Antisense Oligonucleotide Therapy for Patients with Advanced Cancer | Center for Cancer Research
Antisense oligonucleotides (ASOs) may offer advantages over traditional therapies if an appropriate target can be identified. ... Antisense oligonucleotides (ASOs) may offer advantages over traditional therapies if an appropriate target can be identified. ... Modulation of tumor eIF4E by antisense inhibition: A phase I/II translational clinical trial of ISIS183750 - an antisense ... CCR researchers are investigating antisense oligonucleotides as potential treatments for this cancer. ...https://ccr.cancer.gov/news/article/antisense-oligonucleotide-therapy-for-patients-with-advanced-cancer
BNA Gapmer Antisense RNA Oligonucleotides
Bio-Synthesis's BNA gapmers chimeric antisense RNA oligonucleotide give you the highest knock-down, lowest off-target effect ... RNase H-Active Antisense Oligonucleotide Services. Gapmer antisense chimeras are designed to have both 2'OMe RNA and BNA in the ... In antisense technology, a single-stranded oligonucleotide added from outside may bind with target mRNA to form oligonucleotide ... BNA gapmer antisense RNA oligonucleotides offer greater potency and low toxicity than other modified nucleotide. ...http://www.biosyn.com/bna-gapmer-antisense-rna-oligonucleotide.aspx
References - Muscular Dystrophy - Fitness VIP
Gebski, B.L., Mann, C.J., Fletcher, S., and Wilton, S.D. (2003). Morpholino antisense oligonucleotide induced dystrophin exon ... 2007). Local dystrophin restoration with antisense oligonucleotide PRO051. N Engl J Med 357, 2677-2686. ... Summerton, J., and Weller, D. (1997). Morpholino antisense oligomers: design, preparation, and properties. Antisense Nucleic ... Effective exon skipping and restoration of dystrophin expression by peptide nucleic acid antisense oligonucleotides in mdx mice ...https://www.fitness-vip.com/muscular-dystrophy/references-atg.html
Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators | JEM
... in vitro impact of PS backbone-modified miRNA and antisense oligonucleotide G3139 on platelet activation. (a) Occlusion time ... ODN2395-induced signaling and GPVI as target receptor of PS oligonucleotides. (a) Platelet adhesion and thrombus formation ...http://jem.rupress.org/content/212/2/129/tab-figures-data
'oligonucleotides antisense' Protocols and Video...
... oligonucleotides antisense' include 'Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System'. ... Oligonucleotides, Antisense: Short fragments of DNA or RNA that are used to alter the function of target RNAs or DNAs to which ...https://www.jove.com/keyword/oligonucleotides+antisense
Patent US5580767 - Inhibition of influenza viruses by antisense oligonucleotides - Google Patents
In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically ... The oligonucleotide comprises nucleotide units sufficient in identity and number to effect said specific hybridization. In ... In additional preferred embodiments, the oligonucleotides are specifically hybridizable with RNA sequences involved in splicing ... other preferred embodiments, the oligonucleotides are specifically hybridizable with a transcription initiation site, a ...http://www.google.com/patents/US5580767?dq=5,815,488
Antisense Oligonucleotide | Springer for Research & Development
2007) Antisense Oligonucleotide. In: Schmidt R., Willis W. (eds) Encyclopedia of Pain. Springer, Berlin, Heidelberg. * .RIS ...https://rd.springer.com/referenceworkentry/10.1007/978-3-540-29805-2_261
Development of Multiexon Skipping Antisense Oligonucleotide Therapy for Duchenne Muscular Dystrophy
T. Koo and M. Wood, "Clinical trials using antisense oligonucleotides in duchenne muscular dystrophy," Human Gene Therapy, vol ... N. Dias and C. A. Stein, "Antisense oligonucleotides: basic concepts and mechanisms," Molecular Cancer Therapeutics, vol. 1, no ... T. Yokota, S. Takeda, Q.-L. Lu, T. A. Partridge, A. Nakamura, and E. P. Hoffman, "A renaissance for antisense oligonucleotide ... O-methyl-phosphorothioate RNA antisense oligonucleotides in the mdx mouse model," Molecular Therapy, vol. 18, no. 6, pp. 1210- ...https://www.hindawi.com/journals/bmri/2013/402369/ref/
Oligonucleotides, antisense | definition of Oligonucleotides, antisense by Medical dictionary
What is Oligonucleotides, antisense? Meaning of Oligonucleotides, antisense medical term. What does Oligonucleotides, antisense ... antisense in the Medical Dictionary? Oligonucleotides, antisense explanation free. ... oligonucleotide. (redirected from Oligonucleotides, antisense). Also found in: Dictionary, Encyclopedia. oligonucleotide. [ol″ĭ ... Oligonucleotides, antisense , definition of Oligonucleotides, antisense by Medical dictionary https://medical-dictionary. ...https://medical-dictionary.thefreedictionary.com/Oligonucleotides%2C+antisense
DSpace@MIT: Peptide-mediated delivery of antisense oligonucleotides and chemotherapeutics across biological...
Here we explore methods for the peptide-mediated delivery of antisense oligonucleotides (ASOs) and chemotherapeutics. First, we ... Peptide-mediated delivery of antisense oligonucleotides and chemotherapeutics across biological barriers. Research and Teaching ... Peptide-mediated delivery of antisense oligonucleotides and chemotherapeutics across biological barriers. Download ...http://dspace.mit.edu/handle/1721.1/118259
Review on investigations of antisense oligonucleotides with the use of mass spectrometry.
Antisense oligonucleotides have been investigated as potential drugs for years. They inhibit target gene or protein expression ... antisense oligonucleotides with the use of mass spectrometry.". Antisense oligonucleotides have been investigated as potential ... Antisense therapy with the use of antisense oligonucleotides (AON) ha.... Extending Urine Analysis By Direct Mass Spectrometry ... Home » Topics » Antisense therapy » Research » Review on investigations of antisense oligonucleotides with the use of mass ...https://www.bioportfolio.com/resources/pmarticle/1845669/Review-on-investigations-of-antisense-oligonucleotides-with-the-use-of-mass-spectrometry.html
JCI - Antisense oligonucleotides extend survival and reverse decrement in muscle response in ALS models
An early generation antisense oligonucleotide (ASO) targeting SOD1 was identified and tested in a phase I human clinical trial ... Antisense oligonucleotides extend survival and reverse decrement in muscle response in ALS models. ... Antisense oligonucleotides extend survival and reverse decrement in muscle response in ALS models. ... Oligonucleotides containing phosphorothioate backbone modifications (unmodified phosphodiester linkages noted with red o) and 2 ...https://www.jci.org/articles/view/99081/figure/1
Biomedicines | Free Full-Text | Targeting TGFβ Signaling to Address Fibrosis Using Antisense Oligonucleotides
With the recent approvals of two antisense oligonucleotides for the treatment of the genetic diseases Duchenne muscular ... Consideration is given to the advantages antisense oligonucleotides would have as an anti-fibrotic therapy alongside factors ... A prospective outlook for the development of antisense oligonucleotides to target fibrosis is outlined. ... we explore here the potential of antisense oligonucleotides to knockdown the expression of pro-fibrotic proteins. We give an ...https://www.mdpi.com/2227-9059/6/3/74
Dendrimer conjugates for light-activated delivery of antisense oligonucleotides - RSC Advances (RSC Publishing) DOI:10.1039...
There is great interest in therapeutic oligonucleotides (ONs), such as siRNA and antisense oligonucleotides (ASOs), for ... Dendrimer conjugates for light-activated delivery of antisense oligonucleotides†. Ahu Yuanab, Yiqiao Hub and Xin Ming*a a ... M. R. Alam, X. Ming, V. Dixit, M. Fisher, X. Chen and R. L. Juliano, Oligonucleotides, 2010, 20, 103-109 CrossRef CAS PubMed . ... Splice switching oligonucleotide. Acknowledgements. This work was supported by NIH grants 5U54CA151652 and 5R01CA151964 and an ...https://pubs.rsc.org/en/content/articlehtml/2015/ra/c5ra04091d
JCI - Welcome to the splice age: antisense oligonucleotide-mediated exon skipping gains wider applicability
Exon skipping uses antisense oligonucleotides (ASOs) to alter transcript splicing for the purpose of rescuing or modulating ... Welcome to the splice age: antisense oligonucleotide-mediated exon skipping gains wider applicability. ... Welcome to the splice age: antisense oligonucleotide-mediated exon skipping gains wider applicability. ...https://jci.org/articles/view/86799/figure/1
LErafAON-ETU : a Liposome Entrapped c-raf Antisense Oligonucleotide for Advanced Cancer
... May 21, 2005 - 10:42:00 AM ... LErafAON-ETU is NeoPharm's easy-to-use liposomal formulation of an antisense oligonucleotide (AON) complementary to the c-raf ... an Easy-To-Use Formulation of Liposome Entrapped c-raf Antisense Oligonucleotide, in Advanced Cancer Patients," highlights the ...http://www.rxpgnews.com/cancer-therapy/LErafAON-ETU_a_Liposome_Entrapped_c-raf_Antisense__1531_1531.shtml
Treatment of squamous cell carcinoma with HSP27 antisense oligonucleotides and radiotherapy - The University of British Columbia
Suitable antisense oligonucleotides have a length of from 12 to 35 oligonucleotides and have sequence specificity to the hsp27 ... The oligonucleotides employed as antisense or RNAi molecules may be modified to increase the stability of the oligonucleotides ... Liposomal antisense methyl phosphonate oligonucleotides and methods for their preparation and use. 1995-05-23. Tari et al.. ... The amount of antisense oligonucleotide or other therapeutic administered is one effective to reduce the amount of active hsp ...http://www.freepatentsonline.com/9381209.html
Antisense Oligonucleotides as Pharmacological Modulators of Gene Expression | Springer for Research & Development
Lamond Al, Sproat B, Ryder U, Hamm J (1989) Probing the structure and function of U2 snRNP with antisense oligonucleotides made ... Degols G., Leonetti JP., Lebleu B. (1991) Antisense Oligonucleotides as Pharmacological Modulators of Gene Expression. In: ... Cotten M, Schaffner G, Birnstiel ML (1989) Ribozyme, antisense RNA, and antisense DNA inhibition of U7 small nuclear ... Comparative inhibition of chloramphenicol acetyltransferase gene expression by antisense oligonucleotide analogues having alkyl ...https://rd.springer.com/chapter/10.1007/978-3-642-75862-1_9
WO1990005445A1 - Antisense oligonucleotides to c-myb proto-oncogene and uses thereof - Google Patents
These 'antisense' oligonucleotides are hybridizable to the c-myb mRNA transcript. Such oligonucleotides are useful in treating ... Oligonucleotides are provided having a nucleotide sequence complementary to at least a portion of the mRNA transcript of the ... The invention relates to antisense oligonucleotides to proto-oncogenes, and in particular to antisense oligo¬ nucleotides to ... no oligonucleo¬ tide) ; (ii) c-myb antisense alone, t=0 (no PHA) ; (iii) c-myb antisense, t=0; PHA, t=24 hours; (iv) c-myb anti ...https://patents.google.com/patent/WO1990005445A1
Peripheral Reduction of FGFR4 with Antisense Oligonucleotides Increases Metabolic Rate and Lowers Adiposity in Diet-Induced...
Treatment of diet-induce obese (DIO) mice with FGFR4 antisense oligonucleotides (ASO) specifically reduced liver FGFR4 ... Therefore, FGFR4 could be a potential novel target and antisense reduction of hepatic FGFR4 expression could be an efficacious ... Here, we report a novel approach involving antisense inhibition of fibroblast growth factor receptor 4 (FGFR4) in peripheral ...https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0066923
Lipid-Lowering Agents, ApoB Antisense Oligonucleotide | Drug, OTCs & Herbals | Medscape Reference
ApoB Antisense Oligonucleotide: Dosing, Uses, Side Effects, Interactions, Patient Handouts, Pricing and more from Medscape ...https://reference.medscape.com/drugs/lipid-lowering-agents-apob-antisense-oligonucleotide
Preparation of Antisense Oligonucleotides to Inhibit miRNA Function
... *Protocol 11: Inhibiting miRNA Function by Antisense ... Preparation of Antisense Oligonucleotides to Inhibit miRNA Function. (Protocol summary only for purposes of this preview site) ... Protocol 12: Inhibiting miRNA Function by Antisense Oligonucleotides in Drosophila S2 Cells *Panel: RNA Interference and Small ... This protocol is used to design antisense oligonucleotides (ASOs) for specific inhibition of miRNA function in cultured cells. ...http://molecularcloning.com/index.php?prt=210
CD40 antisense oligonucleotide inhibition of trinitrobenzene sulphonic acid induced rat colitis | Gut
Myers KJ, Murthy S, Flanigan A, et al. Antisense oligonucleotide blockade of tumor necrosis factor-α in two murine models of ... Effects of the antisense oligonucleotides (ODNs) on CD40 protein abundance. Cultured rat vascular smooth muscle cells were ... CD40 antisense oligonucleotide effects on T cell infiltration in 2,4,6-trinitrobenzene sulphonic acid (TNBS) induced colitis. ... CD40 antisense oligonucleotide (rAS3) effects compared with control or rScr treatment, on vascular cell adhesion molecule 1 ( ...https://gut.bmj.com/content/54/1/70?ijkey=e33ae7840f6d94201d49d11c6a17a2a7d53ad1a4&keytype2=tf_ipsecsha
Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC...
Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC- ... Gain of toxicity from ALS/FTD-linked repeat expansions in C9ORF72 is alleviated by antisense oligonucleotides targeting GGGGCC- ... Gain of toxicity from ALS/FTD-linked repeat expansions in C9ORF72 is alleviated by antisense oligonucleotides targeting GGGGCC- ... Gain of toxicity from ALS/FTD-linked repeat expansions in C9ORF72 is alleviated by antisense oligonucleotides targeting GGGGCC- ...https://www.ncbi.nlm.nih.gov/pubmed/27112497?access_num=27112497&link_type=MED&dopt=Abstract
JCI - Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide...
In vitro pharmacokinetics of phosphorothioate antisense oligonucleotides. J. Pharmacol. Exp. Ther. 1995. 275:462-473. View this ... Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis. Nat. Biotechnol. 2000 ... Characterization of a potent and specific class of antisense oligonucleotide inhibitor of human protein kinase C-α expression. ... Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice. Diabetes ...https://www.jci.org/articles/view/20911