Tibial Plasmablastic Lymphoma in a HIV-Negative Child: A Novel Extraoral Localisation
Histopathological analysis revealed sheets and aggregates of neoplasm replacing bone marrow interspersed with sclerotic bony ... high-grade non-Hodgkin lymphoma predominantly seen in HIV-infected individuals. Alongside a strong correlation with HIV, PBL ... Plasmablastic lymphoma (PBL) is an aggressive, high-grade non-Hodgkins lymphoma (NHL). Initially considered a variation of ... Plasmablastic lymphoma is an aggressive, high-grade non-Hodgkin lymphoma predominantly seen in HIV-infected individuals. ...
Low-Grade Malignant Triton Tumor of the Neck: A Case Report and Review of the Literature
... a rare neoplasm that poses a diagnostic dilemma in the differential diagnosis of neck masses and portends poor prognosis. We ... The clinical, microscopic, and long-term follow-up of this case are consistent with those of a low-grade malignancy. ... Low-Grade Malignant Triton Tumor of the Neck: A Case Report and Review of the Literature. Taissir Omar. ,1Hanaa Raslan. ,1Sahar ... To further elucidate the natural history and prognosis of this rare neoplasm in the head and neck, we present a case of ...
Precursor Lesions of High-Grade Serous Ovarian Carcinoma: Morphological and Molecular Characteristics
... particularly high grade, have focused attention on identifying putative precursor lesions with distinct morphological and ... A stepwise model of progression from cystadenomas to low-grade carcinomas has been proposed for these neoplasms. ... These are for the most part low-grade tumors that are characterized by a high frequency of mutations of KRAS, BRAF, ERBB2, ... Precursor Lesions of High-Grade Serous Ovarian Carcinoma: Morphological and Molecular Characteristics. Amy L. Gross. ,1Robert J ...
Sentinel Lymph Node Biopsy in Nonmelanoma Skin Cancer Patients
... and other rare skin neoplasms have a well-known risk to spread to regional lymph nodes. The use of sentinel lymph node biopsy ( ... SLNB would not change the prognosis in this low-grade melanocytic neoplasm. As no high-risk PEM has been identified, simple ... M. Beyeler, W. Kempf, J. Hafner, G. Burg, and R. Dummer, "The spectrum of mesenchymal skin neoplasms reflected by the new WHO ... A. Zembowicz, J. A. Carney, and M. C. Mihm, "Pigmented Epithelioid Melanocytoma: a low-grade melanocytic tumor with metastatic ...
Oncosuppressive Role of RUNX3 in Human Astrocytomas
... in I-III grade astrocytomas (n=87). Weighty lower RUNX3 protein level was observed in GMB specimens compared to grade II-III ... expression levels of RUNX3 were measured by methylation-specific PCR and Western blot in 136 and 72 different malignancy grade ... of molecular biology starting from epigenetics to function in particular cases of astrocytic origin tumours of different grade ... Glial brain tumours originating from glial cells are intracranial solid neoplasms. According to classification system of the ...
Pancancer Analysis of Neurovascular-Related NRP Family Genes as Potential Prognostic Biomarkers of Bladder Urothelial Carcinoma
... low-grade glioma (LGG), and stomach adenocarcinoma (STAD) was associated with poor prognosis. A high NRP2 expression in bladder ... and worse stage staging and grade staging. Similarly, a high NRP1 expression in STAD implied a worse grade staging. However, in ... Lymphoid neoplasm diffuse large B-cell lymphoma. ESCA:. Esophageal carcinoma. GBM:. Glioblastoma multiforme. ... Furthermore, in BLCA, NRP2 expression was associated with tumour size, stage staging, and worse grade staging. In KIPR, the ...
Gene Therapy with HSV1-sr39TK/GCV Exhibits a Stronger Therapeutic Efficacy Than HSV1-TK/GCV in Rat C6 Glioma Cells
... especially in those with high grades ones (WHO grades III-IV). The reason for this gloomy prognosis is partly due to the fact ... In order to eradicate this formidable neoplasm, several gene therapy strategies have been developed, including transfection of ... the prognosis of patients with high grade glioma is still extremely poor, with a median survival time of ,1 year [1, 2], and ...
Primary Villoglandular Mucinous Adenocarcinoma of the Vulva
High proportion of MIB-1 positive cells suggested that this neoplasm was adenocarcinoma rather than adenoma. In [11], Karkouche ... c) Tumor cells show high-grade nuclear atypia. (d) PAS staining shows positive staining for the goblet cells. ... In all described villoglandular mucinous adenocarcinomas of vulva [1-12], the clinical behavior of this rare malignant neoplasm ... of mitotic cells and resemblance to well-differentiated adenocarcinoma of the large intestine suggested that this neoplasm was ...
Noninvasive Encapsulated Follicular Variant of Papillary Thyroid Cancer: Clinical Lessons from a Community-Based Endocrine...
11 nodules had grade 2 vascularity (30%), and 14 nodules had grade 3 vascularity (38%). No nodules had grade 4 vascularity. The ... nodules were read as follicular neoplasm/suspicious for follicular neoplasm (Bethesda 4). Nondiagnostic, suspicious for ... Twelve nodules (32%) demonstrated grade 1 vascularity as assessed by Power Doppler, ... Daniels suggested that it might be possible to reclassify some FVPTCs as benign neoplasms [6]. ...
Detection of BRAF V600E Mutation in Ganglioglioma and Pilocytic Astrocytoma by Immunohistochemistry and Real-Time PCR-Based...
Almost all are generally considered WHO grade I tumors [8].. One of the mutations that has aroused considerable interest in ... F. Behling, A. Barrantes-Freer, M. Skardelly et al., "Frequency of BRAF V600E mutations in 969 central nervous system neoplasms ... M. J. Dougherty, M. Santi, M. S. Brose et al., "Activating mutations in BRAF characterize a spectrum of pediatric low-grade ... Gangliogliomas are generally benign WHO grade I tumors, most commonly located in the temporal lobes of children and young ...
Neurotoxicity of Tumor Immunotherapy: The Emergence of Clinical Attention
Most of these adverse effects are grade 1 or 2, but in the clinical treatment process, ≥grade 3 neurologic ir-AEs also occur in ... inhibitor ibrutinib to prevent cytokine-release syndrome after anti-CD19 chimeric antigen receptor T cells for B-cell neoplasms ... Neurologic ir-AEs can be defined and graded using the CTCAE or ASTCT ICANS grading system. Indeed, recent studies have proved ... and grade 3 or 4 neurologic ir-AEs occurred in 11% and 2% patients, respectively [19]. The incidence rate for any grade ICIs- ...
The Clinicopathological Significance of miR-133a in Colorectal Cancer
J. Gaedcke, M. Grade, J. Camps et al., "The rectal cancer microRNAome-microRNA expression in rectal cancer and matched normal ... the expression of miR-133a was also found to be upregulated in CRC patients plasma samples compared to neoplasm-free controls ...
Angiosarcoma Arising in Ovarian Mucinous Tumor: A Challenge in Intraoperative Frozen Section Diagnosis
Angiosarcoma of the ovary is rare but represents an aggressive type of malignant ovarian neoplasms. The purpose of this report ... Angiosarcoma of the ovary is rare but represents an aggressive type of malignant ovarian neoplasms. The purpose of this report ... Another focus of infiltrating undifferentiated carcinoma composed of high-grade pleomorphic spindle and epithelioid cells, ... Angiosarcoma of the ovary is rare but represents an aggressive type of malignant ovarian neoplasms. To our knowledge, less than ...
Surgical Removal of a Canine Aortic Thromboembolism Secondary to Pancreatitis
... as well as a grade II/VI systolic heart murmur, so ischemic neuromyopathy was suspected. Clinicopathologic analysis revealed ... A grade II/VI systolic heart murmur was auscultated. The remainder of the physical examination was within normal limits. ... various neoplasms, protein-losing nephropathy, protein-losing enteropathy, gastric dilatation/volvulus, and trauma [1-8]. In ... Although a grade II/VI systolic heart murmur was auscultated on physical examination, echocardiography revealed severe aortic ...
Phyllodes Tumor of Breast: A Review Article
A. K. El-Naggar, B. Mackay, N. Sneige, and J. G. Batsakis, "Stromal neoplasms of the breast: a comparative flow cytometric ... showed that chromosomal changes detected by comparative genomic hybridization (CGH) could be helpful in grading phyllodes ... In flow cytometric studies, correlations between DNA content, cell proliferation, and histological grade have been demonstrated ... rather than with tumor grade or size [1, 16, 42, 45]. Other studies have shown a higher risk of local recurrence in borderline ...
Tumor-Induced Osteomalacia: Increased Level of FGF-23 in a Patient with a Phosphaturic Mesenchymal Tumor at the Tibia...
If the responsible neoplasm is surgically removed, the abnormalities in phosphate wasting and in vitamin D metabolism typically ... S. Gunia, A. Jain, S. Koch et al., "Periostin expression correlates with pT-stage, grading and tumour size, and independently ... The histopathology of tumors leading to TIO reveals in 70-80% of cases PMTMCTs [2] which are rare neoplasms occurring in ... is a paraneoplastic syndrome caused by the phosphaturic hormone FGF-23 that can be cured by removing the responsible neoplasm. ...
Efficacy Investigation of TACE Combined with Lenvatinib and Sintilimab in Intermediate-Stage Hepatocellular Carcinoma
... which are graded according to NCI-CTCAE version 4.03 [14]. For grade 3 or 4 adverse events, we performed symptomatic treatment ... Hepatocellular carcinoma (HCC) is the sixth most commonly diagnosed and fourth most lethal neoplasm worldwide. The incidence of ...
Development of a Prognostic Model Based on Pyroptosis-Related Genes in Pancreatic Adenocarcinoma
... low-grade tumor cells are closer to normal cells than to high-grade tumor cells. The grading provides advice to physicians ... α are also thought to play an important role in gastroenteropancreatic neuroendocrine neoplasms. In a 2020 article, it was ... Overall, low-grade tumors grow more slowly, while high-grade tumors grow more rapidly. The rate of tumor infiltration and ... Scatter diagram showing (a) age, (b) sex, (c) M stage, (d) N stage, (e) T stage, (f) tumor grade, and (g) clinical stage based ...
The Present Status of the Management of Colon and Rectal Cancer in Nigeria
45% of patients had tumors with unfavorable grade or biology (mucinous 21.7%, signet ring 8.3%, and poorly ... CRC tumour grade/biology: 45% of the tumors had unfavorable histopathologic type or grade with the mucinous type being 21.7%, ... D. O. Akinola and A. O. Arigbabu, "Pattern and presentation of large bowel neoplasms in Nigerians," Central African Journal of ... iii) Aggressive Tumor Type. From our results one will see that almost half of the patients (45%) had unfavorable tumour grade ...
IgG4 as a Biomarker in Graves' Orbitopathy
... which is an often employed and renowned classification used to grade the severity of GO. Average IgG4 levels were vs. vs. mg/dl ... orbital neoplasms, both malignant (e.g., lymphomas) and benign; infections; orbital myositis; and inflammatory orbitopathy, e.g ...
Prediction of Remnant Liver Regeneration after Right Hepatectomy in Patients with Hepatocellular Carcinoma Using Preoperative...
T. Starzl, L. J. Koep, R. Weil III, J. R. Lilly, C. W. Putnam, and J. A. Aldrete, "Right trisegmentectomy for hepatic neoplasms ... N. N. Rahbari, O. James Garden, R. Padbury et al., "Posthepatectomy liver failure: a definition and grading by the ... tumor differentiation grade, and even microvascular invasion were not considered as the retrospective design; thus, we should ... a preliminary correlation study with histological grade," Acta Radiologica (Stockholm, Sweden: 1987), vol. 55, pp. 1270-1277, ...
Evaluation of Magnetic Resonance Imaging for Microsurgical Efficacy and Relapse of Rolandic Meningioma
S. Rohilla, H. Garg, I. Singh, R. Yadav, and D. BDhaulakhandi, "rCBV- and ADC-based grading of meningiomas with glimpse into ... patients with other types of intracranial neoplasms; (iii) patients who received chemotherapy or radiotherapy before surgery; ( ... M.-C. Lin, C.-Z. Li, C.-C. Hsieh et al., "Preoperative grading of intracranial meningioma by magnetic resonance spectroscopy ( ... and high-grade meningioma," British Journal of Radiology, vol. 91, no. 1088, Article ID 20180088, 2018 Jul. ...
Genetic Polymorphism of E2F1 Influences Susceptibility to Ovarian Cancer in a Chinese Population
L. S. Abdullah and N. S. Bondagji, "Histopathological pattern of ovarian neoplasms and their age distribution in the western ... and the expression is related to tumor grade and stage [14]. Li et al. found that E2F1 is overexpressed in breast cancer ...
The Oncogenic Role of ARG1 in Progression and Metastasis of Hepatocellular Carcinoma
The low expression rate of ARG1 in the pathological grades I-II (87.9%, 51/58) was significantly higher as compared with that ... B. C. Yan, C. Gong, J. Song et al., "Arginase-1: A new immunohistochemical marker of hepatocytes and hepatocellular neoplasms ... The staining intensity was graded as follows: no staining (0); weak staining (1); moderate staining (2); and strong staining (3 ... pathological grading, total bilirubin (TB), alanine aminotransferase (ALT), glutamyltransferase (GGT), and alpha fetoprotein ( ...
Analysis of Drug Effects on Primary Human Coronary Artery Endothelial Cells Activated by Serum Amyloid A
J. Fortuny, S. de Sanjose, N. Becker et al., "Statin use and risk of lymphoid neoplasms: results from the European case-control ... was spun down and reconstituted according to the manufacturers instructions in cell culture-grade sterile water to a stock ... even one conveying low-grade inflammation, is a threat to the coronary arteries and early development of cardiovascular ...
Germline Mutations and Polymorphisms in the Origins of Cancers in Women
For example, luminal A cancers are hormone receptor positive, are diagnosed primarily in older women, are low grade with low ... and other neoplasms," Science, vol. 250, no. 4985, pp. 1233-1238, 1990. ... are high grade with high proliferative index, and are associated with higher risk of recurrence [35-38]. Her2-amplified breast ... cancers, regardless of hormone receptor status, are of higher grade and proliferative index, have worse prognosis with higher ...
High Mobility Group B Proteins, Their Partners, and Other Redox Sensors in Ovarian and Prostate Cancer
... being also implicated in the development of benign and malignant neoplasms [67]. HMGA proteins have been related to the process ... "Recurrent BCAM-AKT2 fusion gene leads to a constitutively activated AKT2 fusion kinase in high-grade serous ovarian carcinoma ...