The in silico human surfaceome | PNAS
Surfaceome changes during neurogenesis. (A) Left axis: Surfaceome gene level distribution from day 0 to day 22. Right axis: The ... Surfaceome Adaptation During Neurogenesis.. The quest to find accurate cell-surface markers for the identification and ... We hypothesized that the onset of neurogenesis should be reflected in the surfaceome. The number of different surfaceome genes ... which suggests that already hESCs are expressing genes for neurogenesis. Cluster 2 harbors gene-expression profiles for ...https://www.pnas.org/content/115/46/E10988
NeuroD1 induces terminal neuronal differentiation in olfactory neurogenesis | PNAS
NeuroD1 induces terminal neuronal differentiation in olfactory neurogenesis. Camille Boutin, Olaf Hardt, Antoine de Chevigny, ... NeuroD1 induces terminal neuronal differentiation in olfactory neurogenesis. Camille Boutin, Olaf Hardt, Antoine de Chevigny, ... 2009) Involvement of Ngn2, Tbr and NeuroD proteins during postnatal olfactory bulb neurogenesis. Eur J Neurosci 29:232-243. ... Olfactory neurogenesis is particularly suited to approach these late steps in neuronal differentiation. Here, stem cell ...https://www.pnas.org/content/107/3/1201
Leptin in hippocampus mediates benefits of mild exercise by an antioxidant on neurogenesis and memory | PNAS
Leptin in hippocampus mediates benefits of mild exercise by an antioxidant on neurogenesis and memory. Jang Soo Yook, Randeep ... Leptin in hippocampus mediates benefits of mild exercise by an antioxidant on neurogenesis and memory ... Leptin in hippocampus mediates benefits of mild exercise by an antioxidant on neurogenesis and memory ... Leptin in hippocampus mediates benefits of mild exercise by an antioxidant on neurogenesis and memory ...https://www.pnas.org/content/early/2019/05/09/1815197116.short?rss=1&utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+Pnas-RssFeedOfEarlyEditionArticles+%28Early+Edition%29
Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function | PNAS
2a, asterisk) and SGL of DG, where adult neurogenesis persists (23), expressed higher levels of MBD1 than did NeuN+ granule ... This finding led us to investigate the neurogenesis of adult MBD1-/- mice. We found that cultured MBD1-/- adult neural stem ... Adult MBD1-/- mice have reduced hippocampal neurogenesis. (a) Forebrains of MBD1-/- mice (-/-; n = 20) weigh 15.2% less than ... Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. Xinyu Zhao, Tetsuya ...https://www.pnas.org/content/100/11/6777?ijkey=0fec5cb71ea9c87edfb303675ae5f0d501c3b935&keytype2=tf_ipsecsha
Secretagogin-dependent matrix metalloprotease-2 release from neurons regulates neuroblast migration | PNAS
2004) Proteomic and immunochemical characterization of a role for stathmin in adult neurogenesis. FASEB J 18(2):287-299. ... 2011) Regulation of neurogenesis by extracellular matrix and integrins. Acta Neurobiol Exp (Warsz) 71(1):103-112. ... 2016) Brain size and limits to adult neurogenesis. J Comp Neurol 524(3):646-664. ...https://www.pnas.org/content/114/10/E2006
Chlorovirus ATCV-1 is part of the human oropharyngeal virome and is associated with changes in cognitive functions in humans...
2013) Neurogenesis, inflammation and behavior. Brain Behav Immun 27(1):22-32. ...https://www.pnas.org/content/111/45/16106.full
Childhood maltreatment is associated with reduced volume in the hippocampal subfields CA3, dentate gyrus, and subiculum | PNAS
At the cellular level, the key effects of stress are to suppress ongoing neurogenesis in the dentate gyrus (DG) and to provoke ... Translational studies show that the key consequences of stress exposure on the hippocampus are suppression of neurogenesis in ... the suppressive effects of glucocorticoids on hippocampal neurogenesis depend on NMDA receptors (67). Hence, excess ... excessive exposure to glucocorticoids range from the reversible atrophy of dendritic processes and suppression of neurogenesis ...https://www.pnas.org/content/109/9/E563
Submegabase copy number variations arise during cerebral cortical neurogenesis as revealed by single-cell whole-genome...
The genome-wide location of CNVs throughout neurogenesis does not point to a specific locus promoting cell death, being more ... CNVs are generated and developmentally varied during cortical neurogenesis. (A) The frequency with which each genomic locus is ... The most remarkable aspect of CNV prevalence was variation during cerebral cortical neurogenesis. The number of CNVs per cell ... 2000) Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice. ...http://www.pnas.org/content/115/42/10804
Table of Contents - February 19, 2008, 105 (7) | PNAS
Cell cycle regulation, neurogenesis, and depression Kathryn A. Cunningham and Cheryl S. Watson ...http://www.pnas.org/content/105/7/
Maternal prolactin during late pregnancy is important in generating nurturing behavior in the offspring | PNAS
2012) Prolactin, neurogenesis, and maternal behaviors. Brain Behav Immun 26:201-209. ... 2003) Pregnancy-stimulated neurogenesis in the adult female forebrain mediated by prolactin. Science 299:117-120. ... It is also known that PRL surges early in pregnancy and promotes neurogenesis in the forebrain subventricular zone, which is ...https://www.pnas.org/content/114/49/13042
Improved spatial learning performance of fat-1 mice is associated with enhanced neurogenesis and neuritogenesis by...
These results together provide direct evidence for a promoting effect of DHA on neurogenesis and neuritogenesis and suggest ... Improved spatial learning performance of fat-1 mice is associated with enhanced neurogenesis and neuritogenesis by ... Improved spatial learning performance of fat-1 mice is associated with enhanced neurogenesis and neuritogenesis by ... Improved spatial learning performance of fat-1 mice is associated with enhanced neurogenesis and neuritogenesis by ...https://www.pnas.org/content/106/27/11370.abstract
Context-dependent memory traces in the crab's mushroom bodies: Functional support for a common origin of high-order memory...
Immunohistochemistry and neurogenesis in Neohelice's HBs. (A-C) Confocal laser scan of the lateral protocerebrum labeled with ... 2005) Adult neurogenesis in the central olfactory pathway in the absence of receptor neuron turnover in Libinia emarginata. Eur ... 2007) Adult neurogenesis: A common strategy across diverse species. J Comp Neurol 500(3):574-584. ... 2007) The olfactory pathway of decapod crustaceans--an invertebrate model for life-long neurogenesis. Chem Senses 32(4):365-384 ...https://www.pnas.org/content/113/49/E7957
Differentiation of V2a interneurons from human pluripotent stem cells | PNAS
1999) A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord. Cell 97:903-915. ... V2a interneuron protocol robustly increases hPSC neurogenesis. (A) Gene expression throughout V2a interneuron differentiation ... increased hPSC neurogenesis (βIII tubulin+) and promotion of V2a interneuron (CHX10+ and SOX14+) specification instead of V2b ( ... GATA3+). Notch inhibition of PSCs undergoing neural differentiation generally enhances neurogenesis (32, 33). In our study, the ...https://www.pnas.org/content/114/19/4969
Diminished dosage of 22q11 genes disrupts neurogenesis and cortical development in a mouse model of 22q11 deletion/DiGeorge...
4E). Last, we did not see prolonged neurogenesis. E19.5 birth-dated neurons were not present in LgDel or WT P5 cortex (data not ... 2F). Ranbp1, Cdc45l, and Htf9c are maximally expressed during cortical neurogenesis [E12-postnatal day (P)0] with a large ... 2008) The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone. Genes Dev 22:2479- ... Diminished dosage of 22q11 genes disrupts neurogenesis and cortical development in a mouse model of 22q11 deletion/DiGeorge ...https://www.pnas.org/content/106/38/16434
The Fezf2-Ctip2 genetic pathway regulates the fate choice of subcortical projection neurons in the developing cerebral cortex |...
1985) Neurogenesis of the cat's primary visual cortex. J Comp Neurol 242:611-631. ... 2006) The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells. Nat Neurosci 9:743-751. ... The Timing of Upper-Layer Neurogenesis Is Conferred by Sequential Derepression and Negative Feedback from Deep-Layer Neurons ... 1995) Constructing the cerebral cortex: Neurogenesis and fate determination. Neuron 15:761-768. ...http://www.pnas.org/content/105/32/11382
Very long-term memories may be stored in the pattern of holes in the perineuronal net | PNAS
2006) Neocortical neurogenesis in humans is restricted to development. Proc Natl Acad Sci USA 103(33):12564-12568. ... 2012) Neural functions of matrix metalloproteinases: Plasticity, neurogenesis, and disease. Biochem Res Int 2012:789083. ...https://www.pnas.org/content/110/30/12456?ijkey=27e3049b0554bc72aef61483fa3d2c7702184623&keytype2=tf_ipsecsha
Table of Contents - June 25, 2013, 110 (26) | PNAS
Conserved microRNA pathway regulates developmental timing of retinal neurogenesis Anna La Torre, Sean Georgi, and Thomas A. Reh ...http://www.pnas.org/content/110/26/
Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell...
2006) The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells. Nat Neurosci 9(6):743-751. ... aLaboratory of Organogenesis and Neurogenesis andbDepartment of Medical Embryology, Kyoto University Graduate School of ... aLaboratory of Organogenesis and Neurogenesis andbDepartment of Medical Embryology, Kyoto University Graduate School of ... aLaboratory of Organogenesis and Neurogenesis andbDepartment of Medical Embryology, Kyoto University Graduate School of ...http://www.pnas.org/content/110/50/20284
Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment | PNAS
2010) Epigenetic choreographers of neurogenesis in the adult mammalian brain. Nat Neurosci 13(11):1338-1344. ... 2007) How widespread is adult neurogenesis in mammals? Nat Rev Neurosci 8(6):481-488. ... 2008) Mechanisms and functional implications of adult neurogenesis. Cell 132(4):645-660. ... 2011) Adult hippocampal neurogenesis and its role in Alzheimer's disease. Molecular neurodegeneration 6:85. ...https://www.pnas.org/content/110/23/9523
Antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) are attenuated by antiinflammatory drugs in mice and...
2008) IFN-gamma enhances neurogenesis in wild-type mice and in a mouse model of Alzheimer's disease. FASEB J 22:2843-2852. ... 2006) Hippocampal neurogenesis: Opposing effects of stress and antidepressant treatment. Hippocampus 16:239-249. ... and enhances neurogenesis (25), all of which are consistent with antidepressant-like activity (26). However, it has been ...https://www.pnas.org/content/108/22/9262.full
Histone demethylase Jmjd3 is required for the development of subsets of retinal bipolar cells | PNAS
2011) The time of timing: How Polycomb proteins regulate neurogenesis. Bioessays 33(7):519-528. ... The role of H3K27 in defining the timing of neurogenesis and gliogenesis was shown in cortical neurons by ablating Ezh2 at ...http://www.pnas.org/content/111/10/3751
Exercise training increases size of hippocampus and improves memory | PNAS
2007) An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proc Natl Acad Sci USA 104:5638-5643. ... 3 A and B). This result is consistent with several rodent studies of exercise on neurogenesis and BDNF (20, 21). Improvements ... 2004) Adult hippocampal neurogenesis and voluntary running activity: Circadian and dose-dependent effects. J Neurosci Res 76: ... 2005) Exercise enhances learning and hippocampal neurogenesis in aged mice. J Neurosci 25:8680-8685. ...https://www.pnas.org/content/108/7/3017
Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency | PNAS
2000) DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Mol Cell 5: ... 1998) A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell 95:891-902. ... 2007) BRCA2 is required for neurogenesis and suppression of medulloblastoma. EMBO J 26:2732-2742. ... ATR maintains chromosomal integrity during postnatal cerebellar neurogenesis and is required for medulloblastoma formation ...http://www.pnas.org/content/106/6/1880
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics | PNAS
3C), such as brain cell proliferation/differentiation (neurogenesis, generation of neurons, CNS development, neuron projection ... and resemble stages in neurogenesis. Cancer Cell 9(3):157-173. ... 2011) Neurogenesis in the Adult Brain I: Neurobiology (Springer ...https://www.pnas.org/content/110/10/4009?ijkey=f6be167777cf05e0977f3b82679b437822f1e61a&keytype2=tf_ipsecsha
Table of Contents - May 08, 2001, 98 (10) | PNAS
FGF-2 regulation of neurogenesis in adult hippocampus after brain injury Shinichi Yoshimura, Yasushi Takagi, Jun Harada, ... BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis Kinichi ...http://www.pnas.org/content/98/10