Rho-associated kinase (ROCK) promotes myosin light chain phosphorylation, activates actin severing factor cofilin through LIM ... Vincristine enhances amoeboid-like motility via GEF-H1/RhoA/ROCK/Myosin light chain signaling in MKN45 cells. BMC Cancer 2012, ... Inhibits the kinase activities of ROCK1/ROCK2.. [195]. ROCK1. Fasudil. Inhibits ROCK in the vascular system and is a calcium ... The Rho-associated kinase inhibitor fasudil can replace Y-27632 for use in human pluripotent stem cell research. PLoS ONE 2020 ...

25-Dihydroxyvitamin D protects intestinal epithelial barrier by regulating the myosin light chain kinase signaling pathway. ... Longitudinal Association between n-3 Long-Chain Polyunsaturated Fatty Acid Intake and Depressive Symptoms: A Population-Based ... 25-Dihydroxyvitamin D3-induced monocyte antimycobacterial activity is regulated by phosphatidylinositol 3-kinase and mediated ...

Increase of insulin sensitivity, regulation of adenosine monophosphate-activated protein kinase (AMPK) pathway, improvement of ... Berberine ameliorates intestinal epithelial tight-junction damage and down-regulates myosin light chain kinase pathways in a ... Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab. ... or calmodulin-mediated kinase kinase β (CaMKKβ) [56]. LKB1 and CaMKKβ are the main kinases that activate AMPK via ...

... and M13-like peptides from the CaM-dependent myosin light chain (MLC) kinases found in different species (a) and for the FRCaMP ... and M13-like peptides from the CaM-dependent myosin light chain (MLC) kinases found in different species (a) and for the FRCaMP ... The percentage of identity among M13-like peptides from CaM-dependent myosin light chain kinases between the same species was ... Light power density (9.136 mW/cm2) was measured at the rear focal plane of the objective lens using a PM100D power meter ( ...

... these inflammatory and stress responses may induce phosphorylation of myosin light chain by myosin light chain kinase, ... and stimulation of non-muscle myosin through myosin light chain kinase (MLCK) [60] and Rho GTPases [61]. ... reduces epithelial barrier function in a myosin light chain kinase-dependent fashion. Gastroenterology 2002, 123, 1179-1190. [ ... Finally, tight junctions are regulated by several intracellular pathways including myosin light chain kinase (MLCK), mitogen- ...

... creatine kinase (p = 0.0118), and glucose (p = 0.0151) after acute exercise challenge. The number of type I fibers (slow muscle ... staining of tissues involved use of the Leica antibody to myosin heavy chain fast (WB-MHCf) and myosin heavy chain slow (WB- ... Figure 3. Effect of LP10 supplementation on serum levels of lactate (A); ammonia (B); creatine kinase (CK) (C); glucose (D); ... 5001; PMI Nutrition International, Brentwood, MO, USA) and distilled water ad libitum and housed at 12-h light/12-h dark cycle ...

Myosin Light Chains 2 and 3 (MYL2 and MYL3), and myosin heavy chain 6 (MYH6) encoding cardiac alpha-myosin heavy chain (α-MHC ... protein kinase adenosine monophosphate-activated non-catalytic subunit gamma 2 (PRKAG2) cardiomyopathy, RASopathies (including ... myosin heavy chain-7 (MYH7) encoding for cardiac beta-myosin heavy chain (β-MHC), cardiac myosin binding protein C (MYBPC3), ... since the discovery of the first mutation in the Myosin Heavy Chain-7 (MYH7) gene, encoding β-cardiac myosin heavy chain (β-MHC ...

... nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and NF-E2-related factor 2 (Nrf-2) [104]. NF-κB up- ... Similar to AKT, other kinases, such as cAMP-dependent protein kinase A (PKA), protein kinase C-γ (PKCγ), protein kinase D1 ( ... Mirzoev, T.M.; Sharlo, K.A.; Shenkman, B.S. The Role of GSK-3β in the Regulation of Protein Turnover, Myosin Phenotype, and ... PKD1), protein kinase G (PKG) or mitogen-activated protein kinase-activated protein (MAPKAP) kinase-1, also mediate GSK-3β ...

... long-chain ACAD (LCAD), very long-chain ACAD (VLCAD), and acyl-CoA dehydrogenase 9 (ACAD-9). Among them, long-chain acyl-CoA ... including pyruvate dehydrogenase kinase 1 (PDK1), lactate dehydrogenase A (LDHA), and phosphoglycerate kinase (PGK1) [28]. Our ... This article sheds light on the significance of SIRT3 in regulating vascular cell phenotypes. ... they can be identified through their formation of contractile bundles composed of actin and myosin, development of adhesion ...

... increased beta-myosin heavy chain expression in heart tissue, indicating cardiac injury. In summary, our findings indicate that ... diagnosis of light chain disease or non-secreting MM, renal failure, hypoalbuminemia, hypercalcemia, high β2-microglobulin, ... Dysregulated glycogen synthase kinase-3 beta under metabolic imbalance is suggested to accelerate CRC pathogenesis/progression ... Dysregulated glycogen synthase kinase-3 beta under metabolic imbalance is suggested to accelerate CRC pathogenesis/progression ...

... of myosin-II (−8.30 Kcal/mol), as well as in chain A and C (LYS-199.A, LYS-152.C) of calreticulin (−8.77 Kcal/mol). As for ... Degeneration changes in the proximal tubules with the destruction of the brush border were revealed by light and electron ... and Janus kinase (JAKs) to nip the cytokine storm in the bud. This review critically used information retrieved from PubMed, ... Molecular docking of LL with E. histolytica proteins showed high affinity to ATP-binding catalytic sites in the heavy-chain ( ...