Nigericin acts as an H+, K+, Pb2+ ionophore. Most commonly it is an antiporter of H+ and K+. In the past nigericin was used as ... Nigericin is an antibiotic derived from Streptomyces hygroscopicus. Its isolation was described in the 1950s, and in 1968 the ... Commercial supplier of nigericin sodium (Articles without KEGG source, ECHA InfoCard ID from Wikidata, Articles containing ... The structure and properties of nigericin are similar to the antibiotic monensin. Commercially it is obtained as a byproduct, ...

By the bioinformatics method, our data will facilitate the understanding of nigericin in PC cells, and provide new insight into ... This is the first report that discusses the potential functions of nigericin in cancers through the bioinformatics method. Our ... cell lines were exposed to increasing concentrations of nigericin for different time periods, and the high-throughput ... and these predicted miRNAs or mRNAs might be involved in nigericin damage. ...

We show that NLRP3 activators including bacterial pore-forming toxins, nigericin, ATP, and particulate matter caused ... We show that NLRP3 activators including bacterial pore-forming toxins, nigericin, ATP, and particulate matter caused ...

Next message: Nigericin help * Messages sorted by: [ date ] [ thread ] [ subject ] [ author ] BIOSCI is about halfway to its ...

Nigericin Sodium Salt. Biochemicals , Ionophores , Polyether Ionophores Substance Name:NSC 292567. CAS Number:28643-80-3 ...

PMA-differentiated WT and NLRP3 KO (B) or ASC KO (C) THP-1 cells were treated with 20 μM gefitinib for 8 h or 5 μM nigericin ... 5D), whereas nigericin-induced HMGB1 and mature-IL-1β release was completely attenuated, as well as mature-IL-1β release (Fig. ... D, E Requirement of ASC in gefitinib- or nigericin-induced HMGB1 release. PMA-differentiated WT and ASC KO THP-1 cells were ... 4A). Accordingly, nigericin-induced inflammation and death is largely governed by the NLRP3 inflammasome. However, there is no ...

Nigericin MafB regulates NLRP3 inflammasome activation by sustaining p62 expression in ... 2023 Commun Biol. Cui H. et al. DOI ...

Increased mature interleukin-1β (IL-1β) secretion from THP-1 cells induced by nigericin is a result of activation of p45 IL-1β- ... Perregaux, D. & Gabel, C. A. Interleukin-1β maturation and release in response to ATP and nigericin. Evidence that potassium ...

... diploid heterozygous null mutant is sensitive to chlorpromazine and nigericin Classical Genetics. conditional. *endocytosis: ...

Pyroptosis is a form of inflammatory programmed cell death, triggered by various pathological stimuli such as stroke or cancer.

Take nigericin, for example. Adding this ionophore of monovalent cations (10 mmol/l) and potassium in high concentration (100- ...

Nigericin) group (RASN group); ten animals were allocated to each group. We determined the arthritis index for each group of ... C.-C. Deng, Y. Liang, M. S. Wu et al., "Nigericin selectively targets cancer stem cells in nasopharyngeal carcinoma," The ... Rats in the RASN group were treated with NLRP3 inflammasome activator Nigericin (4 mg/kg) administrated intraperitoneally every ... Nigericin) group (RASN group); ten animals were allocated to each group. We determined the arthritis index for each group of ...

nigericin: ,chemical, An ionophore capable of acting as a carrier for K or Rb or as an exchange carrier for H with K. ...

We have also been working with nigericin, as an alternate inducing agent. ...

... caspase-1-dependent interleukin-18 maturation and caspase-1-independent necrosis triggered by the microbial toxin nigericin. ...

ATP and nigericin cause membrane damage by inducing the formation of a pore [2], while crystals create lysosomal membrane ... Membrane damage appears to be a common step in NLRP3 activation shared by a number of stimuli including ATP, nigericin and ... The bacterial toxin nigericin has also been reported to induce the activation of NLRP3 by causing potassium efflux in a ... Pannexin-1 couples to maitotoxin- and nigericin-induced interleukin-1beta release through a dye uptake-independent pathway. J ...

Where indicated the F505/F440 ratio was converted to absolute pHi by the high-K+/nigericin technique (calibration solutions C6 ...

A side-by-side comparison of known NALP3-inducers (ATP and nigericin) and lysosome disrupting agents (alum and Leu-Leu-OMe ( ...

... and nigericin were purchased from Sigma-Aldrich (St. Louis, MO). BCECF-AM was obtained from Thermo Fisher Scientific (Waltham, ... μM nigericin at pH 8.0 or pH 7.0. ...

In past work, several assays have been used to establish if an observed NPQ is qE, including addition of nigericin to inhibit ... In past work, several assays have been used to establish if an observed NPQ is qE, including addition of nigericin to inhibit ...

... and then stimulated with Nigericin (Nig. ), ATP or Alum. beta-actin served as a loading control. Quantification of Western ...

... or stimulated with nigericin (40 min) in the absence (Nigericin) or presence of curcumin (Nigericin + CUR) or colchicine (5 μM ... or stimulated with nigericin (40 min) in the absence (Nigericin) or presence of curcumin (Nigericin + CUR) or colchicine (5 μM ... then stimulated with nigericin (B) or with curcumin (40 μM) followed by nigericin or MSU stimulation (C). (D) mtROS production ... then stimulated with nigericin (B) or with curcumin (40 μM) followed by nigericin or MSU stimulation (C). (D) mtROS production ...

Inflammasome activation was induced with the addition of particular stimuli: 5 mm ATP (30 min) 10 μm nigericin (1 h) 500 μg/ml ... The InhibitorSelect 384-well protein kinase Library I MNS Bay 11-7082 and nigericin were purchased from Millipore. Anti-FLAG ...

Notably, a higher inducibility of NLRP3 inflammasome activation in response to ATP and nigericin following challenge with ...

The third toxin Nigericin is an ionophore, also synthesized by Streptomyces hygroscopicus. Nigericin possess a high affinity to ... Streptolysin O (a), Nigericin (b) and Hygromycin (c) were applied at different concentrations to NuLi-1 cells and their effects ... In contrast, the EC50 values for Nigericin increased from 0.9 μM (24 h) to 1.1 μM after 48 h. The EC50 value of hygromycin B ... However, Nigericin led first to an increase in impedance, which then slowly decreased depending on the used concentration over ...

Nigericin is a polyether antibiotic which affects ion transport and ATPase activity in mitochondria... ...

Nigericin 3.466672 4.007355 nilotinib 85.8056 91.64786 NL-71-101 242.279 157.1592 Nocodazole 6.511129 7.149245 ...

Nigericin is a polyether antibiotic which affects ion transport and ATPase activity in mitochondria... ...