InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
NF-kappa-B/Dorsal (IPR000451)*Nuclear factor NF-kappa-B, p105 subunit (IPR030503) ...
Viral protein involved in the activation of host NF-kappa-B. This protein is a pleiotropic transcription factor which is ... Several viruses have developed strategies to activate the NF-kappa-B pathway in order to promote viral replication and prevent ... activation by virus of host NF-kappaB transcription factor activity [ GO:0039652 ]. ...
The NF-kappa B family of transcription proteins represents multiple DNA binding, rel related polypeptides that contribute to ... In this study multiple NF-kappa B related polypeptides ranging from 85 to 45 kDa were examined for their capacity to interact ... These experiments emphasize the role of NF-kappa B dimerization as a distinct level of transcriptional control that may permit ... Heterodimerization and transcriptional activation in vitro by NF-kappa B proteins.. Cohen L1, Hiscott J. ...
NF-kappa-B-activating protein is a protein that in humans is encoded by the NKAP gene. GRCh38: Ensembl release 89: ... "Entrez Gene: NKAP NF-kappaB activating protein". Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial ... Zhande R, Karsan A (2007). "Erythropoietin promotes survival of primary human endothelial cells through PI3K-dependent, NF- ... 2004). "Inverse correlation between p16INK4A expression and NF-kappaB activation in melanoma progression". Hum. Pathol. 35 (8 ...
The IKK NF-kappa B system: a treasure trove for drug development.. Karin M1, Yamamoto Y, Wang QM. ...
In the cytosol, when complexed to an inhibitory molecule, I kappa B, NF-kappa B is in an inactive form and cannot bind DNA. ... Activation of cells with appropriate stimuli results in the dissociation of NF-kappa B from I kappa B and its translocation to ... Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro.. M B Toledano and W J Leonard ... We now demonstrate that NF-kappa B binding in vitro can be inhibited by agents that modify free sulfhydryls. Binding is ...
NFX1 Plays a Role in Human Papillomavirus Type 16 E6 Activation of NFκB Activity Mei Xu, Rachel A. Katzenellenbogen, Carla ... Herpes Simplex Virus 1 Ubiquitin-Specific Protease UL36 Abrogates NF-κB Activation in DNA Sensing Signal Pathway Ruijie Ye, ... Molluscum Contagiosum Virus Protein MC005 Inhibits NF-κB Activation by Targeting NEMO-Regulated IκB Kinase Activation Gareth ... Cooperation of the Ebola Virus Proteins VP40 and GP1,2 with BST2 To Activate NF-κB Independently of Virus-Like Particle ...
Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from ... the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B ... Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from ... the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B ...
I kappa B-alpha mRNA and protein levels are quickly induced by the activated NF-kappa B. This resurgence of I kappa B-alpha ... Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha.. K Brown, S Park, T Kanno, G ... We propose a model in which NF-kappa B and I kappa B-alpha mutually regulate each other in a cycle: saturating amounts of the ... Transfection studies reveal that the I kappa B-alpha mRNA and the encoded protein are potently induced by NF-kappa B and by ...
... Paulina Kleniewska,1 ... The aim of the present study was to assess whether BAY 11-7082, a nuclear factor-kappaB (NF-κB) inhibitor, influences the level ... control). ET-1 administration slightly downregulated gene expression of p65 of NF-κB but potently and in a dose-dependent way ... of reactive oxygen species (ROS), tumor necrosis factor alpha (TNF-α), and NF-κB related signaling pathways in the liver. The ...
... that interacts with a defined site in the kappa immunoglobulin enhancer. This protein can be induced in pre-B cells by ... NF-kappa B is a nuclear protein, found only in cells that transcribe immunoglobulin light chain genes, ... Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism Cell. 1986 Dec 26;47( ... NF-kappa B is a nuclear protein, found only in cells that transcribe immunoglobulin light chain genes, that interacts with a ...
It is critical in HIV gene expression as it has kappa B binding sites in the HIV-1 long-terminal repeat. Hence, targeting NF- ... NF-kappaB) is an important transcription factor, involved in many immune and inflammatory responses. ... Evans Blue is an inhibitor of nuclear factor-kappa B (NF-kappaB)-DNA binding Bioorg Med Chem Lett. 2004 Dec 20;14(24):6123-7. ... Nuclear factor-kappa B (NF-kappaB) is an important transcription factor, involved in many immune and inflammatory responses. It ...
NF-κB signaling is regulated by SIRT6, which is recruited to NF-κB target gene promoters by physical interaction with the NF-κB ... Researchers are increasingly linking aging and inflammation, and they are focusing their attention on the NF-kappa B (NF-κB) ... NF-κB (p65) is normally present in the cytoplasm in an inactive state. Figure 7(a) shows that very low NF-κB (p65) cytoplasmic ... For NF-κB (p65) staining, cells were incubated with the primary antibodies (NF-κB antibody, 1 : 500 dilution) for 2 hours at 37 ...
It is demonstrated here that the same pathway mediates induction of NF-kappa B by UV. Because inactive NF-kappa B is stored in ... and nuclear factor kappa B (NF-kappa B). This was postulated to occur by induction of a nuclear signaling cascade by damaged ... Enucleated cells are fully responsive to UV both in NF-kappa B induction and in activation of another key signaling event. ... NF-kappa B activation by ultraviolet light not dependent on a nuclear signal ...
In addition, we inhibited NF-κB activity in these cells and analyzed the effects on myogenic differentiation. We show that ... However, after treatment of the cells with two different small-molecule NF-κB-inhibiting compounds, the IKK inhibitor curcumin ... Thus, here, we tested whether the ubiquitous transcription factor NF-κB, which regulates myogenic differentiation and is also a ... For this purpose, we analyzed NF-κB activity (classical pathway) in myoblasts with different differentiation potential, ...
Jr Selective activation of NF-kappa B subunits in human breast cancer: potential roles for NF-kappa B2/p52 and for Bcl-3. ... NF-kappa B genes have a major role in Inflammatory Breast Cancer. Florence Lerebours,. 1,2 Sophie Vacher,1,2 Catherine Andrieu, ... NF-kappa B activation in human breast cancer specimens and its role in cell proliferation and apoptosis. Proc Natl Acad Sci USA ... The 35 upregulated genes included NF-κB genes (NFKB1, RELA, IKBKG, NFKBIB, NFKB2, REL, CHUK) and NF-κB-regulated genes involved ...
... kappa]B/c-Jun/AP-1-dependent pathway.(Research, cyclooxygenase-2, nuclear factor, Report) by Environmental Health Perspectives ... kappa]B[alpha] [inhibitor of transcription factor NF[kappa]B-[alpha]), phosphorylated I[kappa]B[alpha] (P-I[kappa]B[alpha]), c- ... kappa]B (I[kappa]B) kinase [beta]; an upstream kinase responsible for nuclear factor [kappa]B (NF[kappa]B) activation] or ... of COX-2 and activation of AP-1 and NF[kappa]B, and show that both AP-1 and NF[kappa]B are required for Cr(VI)-induced COX-2 ...
Results Administration with LV-ShRNA-Panx1 markedly decreased the expression levels of TLR2/4/NF-κB pathway-related agents in ... On the contrary, administration of LV-Panx1-EGFP elevated the expressions of TLR2/4/NF-κB pathway-related agents, which ... Conclusion Pannexin-1 channels may contribute to inflammatory response and neurobehavioral dysfunction through the TLR2/TLR4/NF ... and western blotting were performed to explore the potential interactive mechanism between Pannexin-1 channels and TLR2/TLR4/NF ...
... kappa $B signaling. Here we present a systematic way to derive a minimal model from an up-to-dated and detailed NF-$\kappa $B ... kappa $B signaling. Simulating the detailed ODE model for NF-$\kappa $B signaling network with large sets of the parameter ... Abstract: D35.00012 : Understanding Dynamic Patterns of NF-$\kappa $B Signaling: Derivation and Analysis of a Minimal Model ... Understanding the pleiotropism of NF-$\kappa $B signal transduction is a challenge of clear medical importance and systems ...
In addition, NF-kappa B p65 (RelA), but not NF-kappa B p50 (NFKB1), binds specifically to the NF-kappa B site. When incubated ... overexpression of the NF-kappa B inhibitor molecule, I kappa B, abolished the RelA- and RelA/NF-IL-6-dependent synergistic ... Synergistic transcriptional activation of the IL-8 gene by NF-kappa B p65 (RelA) and NF-IL-6.. C Kunsch, R K Lang, C A Rosen ... Because adjacent binding sites for the inducible transcription factors NF-kappa B and NF-IL-6 are located within this region, ...
Nuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and ... NF-kappa B signaling pathway - Homo sapiens (human) [ Pathway menu , Organism menu , Pathway entry , Download KGML , Show ... There are several pathways leading to NF-kappa B-activation. The canonical pathway is induced by tumour necrosis factor-alpha ( ... which allows the p50/p65 NF-kappa B dimer to enter the nucleus and activate gene transcription. Atypical pathways are IKK- ...
... on IL-1β-mediated NF-κB-activation were examined. Results IL-1β increased NF-κB luciferase activity (8-fold) and NF-κB ... Our data suggest the inhibitory effects of L-Arg on NF-κB activation are mediated in part by iNOS since SNP preserves and NNA ... Conclusion The inhibitory effects of L-Arg on IL-1β-mediated NF-κB-activation in Caco-2 cells involve L-Arg transport activity ... System y+ CAT1 siRNA decreased CAT1 expression, L-Arg transport activity and attenuated the inhibitory effects of L-Arg on NF- ...
... nuclear factor-kappa B (NF-kappa B), in normal human monocytes (Mono Mac 6 cells: MM6). The study revealed ... 0/DNA-Binding Proteins; 0/I-kappa B Proteins; 0/Iron Radioisotopes; 0/NF-kappa B; 9007-49-2/DNA ... nuclear factor-kappa B (NF-kappa B), in normal human monocytes (Mono Mac 6 cells: MM6). The study revealed that the exposure of ... and that the heavy ion-induced activation of NF-kappa B is mediated through phosphorylation of I-kappa B alpha and the ...