Comparative in silico analysis identifies bona fide MyoD binding sites within the myocyte stress 1 gene promoter -...
Background Myocyte stress 1 (MS1) is a striated muscle actin binding protein required for the muscle specific activity of the ... We believe, through its activation of ms1, this is the first study to demonstrate a direct link between MyoD activity and SRF ... Subsequent mutagenesis and EMSA analysis demonstrated specific targeting of MyoD at two distinct E-Boxes (E1 and E2) within ... Comparative in silico analysis identifies bona fide MyoD binding sites within the myocyte stress 1 gene promoter ...http://westminsterresearch.wmin.ac.uk/13378/
The muscle regulators MyoD and Myf-5 control cell cycle induction and - Role of adrenergic receptors in human coronary...
On the other hand Myf-5 protein can be saturated in G0 lowers during G1 and reappears by the end of G1 to stay steady until ... The muscle regulators MyoD and Myf-5 control cell cycle induction and. November 3, 2016. The muscle regulators MyoD and Myf-5 ... MyoD can be absent in G0 peaks in mid-G1 falls to its minimum amount level at G1/S and reaugments from S to M. ... Thus MyoD expression is maintained at high levels at the M to G1 transition. The pattern of expression observed during ...http://researchreportone.com/?p=1514
Myogenin Summary Report | CureHunter
Contractile Proteins: 345*Muscle Proteins: 1046*Myogenic Regulatory Factors: 43*Myogenin: 294*human MYOG protein ... 05/01/1999 - "Neither myogenin nor MyoD appear to play a critical role in the muscular atrophy that occurs during ... Amino Acids, Peptides, and Proteins*Proteins: 90489*Transcription Factors: 20597*Basic Helix-Loop-Helix Transcription Factors: ... DNA-Binding Proteins: 1111*Basic Helix-Loop-Helix Transcription Factors: 68*Myogenic Regulatory Factors: 43*Myogenin: 294*human ...http://www.curehunter.com/public/keywordSummaryD018008-Myogenin.do
MyoD muscle protein-DNA complex - Stock Image C015/2659 - Science Photo Library
Molecular model of the MyoD muscle protein (green and blue) bound to a strand of DNA (deoxyribonucleic acid, orange and green ... MyoD's role as a protein is to aid the regulation of muscle differentiation, the process where basic cell types become more ... MyoD is an example of a basic helix-loop-helix (bHLH) transcription factor. - Stock Image C015/2659 ... Caption: MyoD muscle protein-DNA complex. Molecular model of the MyoD muscle protein (green and blue) bound to a strand of DNA ...http://www.sciencephoto.com/media/498163/view
Activation of Xenopus MyoD transcription by members of the MEF2 protein family. - PubMed - NCBI
Activation of Xenopus MyoD transcription by members of the MEF2 protein family.. Wong MW1, Pisegna M, Lu MF, Leibham D, Perry M ... Both proteins are highly homologous to each other, belong to the MADS (MCM1 agamous deficiens SRF) protein family, and are most ... Proteins that bind specifically to this site were present at low levels during early development and increased in abundance ... Members of the MEF2 family of DNA binding proteins interact with a set of AT-rich sequences commonly found in the promoters and ...https://www.ncbi.nlm.nih.gov/pubmed/7813786?dopt=Abstract
Rhabdomyosarcoma | Cancer Genetics Web
PUM, MYF3, MYOD, bHLHc1. -MYOD1 and Rhabdomyosarcoma. 41. CDK4. 12q14. CMM3, PSK-J3. -CDK4 Amplification in Rhabdomyosarcoma. ... which inhibits protein kinase Cα-mediated activation of mitogen-activated protein kinases (MAPKs), especially p38MAPK ... Mutated Genes and Abnormal Protein Expression (19). Clicking on the Gene or Topic will take you to a separate more detailed ... The effect of YM155 on survivin expression in the RD cell line was examined at both mRNA and protein levels using real-time PCR ...http://www.cancerindex.org/geneweb/X2002.htm
Immunofluorescence localization of cell type-specific | Open-i
Immunofluorescence localization of cell type-specific proteins and BrdU in G8-positive cells in vitro. Cells from fetal organs ... All G8-positive cells contained MyoD protein, and all cells with MyoD were stained for G8 (Fig. 5, A, D, E, and G). Most of the ... All G8-positive cells contained MyoD protein, and all cells with MyoD were stained for G8 (Fig. 5, A, D, E, and G). Most of the ... Bottom Line: Most, if not all, of the muscle that formed in culture arose from cells that expressed MyoD and G8 in vivo.This ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2150848_0105139f5&req=4
The Molecular Bases of Training Adaptation | SpringerLink
Skeletal muscle is a malleable tissue capable of altering the type and amount of protein in response to disruptions to cellular ... Tumor necrosis factor-α inhibits myogenic differentiation through MyoD protein destabilization. FASEB J 2004; 18 (2): 227-37 ... 5'-AMP-activated protein kinase activity and protein expression are regulated by endurance training in human skeletal muscle. ... AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of ...https://link.springer.com/article/10.2165%2F00007256-200737090-00001
Harold M. Weintraub - Wikipedia
When expressed, the myoD gene produces a protein referred to as MyoD (or MyoD1), which can bind certain DNA sequences, stop ... "MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase ... Weintraub's work used myoD to delve broadly and deeply into the areas of regulatory proteins, gene expression, and the ... "Differences and similarities in DNA-binding preferences of MyoD and E2A protein complexes revealed by binding site selection". ...https://en.wikipedia.org/wiki/Harold_M._Weintraub
The Effect of Anti-Tumor Necrosis Factor-Alpha Treatment on Muscle Performance and Endurance in Patients With Ankylosing...
Tumor necrosis factor-alpha inhibits myogenic differentiation through MyoD protein destabilization. FASEB J 2004;18:227-37. [4 ... C-reactive protein, erythrocyte sedimentation rate, Ankylosing Spondylitis Disease Activity ScoreC-reactive protein and ... It is thought that TNF-[alpha] causes muscle loss by stimulating the destruction of muscle protein and inhibiting myogenic ... Long-term exposure to TNF-[alpha] activates the ubiquitin-proteasome pathway with a catabolic effect, thereby causing protein ...https://www.thefreelibrary.com/The+Effect+of+Anti-Tumor+Necrosis+Factor-Alpha+Treatment+on+Muscle+...-a0528615309
Staufen1 expression is modulated during skeletal muscle | Open-i
A) Western blots showing Staufen1, c-myc, and myogenin protein levels in reg ... Myogenin protein expression was initially analyzed. Note that in contrast to myotubes, adult muscles express low levels of ... as evidenced by reductions in the differentiation and fusion indices and decreases in MyoD, myogenin, MEF2A, and MEF2C, ... Myogenin protein expression was initially analyzed. Note that in contrast to myotubes, adult muscles express low levels of ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4230783_3765fig2&req=4
adult pleomorphic rhabdomyosarcoma 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Chemical-registry-number] 0 / Actins; 0 / Biomarkers, Tumor; 0 / Desmin; 0 / MYOG protein, human; 0 / MyoD Protein; 0 / MyoD1 ... Proto-Oncogene Proteins / genetics. Proto-Oncogene Proteins / metabolism. Repressor Proteins / genetics. Repressor Proteins / ... Bone Morphogenetic Proteins; 0 / Carrier Proteins; 0 / DNA Primers; 148294-77-3 / noggin protein; EC 18.104.22.168 / FGFR1 protein, ... Chemical-registry-number] 0 / Myeloid Cell Leukemia Sequence 1 Protein; 0 / Proto-Oncogene Proteins c-bcl-2; 0 / RNA, Messenger ...http://www.bmlsearch.com/?kwr=adult+pleomorphic+rhabdomyosarcoma+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
Cellular caspase-8-like inhibitory protein (cFLIP) prevents inhibition of muscle cell differentiation induced by cancer cells. ...
Stable expression of IKBSR, a known repressor of NF-kappaB activation, and cellular caspase-8-like inhibitory protein (cFLIP) ... In contrast, overexpression of antiapoptotic protein Bcl-xL did not protect myoblast cells exposed to the same treatment. ... activation of NF-kappaB in cancer cell media-treated muscle cells with an accompanying enhancement of myogenic protein ... Tumor necrosis factor-alpha inhibits myogenic differentiation through MyoD protein destabilization. R. C. Langen, D. Van, +3 ...https://www.semanticscholar.org/paper/Cellular-caspase-8-like-inhibitory-protein-%28cFLIP%29-Jiang-Clemens/aed302281d49ccd14b6522aaa7a7d2b1e8726a5e
ZFIN Publication: Neyt et al., 2000
MyoD Protein/biosynthesis. *MyoD Protein/genetics. *Zebrafish. PubMed:. 11081511 Full text @ Nature ...https://zfin.org/ZDB-PUB-001205-1
Isolation, Culture, and Staining of Single Myofibers
Immunostaining of satellite cells for Pax7 and MyoD protein. * With a pipette, carefully remove 2 ml of MfGM, leaving remaining ... Pax7 + /MyoD - ）相关。在培养物中约24小时时，卫星细胞通过上调MyoD（Pax7 + sup/+/MyoD + ）进行其第一轮细胞分裂，并通过72小时增殖形成细胞聚集。培养的肌纤维外植体上的卫星细胞可以终末分化（Pax7 /MyoD + ... 对于单个实验，样品大小应通过功率分析确定。对于我们https://bio-protocol.org/cn/e1942
Cardozo CP[au] - PubMed - NCBI
Nandrolone-induced nuclear accumulation of MyoD protein is mediated by Numb, a Notch inhibitor, in C2C12 myoblasts. ... Activation of Protein Kinase A in Mature Osteoblasts Promotes a Major Bone Anabolic Response. ... C-terminal Hsp-interacting protein slows androgen receptor synthesis and reduces its rate of degradation. ... Nandrolone, an anabolic steroid, stabilizes Numb protein through inhibition of mdm2 in C2C12 myoblasts. ...https://www.ncbi.nlm.nih.gov/pubmed?access_num=Cardozo+CP&link_type=AUTHORSEARCH&cmd=search&term=Cardozo+CP%5Bau%5D&dispmax=50
"The myogenic basic helix-loop-helix family of transcription factors sh" by Kanaklata Roy, Ivana L. de la Serna et al.
We proposed that SWI/SNF enzymes are required for the induction of all muscle-specific gene expression by MyoD, Myf5, and MRF4 ... To ascertain the requirement for SWI/SNF enzymes in muscle differentiation mediated by different MyoD family members, we ... We demonstrated previously that SWI/SNF enzymes promote MyoD-mediated muscle differentiation. ... examined MyoD, Myf5, MRF4, and myogenin-mediated induction of muscle differentiation in cells expressing dominant negative ...https://escholarship.umassmed.edu/oapubs/728/
SMART: HLH domain annotation
Peptides were prepared that span this motif in the MyoD protein; in solution, they formed alpha-helical dimers and tetramers. ... are buried at the protein-DNA interface. These residues are not available for direct protein-protein contacts, but they may ... domain mediates protein dimerization and has been found in the proteins listed below [(PUBMED:1521738)]. Most of these proteins ... Click on the protein counts, or double click on taxonomic names to display all proteins containing HLH domain in the selected ...http://smart.embl.de/smart/do_annotation.pl?DOMAIN=HLH&BLAST=DUMMY
UCD Conway Institute of Biomolecular and Biomedical Research
Reynaud E.G., Guillier, M., Leibovitch, M.P. and Leibovitch, S.A. ; (1999) 'p57(Kip2) stabilizes the MyoD protein by inhibiting ... Reynaud, E.G., Leibovitch, M.P., Tintignac, L.A., Pelpel, K., Guillier, M. and Leibovitch, S.A. ; (2000) 'Stabilization of MyoD ... Palidwor, G., Reynaud, E.G. and Miguel, A. ; (2006) 'Andrade Taxonomic colouring of protein derived phylogenetic trees'. BMC ... Detection and quantification of protein-microtubules interaction using GFP photo-conversion'. Traffic, 7 (9):1283-1289. [DOI] [ ...http://www.ucd.ie/conway/research/researchers/conwayfellowsa-z/dremmanuelreynaud/
miR-203b: a novel regulator of MyoD expression in tilapia skeletal muscle.
Tight regulation of MyoD protein level is necessary for the precise regulation of skeletal muscle development. MicroRNAs ( ... MyoD is one of the helix-loop-helix proteins regulating muscle-specific gene expression in tilapia. ... MyoD is one of the helix-loop-helix proteins regulating muscle-specific gene expression in tilapia. Tight regulation of MyoD ... miR-203b suppression leads to a significant increase in MyoD expression, thereby activating MyoD downstream gene. 3'-UTR ...http://www.biomedsearch.com/nih/miR-203b-novel-regulator-MyoD/23038733.html
NF-IL6 and AP-1 cooperatively modulate the activation of the TSG-6 gene by tumor necrosis factor alpha and interleukin-1.
Functional antagonism between c-Jun and MyoD proteins: a direct physical association. Cell. 1992 Feb 7;68(3):507-519. [PubMed] ... Homology between the DNA-binding domain of the GCN4 regulatory protein of yeast and the carboxyl-terminal region of a protein ... Descombes P, Schibler U. A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP ... The DNA binding domain of the rat liver nuclear protein C/EBP is bipartite. Science. 1989 Mar 31;243(4899):1681-1688. [PubMed] ...http://pubmedcentralcanada.ca/pmcc/articles/PMC359186/?lang=en-ca
Myoblasts generated by lentiviral mediated MyoD transduction of myotonic dystrophy type 1 (DM1) fibroblasts can be used for...
The disease is caused by a triplet expansion in the 3'end of the myotonic dystrophy protein kinase (DMPK) gene. In order to ... cell model for investigation of possible effects of antisense and RNAi effector molecules we have used lentiviral mediated myoD ... Transfer of the myoD gene has previously been shown to convert fibroblasts into myoblasts . The myoD protein activates ... The lentiviral vector encoding myoD was generated by replacing the puro gene in pCCL-WPS-PGK-puro-WHV  with myoD cDNA. For ...https://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0500-4-490
C-jun - Wikipedia
"Functional antagonism between c-Jun and MyoD proteins: a direct physical association". Cell. 68 (3): 507-19. doi:10.1016/0092- ... It encodes a protein that is highly similar to the viral protein, and that interacts directly with specific target DNA ... Finkel T, Duc J, Fearon ER, Dang CV, Tomaselli GF (1993). "Detection and modulation in vivo of helix-loop-helix protein-protein ... Na SY, Choi JE, Kim HJ, Jhun BH, Lee YC, Lee JW (1999). "Bcl3, an IkappaB protein, stimulates activating protein-1 ...https://en.wikipedia.org/wiki/C-jun
The circuitry of a master switch: Myod and the regulation of skeletal muscle gene transcription | Development
Id proteins are expressed in the myoblast and dimerize with E-proteins, preventing the formation of Myod/E-protein heterodimers ... Surprisingly, some RNAs induced by Myod coded for proteins that inhibit Myod activity, such as the Id proteins (Benezra et al ... For example, the Myod, Neurod and E-protein families can all bind to similar sites: yet Myod makes muscle; Neurod makes neurons ... Myod forms heterodimers with the nearly ubiquitous E-protein sub-family of bHLH proteins through the interaction of the HLH ...https://dev.biologists.org/content/132/12/2685?ijkey=7724ab88443dfd524d468eae78f0fd9d40c61458&keytype2=tf_ipsecsha
UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF1) Antibodies
UPF1 acts as an E3 ligase via its RING domain to promote MYOD protein ubiquitination and degradation and repress myogenesis. ... Protein Summary This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear ... This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional ... anti-Uncoupling Protein 3 (Mitochondrial, Proton Carrier) Antibodies * anti-Uncoupling Protein 2 (Mitochondrial, Proton Carrier ...http://www.antibodies-online.com/abstract/UPF1+Regulator+of+Nonsense+Transcripts+Homolog+