The principal regulator of inflammatory gene expression is nuclear factor kappa B (NFκB), a transcription factor. Nuclear NFκB ... affect the core IκB-NFκB signaling module to modulate NFκB activation in response to several stimuli. We review some well- ... Signaling Crosstalk Mechanisms That May Fine-Tune Pathogen-Responsive NFκB. Creators. Adelaja, Adewunmi Hoffmann, Alexander ... The IκB-NFκB signaling module receives input signals from a variety of pathogen sensors, such as toll-like receptors (TLRs). ...