Nafoxidine - Wikipedia
Nafoxidine (INNTooltip International Nonproprietary Name; developmental code names U-11,000A) or nafoxidine hydrochloride ( ... Nafoxidine is a long-acting estrogen receptor ligand, with a nuclear retention in the range of 24 to 48 hours or more. Elks J ( ... Nafoxidine was assessed in clinical trials in the treatment of breast cancer and was found to be effective. However, it ... Steinbaum FL, De Jager RL, Krakoff IH (1978). "Clinical trial of nafoxidine in advanced breast cancer". Medical and Pediatric ...
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4, E and F) sulfonation, except nafoxidine did not inhibit human liver cytosolic GLCA (Fig. 4C) or TLCA (Fig. 4E) sulfonation. ... In contrast to lasofoxifene, nafoxidine, which is a structural analog of lasofoxifene, has an IC50 value that was 6- to 13-fold ... Another tetrahydronaphthalene derivative, nafoxidine, which has a 7-methoxy group and a double bond between the two phenyl ... A plausible explanation is that the double bond in nafoxidine may constrain the free movement of phenyl groups, which results ...
DeCS 2019 - June 12, 2019 version
Genistein - Wikipedia
Genistein and other isoflavones have been identified as angiogenesis inhibitors, and found to inhibit the uncontrolled cell growth of cancer, most likely by inhibiting the activity of substances in the body that regulate cell division and cell survival (growth factors). Various studies have found that moderate doses of genistein have inhibitory effects on cancers of the prostate,[39][40] cervix,[41] brain,[42] breast[39][43][44] and colon.[17] It has also been shown that genistein makes some cells more sensitive to radio-therapy.;[45] although, timing of phytoestrogen use is also important.[45] Genisteins chief method of activity is as a tyrosine kinase inhibitor. Tyrosine kinases are less widespread than their ser/thr counterparts but implicated in almost all cell growth and proliferation signal cascades. Inhibition of DNA topoisomerase II also plays an important role in the cytotoxic activity of genistein.[27][46] The observation that transition of normal lymphocytes from quiescence (G0) to ...
DeCS 2019 - June 12, 2019 version
DeCS 2018 - July 31, 2018 version
DeCS 2017 - July 04, 2017 version
DeCS 2018 - July 31, 2018 version
Contraceptives postcoital hormonal. Medical search
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US Patent Application for PEPTIDE-LIPOSOME COMPLEX FOR MULTIVALENT CROSSLINKING WITH PD-L1 AND COMPOSITION INCLUDING THE SAME...
Anisomycin | Profiles RNS
MeSH Browser
Nafoxidine | Profiles RNS
"Nafoxidine" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Nafoxidine" by people in this website by year, and whether " ... Below are the most recent publications written about "Nafoxidine" by people in Profiles. ...
"Estrogenic effects of nafoxidine on ovarian-dependent and independent " by C S. Watson, D Medina et al.
Interactions of antiestrogens with human breast cancer in long-term tissue culture - PubMed
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Registration Dossier - ECHA
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
DeCS 2017 - December 21, 2017 version
Code System Concept
MeSH Browser
Nafoxidine Hydrochloride Narrower Concept UI. M0330055. Registry Number. SU8WBD61G1. Terms. Nafoxidine Hydrochloride Preferred ... Nafoxidine Preferred Term Term UI T027630. Date01/01/1999. LexicalTag NON. ThesaurusID ... Nafoxidine Preferred Concept UI. M0014421. Registry Number. 4RIY10WM82. Related Numbers. 1845-11-0. 1847-63-8. SU8WBD61G1. ... Nafoxidine Hydrochloride U-11,100A U-11000A Pharm Action. Estrogen Antagonists. Antineoplastic Agents, Hormonal. Registry ...
MeSH Browser
Nafoxidine Hydrochloride Narrower Concept UI. M0330055. Registry Number. SU8WBD61G1. Terms. Nafoxidine Hydrochloride Preferred ... Nafoxidine Preferred Term Term UI T027630. Date01/01/1999. LexicalTag NON. ThesaurusID ... Nafoxidine Preferred Concept UI. M0014421. Registry Number. 4RIY10WM82. Related Numbers. 1845-11-0. 1847-63-8. SU8WBD61G1. ... Nafoxidine Hydrochloride U-11,100A U-11000A Pharm Action. Estrogen Antagonists. Antineoplastic Agents, Hormonal. Registry ...
Bisphenol F - Wikipedia
BPF has estrogenic, progesteronic, and anti-androgenic effects. The overarching implications of these hormonal changes for humans are decreases in testosterone secretions, especially in male testes, and increases in the activity of estrogen. The effects are greatest in the fetal testis, which is primed to be more easily affected due to its plasticity and massive period of growth. One study[7] found that BPF had the same effect in lowering testosterone secretions as BPA, increasing over 80% compared to the control in the human fetal testes. It is important to note that this research is done using an in vitro method of fetal testis assay (FeTA), and does not necessarily reflect the mechanisms BPF would undergo if ingested by humans. For example, the ability for BPF to activate oestrogen in the receptors is lower than that of BPA, (one study[7] suggests 5- to 10-fold lower) and the actions of these bisphenols are likely not directly through these receptors, but rather more indirect. As such, most ...
I am a non-smoker, how is it possible that cotinine showed up in my blood work - lookformedical.com
Descriptors in 2013 MeSH. Preferred term only. December 14, 2012
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clomid in males side effects In the presence of 60 n m estradiol and 5 Ој m of either tamoxifen, nafoxidine, or ICI, the ОІ ...
FastHealth Medical Dictionary N-Neo
Cannabis Ruderalis - THC Science
Kaempferol is common in Pteridophyta, Pinophyta, and Angiospermae. Within Pteridophyta and Pinophyta, kaempferol has been found in diverse families. Kaempferol has also been identified in Dicotyledons and Monocotyledons of Angiosperms.[3] The total average intake of flavonols and flavones in a normal diet is estimated as 23 mg/day, to which kaempferol contributes approximately 17%.[4] Common foods that contain kaempferol include: apples,[5] grapes,[5] tomatoes,[5] green tea,[5] potatoes,[4] onions,[3] broccoli,[3] Brussels sprouts,[3] squash,[3] cucumbers,[3] lettuce,[3] green beans,[3] peaches,[3] blackberries,[3] raspberries,[3] and spinach.[3] Plants that are known to contain kaempferol include Aloe vera,[3] Coccinia grandis,[3] Cuscuta chinensis,[6] Euphorbia pekinensis,[3] Glycine max,[3] Hypericum perforatum,[3] Pinus sylvestris,[7] Moringa oleifera,[8] Rosmarinus officinalis,[3] Sambucus nigra,[3] and Toona sinensis,[3] and Ilex.[3] It also is present in endive.[9] ...