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*  Marine Drugs | Free Full-Text | Omega-Conotoxins as Experimental Tools and Therapeutics in Pain Management | Notes
Although ω-conotoxins demonstrate analgesic efficacy in animal models of neuropathic pain and in human clinical trials, there ... In this review we discuss the growing application of ω-conotoxins, small peptides isolated from Conus species, in the ... The potency and selectivity with which ω-conotoxins inhibit their molecular targets, voltage-gated Ca2+ channels, is ...
http://www.mdpi.com/1660-3397/11/3/680/notes
*  Marine Drugs | Free Full-Text | ω-Conotoxins GVIA, MVIIA and CVID: SAR and Clinical Potential | HTML
This review compares the action of three ω-conotoxins, GVIA, MVIIA and CVID, describing their structure-activity relationships ... the ω-conotoxins) have emerged as a new class of therapeutics for the treatment of chronic and neuropathic pain. Earlier in ... Nielsen, K. J.; Thomas, L.; Lewis, R. J.; Alewood, P. F.; Craik, D. J. A consensus structure for omega-conotoxins with ... Wright, C. E.; Robertson, A. D.; Whorlow, S. L.; Angus, J. A. Cardiovascular and autonomic effects of omega-conotoxins MVIIA ...
http://www.mdpi.com/1660-3397/4/3/193/htm
*  N-Type Calcium Channels - N-Type Calcium Channel Summary Report | CureHunter
Omega toxins inhibit the actions of these channels by altering their voltage dependence. ... omega-Conotoxins 8. Sympatholytics 9. Desoxycorticosterone (DOCA) 10. Opioid Analgesics (Opioids) Related Therapies and ... Omega toxins inhibit the actions of these channels by altering their voltage dependence. ...
http://www.curehunter.com/public/keywordSummaryD020864-N-Type-Calcium-Channels-N-Type-Calcium-Channel.do
*  Plus it
1989) The inhibitory effects of omega-conotoxins on Ca channels and synapses. Ann N Y Acad Sci 560:230-248, doi:10.1111/j.1749- ...
http://www.jneurosci.org/content/35/5/2083
*  Molecules | Free Full-Text | Action of Natural Products on P2 Receptors: A Reinvented Era for Drug Discovery | HTML
Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes. J. Biol. Chem. 2000, 275, 35335- ... Lalo, U.V.; Pankratov, Y.V.; Arndts, D.; Krishtal, O.A. Omega-conotoxin GVIA potently inhibits the currents mediated by P2X ... Another family of peptides denominated as conotoxins, which belong to a group of neurotoxic peptides isolated from the venom of ...
http://www.mdpi.com/1420-3049/17/11/13009/htm
*  Conotoxin - Wikipedia
The cysteine arrangements are the same for omega, delta and kappa families, even though omega conotoxins are calcium channel ... Omega, delta and kappa families of conotoxins have a knottin or inhibitor cystine knot scaffold. The knottin scaffold is a very ... Nielsen KJ, Schroeder T, Lewis R (2000). "Structure-activity relationships of omega-conotoxins at N-type voltage-sensitive ... Mu-conotoxins have two types of cysteine arrangements, but the knottin scaffold is not observed. Mu-conotoxins target the ...
https://en.wikipedia.org/wiki/Conotoxin
*  Product Overview anti-CACNA1B Antibodies
Cav2.2 alpha2delta auxiliary subunit binds to omega-conotoxins * Activation of PKC resulted in its recruitment to and ... This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript ... Molecular cloning of the alpha-1 subunit of an omega-conotoxin-sensitive calcium channel. in Proceedings of the National ... calcium channels by analgesic alpha-conotoxins Vc1.1 and RgIA. ...
https://www.antibodies-online.com/abstract/Calcium+Channel%2C+Voltage-Dependent%2C+N+Type%2C+alpha+1B+Subunit+
*  Plus it
1994) Calcium channel diversity and neurotransmitter release: the omega-conotoxins and omega-agatoxins. Annu Rev Biochem 63:823 ...
http://www.jneurosci.org/content/28/46/11768
*  Professor Macdonald Christie - The University of Sydney
Sadeghi, M., Murali, S., Lewis, R., Alewood, P., Mohammadi, S., Christie, M. (2013). Novel [omega]-conotoxins from C. catus ... Sadeghi, M., Murali, S., Lewis, R., Alewood, P., Mohammadi, S., Christie, M. (2013). Novel [omega]-conotoxins from C. catus ... Jayamanne, A., Jeong, H., Schroeder, C., Lewis, R., Christie, M., Vaughan, C. (2013). Spinal actions of omega-conotoxins, CVID ... Jayamanne, A., Jeong, H., Schroeder, C., Lewis, R., Christie, M., Vaughan, C. (2013). Spinal actions of omega-conotoxins, CVID ...
http://sydney.edu.au/medicine/people/academics/profiles/mac.christie.php
*  CACNA1B - Wikipedia
"The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels". The ...
https://en.wikipedia.org/wiki/CACNA1B
*  Calcium Channel Diversity at the Vertebrate Neuromuscular Junction | Springer for Research & Development
... the omega-conotoxins and omega-agatoxins. Annu. Rev. Biochem. 63: 823-67.PubMedCrossRefGoogle Scholar ... high threshold current resistant to dihydropiridine blockers and omega-conotoxin. Neuron 6: 268-80.CrossRefGoogle Scholar ...
https://rd.springer.com/chapter/10.1007/978-1-4757-9555-4_4
*  Omega-conotoxin SVIA precursor - Conus striatus (Striated cone)
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). In vivo, this toxin is ... "Novel alpha- and omega-conotoxins from Conus striatus venom.". Ramilo C., Zafaralla G.C., Nadasdi L., Hammerland L.G., ... "Novel alpha- and omega-conotoxins from Conus striatus venom.". Ramilo C., Zafaralla G.C., Nadasdi L., Hammerland L.G., ... "Novel alpha- and omega-conotoxins from Conus striatus venom.". Ramilo C., Zafaralla G.C., Nadasdi L., Hammerland L.G., ...
http://www.uniprot.org/uniprot/P28880
*  Dr Greg Bourne - UQ Researchers
From Omega-Conotoxins to Macrocycle Mimetics. Schroeder, CI, Nielsen, KJ, Adams, DA, Loughnan, M, Thomas, L, Bourne, GT, Smythe ... ML, Alewood, PF, Craik, DJ and Lewis, RJ (2004). From Omega-Conotoxins to Macrocycle Mimetics. In: Journal of Peptide Science. ...
http://researchers.uq.edu.au/researcher/26
*  ASMscience | Biological Toxins: Safet
Omega-conotoxins as experimental tools and therapeutics in pain management. Mar Drugs 11 : 680- 699.[CrossRef][PubMed]. ... Conotoxins that confer therapeutic possibilities. Mar Drugs 10 : 1244- 1265.[CrossRef][PubMed]. ...
http://www.asmscience.org/content/book/10.1128/9781555819637.ch11
*  PROSITE
The omega conotoxins are calcium channel blockers, whereas delta conotoxins delay the inactivation of sodium channels [1]. The ... OMEGA_CONOTOXIN, PS60004; Omega-conotoxin family signature (PATTERN). * Consensus pattern:. C-[SREYKLIMQVN]-x(2)-[DGWET]-x-[ ... Lambda-conotoxins, a new family of conotoxins with unique disulfide pattern and protein folding. Isolation and characterization ... Omega, delta and kappa families of conotoxins have a knottin or inhibitor cystine knot scaffold. The knottin scaffold is a very ...
https://prosite.expasy.org/doc/PS60019
*  Calcium Channel α2δ1 Subunit Mediates Spinal Hyperexcitability in Pain Modulation
The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels. J Biol ... Structure and functional expression of an omega-conotoxin-sensitive human N-type calcium channel. Science. 1992;257:389-95. [ ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC1635965/?lang=en-ca
*  Insect toxin - Wikipedia
They are relatively homologous to the calcium channel blockers omega-conotoxins from marine cone snails and belong to the four- ...
https://en.wikipedia.org/wiki/Insect_toxin
*  Richard Tsien | Stanford Medicine Profiles
... expressed in Xenopus oocytes were blocked with a variety of omega-conotoxins, including omega-CTx-GVIA, omega-CTx-MVIIA, and ... Preferential interaction of omega-conotoxins with inactivated N-type Ca2+ channels JOURNAL OF NEUROSCIENCE Stocker, J. W., ... The selective block of N-type Ca2+ channels by omega-conotoxins has been a hallmark of these channels, critical in delineating ... Because omega-conotoxins act exclusively outside cells, our results suggest that voltage-dependent inactivation of Ca2+ ...
https://med.stanford.edu/profiles/richard-tsien
*  Conotoxin protein classification using free scores of words and support vector machines | BMC Bioinformatics | Full Text
... and omega-conotoxins from Conus striatus venom. Biochemistry 1992, 31(41):9919-9926. 10.1021/bi00156a009View ArticlePubMed ... Conotoxins are parts of the neurotoxic peptides isolated from the venom of the marine cone snail of the Genus Conus. They are ... We set out with the aim of providing a more accurate method of classifying protein sequences, using conotoxins as an example. ... Craik DJ, Adams DJ: Chemical modification of conotoxins to improve stability and activity. ACS Chem Biol 2007, 2: 457-468. ...
https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-12-217
*  List of MeSH codes (D20) - Wikipedia
... conotoxins MeSH D20.888.590.162.720 --- omega-conotoxins MeSH D20.888.590.162.720.700 --- omega-conotoxin gvia MeSH D20.888. ... omega-agatoxin iva MeSH D20.888.065.970 --- wasp venoms MeSH D20.888.230 --- cnidarian venoms MeSH D20.888.370 --- fish venoms ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D20)
*  List of MeSH codes (D23) - Wikipedia
... conotoxins MeSH D23.946.580.590.162.720 --- omega-conotoxins MeSH D23.946.580.590.162.720.700 --- omega-conotoxin gvia MeSH ... conotoxins MeSH D23.946.833.590.162.720 --- omega-conotoxins MeSH D23.946.833.590.162.720.700 --- omega-conotoxin gvia MeSH ... omega-agatoxin iva MeSH D23.946.833.065.970 --- wasp venoms MeSH D23.946.833.230 --- cnidarian venoms MeSH D23.946.833.370 --- ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D23)
*  Analgesic effect of highly reversible ω-conotoxin FVIA on N-type Ca2+ channels | Molecular Pain | Full Text
Stocker JW, Nadasdi L, Aldrich RW, Tsien RW: Preferential interaction of omega-conotoxins with inactivated N-type Ca 2+ ... Lewis RJ, Nielsen KJ, Craik DJ, Loughnan ML, Adams DA, Sharpe IA, et al.: Novel omega-conotoxins from Conus catus discriminate ... Scott DA, Wright CE, Angus JA: Actions of intrathecal omega-conotoxins CVID, GVIA, MVIIA, and morphine in acute and neuropathic ... Wright CE, Robertson AD, Whorlow SL, Angus JA: Cardiovascular and autonomic effects of omega-conotoxins MVIIA and CVID in ...
https://molecularpain.biomedcentral.com/articles/10.1186/1744-8069-6-97
*  COMPOSITIONS COMPRISING OPA PROTEIN EPITOPES - Patent application
Methods and compositions for the management of pain using omega-conotoxins. 2011-06-02. Vaccine formulations comprising saponin ...
http://www.patentsencyclopedia.com/app/20100183676
*  What's New in 2001
They are relatively homologous to the calcium channel blockers omega-conotoxins from marine cone snails and belong to the four- ... Novel omega-conotoxin from Conus consors: Dr. Favreau and colleages from France, report on a novel omega-conotoxin (omega-Ctx ... Omega-Conotoxin GVIA modulates purinergic receptors : Lalo, U.V., Pankratov, Y.V., Arndts, D. and Krishtal, O.A. (2001) Omega- ... Site Map of Cone Shells and Conotoxins HomePage SEARCH this Cone Shells and Conotoxins site. Enter your search word below :. ...
http://grimwade.biochem.unimelb.edu.au/cone/new2001.html