Research Synopsis: Theoretical studies of nucleic acid conformation, properties, and interactions *[email protected] ...

Nucleic Acids Res. 2010; 38: 214-220.. 23. Ng PC, Henikoff S. Predicting deleterious amino acid substitutions. Genome Res. 2001 ... The mutant residue prefers to be in another secondary structure; therefore the local conformation will be slightly destabilized ... Nucleic Acids Res. 2005; 33: 306-310. 26. Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, et al. UCSF ... Nucleic Acids Res. 42: D86-D91.. 29. Kelly BT, Tam JS, Verbsky JW, Routes JM. Screening for severe combined immunodeficiency in ...

Nucleic Acids Research, 2012. 40(16): p. 7622-7632. ISI[000308959800011].. [WOS]. HIV_1026-110812. ... Disrupting the Native Conformations of DNA/RNA.Xu, X., X. Wang, Y. Li, Y.H. Wang, and L. Yang. ... Preparation of Phenylacetic acid Derivatives as Inhibitors of Viral Replication. Chasset, S., F. Chevreuil, B. Ledoussal, and F ...

Nucleic_Acid_Hybridization,modify,28-JUL-08,(null),(null) C51108,CEB1_wt_Allele,modify,28-JUL-08,(null),(null) C29992,Cyclin-E_ ... Conformation_Dependent_Mutation_Detection,modify,28-JUL-08,(null),(null) C19230,Dideoxy_Fingerprinting,modify,28-JUL-08,(null ... Nucleic_Acid_Amplification_Tests,modify,28-JUL-08,(null),(null) C17562,in_situ_Hybridization,modify,28-JUL-08,(null),(null) ... Acid,modify,28-JUL-08,(null),(null) C545,Hexestrol,modify,28-JUL-08,(null),(null) C29530,Undecyclenic_Acid,modify,28-JUL-08,( ...

DynaMut: predicting the impact of mutations on protein conformation, flexibility and stability. Nucleic Acids Res. 2018;46(W1): ... The amino acids are colored according to the vibrational entropy change upon mutation. Blue represents a rigidification of the ... They showed as sticks alongside with the surrounding amino acids which are implicated on any type of interactions. B) The ... This mutation would lead to substitution of an important positive charged amino acid into another one with a small size and a ...

The conformation of the low-temperature form may represent a sequence-dependent structural feature important in natural DNA, ... The form that predominates at higher temperatures resembles B-DNA, but the other, while of similar conformation at the ends of ... High-field NMR techniques allow the conformations of these species to be examined. Both forms are right-handed double-helical ... Two conformations adopted by the tetranucleoside triphosphate d(TCGA) in aqueous solution are in slow-exchange equilibrium on ...

changes in the level and conformation of proteins, lipids, nucleic acids and carbohydrates ... You can extract a full spectrum of chemical information (from entities such as nucleic acids, proteins and lipids) without the ...

Read how to use locked nucleic acids to Increase oligo hybridization Tm, target affinity, nuclease resistance, and mismatch ... endo conformation. ... What are locked nucleic acids?. Locked nucleic acids are ... Manage sequence Tm using locked nucleic acid bases. Because of the afforded increase in Tm, locked nucleic acid qPCR probes can ... Locked nucleic acid oligonucleotides give control over hybridization. Locked nucleic acid oligonucleotides are useful in ...

H. Conformation of nucleic acids (helix (A, B, Z), t-RNA, micro-RNA).. I. Stability of proteins and nucleic acids.. J. ... Isolation of specific nucleic acid sequences. Generation of genomic and cDNA libraries in plasmid, phage, cosmid, BAC and YAC ... B Composition, structure and function of biomolecules (carbohydrates, lipids, proteins, nucleic acids and vitamins).. C. ... G. Conformation of proteins (Ramachandran plot, secondary structure, domains, motif and folds).. ...

Analysis of protein conjugates, micelle-solubilized membrane proteins, protein-nucleic acid complexes, nanoconjugates. ... Measurements of the second virial coefficient, conformation, and polymer branching.. Basic instrument specifications: This ...

Nucleic Acids Res 48(4):1800-1810. Ambient air pollution associated with breast cancer risk. Using several modeling approaches ... Estrogen-induced transcription at individual alleles is independent of receptor level and active conformation but can be ...

Protein Conformation16. *Molecular Structure11. *Research Support as Topic5. *Nucleic Acids3 ... 1. A Proposed Structure for the Nucleic Acids Creator: Pauling, Linus, 1901-1994 Date: [November-December 1952] Genre: Drafts ( ...

Protein Conformation16. *Molecular Structure11. *Research Support as Topic5. *Nucleic Acids3 ... A Proposed Structure for the Nucleic Acids Creator: Pauling, Linus, 1901-1994 Date: [November-December 1952] Genre: Drafts ( ... 7. Molecular Models of Amino Acids, Peptides, and Proteins Creator: Corey, Robert B.. Pauling, Linus, 1901-1994 Date: August ...

Protein Conformation16. *Molecular Structure11. *Research Support as Topic5. *Nucleic Acids3 ... 7. Molecular Models of Amino Acids, Peptides, and Proteins Creator: Corey, Robert B.. Pauling, Linus, 1901-1994 Date: August ...

Nucleic acids with their essential function as genetic information carriers serve as a very general pathogen-derived pattern ... The instability of such dimeric cGAS conformation is another enigma to be clarified, since cGAS2:DNA2 species could only be ... Nucleic acids with their essential function as genetic information carriers serve as a very general pathogen-derived pattern ... Another part of this thesis was dedicated to discover other physiological nucleic acid ligands of cGAS. Cell line experiments ...

The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis. Nucleic Acids Res 44(13): ... The best-studied mechanism is how ppGpp helps E. coli to cope with amino acid starvation by RelA and "ribosome stalling" [12][ ... Wang B, Grant RA, Laub MT (2020). ppGpp Coordinates Nucleotide and Amino-Acid Synthesis in E. coli During Starvation. Mol Cell ... During amino acid starvation, the levels of uncharged tRNAs increase, which leads to the stalling of ribosomes on mRNA ...

Tuning the PNA backbone conformation: synthesis and biophysical studies of dialkyl substituted peptide nucleic acids  ... Use of zinc in reformatsky reaction of chloroester, transesterification of ketoesters, synthesis of lipoic acid and utility of ... Understanding N-containing sachharides, their valorisation by solid acids and HPLC method development for separation and ...

DNA, Models, Molecular, Molecular Conformation, Nuclear Magnetic Resonance, Biomolecular, Nucleic Acid Conformation, ...

Nucleic Acids A. Isolated Nucleic Acids B. Recombinant Nucleic Acids C. Compositions Comprising Nucleic Acids IV. Methods for ... Homologous conformation may also be achieved by appropriate insertion, deletion, substitution, or modification of amino acid ... Other similar nucleic acids may be selected for by using homologous nucleic acids. Alternatively, nucleic acids encoding these ... Both a nucleic acid sequence and its corresponding protein sequence are provided. The nucleic acid sequence corresponds to Seq ...

Base Composition, Base Sequence, DNA, Hydrogen Bonding, Models, Molecular, Nucleic Acid Conformation, Oligodeoxyribonucleotides ...

Amino Acid; Sequence Homology, Nucleic Acid; Species Specificity; Tissue Distribution; Vacuoles / enzymology ... Protein Conformation; Proteolipids / genetics; Proton-Translocating ATPases / genetics; Restriction Mapping; Sequence Analysis ... Nucleic Acid / genetics; Tobacco / genetics; Transcription, Genetic / genetics ... MeSH headings : Amino Acid Sequence; Animals; Bacillus / enzymology; Bacillus / genetics; Bacteriophage lambda / genetics; Base ...

KinaMetrix: a web resource to investigate kinase conformations and inhibitor space. Nucleic Acids Res. 47(Database-Issue): D361 ...

... and nucleic acids. Includes introduction to membranes, enzyme mechanisms, prosthetic groups, macromolecular conformations and ... Polyfunctional compounds and natural products, lipids, carbohydrates, amino acids, proteins, ... Polyfunctional compounds and natural products, lipids, carbohydrates, amino acids, proteins, and nucleic acids. Includes ... introduction to membranes, enzyme mechanisms, prosthetic groups, macromolecular conformations and supramolecular architecture. ...

... and nucleic acids. Includes introduction to membranes, enzyme mechanisms, prosthetic groups, macromolecular conformations and ... Polyfunctional compounds and natural products, lipids, carbohydrates, amino acids, proteins, ... Polyfunctional compounds and natural products, lipids, carbohydrates, amino acids, proteins, and nucleic acids. Includes ... introduction to membranes, enzyme mechanisms, prosthetic groups, macromolecular conformations and supramolecular architecture. ...

Nucleic Acids Research, 39: D451-455 (2011). [LaHw09a] Lakkaraju, S.K. and Hwang, W., ``Critical buckling length versus ... Hw07] Hwang, W., ``Calculation of conformation-dependent biomolecular forces, J Chem Phys. 127 175104 (2007) ... persistence length: What governs biofilament conformation? Phys Rev Lett. 102 118102 (2009) ...

... protein-nucleic acid, and protein-ligand or substrate interaction. It is applicable to any protein. The optimized protocol uses ... 2020). Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science 367, 1260-1263. doi: 10.1126/science. ... other amino acid residues in the RBD; and , other amino acid residues outside the RBD. Other predicted domains: surface (S), ... Other amino acid residues susceptible to oxidative damage were also depleted in functional domains: met 0.6, tyr 0.8, and trp ...

Nucleic Acid Conformation, Protein Conformation ...

To build the missing region of S2-pep3 on the S protein, int-FOLD server (Mcguffin LJ et.al, Nucleic Acids Res. (2019) 47:W408- ... CoV-2 structure both in the context of open and closed conformation. The location and conformation of both, Sl-pepl and RBD- ... T-helper cell epitopes can contain 9 core amino acids with 3 flanking amino acids on each side for a total of 15 amino acids. ... "Codon-optimization" is defined herein as modifying a nucleic acid sequence for enhanced expression in a specified host cell by ...

... induction and contains a Z-nucleic acid binding (Z,jats:italic,α,/jats:italic,) domain. We report that knock-in mice bearing ... In summary, our results reveal that endogenous RNAs in Z-conformation have immunostimulatory potential that is curtailed by ... which abolish binding to Z-form nucleic acids, spontaneously induced type I IFNs and IFN-stimulated genes (ISGs) in multiple ... jats:title,Abstract,/jats:title,,jats:p,Nucleic acids are powerful triggers of innate immunity and can adopt the unusual Z- ...

... a high-order nanostructure assembled by parallel G-quadruplex units.1 The conformation-specific catalytic activity of G- ... Hanbin Mao Chemistry & Biochemistry , Mechanical Properties of DNA G-Quadruplex Structures The conformation of G-quadruplex ... Nucleic Acids Research 31, 1156-1163 (2003).. *Z. Tang, D.P.N. Gonçalves, M. Wieland, A. Marx, and J. S. Hartig, Novel DNA ... The conformation of G-quadruplex is an important property for applications based on this structure. For example, Miyoshi ...