/64/9/3171
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... erbB proteins of ∼170-185 kDa are constitutively phosphorylated on tyrosine residues. Examination of erbB protein ... erbB2 using Oncogene OP15 (Oncogene Science Inc. Pharmaceuticals), 1 μg/100 μl lysate; and erbB3 with Santa Cruz SC-285 (Santa ... In addition to mitogenic signals, erbB proteins provide survival signals in some cells, in part by activation of the Akt kinase ... Analysis of tyrosine phosphorylation of the erbB proteins in these cells show that CP-654577 is markedly more potent than ...
http://cancerres.aacrjournals.org/content/63/15/4450
*  Hsp90 Inhibition Suppresses Mutant EGFR-T790M Signaling and Overcomes Kinase Inhibitor Resistance | Cancer Research
Gene and protein expression profiling of human ovarian cancer cells treated with the heat shock protein 90 inhibitor 17- ... ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines. Proc Natl Acad ... Addiction to oncogenes-the Achilles heal of cancer. Science 2002; 297: 63-4. ... Protein concentrations were determined using the bicinchoninic acid protein assay kit (Pierce) and equivalent amounts (50 μg) ...
http://cancerres.aacrjournals.org/content/68/14/5827.full
*  Nuclear ErbB2 Enhances Translation and Cell Growth by Activating Transcription of Ribosomal RNA Genes | Cancer Research
A ligand for the erbB-2 oncogene product (gp30) induces differentiation of human breast cancer cells. Cell Growth Differ 1992;3 ... we therefore analyzed total protein content and protein biosynthetic rate. Total protein level was apparently increased in MCF- ... Nuclear trafficking of the epidermal growth factor receptor family membrane proteins. Oncogene 2010;29:3997-4006. ... Nuclear ErbB2 increases protein synthesis and cell size. A, left, total protein contents from equal cell numbers of MCF-7 and ...
http://cancerres.aacrjournals.org/content/71/12/4269.long
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Antitumor effects of PLC-γ-(SH2)2-TAT fusion proteins on EGFR/c-erbB-2-positive breast cancer cells. Br J Cancer 2004; 90: 230- ... Oncogene 2005; 24: 7821-9.. OpenUrlCrossRefPubMed. *↵ Takenawa T, Miki H. WASP and WAVE family proteins: key molecules for ... Among the different Rac downstream effectors, Wiskott-Aldrich syndrome protein (WASP) family proteins seems to have an ... The homogenates were then centrifuged at 13,000 rpm for 10 min at 4°C, and the protein concentration was determined using a Bio ...
http://cancerres.aacrjournals.org/content/68/24/10187
*  DNA Vaccination Controls Her-2+ Tumors that Are Refractory to Targeted Therapies | Cancer Research
The neu oncogene encodes an epidermal growth factor receptor-related protein. Nature 1986; 319: 226-30. ... The neu oncogene, identified in ethylnitrosourea-induced rat neuroglioblastomas, is a homologue of human ErbB-2 ( 22). ... Akiyama T, Matsuda S, Namba Y, Saito T, Toyoshima K, Yamamoto T. The transforming potential of the c-erbB-2 protein is ... ErbB-2/Her-2/neu, a member of the ErbB receptor tyrosine kinase family, is weakly to moderately expressed in normal adult ...
http://cancerres.aacrjournals.org/content/68/18/7502.long
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Oncogene-induced senescence (OIS) plays a pivotal role in tumorigenesis. However, the metabolic programming events and the ... EGFR-mediated activation of MET was due to stabilization of MET protein expression and predominant MAP kinase signaling. Both ... and EGFR signaling led to the upregulation of MET without the involvement of other ERBB family of receptors. ... Resistance in this setting is primarily driven by secondary mutations in the KRAS oncogene, a downstream component of the EGFR ...
http://cancerres.aacrjournals.org/content/73/15/4595
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Roberts R. A., James N. H., Cosulich S. C. The role of protein kinase B and mitogen activated protein kinase in epidermal ... Pinkas-Kramarski R., Alroy I., Yarden Y. ErbB receptors and EGF-like ligands: cell lineage determination and oncogenesis ... Oncogene, 19: 6550-6565, 2000.. OpenUrlCrossRefPubMed. *↵ Crawford S. E., Stellmach V., Murphy-Ullrich J. E., Riberiro M. F., ... CD47/integrin-associated protein is a pentaspan membrane protein that signals via heterotrimeric Gi (26) to augment the ...
http://cancerres.aacrjournals.org/content/64/3/1026
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A number of oncogenes, including K-ras, Myc, ERBB gene family, and MET can be overexpressed or mutated in lung cancer, as well ... The focal adhesion protein paxillin is a target of a number of oncogenes involved in key signal transduction and important in ... Expression of the focal adhesion protein paxillin in lung cancer and its relation to cell motility. Oncogene 1999; 18: 67-77. ... Increased tyrosine phosphorylation of focal adhesion proteins in myeloid cell lines expressing p210BCR/ABL. Oncogene 1995; 11: ...
http://cancerres.aacrjournals.org/content/68/1/132
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Mammary or tumor protein (10 μg) was loaded onto 12% polyacrylamide gels for SDS-PAGE. Equal protein loading was determined by ... In many oncogene-induced models of mammary cancer, transgenic mice develop tumors with very short latencies, making it ... Pathway pathology: histological differences between ErbB/Ras and Wnt pathway transgenic mammary tumors. Am J Pathol 2002; 161: ... The protein concentrations of supernatants were determined by Bio-Rad detergent-compatible protein assay (Bio-Rad Laboratories ...
http://cancerres.aacrjournals.org/content/65/19/8617
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Reversion-inducing cysteine-rich protein with Kazal motifs interferes with epidermal growth factor receptor signaling. Oncogene ... Altered ErbB receptor signaling and gene expression in cisplatin-resistant ovarian cancer. Cancer Res 2005;65:6789-800. ... Principles of cancer therapy: oncogene and non-oncogene Addiction. Cell 2009;136:823-37. ... protein-protein interactions, and curated pathways. Gene set enrichment analysis is a widely used method for interpreting ...
http://cancerres.aacrjournals.org/content/71/13/4550
*  Down-regulation of Integrin α2 Surface Expression by Mutant Epidermal Growth Factor Receptor (EGFRvIII) Induces Aberrant Cell...
P130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading. Mol Biol Cell 2004; ... Potential benefits of the irreversible pan-erbB inhibitor, CI-1033, in the treatment of breast cancer. Semin Oncol 2002; 29: 11 ... EOC displays many genetic defects and altered expression of oncogenes and tumor suppressors, including elevated epidermal ... 3B), and total integrin α2 protein levels were reduced ( Fig. 4A, top, compare lanes 1, 3, and 5). In contrast, a modest ...
http://cancerres.aacrjournals.org/content/65/20/9280.long
*  Lineage Infidelity of MDA-MB-435 Cells | Cancer Research
The protein levels were quantified using the BCA Protein Assay kit (Pierce, Rockford, IL). Protein lysates were boiled for 5 ... Tan M, Yao J, Yu D. Overexpression of the c-erbB-2 gene enhanced intrinsic metastasis potential in human breast cancer cells ... Oncogene, 10: 167-75, 1995.. OpenUrlPubMed. *↵ Hochberg M, Lotem M, Gimon Z, Shiloni E, Enk CD. Expression of tyrosinase, MIA ... We examined the expression of the epithelial-specific proteins cytokeratin and EMA and the melanoma-specific proteins HMB45 ...
http://cancerres.aacrjournals.org/content/64/10/3479?ijkey=ce16e16cba75a0548088bd96dbab7f91a995c2ec&keytype2=tf_ipsecsha
*  Targeting HER-2/neu in Early Breast Cancer Development Using Dendritic Cells with Staged Interleukin-12 Burst Secretion |...
Peptides derived from a wild-type murine proto-oncogene c-erbB-2/HER2/neu can induce CTL and tumor suppression in syngeneic ... Vaccination with novel combinations of anti-HER2/neu cytokines fusion proteins and soluble protein antigen elicits a protective ... Human ErbB-2 (Her-2) transgenic mice: a model system for testing Her-2 based vaccines. J Immunol 2003; 171: 5787-94. ... Generation of T-cell immunity to the HER-2/neu protein after active immunization with HER-2/neu peptide-based vaccines. J Clin ...
http://cancerres.aacrjournals.org/content/67/4/1842.long
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Nakae S, Shimada E, Urakawa T. Study of c-erbB-2 protein and epidermal growth factor receptor expression and DNA ploidy pattern ... Oncogene Res 1987; 1: 149-68.. OpenUrlPubMed. * Cartwright CA, Meisler AI, Eckhart W. Activation of pp60(c-Src) protein kinase ... The protein concentration of cell lysates was determined using the BCA protein assay (Pierce, Rockford, IL) and total proteins ... protein levels were analyzed by immunoblotting (WB: α β-cat). The blot was reprobed to assess TCF4 (66 kDa) protein content. HC ...
http://cancerres.aacrjournals.org/content/66/4/2279
*  Index by author | Cancer Research
Expression of c-erbB-3 and c-erbB-4 Proteins in Papillary Thyroid Carcinomas ... Germline and Somatic Mutations in an Oncogene: RET Mutations in Inherited Medullary Thyroid Carcinoma ... Expression of c-erbB-3 and c-erbB-4 Proteins in Papillary Thyroid Carcinomas ... Expression of c-erbB-3 and c-erbB-4 Proteins in Papillary Thyroid Carcinomas ...
http://cancerres.aacrjournals.org/content/56/6.index-by-author
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Silencing the MET oncogene leads to regression of experimental tumors and metastases. Oncogene 2008;27:684-93. ... Discrepancies in ERBB-MET interactions among NSCLC cell lines arise from underlying differences in ERBB mutational status and ... In addition to regulating MET protein stability, it is possible that EGFR activates MET through signaling proteins such as Src ... EGFR, ERBB2, and ERBB3 have all been implicated in ERBB-MET signaling cross-talk. However, promiscuous ERBB dimerization and ...
http://cancerres.aacrjournals.org/content/73/16/5053
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Oncogene 2002; 21: 5529-39.. OpenUrlCrossRefPubMed. *↵. Ruppert JM, Vogelstein B, Kinzler KW. The zinc finger protein GLI ... ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer 2005; 5: 341-54. ... 1- 3). HH signaling is initiated by the binding of HH protein to its receptor Patched (PTCH), a transmembrane domain protein ... In our studies, EGFR did not affect the levels of GLIact proteins (see Fig. 3C; data not shown) and the synergistic activation ...
http://cancerres.aacrjournals.org/content/69/4/1284
*  Cocarcinogenic Effect of Capsaicin Involves Activation of EGFR Signaling but Not TRPV1 | Cancer Research
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene 2007;26:3291-310. ... Untangling the ErbB signalling network. Nat Rev Mol Cell Biol 2001;2:127-37. ... Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red ... Genomic PCR and Western blot analysis verified that the TRPV1 gene and protein were only detected in TRPV1/WT MEFs (Fig. 3A). ...
http://cancerres.aacrjournals.org/content/70/17/6859.full