Neurogenesis in Adult Subventricular Zone | Journal of Neuroscience
Local neutralization of BMP signaling, a neurogenesis inhibitor, by ependymal noggin may be critical for SVZ neurogenesis (Lim ... 2001a) Neurogenesis in the subventricular zone and rostral migratory stream of the neonatal and adult primate forebrain. Exp ... Neurogenesis in the adult brain is restricted to particular niches. Is it the astrocytes, the microenvironment, or both that ... Neurogenesis may in adult animals may allow brain circuitry involved in sexual behavior to be modified. In birds, steroid ...http://www.jneurosci.org/content/22/3/629.long
Reduced Neurogenesis after Neonatal Seizures | Journal of Neuroscience
It is known that postnatal neurogenesis can be modified by many factors. Neurogenesis in the dentate gyrus of adult rodents has ... It is now well established that dentate granule cell neurogenesis continues into adulthood, although the rate of neurogenesis ... However, the chronic effect of recurrent seizures is a reduction in neurogenesis. Because the reduction of neurogenesis extends ... Reduced Neurogenesis after Neonatal Seizures. Bridget K. McCabe, Diosely C. Silveira, Maria Roberta Cilio, Byung Ho Cha, ...http://www.jneurosci.org/content/21/6/2094.long
Olig Transcription Factors Are Expressed in Oligodendrocyte and Neuronal Cells in Human Fetal CNS | Journal of Neuroscience
Is Olig2 important for neurogenesis?. Several lines of evidence indicate the existence of a common progenitor for cortical ...http://www.jneurosci.org/content/25/44/10064?ijkey=fd35ef11a033d735f7a730fce36c7290d21b5018&keytype2=tf_ipsecsha
Neurogenesis in the Adult Brain | Journal of Neuroscience
A fundamental question raised in the last review asks to what extent the mechanisms of neurogenesis in development and in the ... Finally, the two unresolved questions that all agree on are: (1) why does adult neurogenesis persist in only a few identified ... Gerd Kempermann returns to neurogenesis in the dentate gyrus and focuses on the role of behavioral activity on the regulation ... Will better techniques reveal more neurogenesis in more areas?. Another theme that all of the authors developed and acknowledge ...http://www.jneurosci.org/content/22/3/612
Dcx is essential for neurogenesis. A role for Dcx in neurogenesis and proliferation has not previously been reported, and DCX ... Lis1 and Dcx are required to maintain the progenitor pool during neurogenesis. During radial glial neurogenesis, the ... Other Dcx homologues are clearly involved in neurogenesis; Dclk is highly expressed in regions of active neurogenesis in the ... Summary of neuronal migration and neurogenesis defects found in single Lis1+/ko and Dcxko/Y mutants and double Lis1+/ko;Dcxko/Y ...http://www.jneurosci.org/content/30/8/3002
Leukemia Inhibitory Factor Promotes Neural Stem Cell Self-Renewal in the Adult Brain | Journal of Neuroscience
LIF reduces neurogenesis in the OB. We focused our study on the SVZ, a well described system that generates neurons in the OB ( ... LIF reduces neurogenesis in the OB. A , Double staining for BrdU and the mature neuronal marker NeuN indicates that most BrdU+ ... 2005) Neurogenesis in the hypothalamus of adult mice: potential role in energy balance. Science 310:679-683. ... For example, a high dose of CNTF results in the promotion of neurogenesis in the hypothalamus [656 ng/d (Kokoeva et al., 2005 ...http://www.jneurosci.org/content/26/46/12089.long
Transcription Factor Expression and Notch-Dependent Regulation of Neural Progenitors in the Adult Rat Spinal Cord | Journal of...
1997) Neurogenesis in postnatal rat spinal cord: a study in primary culture. Science 276:586-589. ... Inhibition of neurogenesis by Notch signaling. The above results suggest that endogenous progenitors can respond to injury in ... 1994) An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells. Development 120:2421- ... Attenuation of Notch signals by Dll1-A may had enhanced neurogenesis at the expense of astrogenesis. Alternatively, Dll1-A may ...https://www.jneurosci.org/content/21/24/9814?ijkey=c2fd9cd6810b40ad1962681a045d94223198b1b2&keytype2=tf_ipsecsha
Intracerebral Peripheral Blood Stem Cell (CD34+) Implantation Induces Neuroplasticity by Enhancing β1 Integrin-Mediated...
Louissaint A Jr, Rao S, Leventhal C, Goldman SA (2002) Coordinated interaction of neurogenesis and angiogenesis in the adult ... Intracerebral PBSC transplantation enhances neurogenesis in vivo. To determine whether exogenous transplanted PBSCs and ... and neurogenesis (Stumm et al., 2002), thereby alleviating stroke symptoms. As a consequence of this autocrine regulatory ... and to provide an environment conducive to neurogenesis (Valable et al., 2003). In conclusion, we believe that the combination ...http://www.jneurosci.org/content/26/13/3444?ijkey=80685d7ca33c3b947d371572b58a5cda4e40d97a&keytype2=tf_ipsecsha
Experience-Induced Neurogenesis in the Senescent Dentate Gyrus | Journal of Neuroscience
Experience-Induced Neurogenesis in the Senescent Dentate Gyrus Message Subject (Your Name) has forwarded a page to you from ... Experience-Induced Neurogenesis in the Senescent Dentate Gyrus. Gerd Kempermann, H. Georg Kuhn and Fred H. Gage ... Neurogenesis decreased with increasing age. Stimulation of adult and aged mice by switching from standard housing to an ... Neurogenesis was investigated by confocal microscopy of three-channel immunofluorescent staining for the proliferation marker ...http://www.jneurosci.org/content/18/9/3206.abstract
Heterotopic Neurogenesis in a Rat with Cortical Heterotopia | Journal of Neuroscience
Heterotopic Neurogenesis in a Rat with Cortical Heterotopia. Kevin S. Lee, Jennifer L. Collins, Matthew J. Anzivino, Eric A. ... Heterotopic Neurogenesis in a Rat with Cortical Heterotopia. Kevin S. Lee, Jennifer L. Collins, Matthew J. Anzivino, Eric A. ... Heterotopic Neurogenesis in a Rat with Cortical Heterotopia. Kevin S. Lee, Jennifer L. Collins, Matthew J. Anzivino, Eric A. ... Heterotopic Neurogenesis in a Rat with Cortical Heterotopia Message Subject (Your Name) has forwarded a page to you from ...http://www.jneurosci.org/content/18/22/9365
Fgfr1 Is Required for Cortical Regeneration and Repair after Perinatal Hypoxia | Journal of Neuroscience
Neurogenesis was also assessed in the OB at P48, after the cumulative BrdU injections at P17. The results indicate that while ... 1996) Neurogenesis in neonatal rat brain is regulated by peripheral injection of basic fibroblast growth factor (bFGF) J Comp ... 2001) FGF-2 regulation of neurogenesis in adult hippocampus after brain injury. Proc Natl Acad Sci U S A 98:5874-5879. ... 2005) Neurogenesis in rats after focal cerebral ischemia is enhanced by indomethacin. Stroke 36:2718-2724. ...http://www.jneurosci.org/content/29/4/1202.long
No neurogenesis was noted in the untreated adult striatum. To assess the incidence, if any, of neuronal addition to the normal ... 1981) Neurogenesis in the 3 month-old rat visual cortex. J. Comp Neurol 195:323-338. ... 1992) In vitro neurogenesis by neuronal precursor cells derived from the adult songbird brain. J Neurosci 12:2532-2541. ... 2000) In vitro neurogenesis by neural progenitor cells isolated from the adult human hippocampus. Nat Med 6:271-277. ...http://www.jneurosci.org/content/21/17/6718
Exercise Enhances Learning and Hippocampal Neurogenesis in Aged Mice | Journal of Neuroscience
Exercise Enhances Learning and Hippocampal Neurogenesis in Aged Mice. Henriette van Praag, Tiffany Shubert, Chunmei Zhao, Fred ... Exercise Enhances Learning and Hippocampal Neurogenesis in Aged Mice. Henriette van Praag, Tiffany Shubert, Chunmei Zhao, Fred ... The decline in neurogenesis in aged mice was reversed to 50% of young control levels by running. Moreover, fine morphology of ... Exercise Enhances Learning and Hippocampal Neurogenesis in Aged Mice Message Subject (Your Name) has forwarded a page to you ...http://www.jneurosci.org/content/25/38/8680.abstract
Exercise Enhances Learning and Hippocampal Neurogenesis in Aged Mice | Journal of Neuroscience
... indicated that running enhanced neurogenesis in both young and aged groups. Young runners had the most neurogenesis (∼81.3%), ... Exercise Enhances Learning and Hippocampal Neurogenesis in Aged Mice. Henriette van Praag, Tiffany Shubert, Chunmei Zhao, Fred ... Exercise Enhances Learning and Hippocampal Neurogenesis in Aged Mice. Henriette van Praag, Tiffany Shubert, Chunmei Zhao, Fred ... The decline in neurogenesis in aged mice was reversed to 50% of young control levels by running. Moreover, fine morphology of ...http://www.jneurosci.org/content/25/38/8680
The Biology of Memory: A Forty-Year Perspective | Journal of Neuroscience
6. What is the function of neurogenesis in the hippocampus?. Neurogenesis may be important for some aspects of memory storage, ... How are these two mechanisms related? Are there as yet undetected roles for hippocampal neurogenesis? ...http://www.jneurosci.org/content/29/41/12748.full
The restriction of neurogenesis to these few sites reflects the persistence of discrete environmental niches for neurogenesis. ... 1992) NSCL-2: a basic domain helix-loop-helix gene expressed in early neurogenesis. Cell Growth Differ 3:143-148. ... 2000b) In vitro neurogenesis by progenitor cells isolated from the adult human hippocampus. Nat Med 6:271-277. ... 1998) Adult neurogenesis: from canaries to the clinic. J Neurobiol 36:267-286. ...http://www.jneurosci.org/content/26/48/12544
Interruption of β-Catenin Signaling Reduces Neurogenesis in Alzheimer's Disease | Journal of Neuroscience
2004) Neurogenesis of corticospinal motor neurons extending spinal projections in adult mice. Proc Natl Acad Sci U S A 101: ... 2006) Neocortical neurogenesis in humans is restricted to development. Proc Natl Acad Sci U S A 103:12564-12568. ... This reduction in neurogenesis was also accompanied by disrupted β-catenin signaling in AD versus HC GPCs and their progeny. We ... Aβ production, neurogenesis, and proneural gene products in AD versus HC progenitor cells. Second passage GPCs from AD and HC ...http://www.jneurosci.org/content/29/20/6545.long
Mash1 function in oligodendrogenesis is independent from its role in neurogenesis. The loss of OPCs in Mash1−/− embryos could ... 7C,D). The role of Mash1 in oligodendrogenesis is therefore independent of the level of neurogenesis, arguing for a direct role ... Mash1 is broadly expressed by brain and spinal cord progenitors and plays a major role in neurogenesis (Casarosa et al., 1999; ... Mash1 requirement for the generation of OPCs is independent of neurogenesis. Telencephalic coronal sections of wild-type (A, B ...http://www.jneurosci.org/content/27/16/4233
MicroRNA-9 Regulates Neurogenesis in Mouse Telencephalon by Targeting Multiple Transcription Factors | Journal of Neuroscience
Early neurogenesis in miR-9-2/3 double-mutant pallium. A-R, Marker analyses of early-born neurons at E12.5. A-H, K, L, and Q-T ... MicroRNA-9 Regulates Neurogenesis in Mouse Telencephalon by Targeting Multiple Transcription Factors. Mikihito Shibata, Hiromi ... Neither miR-9-2 nor miR-9-3 single homozygous mutants exhibited any apparent defects in neurogenesis of pallium or subpallium ( ... The miR-9-2/3 double mutants demonstrate that miR-9 orchestrates neurogenesis in the pallium and subpallium by regulating the ...http://www.jneurosci.org/content/31/9/3407
Disruption of Interneuron Neurogenesis in Premature Newborns and Reversal with Estrogen Treatment | Journal of Neuroscience
Hence, preterm birth disrupts interneuron neurogenesis in the MGE and estrogen treatment reverses interneuron neurogenesis in ... Disruption of Interneuron Neurogenesis in Premature Newborns and Reversal with Estrogen Treatment. Mahima Tibrewal, Bokun Cheng ... Disruption of Interneuron Neurogenesis in Premature Newborns and Reversal with Estrogen Treatment ... Here, we show that preterm birth disrupts interneuron neurogenesis in the MGE, and more importantly, estrogen treatment ...http://www.jneurosci.org/content/early/2017/12/15/JNEUROSCI.1875-17.2017
Coxsackievirus Adenovirus Receptor Loss Impairs Adult Neurogenesis, Synapse Content, and Hippocampus Plasticity | Journal of...
Impaired adult hippocampal neurogenesis. Adult neurogenesis influences learning and memory by the generation and integration of ... CAR loss of function and neurogenesis. Both intrinsic and extrinsic mechanisms regulate adult neurogenesis. Like some NCAM ... 2015) Adult neurogenesis and the future of the rejuvenating brain circuits. Neuron 86:387-401, doi:10.1016/j.neuron.2015.01.002 ... CAR involvement in adult neurogenesis. GCL of the DG (A) and SLu (B) of CT mice were stained with anti-CAR, anti-PSA-NCAM, and ...http://www.jneurosci.org/content/36/37/9558.full
Activated T-Cells Inhibit Neurogenesis by Releasing Granzyme B: Rescue by Kv1.3 Blockers | Journal of Neuroscience
4B) inhibition of NPC neurogenesis. To further confirm the role of Kv1.3 in inhibiting NPC neurogenesis, we delivered siRNA to ... Activated T-cells inhibited NPC neurogenesis through release of GrB. The effect of activated T-cells on neurogenesis was ... Kv1.3 mediates effect of GrB on NPC neurogenesis. To monitor NPC neurogenesis, NPC cultures were cultured in differentiating ... A, Kv1.3-selective blocker MgTX (10 nm) prevented the effects of GrB (4 nm) on NPC neurogenesis. B, MgTX also attenuated the ...http://www.jneurosci.org/content/30/14/5020.long
Seizure-Associated, Aberrant Neurogenesis in Adult Rats Characterized with Retrovirus-Mediated Cell Labeling | Journal of...
Seizure-Associated, Aberrant Neurogenesis in Adult Rats Characterized with Retrovirus-Mediated Cell Labeling. Sebastian ... Seizure-Associated, Aberrant Neurogenesis in Adult Rats Characterized with Retrovirus-Mediated Cell Labeling ... Seizure-Associated, Aberrant Neurogenesis in Adult Rats Characterized with Retrovirus-Mediated Cell Labeling ... Seizure-Associated, Aberrant Neurogenesis in Adult Rats Characterized with Retrovirus-Mediated Cell Labeling ...http://www.jneurosci.org/content/27/35/9400/tab-figures-data
Early Pharmacotherapy Restores Neurogenesis and Cognitive Performance in the Ts65Dn Mouse Model for Down Syndrome | Journal of...
Neurogenesis in the DG is mainly a postnatal event and in rodents ∼80% of the granule cells are born postnatally, with a peak ... Fluoxetine-induced neurogenesis increase in the dentate gyrus of Ts65Dn mice is associated with increases in 5-HT1A receptor ... 2008) Neurogenesis impairment and increased cell death reduce total neuron number in the hippocampal region of fetuses with ... 2007) Adult neurogenesis and local neuronal progenitors in the striatum. Neurodegener Dis 4:322-327. ...http://www.jneurosci.org/content/30/26/8769
Prenatal Exposure to Nicotine Stimulates Neurogenesis of Orexigenic Peptide-Expressing Neurons in Hypothalamus and Amygdala |...
This stimulation of neurogenesis was indicated by an increased density of single-labeled BrdU+ cells and of BrdU+ neurons that ... Prenatal nicotine stimulates neurogenesis in P15 offspring exposed to 0.75 mg/kg/d or 1.5 mg/kg/d nicotine relative to control ... 2005) Thyroid hormone regulates hippocampal neurogenesis in the adult rat brain. Mol Cell Neurosci 29:414-426, doi:10.1016/j. ... 2008) Leptin increases adult hippocampal neurogenesis in vivo and in vitro. J Biol Chem 283:18238-18247, doi:10.1074/jbc. ...http://www.jneurosci.org/content/33/34/13600