Radical Lung Radiotherapy Plus Nelfinavir - Full Text View - ClinicalTrials.govRadical Lung Radiotherapy Plus Nelfinavir - Full Text View - ClinicalTrials.gov

Nelfinavir given in combination with radical RT. Drug: nelfinavir Nelfinavir tablets BD 7 days per week from D-7 of starting ... One effect of nelfinavir is to interfere with the function of a particular protein in cells (called AKT). The degree to which ... However, in this case nelfinavir was taken at a dose 3-fold higher than the highest dose level to be tested in this trial. An ... Nelfinavir. HIV Protease Inhibitors. Protease Inhibitors. Enzyme Inhibitors. Molecular Mechanisms of Pharmacological Action. ...
more infohttps://clinicaltrials.gov/show/NCT01447589?order=200

Clinical Trial of Oral Nelfinavir before and during Radiation Therapy for Advanced Rectal Cancer. - Oxford Clinical Trials...Clinical Trial of Oral Nelfinavir before and during Radiation Therapy for Advanced Rectal Cancer. - Oxford Clinical Trials...

EXPERIMENTAL DESIGN: Ten patients with T3-4 N0-2 M1 rectal cancer received 7 days of oral nelfinavir (1,250 mg b.i.d.) and a ... The efficacy of nelfinavir-RT versus RT alone merits clinical evaluation, including measurement of tumor blood flow. ... It has shown that nelfinavir-RT is well tolerated and is associated with increased blood flow to rectal tumors. ... We conducted an early-phase study to demonstrate the safety of nelfinavir combined with hypofractionated radiotherapy (RT) and ...
more infohttps://www.octru.ox.ac.uk/publications/601632

Bortezomib targets the caspase-like proteasome activity in cervical cancer cells, triggering apoptosis that can be enhanced by...Bortezomib targets the caspase-like proteasome activity in cervical cancer cells, triggering apoptosis that can be enhanced by...

Nelfinavir exhibited no effects on proteasomal activity in cervical cancer cells and leukemia cells. Although both bortezomib ... We tested the proteasome inhibitor bortezomib and the HIV protease inhibitor nelfinavir on human cervical cancer cells. Both ... These results suggest that both bortezomib and nelfinavir are effective agents against chemoresistant cervical cancer cells and ... and nelfinavir acted on cisplatin-resistant cervical cancer cells (SiHa), neither of the drugs induced a sensitization to ...
more infohttps://www.semanticscholar.org/paper/Bortezomib-targets-the-caspase-like-proteasome-act-Bruning-Vogel/92295776388b0e01415827229dd17a31138bfa6a

Contribution and limit of the model of perfused cotyledon to the study of placental transfer of drugs. Example of a protease...Contribution and limit of the model of perfused cotyledon to the study of placental transfer of drugs. Example of a protease...

Here we studied placental transfer of the human immunodeficiency virus protease inhibitor nelfinavir using the non- ... RESULTS: The mean clearance index of nelfinavir was very weak when maternal concentrations were under 500 microg/l (0.03+/-0.05 ... Here we studied placental transfer of the human immunodeficiency virus protease inhibitor nelfinavir using the non- ... Our study with nelfinavir has achieved a good correlation between ex vivo and in vivo data. Our results also indicate that ...
more infohttp://www.biomedsearch.com/nih/Contribution-limit-model-perfused-cotyledon/19773109.html

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A prospective, 96-week study of the impact of Trizivir, Combivir/nelfinavir, and lamivudine/stavudine/nelfinavir on lipids, ...
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IDEALS @ Illinois: Stimulating antibiotic development by targeting virulence and facilitating natural product discoveryIDEALS @ Illinois: Stimulating antibiotic development by targeting virulence and facilitating natural product discovery

nelfinavir CaaX protease natural products reactivity based screening. Abstract:. Antibiotics are a cornerstone of modern ... In chapter 2, I demonstrate that the FDA approved HIV protease inhibitor nelfinavir can be repurposed as an inhibitor of the ... biosynthesis of the Streptococcus pyogenes cytolytic toxin streptolysin S. Nelfinavir was utilized to explore the proteolytic ...
more infohttps://www.ideals.illinois.edu/handle/2142/90486

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... zidovudine and either nevirapine or nelfinavir in breast milk. J Antimicrob Chemother. Bae WH, Wester C, Smeaton LM et al. ...
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nelfinavir, Viracept: Drug Facts, Side Effects and Dosingnelfinavir, Viracept: Drug Facts, Side Effects and Dosing

Nelfinavir (Viracept) is a drug prescribed to treat HIV infection. Viracept is prescribed to be used in combination with other ... nelfinavir. *What is nelfinavir, and how does it work (mechanism of action)? ... Nelfinavir is an oral medication that is used for treating infections with the human immunodeficiency virus (HIV). It is in a ... Nelfinavir should be administered with food or a light snack. The tablets may be crushed and dissolved in water or mixed with ...
more infohttps://www.medicinenet.com/nelfinavir/article.htm

Nelfinavir - WikipediaNelfinavir - Wikipedia

Nelfinavir should be taken with food. The bioavailability of Nelfinavir is increased 2.5 to 5 times when taken with food.[ ... Nelfinavir inhibits maturation and export of the Herpes Simplex 1 virus and the Kaposis Sarcoma virus. Since 2009, nelfinavir ... Nelfinavir is a competitive inhibitor (2 nM) which is designed to bind tightly and is not cleaved due to the presence of a ... Nelfinavir is a protease inhibitor: it inhibits HIV-1 and HIV-2 proteases. HIV protease is an aspartate protease which splits ...
more infohttps://en.wikipedia.org/wiki/Nelfinavir

Nelfinavir: MedlinePlus Drug InformationNelfinavir: MedlinePlus Drug Information

Nelfinavir: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Do not mix nelfinavir oral powder with acidic food or juice (orange juice, apple juice, or apple sauce). Do not mix nelfinavir ... Nelfinavir controls HIV infection but does not cure it. Continue to take nelfinavir even if you feel well. Do not stop taking ... Before taking nelfinavir,. *tell your doctor and pharmacist if you are allergic to nelfinavir, any other medications, or any of ...
more infohttps://medlineplus.gov/druginfo/meds/a697034.html

Nelfinavir (Viracept) | TheBodyNelfinavir (Viracept) | TheBody

What Is Nelfinavir? Who Should Take Nelfinavir? What About Drug Resistance? How Is Nelfinavir Taken? What Are the Side Effects ... How Does Nelfinavir React With Other Drugs? What Is Nelfina ... How Is Nelfinavir Taken?. Nelfinavir is taken by mouth as a ... Who Should Take Nelfinavir?. Nelfinavir was approved in 1997 as an antiretroviral drug (ARV) for people with HIV infection of ... What Is Nelfinavir?. Nelfinavir, also called Viracept, is a drug used as part of antiretroviral therapy (ART). It is ...
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Nelfinavir - DrugBankNelfinavir - DrugBank

Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in ... Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV ... Nelfinavir. Accession Number. DB00220 (APRD00003) Type. Small Molecule. Groups. Approved. Description. Nelfinavir is a potent ... and unchanged nelfinavir (22%). Only 1-2% of the dose was recovered in urine, of which unchanged nelfinavir was the major ...
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... is a combination medicine used to treat HIV, the virus that can cause acquired ... nelfinavir, and tenofovir are antiviral drugs that prevent human immunodeficiency virus (HIV) from multiplying in your body. ... What is emtricitabine, nelfinavir, and tenofovir?. Emtricitabine, nelfinavir, and tenofovir are antiviral drugs that prevent ... You must be HIV-negative and an adult to use the medicine for this purpose. Emtricitabine, nelfinavir, and tenofovir may not ...
more infohttps://www.rexhealth.com/rh/health-library/document-viewer/?id=d07532a1

Viracept (nelfinavir) Uses, Dosage, Side Effects - Drugs.comViracept (nelfinavir) Uses, Dosage, Side Effects - Drugs.com

Generic Name: nelfinavir (nel FIN a veer). Brand Names: Viracept. Medically reviewed by Drugs.com. Last updated on May 13, 2019 ... For twice daily dosing, nelfinavir tablets are recommended for children weighing 16 kg or more.. Tablets (250 mg):. 10 to 12 kg ... Viracept (nelfinavir) is an antiviral medicine that prevents human immunodeficiency virus (HIV) cells from multiplying in your ... You should not take Viracept if you are allergic to nelfinavir, or if you have moderate or severe liver disease. ...
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Nelfinavir - Proteopedia, life in 3DNelfinavir - Proteopedia, life in 3D

Nelfinavir to these conserved sequences within the HIV Protease tunnel, preventing the nascent polyproteins from entering. ...
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Radical Lung Radiotherapy Plus NelfinavirRadical Lung Radiotherapy Plus Nelfinavir

The aim of this clinical trial is to test whether the drug nelfinavir, which can increase the effectiveness of radiotherapy, ... the start of nelfinavir treatment. Ie any neoadjuvant treatment must be completed 4. weeks prior.. - Liver impairment (serum ... Known hypersensitivity to nelfinavir or any of its excipients. - Other psychological, social or medical condition, physical ... To establish the maximum tolerated dose of nelfinavir in combination with radical radiotherapy for patients with non-small cell ...
more infohttp://www.knowcancer.com/cancer-trials/NCT01447589/

Viracept (Nelfinavir Mesylate): Side Effects, Interactions, Warning, Dosage & UsesViracept (Nelfinavir Mesylate): Side Effects, Interactions, Warning, Dosage & Uses

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more infohttps://www.rxlist.com/viracept-drug.htm

Emtricitabine, nelfinavir, and tenofovir Uses, Side Effects & Warnings - Drugs.comEmtricitabine, nelfinavir, and tenofovir Uses, Side Effects & Warnings - Drugs.com

... nelfinavir, and tenofovir patient information - includes emtricitabine, nelfinavir, and tenofovir description, dosage and ... emtricitabine, nelfinavir, and tenofovir. Generic Name: emtricitabine, nelfinavir, and tenofovir (em trye SYE ta been, nel FIN ... Emtricitabine, nelfinavir, and tenofovir side effects. Get emergency medical help if you have signs of an allergic reaction: ... To make sure emtricitabine, nelfinavir, and tenofovir is safe for you, tell your doctor if you have ever had:. * a bleeding or ...
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Nelfinavir and Combivir - Forum on Understanding Your Labs -- TheBody.comNelfinavir and Combivir - Forum on Understanding Your Labs -- TheBody.com

Nelfinavir (Viracept) and combivir (AZT + 3TC) are indeed three medicines. Epivir (lamivudine), is 3TC only. Retrovir ( ... Nelfinavir and Combivir. Aug 18, 1998. Writeups on Nelfinavir and Combivir recommend triple medication. A friend who is on this ... Nelfinavir (Viracept) and combivir (AZT + 3TC) are indeed three medicines. Epivir (lamivudine), is 3TC only. Retrovir ( ...
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HIV And Breast Cancer May Share A Common Enemy: NelfinavirHIV And Breast Cancer May Share A Common Enemy: Nelfinavir

Johns Hopkins researchers have discovered that the anti-HIV drug nelfinavir slows the progress of HER2-positive tumor cells, ... the team gave mice a fake drug or a human-dose equivalent of nelfinavir, then measured tumor size for a month. Nelfinavir ... To see if nelfinavir could slow the growth of tumors that had become resistant to the commonly used breast cancer drugs ... Nelfinavir was also already known to have a broad anti-cancer effect against melanoma, non-small-cell lung cancer and ...
more infohttp://www.newswise.com/articles/hiv-and-breast-cancer-may-share-a-common-enemy-nelfinavir

Radical Lung Radiotherapy Plus Nelfinavir - Full Text View - ClinicalTrials.govRadical Lung Radiotherapy Plus Nelfinavir - Full Text View - ClinicalTrials.gov

Nelfinavir given in combination with radical RT. Drug: nelfinavir Nelfinavir tablets BD 7 days per week from D-7 of starting ... Radical Lung Radiotherapy Plus Nelfinavir (NelfLung). The safety and scientific validity of this study is the responsibility of ... One effect of nelfinavir is to interfere with the function of a particular protein in cells (called AKT). The degree to which ... However, in this case nelfinavir was taken at a dose 3-fold higher than the highest dose level to be tested in this trial. An ...
more infohttps://clinicaltrials.gov/show/NCT01447589?order=112

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