Ethanol had no effect on cell adhesion or aggregation in a myeloma cell line expressing full-length human L1. In contrast, the ... The same effect was found with soluble L1-Fc, thus showing that the inhibitory effect is not dependent on cell adhesion. In ... a neural cell adhesion molecule. This observation suggests that inhibition of L1 plays a role in the pathogenesis of alcohol- ... a neural cell adhesion molecule. The neuropathology of the effects of ethanol on the developing central nervous system are ...

Cell aggregation assays were carried out in ethanol-sensitive, human L1-transfected NIH/3T3 cells in the absence and presence ... discrete sites to antagonize the actions of ethanol and 1-butanol on L1-mediated cell-cell adhesion. 1-Octanol antagonizes ... discrete sites to antagonize the actions of ethanol and 1-butanol on L1-mediated cell-cell adhesion. ... ethanol inhibition of L1-mediated cell adhesion and prevents ethanol teratogenesis in mouse whole embryo culture. Herein, we ...