Spitz nevus is named after Dr. Sophie Spitz, who in 1948 reported a case series of ... Spindle cell and epithelioid cell nevi with atypia and metastasis (malignant Spitz nevus). Am J Surg Pathol. 1989 Nov. 13(11): ... Pigmented spindle cell nevus (Reed nevus). Pigmented spindle cell nevus (Reed nevus) is either a junctional or a superficial ... Spitz nevi are composed of spindled and/or epithelioid melanocytes; the proportion of spindled versus epithelioid cells varies ...

Three distinct cell types are recognized in uveal melanomas: spindle A, spindle B, and epithelioid. ... Patients with choroidal nevi, a family history of uveal melanoma, congenital ocular melanocytosis, dysplastic nevus syndrome, ... Three distinct cell types are recognized in uveal melanomas, spindle A, spindle B, and epithelioid. ... Spindle B cells have an elongated profile, but they are slightly larger than spindle A cells and have prominent nucleoli. They ...

Three distinct cell types are recognized in uveal melanomas: spindle A, spindle B, and epithelioid. ... Patients with choroidal nevi, a family history of uveal melanoma, congenital ocular melanocytosis, dysplastic nevus syndrome, ... Three distinct cell types are recognized in uveal melanomas, spindle A, spindle B, and epithelioid. ... Spindle B cells have an elongated profile, but they are slightly larger than spindle A cells and have prominent nucleoli. They ...

A type of melanocytic nevus, it affects the epidermis and dermis. It is also known as an epithelioid and spindle-cell nevus, ... Spitz nevi characteristically have vertically arranged nests of nevus cells that have both a spindled and an epithelioid ... The main histologic differential diagnoses are pigmented spindle cell nevus and malignant melanoma. Surgical removal is usually ... Genetic studies of Spitz nevi have shown that most cells have the normal number of chromosomes, however a minority (25%) of ...

Spindle cell and epithelioid cell nevi with atypia and metastasis (malignant Spitz nevus). Am J Surg Pathol. 1989; 13: 931-939 ... Nevoid melanoma: a clinicopathological study of seven cases of malignant melanoma mimicking spindle and epithelioid cell nevus ... Epithelioid blue nevus occurring in children with no evidenice of Carney complex. Am J Dermatopathol. 1999; 21: 483-486. ... The epithelioid blue nevus. A multicentric familial tumor with important associations, including cardiac mixoma and ...

Oral melanocytic nevi are benign proliferations of nevus cells in the epithelial layer, the submucosal layer, or both. ... Field and Ackermann described the features characteristic of intraoral nevi. ... Teh M, Sinniah R. Spindle and epithelioid cell nevus of tongue at an unusual site. Oral Surg Oral Med Oral Pathol. 1989 Jan. 67 ... cellular blue nevi, congenital nevi, combined nevi, balloon cell nevi, epithelioid blue nevi, plaque-type blue nevi, halo nevi ...

Clinical review of 247 case records of Spitz nevus (epithelioid cell and/or spindle cell nevus). Dermatology 1997;194(1): 20-5 ... Since the first description of spindle cell nevus by Sophie Spitz in 1948, numerous papers have been published on this ... "Atypical" Spit`z nevus, "malignant" Spit`s nevus, and "metastasizing" Spitz`s nevus: a critique in historical respective of ... Spitz nevus prevalence among removed nevi in 8-year period is 0.6%.In our series 68.4% of patients were younger than 20 years ...

Figure 12-16 Spindle-cell choroidal nevus (between arrows) is composed of slender spindle-shaped cells with thin, homogeneously ... Spindle cell melanoma has the best prognosis; epithelioid melanoma, the worst. Melanomas of mixed-cell type have an ... Spindle cell melanoma consists primarily of spindle-B melanoma cells (see Fig 12-18). It may also contain spindle-A cells (see ... Tumors composed of a mix of spindle-A and spindle-B melanoma cells are designated spindle cell melanomas.. ...

Nevus, Spindle Cell, Epithelioid Cells, Nevus, Epithelioid and Spindle Cell, Nevus, Pigmented, Keratosis, Keratosis, Seborrheic ... Stem Cells, Pharmacogenetics, Drug Resistance, Toxicity, Cell Division, Genetics, Genetic Phenomena, 37643, Genetic Structures ... Medicine, Melanoma, Melanoma, Amelanotic, Nevus, Drug Therapy, Radiotherapy, Medical Oncology, Molecular Biology, Pathology, ... Stromal Cells, Adipocytes, Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved = ...

Epithelioid and spindle cell nevus (morphologic abnormality). Code System Preferred Concept Name. Epithelioid and spindle cell ... M]Spitz nevus Active Synonym false false 1218542014 [M]Epithelioid and spindle cell nevus Active Synonym false false ... Epithelioid and spindle cell nevus Active Synonym false false 146020010 Juvenile nevus Active Synonym false false ... M]Juvenila nevus Active Synonym false false 1218541019 [ ... Pigmented spindle cell nevus of Reed Active Synonym false false ...

Case Example Atypical Spitz Nevus Affirmed at Melanoma Tumor Board on 1-24-11 by Hoffman H, Swick B, Liu V, and Stone M ... Spitz Nevus return to: Melanoma (Evaluation and Management) see also: ... is defined by the presence of distinctive-appearing spindle or epithelioid cells on light microscopy in a recognizable nevus- ... Spindle cell melanocytic lesions -- part I: an approach to compound naevoidal pattern lesions with spindle cell morphoogy and ...

epithelioid and spindle cell nevus DOID:2413 * Fibroma HP:0010614 * basaloid squamous cell carcinoma ...

Nevus, Epithelioid and Spindle Cell, ROC Curve, Reproducibility of Results, Sensitivity and Specificity, Skin Neoplasms, ... keywords = "Dermatology, Humans, Logistic Models, Melanoma, Microscopy, Models, Theoretical, Nevus, Epithelioid and Spindle ... Cell, ROC Curve, Reproducibility of Results, Sensitivity and Specificity, Skin Neoplasms, Software, Dermatology, Humans, ...

WC), Blue nevus - intermed. mag. (WC) [5] Cellular blue nevus dermal lesion with pigmented spindle cells & epithelioid cells ... Pigmented spindle cell nevus of Reed (AKA Pigmented spindle cell nevus) nests of heavily pigmented spindle cells, DE junction ... Spitz nevus (epithelioid and spindle-cell nevus) long axis of nests perpendicular to surface, DE junction lesion spindled, ... The pigmented cells are negative on the Prussian blue stain. Sclerosing blue nevus. The sections show pigmented spindle cells ...

Figure 2B: Histopathologic examination reveals a heavily pigmented tumor composed of spindle B and epitheloid cells as well as ... It is important to remember iris nevi can also be associated with ectropion uveae so the presence of this does not imply ... Histopathologic examination reveals a minimally pigmented vascularized tumor composed of spindle A and spindle B cells. ... Histopathologic examination reveals a minimally pigmented vascularized tumor composed of spindle A and spindle B cells. ...

Nevus, Spindle Cell, Epithelioid Cells, Nevus, Epithelioid and Spindle Cell, Nevus, Pigmented, Keratosis, Keratosis, Seborrheic ... Neoplasms, Medical Oncology, Oncology Service, Hospital, Lung, Lung Neoplasms, Carcinoma, Small Cell, Carcinoma, Non-Small-Cell ... Medicine, Melanoma, Melanoma, Amelanotic, Nevus, Drug Therapy, Radiotherapy, Medical Oncology, Molecular Biology, Pathology, ... Endocrinology, Diagnostic Techniques, Endocrine, Endocrine Surgical Procedures, Metabolism, Insulin-Secreting Cells, Diabetes ...

Nevus, melanoma, dermatofibroma, neurofibroma, adnexal neoplasm. Nests and fascicles of spindle to epithelioid cells variably ... PAS+ clear cells at base. CD34+ outer root sheath cells. Exophytic (verrucous) HSV infection. SCC. Multinucleation, chromatin ... Follicles and plasma cells, no atypia, polyclonal, TCR-. BCC: Basal cell carcinoma; HSV: Herpes simplex virus; MAC: Microcystic ... Blue nevus-like metastatic melanoma. Benign blue nevus. Mitoses, necrosis, nuclear atypia. FISH for 6q23, 6p25, 11q13 and ...

Richard Scolyer: Pigmented Spindle Cell Nevus. *Arnaud de la Fouchardiere: Malignant Spitz Tumor/SPitz Nevus/Pigmented Spindle ... Artur Zembowicz: Pigmented Epithelioid Melanocytoma. *Arnaud de la Fouchardiere: Deep Penetrating Nevus Combined Naevus ... Subcutaneous Panniculitis-like T Cell Lymphoma Primary Cutaneous Gamma/Delta T Cell Lymphoma, Extranodal NK/T Cell Lymphoma; ... Primary Cutaneous Acral CD8+ T-Cell Lymphoma; Primary Cutaneous CD4+ Small/Medium T-Cell Lymphoproliferative Disorder) ...

Oral melanocytic nevi are benign proliferations of nevus cells in the epithelial layer, the submucosal layer, or both. ... Field and Ackermann described the features characteristic of intraoral nevi. ... Teh M, Sinniah R. Spindle and epithelioid cell nevus of tongue at an unusual site. Oral Surg Oral Med Oral Pathol. 1989 Jan. 67 ... cellular blue nevi, congenital nevi, combined nevi, balloon cell nevi, epithelioid blue nevi, plaque-type blue nevi, halo nevi ...

Oral melanocytic nevi are benign proliferations of nevus cells in the epithelial layer, the submucosal layer, or both. ... Field and Ackermann described the features characteristic of intraoral nevi. ... Teh M, Sinniah R. Spindle and epithelioid cell nevus of tongue at an unusual site. Oral Surg Oral Med Oral Pathol. 1989 Jan. 67 ... cellular blue nevi, congenital nevi, combined nevi, balloon cell nevi, epithelioid blue nevi, plaque-type blue nevi, halo nevi ...

No clear consensus exists for the management of Spitz nevi (SNs) or atypical Spitz tumors (ASTs), particularly in the pediatric ... Spindle and epithelioid cell nevus (Spitz nevus): natural history following biopsy. Arch Dermatol. 1990;126(12):1581-1583. ... Spindle and epithelioid cell nevus (Spitz nevus): natural history following biopsy. Arch Dermatol. 1990;126(12):1581-1583. ... A, Spitz nevus with typical histologic characteristics. B, Spitz nevus with typical histologic characteristics and a positive ...

Spitz nevi are benign melanocytic melanomas composed of epithelioid or spindle cell melanocytes. They usually present as ... Over time, nevus spilus may give rise to common lentigines, melanocytic nevi, Spitz nevi, and melanomas (summary by Sarin et al ... Nevus spilus, also known as speckled lentiginous nevus, is a congenital hyperpigmented patch that progressively evolves, with ... Large congenital melanocytic nevus. MedGen UID: 330752. •Concept ID: C1842036. •. Neoplastic Process. ...

Spitz nevi are benign melanocytic melanomas composed of epithelioid or spindle cell melanocytes. They usually present as ... Over time, nevus spilus may give rise to common lentigines, melanocytic nevi, Spitz nevi, and melanomas (summary by Sarin et al ... Nevus spilus, also known as speckled lentiginous nevus, is a congenital hyperpigmented patch that progressively evolves, with ... Large congenital melanocytic nevus. MedGen UID: 330752. •Concept ID: C1842036. •. Neoplastic Process. ...

In other areas, pigmented spindled and dendritic cells infiltrated thickened collagen bundles in a pattern of a blue nevus. A ... A nodular proliferation of epithelioid melanocytes was seen within the deep dermis and subcutaneous tissue. The periphery of ... keywords = "Balloon cell change, Blue nevus, Combined melanocytic nevus, Congenital nevus, Proliferative nodule, Rosette ... In other areas, pigmented spindled and dendritic cells infiltrated thickened collagen bundles in a pattern of a blue nevus. A ...

... "pigmented spindle cell nevus", thought to be a Spitz nevus variant), peripheral circumscription (cell aggregates rather than ... 6C) Epithelioid cells have abundant amphophilic cytoplasm, well-defined cell borders, and large vesicular nuclei with ... Combined melanocytic nevi, comprising a Spitz nevus component in conjunction with another nevus type [usually acquired nevi] ... myxoid and plexiform Spitz nevi (Lyon, 2010), and pigmented spindle cell nevus (Ferrara et al., 2005; Mooi, 2002). ...

events include the transformation of the cells within the nevi to a spindle-cell and buy eFT508 eventually epithelioid-cell ... Epithelioid cells are considered the most aggressive type of uveal melanoma Org 27569 cells and carry the worst prognosis. This ... Methods Cell culture B16-F10 melanoma cells which can grow in the C57BL/6 strain mouse were purchased from the National Cell ... is expressed on various cell types, including endothelial cells,[12, 13] CD34-positive hematopoietic cells,[14] and peripheral ...

Deep penetrating nevi (DPN) are uncommon but distinctive melanocytic neoplasms that show an epithelioid to spindle cell ... We characterized the immune cell repertoire in peripheral blood and the capacity of immune cells to respond ex vivo to ... Finally, immunological synapses between FAP cytotoxic T cells and tumor target cells were more poorly structured. Our findings ... T cell migration and effector function differences in familial adenomatous polyposis patients with APC gene mutations. ...

We analyzed a check details series of spindled and epithelioid cell nevi (Spitz) and primary cutaneous nodular melanomas to ... Malignant transformation to metaplastic carcinoma of the spindle-cell type was observed following surgical resection. This ... more trans conformation, rescued the levels of A beta PP at the plasma membrane in Pin1 knockout cells. learn more Thus, loss ... Regional loss of the TRPM1 mRNA expression by a significant subset of dermal tumor cells or a complete absence of TRPM1 ...

... spindle-A, and spindle-B cells (mixed-cell melanomas). Pure epithelioid-cell primary melanomas are infrequent (approximately 3 ... Melanocytic stromal proliferations and nevi of the iris are the most common tumors of the iris, but melanoma is rare.[. 1. ,. 2 ... spindle-shaped cells with slender nuclei and lacking visible nucleoli).. * Spindle-B cells (spindle-shaped cells with larger ... Epithelioid cells (larger polygonal cells with one or more prominent nucleoli).. * Intermediate cells (similar to but smaller ...