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*  14-3-3 Is a Regulator of the Cardiac Voltage-Gated Sodium Channel Nav1.5 | Circulation Research
14-3-3 Is a Regulator of the Cardiac Voltage-Gated Sodium Channel Nav1.5. Marie Allouis, Françoise Le Bouffant, Ronald Wilders ... 14-3-3 Is a Regulator of the Cardiac Voltage-Gated Sodium Channel Nav1.5 ... 14-3-3 Is a Regulator of the Cardiac Voltage-Gated Sodium Channel Nav1.5 ... 14-3-3 Is a Regulator of the Cardiac Voltage-Gated Sodium Channel Nav1.5 ...
http://circres.ahajournals.org/content/98/12/1538
*  Provocation of an Autoimmune Response to Cardiac Voltage-Gated Sodium Channel NaV1.5 Induces Cardiac Conduction Defects in Rats...
cardiac voltage-gated sodium channel α-subunit. SCN5A. cardiac voltage-gated sodium channel α-subunit gene. TIMP. tissue ... Provocation of an Autoimmune Response to Cardiac Voltage-Gated Sodium Channel NaV1.5 Induces Cardiac Conduction Defects in Rats ... cardiac voltage-gated sodium-channel current. Ito. cardiac transient outward potassium current. LV. left ventricular. MMP. ... on the density of voltage-gated sodium current (INa), transient outward potassium current (Ito) and voltage-gated L-type ...
http://www.onlinejacc.org/content/62/4/340
*  2nsq - Proteopedia, life in 3D
Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination. Circ Res. 2004 Aug 6;95(3):284-91 ... Henke G, Maier G, Wallisch S, Boehmer C, Lang F. Regulation of the voltage gated K+ channel Kv1.3 by the ubiquitin ligase Nedd4 ... The ubiquitin E3 protein ligase Nedd4-2 is a physiological regulator of the epithelial sodium channel ENaC, which is essential ... Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, ...
http://proteopedia.org/wiki/index.php/2nsq
*  British Library EThOS: Pharmacological studies of voltage-gated sodium channel expression in human breast cancer cells :...
The overall aim of this PhD was to improve our understanding, including the clinical potential, of neonatal Nav1.5 (nNav1.5) ... Pharmacological studies of voltage-gated sodium channel expression in human breast cancer cells : control of metastatic cell ... The specific aims were threefold, as follows: 1) To test the effects of several types of voltage-gated sodium channel (VGSC) ...
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539266
*  Interplay between R513 methylation and S516 phosphorylation of the cardiac voltage-gated sodium channel
... including the cardiac sodium channel, Nav1.5. We show that Nav1.5 R513 methylation decreases S516 phosphorylation rate by 4 ... Interplay between R513 methylation and S516 phosphorylation of the cardiac voltage-gated sodium channel. Beltrán-Álvarez, Pedro ... Interplay between R513 methylation and S516 phosphorylation of the cardiac voltage-gated sodium channel. Repositori DSpace/ ... including the cardiac sodium channel, Nav1.5. We show that Nav1.5 R513 methylation decreases S516 phosphorylation rate by 4 ...
http://dugi-doc.udg.edu/handle/10256/10361
*  The Role of Non-pore-Forming β Subunits in Physiology and Pathophysiology of Voltage-Gated Sodium Channels | SpringerLink
Voltage-gated sodium channel β1 and β2 subunits were discovered as auxiliary proteins that co-purify with pore-forming α ... Abriel H, Kass RS (2005) Regulation of the voltage-gated cardiac sodium channel Nav1.5 by interacting proteins. Trends ... Brackenbury WJ (2012) Voltage-gated sodium channels and metastatic disease. Channels 6(5):352-361PubMedCentralPubMedGoogle ... Johnson D, Bennett ES (2006) Isoform-specific effects of the beta2 subunit on voltage-gated sodium channel gating. J Biol Chem ...
https://link.springer.com/chapter/10.1007/978-3-642-41588-3_4
*  Long QT syndrome - Wikipedia
... the NaV1.5 voltage-gated sodium channel sits. Similar to LQT3, these particular mutations increase so-called 'late' sodium ... an auxiliary subunit to the pore-forming NaV1.5 (gene: SCN5A) subunit of the voltage-gated sodium channel of the heart. The ... Mexiletine, a sodium channel blocker: In LQT3, the sodium channel does not close properly. Mexiletine closes these channels and ... KCNQ1 codes for the voltage-gated potassium channel KvLQT1 that is highly expressed in the heart. The product of the KCNQ1 gene ...
https://en.wikipedia.org/wiki/Long_QT_syndrome
*  NEDD4-2 | Springer for Research & Development
Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination. Circ Res. 2004;95(3):284-91. ... Dysregulation of voltage-gated sodium channels by ubiquitin ligase NEDD4-2 in neuropathic pain. J Clin Invest. 2013;123(7):3002 ... Fotia AB, Ekberg J, Adams DJ, Cook DI, Poronnik P, Kumar S. Regulation of neuronal voltage-gated sodium channels by the ... mediated activity of voltage-gated sodium channels in primary cortical neurons. Biochem J. 2014;457(1):27-31.CrossRefPubMed ...
https://rd.springer.com/referenceworkentry/10.1007%2F978-3-319-67199-4_101704
*  Scn5a - Sodium channel protein type 5 subunit alpha - Rattus norvegicus (Rat) - Scn5a gene & protein
Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium- ... This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by ... It is a tetrodotoxin-resistant Na(+) channel isoform. ... selective channel through which Na(+) ions may pass in ... This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. ...
https://www.uniprot.org/uniprot/P15389
*  WikiGenes - NEDD4L - neural precursor cell expressed,...
Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination. van Bemmelen, M.X., Rougier, J.S ... Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination [19]. ... Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins. Rougier, J.S., van Bemmelen ... By targeting the epithelial sodium channel (ENaC) for degradation, NEDD4L is a significant determinant of sodium reabsorption ...
https://www.wikigenes.org/e/gene/e/23327.html
*  Fluorescent Na+ and K+ Indicators-Section 21.1 | Thermo Fisher Scientific - CN
SBFI and PBFI are fluorescent indicators for sodium and potassium, respectively. Although the selectivity of SBFI and PBFI for ... Determining voltage-gated sodium channel NaV1.5-driven endosomal Na+ levels in macrophages. ... voltage-gated channels open or close in response to changes in membrane potential,. whereas ligand-gated or ion-activated ... several members of the voltage-gated K+ channel (Kv) gene family and two members of the inwardly rectifying K+ channel (Kir) ...
https://www.thermofisher.com/cn/zh/home/references/molecular-probes-the-handbook/indicators-for-na-k-cl-and-miscellaneous-ions/fluorescent-na-and-k-indicators.html
*  GDF15 regulates Kv2.1-mediated outward K+ current through the Akt/mTOR signalling pathway in rat cerebellar granule cells |...
2004) Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination. Circ. Res. 95:284-291, doi: ... 2005) Kv2.1: a voltage-gated K+ channel critical to dynamic control of neuronal excitability. Neurotoxicology 26:743-752, doi: ... The IK is one of the most ubiquitously expressed voltage-gated K+ channels and plays many diverse physiological roles. Kv2.1 is ... 2010) Transmembrane segments prevent surface expression of sodium channel Nav1.8 and promote calnexin-dependent channel ...
http://www.biochemj.org/content/460/1/35
*  Mauro D'Amato | Profile page | Karolinska Institutet
Loss-of-function of the voltage-gated sodium channel NaV1.5 (channelopathies) in patients with irritable bowel syndrome. Beyder ... A GWAS meta-analysis suggests roles for xenobiotic metabolism and ion channel activity in the biology of stool frequency.. ... A GWAS meta-analysis suggests roles for xenobiotic metabolism and ion channel activity in the biology of stool frequency. ...
https://ki.se/en/people/maudam
*  anti-Dynamitin Primary Antibodies
Dynamitin affects cell-surface expression of voltage-gated sodium channel Nav1.5. in The Biochemical journal 2014 (PubMed) ... dynamitin is involved in the regulation of Nav1.5 (zeige SCN5A Antikörper) cell-surface density ...
https://www.antikoerper-online.de/m-phase-pathway-68/dynamitin-antibody-6781/
*  Applications filed at Mar 22 2018 | ASSEMBLY OF GAS-TIGHT COMPARTMENT AND OPTICAL VOLTAGE SENSOR | Patents.com
Provided are a cell line stably expressing voltage-gated sodium channel (Nav1.5), wherein a SCN5A gene (NCBI accession no. NM_ ... ASSEMBLY OF GAS-TIGHT COMPARTMENT AND OPTICAL VOLTAGE SENSOR. The invention relates to an assembly of a gas-tight compartment ... CELL LINE STABLY EXPRESSING Nav1.5 AND METHOD OF SCREENING THERAPEUTIC AGENT USING THE CELL LINE. ... 198056) encoding Nav1.5 and a... 2018/0080923. Toilet Bowl Optical Engine. An optical engine directly attached to a surface of ...
http://www.patents.com/ap-20180322-p75.html
*  С ?? ҩ ??.??Ϣ?? .11447001??11447500
11447142:14-3-3 Is a Regulator of the Cardiac Voltage-Gated Sodium Channel Nav1.5 ... 11447083:Cardiac Sodium Channel Nav1.5 Is Regulated by a Multiprotein Complex Composed of Syntrophins and Dystrophin ... 11447232:Calmodulin Is Essential for Cardiac IKS Channel Gating and Assembly. *11447233:KCNQ1 Assembly and Function Is Blocked ... 11447275:No Apparent Requirement for Neuronal Sodium Channels in Excitation-Contraction Coupling in Rat Ventricular Myocytes ...
http://www.100md.com/index/other/byinfono/022/895.htm
*  Nav1.5 - Wikipedia
NaV1.5 is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. NaV1.5 is found ... neuronal channels (NaV1.7, NaV1.8 and NaV1.9), skeletal muscle channels (NaV1.4) and the cardiac sodium channel NaV1.5. SCN5A ... NaV1.5 channels predominantly mediate the sodium current (INa) in cardiac cells. INa is responsible for the fast upstroke of ... The conformational state of the channel, which is both voltage and time-dependent, determines whether the channel is opened or ...
https://en.wikipedia.org/wiki/Nav1.5
*  PR interval association results for 2.8 million SNPs ac | Open-i
NAV1.5 Voltage-Gated Sodium Channel. *NAV1.8 Voltage-Gated Sodium Channel. *Neoplasm Proteins/genetics ... We observed a strong signal (rs3922844) within the gene encoding the cardiac sodium channel (SCN5A) with genome-wide ... We observed a strong signal (rs3922844) within the gene encoding the cardiac sodium channel (SCN5A) with genome-wide ... NAV1.5 Voltage-Gated Sodium Channel. *NAV1.8 Voltage-Gated Sodium Channel. *Neoplasm Proteins/genetics ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC3037415_pgen.1001304.g002&req=4
*  Pedigree information of the family with the SCN5A-delQK | Open-i
NAV1.5 Voltage-Gated Sodium Channel. *Prevalence. *Risk Factors. *Syndrome. Related in: MedlinePlus ... The cardiac sodium channel mutation delQKP 1507-1509 is associated with the expanding phenotypic spectrum of LQT3, conduction ... The cardiac sodium channel mutation delQKP 1507-1509 is associated with the expanding phenotypic spectrum of LQT3, conduction ... Aim: We report diverse phenotypic consequences of the delQKP-1507-1509 cardiac sodium channel mutation in three generations of ...
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2573028_eun20201&req=4
*  SCN5A antibody | pab0281 | Covalab - Covalab Biotechnology
Sodium channel protein type V subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.5, SCN5A ... Sodium channel protein type 5 subunit alpha (SCN5A) antibody , Q14524 , HH1, Sodium channel protein cardiac muscle subunit ... Sodium channel protein type V subunit alpha. Voltage-gated sodium channel subunit alpha Nav1.5. Gene name : SCN5A Sodium ... Sodium channel protein type 5 subunit alpha (SCN5A) antibody. Sodium channel protein type 5 alpha subunit. HH1. Sodium channel ...
https://www.covalab.com/sodium-channel-protein-type-5-subunit-alpha-scn5a-antibody-2.html
*  Kappa-theraphotoxin elisa and antibody
ND1). Also inhibits voltage-gated sodium channels of subtype Nav1.5/SCN5A (in cardiac myocytes). The toxin shifts activation ... Inhibits voltage-gated potassium channels (Kv2.1/KCN. >>>. B1 > Kv4.2/KCND2 > Kv4.1/KCND1). Also inhibits voltage-gated sodium ... Inhibits voltage-gated potassium channels (Kv2.1/KCN. >>>. B1 > Kv4.2/KCND2 > Kv4.1/KCND1). Also inhibits voltage-gated sodium ... Inhibits voltage-gated potassium channels (Kv2.1/KCN. >>>. B1 > Kv4.2/KCND2 > Kv4.1/KCND1). Also inhibits voltage-gated sodium ...
https://www.mybiosource.com/protein_family.php?root=kappa-theraphotoxin
*  Abstracts of Papers at the sixty-second annual meeting of the society of general physiologists | JGP
Additionally, we are actively characterizing the role of ankyrin-G in targeting of voltage-gated sodium channel Nav1.5 (SCN5A) ... Intracellular Ca2+ can mediate bimodal regulation of the voltage-gated cardiac sodium channel (NaV1.5) through its C terminus ( ... We next explored the role of voltage-gated Ca2+ channels (VGCCs) to Ca2+ influx with the use of 5 mM cobalt. Co2+ did not ... clh-3 encodes two splice variants, CLH-3a and CLH-3b, of a Caenorhabditis elegans voltage-gated ClC Cl− channel. CLH-3b is ...
http://jgp.rupress.org/content/132/1/3a
*  UniversitätsKlinikum Heidelberg: Reserach group Ion channel signalling complexes
Provocation of an autoimmune response to cardiac voltage-gated sodium channel NaV1.5 induces cardiac conduction defects in rats ... autoantibodies and conduction disease by provocating an autoimmune response to cardiac voltage-gated sodium channel Nav1.5. In ... Regulation of endothelial and mycardial aquaporin-1 channels Aquaporin-1 channels are the functionally dominant water channels ... and on aquaporin-1 channels, which form a water channel in cardiomyocytes. In an innovative interdisciplinary cooperation with ...
https://www.klinikum.uni-heidelberg.de/index.php?id=118631&L=1
*  Frequency distribution analysis of activation times and regional fibrosis in murine Scn5a+/- hearts: the effects of ageing and...
NAV1.5 Voltage-Gated Sodium Channel, Sex Characteristics ... epicardial activation obtained from a 64-channel multi- ...
http://epubs.surrey.ac.uk/827842/