Analysis of a zebrafish dync1h1 mutant reveals multiple functions for cytoplasmic dynein 1 during retinal photoreceptor...
Furthermore, dosage-dependent antisense oligonucleotide knock-down of dync1h1 revealed outer segment abnormalities in the ...
Activation of endogenous deltaF508 cystic fibrosis transmembrane conductance regulator by phosphodiesterase inhibition
Preincubation of CF-T43 cells with CFTR anti-sense oligonucleotides prevented an increase in 36Cl- efflux in response to beta- ...
Peripheral androgen receptor gene suppression rescues disease in mouse models of spinal and bulbar muscular atrophy
We developed antisense oligonucleotides that suppressed AR gene expression in the periphery but not the CNS after subcutaneous ...
Light-directed gene delivery by photochemical internalisation
Oligonucleotides, Antisense / administration & dosage * Organometallic Compounds / administration & dosage * Organometallic ...
Hepatitis B virus persistence after recovery from acute viral hepatitis
Oligonucleotides, Antisense Grants and funding * AI-20001/AI/NIAID NIH HHS/United States ...
MicroRNA silencing and the development of novel therapies for liver disease
Oligonucleotides, Antisense Grants and funding * R01 AA011576/AA/NIAAA NIH HHS/United States ...
Reid C[au] - Search Results - PubMed
Antisense oligonucleotide therapy for KCNT1 encephalopathy. Burbano LE, Li M, Jancovski N, Jafar-Nejad P, Richards K, Sedo A, ...
Amputation-induced reactive oxygen species are required for successful Xenopus tadpole tail regeneration
Oligonucleotides, Antisense / metabolism * Reactive Oxygen Species / metabolism* * Regeneration* / drug effects * Tail / drug ...
Eck SL[au] - Search Results - PubMed
Antisense oligonucleotides for therapeutic intervention. Eck SL, Nabel GJ. Eck SL, et al. Curr Opin Biotechnol. 1991 Dec;2(6): ...
Panagiotis Zis - Search Results - PubMed
Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS. Miller TM, Cudkowicz ME, Genge A, Shaw PJ, Sobue G, Bucelli RC, Chiò ...
Novel antisense anti-MDM2 mixed-backbone oligonucleotides: proof of principle, in vitro and in vivo activities, and mechanisms
... ... Antisense mixed-backbone oligonucleotides (MBO) specifically inhibit MDM2 expression in a dose- and time-dependent manner, ... These results provide a basis for clinical evaluation of antisense anti-MDM2 oligonucleotides as chemosensitizers and ... we have chosen to use gene silencing technologies including antisense oligonucleotides and RNA interference. In this article, ...
Van Damme P[au] - Search Results - PubMed
Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS. Miller TM, Cudkowicz ME, Genge A, Shaw PJ, Sobue G, Bucelli RC, Chiò ... Phase 1-2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS. Miller T, Cudkowicz M, Shaw PJ, Andersen PM, Atassi N, ...
Andrews J[au] - Search Results - PubMed
Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS. Miller TM, Cudkowicz ME, Genge A, Shaw PJ, Sobue G, Bucelli RC, Chiò ...
GEO Accession viewer
Embryonic Stem Cells_control_antisense_oligonucleotide. Organism. Mus musculus. Characteristics. cell type: ES cells. cell line ...
Intracellular distribution and mechanism of delivery of oligonucleotides mediated by cationic lipids
... at an early stage of the endocytotic pathway which leads to a marked increase in antisense activity and oligonucleotide nuclear ... Oligonucleotides are delivered by cationic lipids into the cytoplasm ... Conclusions: Oligonucleotides are delivered by cationic lipids into the cytoplasm at an early stage of the endocytotic pathway ... Intracellular distribution and mechanism of delivery of oligonucleotides mediated by cationic lipids Pharm Res. 1996 Sep;13(9): ...
Takahashi MK[au] - Search Results - PubMed
Identifying Antisense Oligonucleotides to Disrupt Small RNA Regulated Antibiotic Resistance via a Cell-Free Transcription- ...
Elgersma Y[au] - Search Results - PubMed
Antisense oligonucleotide treatment rescues UBE3A expression and multiple phenotypes of an Angelman syndrome mouse model. ...
New Approaches Targeting the Renin-Angiotensin System: Inhibition of Brain Aminopeptidase A, ACE2 Ubiquitination, and...
... antisense oligonucleotides or small interfering ribonucleic acids suppress hepatic angiotensinogen for weeks to months after 1 ...
Antisense targeting of 3' end elements involved in DUX4 mRNA processing is an efficient therapeutic strategy for...
... end elements involved in mRNA processing using antisense oligonucleotide drugs can be used as a strategy for gene silencing ... Antisense targeting of 3 end elements involved in DUX4 mRNA processing is an efficient therapeutic strategy for ... We conclude that targeting key functional 3 end elements involved in pre-mRNA to mRNA maturation with antisense drugs can lead ... and thus all mRNAs are virtually eligible for this antisense-mediated knockdown strategy. ...
Targeted gene correction by small single-stranded oligonucleotides in mammalian cells
ODN with a homology of 45 nucleotides showed the highest frequency and ODN with antisense orientation showed a 1000-fold higher ... Targeted gene correction by small single-stranded oligonucleotides in mammalian cells Gene Ther. 2001 Mar;8(5):391-9. doi: ... Surprisingly, these short single-stranded oligonucleotides (ODN) showed a similar gene correction frequency to chimeric RNA-DNA ... Deoxyoligonucleotides showed a higher frequency of gene correction than ribo-oligonucleotides of the identical sequence. These ...
Sarcoglycanopathy (Concept Id: C2936331)
- MedGen - NCBI
Designing Effective Antisense Oligonucleotides for Exon Skipping.. Shimo T, Maruyama R, Yokota T. Methods Mol Biol 2018;1687: ... Tips to Design Effective Splice-Switching Antisense Oligonucleotides for Exon Skipping and Exon Inclusion. ...
Amyotrophic lateral sclerosis type 10 (Concept Id: C2677565)
- MedGen - NCBI
Antisense oligonucleotide targeting DMPK in patients with myotonic dystrophy type 1: a multicentre, randomised, dose-escalation ...
GEO Accession viewer
XIAP antisense is now in clinical development in oncology.. Overall design. Human HCT116 colon cancer cell lines were ...
GEO Accession viewer
Fluorescent antisense cRNA was synthesized with cyanine 5-CTP (Cy5-CTP) or 3-CTP (Cy3-CTP), and T7 polymerase. The fluorescent- ... Fluorescent antisense cRNA was synthesized with cyanine 5-CTP (Cy5-CTP) or 3-CTP (Cy3-CTP), and T7 polymerase. The fluorescent- ... labeled antisense cRNA was purified with miRNeasy columns (Qiagen) according to manufacturers protocols and resuspended in ... labeled antisense cRNA was purified with miRNeasy columns (Qiagen) according to manufacturers protocols and resuspended in ...
GEO Accession viewer
... which may be useful near promoters where sufficient sense/anti-sense transcript mapping information is lacking. PIP-seq ...
GEO Accession viewer
Besides, sense to antisense reads ratio was calculated to indicate strand specificity. Hierarchical clustering and heatmap ...
GEO Accession viewer
Besides, sense to antisense reads ratio was calculated to indicate strand specificity. Hierarchical clustering and heatmap ...
Citrin Deficiency - GeneReviews® - NCBI Bookshelf
A complex allele with an insertion of 2667 nucleotides of processed cDNA in antisense orientation of NUS1 at 6q22.31 (reference ... Utility of oligonucleotide array-based comparative genomic hybridization for detection of target gene deletions. Clin Chem. ...