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*  Pioglitazone mimics preconditioning in the isolated perfused rat heart - A role for the prosurvival kinases PI3K and P42/44MAPK...
... hypothesized that pioglitazone could protect the myocardium when given prior to myocardial ischemia/reperfusion injury. ... infarct, ischemia, myocardium, pioglitazone, reperfusion, thiazolidinedione, ISCHEMIA-REPERFUSION INJURY, PPAR-GAMMA, GLUCOSE ... In conclusion pioglitazone induced significant protection against ischemia/reperfusion injury when administered prior to ... However when the inhibitors were given at reperfusion, the protection was abrogated by blocking either pathway (pioglitazone+ ...
http://discovery.ucl.ac.uk/113200/
*  Myocardial reperfusion injury: looking beyond primary PCI - UCL Discovery
Myocardial reperfusion injury, ST-elevation myocardial infarction, Primary percutaneous coronary intervention, Cardioprotection ... Myocardial reperfusion injury: looking beyond primary PCI. EUROPEAN HEART JOURNAL , 34 (23) 1714-+. 10.1093/eurheartj/eht090. ...
http://discovery.ucl.ac.uk/1389522/
*  Browse by UCL Departments and Centres - UCL Discovery
Transforming growth factor beta 1 attenuates myocardial injury when given at reperfusion. In: CIRCULATION. (pp. 9 - 9). ... CRH-like peptides protect cardiac myocytes from lethal ischaemic injury. MOL CELL ENDOCRINOL , 158 (1-2) 55 - 63. ... Potential cardioprotective role of insulin at reperfusion by a possible anti-apoptotic mechanism. In: (pp. p. 364). ... Cardioprotective role of insulin at reperfusion may in part be due to an anti-apoptotic mechanism. In: CIRCULATION. (pp. 10 - ...
http://discovery.ucl.ac.uk/view/UCL/ICD/1999.html
*  Angina: who needs it? Cardioprotection in the preconditioning era. - UCL Discovery
... decade has alluded to the cellular mechanisms underlying this powerful means of reducing myocardial ischemia-reperfusion injury ... which has significantly enhanced our understanding of the pathogenesis of ischemia-reperfusion injury. An insight into the ... Angina Pectoris, Humans, Ischemic Preconditioning, Myocardial. UCL classification:. UCL , School of Life and Medical Sciences. ... and some early reports provide some basis for optimism that a beneficial and clinically detectable improvement in myocardial ...
http://discovery.ucl.ac.uk/74893/
*  Remote ischaemic pre- and delayed postconditioning - similar degree of cardioprotection but distinct mechanisms - UCL Discovery
REPERFUSION INJURY, PRECONDITIONING PROTECTS, MYOCARDIAL REPERFUSION, LIMB ISCHEMIA, HEART, PORE, INHIBITION, ACTIVATION. ...
http://discovery.ucl.ac.uk/1346179/
*  Postconditioning: Current Controversies and Clinical Implications - UCL Discovery
Reperfusion injury, MITOCHONDRIAL PERMEABILITY TRANSITION, ISCHEMIA-REPERFUSION INJURY, ACUTE MYOCARDIAL-INFARCTION, K-ATP- ... Postconditioning has been shown to be successful in reducing ischaemia-reperfusion injury in both animal models and clinical ... offers an exciting avenue towards amelioration of ischaemia-reperfusion injury. Born from the concept of ischaemic ... particularly within the field of vascular surgery where ischaemia-reperfusion occurs by nature of both - the disease and the ...
http://discovery.ucl.ac.uk/1299342/
*  Failure of the Adipocytokine, Resistin, to Protect the Heart From Ischemia-Reperfusion Injury - UCL Discovery
... were investigated in in vivo and in vitro rodent and in vitro human models of myocardial ischemia-reperfusion (I/R) injury. ... Failure of the Adipocytokine, Resistin, to Protect the Heart From Ischemia-Reperfusion Injury. J CARDIOVASC PHARM T , 16 (1) 63 ... resistin, cardioprotection, ischemia-reperfusion injury, RISK pathway, PERMEABILITY TRANSITION PORE, HUMAN ENDOTHELIAL-CELLS, ... Failure of the Adipocytokine, Resistin, to Protect the Heart From Ischemia-Reperfusion Injury ...
http://discovery.ucl.ac.uk/1224479/
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XANTHINE-OXIDASE - A CRITICAL MEDIATOR OF MYOCARDIAL INJURY DURING ISCHEMIA AND REPERFUSION. ACTA PHYSIOL SCAND , 126 65 - 78. ... REGIONAL MYOCARDIAL AND ORGAN BLOOD-FLOW AFTER MYOCARDIAL-INFARCTION - APPLICATION OF THE MICROSPHERE PRINCIPLE IN MAN. ... LIMITATION OF MYOCARDIAL NECROSIS WITH VERAPAMIL 2J AND 48H AFTER CORONARY-ARTERY OCCLUSION. CLIN INVEST MED , 9 (3) B77 - B77 ... VERAPAMIL LIMITS MYOCARDIAL NECROSIS ONLY IN THE PRESENCE OF SIGNIFICANT CORONARY COLLATERAL FLOW. J MOL CELL CARDIOL , 18 A10 ...
http://discovery.ucl.ac.uk/view/UCL/ICS/1986.html
*  Browse by UCL Departments and Centres - UCL Discovery
Metformin protects against myocardial reperfusion injury via PI3-kinase-dependent inhibition of mitochondrial permeability ... Erythropoietin protects against ischaemia-reperfusion injury in the human muscle via PI3-kinase activation. In: JOURNAL OF ... Leptin, the obesity-related adipocytokine, protects the myocardium against ischaemia-reperfusion injury. In: JOURNAL OF ... Postconditioning protects against endothelial ischemia-reperfusion injury in the human forearm. CIRCULATION , 113 (7) 1015 - ...
http://discovery.ucl.ac.uk/view/UCL/ICS9/2006.type.html
*  Characterisation and validation of a murine model of global ischaemia-reperfusion injury - UCL Discovery
mouse, ischemia, ischaemia-reperfusion, myocardial infarction, murine, Langendorff, lactate dehydrogenase, HEART, ... Characterisation and validation of a murine model of global ischaemia-reperfusion injury. MOL CELL BIOCHEM , 186 (1-2) 61 - 68 ... Characterisation and validation of a murine model of global ischaemia-reperfusion injury ... Characterisation and validation of a murine model of global ischaemia-reperfusion injury. ...
http://discovery.ucl.ac.uk/75010/
*  WHOLE-BODY HEAT-STRESS FAILS TO LIMIT INFARCT SIZE IN THE REPERFUSED RABBIT HEART - UCL Discovery
MYOCARDIAL REPERFUSION, GENE-EXPRESSION, RAT HEARTS, ISCHEMIA, INJURY, NECROSIS, AORTA. UCL classification:. UCL , School of ... STRESS PROTEINS, HEAT SHOCK, MYOCARDIAL ISCHEMIA, REPERFUSION, POSTISCHEMIC VENTRICULAR RECOVERY, SHOCK PROTEINS, ... Objective: It has recently been shown that induction of heat stress proteins by whole body heat stress confers myocardial ... rabbits were reanaesthetised and the hearts subjected to a 45 min period of regional ischaemia followed by 3 h reperfusion. The ...
http://discovery.ucl.ac.uk/78134/
*  Erythropoietin: ready for prime-time cardioprotection - UCL Discovery
ISCHEMIA-REPERFUSION INJURY, ACUTE MYOCARDIAL-INFARCTION, IMPROVES CARDIAC-FUNCTION, GLYCOGEN-SYNTHASE KINASE-3-BETA, ... Activation of the reperfusion injury salvage kinase pathway at the moment of reperfusion appears to be a pivotal mechanism in ... To improve clinical outcomes in patients presenting with an acute myocardial infarction, new strategies to limit infarct size ... is the possibility that erythropoietin could protect the myocardium when administered well after the onset of reperfusion. In ...
http://discovery.ucl.ac.uk/154420/
*  The molecular basis of adaptation to ischemia in the heart: the role of stress proteins and anti-oxidants in the ischemic and...
Myocardial, Molecular Structure, Myocardial Ischemia, Myocardial Reperfusion Injury, Protein Processing, Post-Translational, ...
http://discovery.ucl.ac.uk/78073/
*  Protection of organs other than the heart by remote ischemic conditioning - UCL Discovery
... reperfusion, randomized-controlled-trial, acute kidney injury, abdominal aortic-aneurysm, myocardial infarct size, artery- ... Organ or tissue dysfunction due to acute ischemia-reperfusion injury (IRI) is the leading cause of death and disability ... bypass surgery, gut barrier function, acute-renal-failure, hind-limb ischemia, k-atp channels, reperfusion injury. ... Acute IRI induces cell injury and death in a wide variety of organs and tissues in a large number of different clinical ...
http://discovery.ucl.ac.uk/1378777/
*  Mechanisms underlying leptininduced cardioprotection - UCL Discovery
Finally, leptin was shown to protect against ischaemia-reperfusion injury in an in vivo rat model of I/R injury. CONCLUSION: ... BACKGROUND: The tissue damage resulting from myocardial ischaemia/reperfusion (I/R) leads to a large proportion of the deaths ... METHODS & RESULTS: Using an isolated rat heart model of I/R injury, it was confirmed that leptin given at reperfusion protects ... Even if patients survive a myocardial infarction, I/R injury is associated with decreased cardiac function and a higher ...
http://discovery.ucl.ac.uk/19641/
*  CARDIAC STRESS PROTEIN ELEVATION 24 HOURS AFTER BRIEF ISCHEMIA OR HEAT-STRESS IS ASSOCIATED WITH RESISTANCE TO MYOCARDIAL...
Myocardial stress protein induced by either sublethal thermal or ischemic injury is associated with myocardial salvage. Our ... Ischemic pretreatment (n=15) comprised four 5-minute episodes of coronary ligation separated by 10 minutes of reperfusion. The ... Myocardial HSP72 content assessed by Western blotting was elevated by both ischemic and thermal pretreatments (2.5+/-0.2 units ... To test the hypothesis that the heat shock response is associated with myocardial salvage, the heat stress protein (HSP) ...
http://discovery.ucl.ac.uk/142594/
*  The neural and humoral pathways in remote limb ischemic preconditioning - UCL Discovery
Remote ischaemic preconditioning (RIPC) is a therapeutic intervention that has been demonstrated to reduce myocardial injury in ... REPERFUSION INJURY, CARDIOPROTECTION, MYOCARDIUM, MECHANISMS, PROTECTION, HEART, ADENOSINE, SURGERY. UCL classification:. UCL ... mice were anaesthetised and subjected to in vivo 30 min coronary artery ischaemia followed by 120 min of myocardial reperfusion ... was induced by 3 cycles of 5 min left femoral artery occlusion interspersed with 5 min reperfusion before prolonged myocardial ...
http://discovery.ucl.ac.uk/120693/
*  Atorvastatin, administered at the onset of reperfusion, and independent of lipid lowering, protects the myocardium by up...
... limits myocardial necrosis when administered as an adjunct to reperfusion.BACKGROUND Statins inhibit HMG-CoA reductase to ... was abrogated by the administration of wortmannin.CONCLUSIONS Atorvastatin attenuates lethal reperfusion-induced injury in a ... Atorvastatin, administered at the onset of reperfusion, and independent of lipid lowering, protects the myocardium by up- ... Atorvastatin, administered at the onset of reperfusion, and independent of lipid lowering, protects the myocardium by up- ...
http://discovery.ucl.ac.uk/124346/
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DJ-1 protects against cell death following acute cardiac ischemia-reperfusion injury. Cell Death Dis , 5 , Article e1082. ... The effect of cyclosporin-A on peri-operative myocardial injury in adult patients undergoing coronary artery bypass graft ... Pharmacologic Therapy That Simulates Conditioning for Cardiac Ischemic/Reperfusion Injury. J Cardiovasc Pharmacol Ther , 19 (1 ... Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. [Letter]. Nature , 515 (7527) 431 - ...
http://discovery.ucl.ac.uk/view/UCL/ICS9/2014.html
*  Representational difference analysis of cDNA identifies novel genes expressed following preconditioning of the heart - UCL...
... which identified the reperfusion injury salvage kinase pathway in mediating the protective effects of ischaemic preconditioning ... gene expression profiling, heat-shock response, ischemic preconditioning, myocardial, myocardial ischemia, myocardium, ... reperfusion, PROTEIN PHOSPHATASE 2A, GROWTH-FACTOR-BETA, SERINE/THREONINE PHOSPHATASES, MYOCARDIAL-INFARCTION, MAP KINASE, RAT ... Genes up-regulated in rabbit myocardium in vivo by ischaemic preconditioning following reperfusion for 2 h, 4 h and 6 h post ...
http://discovery.ucl.ac.uk/75017/
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Remote ischemic preconditioning provides early and late protection against endothelial ischemia-reperfusion injury in humans - ... Myocardial contrast echocardiography accurately reflects transmurality of myocardial necrosis and predicts contractile reserve ... Prediction of transmurality of acute myocardial infarction - comparison between myocardial contrast echocardiography and ... Prediction of transmurality of acute myocardial infarction-comparison between myocardial contrast echocardiography and ...
http://discovery.ucl.ac.uk/view/UCL/ICS11/2005.html
*  Quarterly statistics: Population Health Sciences, Q3 2014 - UCL Discovery
Barry, S.P.; (2009) Investigating the role of the JAK/STAT and MAPK pathways in ischaemia/reperfusion injury and inflammation. ... Combination antiretroviral therapy and the risk of myocardial infarction. NEW ENGLAND JOURNAL OF MEDICINE , 349 (21) 1993 - ...
http://discovery.ucl.ac.uk/past_stats/faculty/pop-health-2014-3.html
*  Quarterly statistics: Population Health Sciences, Q4 2013 - UCL Discovery
Barry, S.P.; (2009) Investigating the role of the JAK/STAT and MAPK pathways in ischaemia/reperfusion injury and inflammation. ... Class of antiretroviral drugs and the risk of myocardial infarction. NEW ENGL J MED , 356 (17) 1723 - 1735. 109. ...
http://discovery.ucl.ac.uk/past_stats/faculty/pop-health-2013-4.html