Prostate-specific IL-6 transgene autonomously induce prostate neoplasm through amplifying inflammation in the prostate and peri...
... autonomously induce prostate neoplasm through amplifying inflammation in the prostate and peri-prostatic adipose tissue January ... amplifies inflammation in the prostate and peri-prostatic adipose tissue.. The pro-inflammatory IL-6 is autonomous oncogene for ... With this model, we demonstrate that IL-6 induces prostate neoplasm autonomously. We further demonstrate that transgenic ... induces autocrine IL-6 secretion and steadily-state of STAT3 activation in the prostate tissue, upregulates paracrine insulin- ...