The proopiomelanocortin system in cutaneous neuroimmunomodulation. An introductory overview · Pediatric Palliative Care Library
The proopiomelanocortin system in cutaneous neuroimmunomodulation. An introductory overview. Title. The proopiomelanocortin ... Luger TA; Paus R; Slominski A; Lipton J, "The proopiomelanocortin system in cutaneous neuroimmunomodulation. An introductory ... Humans; Animals; Biomarkers of Pain; Neuroimmunomodulation/physiology; Pro-Opiomelanocortin/physiology; Skin Physiology; Skin/ ... Neuroimmunomodulation/physiology, Paus R, Pro-Opiomelanocortin/physiology, Skin Physiology, Skin/immunology, Slominski A ...
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Therapeutic effect of urocortin and adrenomedullin in a murine model of Crohn's disease | Gut
The present study has shown that UCN and AM are two potent anti-inflammatory agents that provide highly effective treatment for TNBS induced colitis, a murine experimental model of CD. A single injection of UCN or AM (450 μg/kg) at the onset of the disease ameliorated the clinical and histopathological severity of the wasting disease, abrogating body weight loss, diarrhoea, and intestinal inflammation, and reduced the high mortality caused by this syndrome. From a therapeutic point of view, it is extremely important to take in account that delayed treatment with UCN or AM was able to reduce colitis severity in animals with established disease, and that an initial treatment with UCN or AM prevented recurrence of the disease in mice given a second dose of TNBS.. There are several potential mechanisms by which therapy with UCN and AM can modulate the effector phase of TNBS colitis. CD and TNBS induced colitis are characterised by transmural inflammation of the colon due to an IL-12 driven, Th1 ...