Myelin proteolipid protein (PLP or lipophilin) is the major myelin protein from the central nervous system (CNS). It plays an ... Weimbs T, Sto ffel W (1992). "Proteolipid protein (PLP) of CNS myelin: positions of free, disulfide-bonded, and fatty acid ... GPM6A; GPM6B; PLP1; PLP2 Dautigny A, Popot JL, Pham Dinh D (1991). "Major Myelin proteolipid: the 4-alpha-helix topology". J. ... Stoffel W, Schliess F (1991). "Evolution of the myelin integral membrane proteins of the central nervous system". Biol. Chem. ...

Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T ... Here, we investigated whether in MS patients oral myelin treatment, containing both myelin basic protein (MBP) and proteolipid ... 17 orally treated with bovine myelin daily for a minimum of 2 yr as compared to 17 nontreated patients. We found a marked ... cells by oral administration of myelin in multiple sclerosis patients.. H Fukaura, S C Kent, M J Pietrusewicz, S J Khoury, H L ...

Purified myelin proteolipid protein (PLP) for PLP-induced EAE models in mouse and rat. Multiple Sclerosis (MS) is a ... Myelin Proteolipid Protein (PLP 139-151), 15 mg. Purified myelin proteolipid protein (PLP) for PLP-induced EAE models in mouse ... Myelin Proteolipid Protein (PLP 139-151), 15 mg. Home / Neurology / Myelin Proteolipid Protein (PLP 139-151), 15 mg ... Purified myelin proteolipid protein (PLP) for PLP-induced EAE models in mouse and rat. ...

Categorized as Encephalitogenic Myelin Proteolipid Fragment Tagged purchase TAK-875, Rabbit polyclonal to Transmembrane protein ... Categorized as Encephalitogenic Myelin Proteolipid Fragment Tagged Decitabine biological activity, Nedd4l. (BS) or is known as ... Categorized as Encephalitogenic Myelin Proteolipid Fragment Tagged CD44, purchase Isotretinoin. Objective: To determine whether ... Categorized as Encephalitogenic Myelin Proteolipid Fragment Tagged AB1010 irreversible inhibition. Infections with remain a ...

Purified myelin proteolipid protein (PLP) for PLP-induced EAE models in mouse and rat. Multiple Sclerosis (MS) is a ... Myelin Proteolipid Protein (PLP 139-151), 15 mg. Home / Proteins / Myelin Proteolipid Protein (PLP 139-151), 15 mg ... Myelin Proteolipid Protein (PLP 139-151), 15 mg. Purified myelin proteolipid protein (PLP) for PLP-induced EAE models in mouse ... Purified myelin proteolipid protein (PLP) for PLP-induced EAE models in mouse and rat. ...

Human PLPL(Myelin Proteolipid Protein Like Protein) ELISA Kit Human PLPL(Myelin Proteolipid Protein Like Protein) ELISA Kit. To ... Description: Recombinant Human Myelin proteolipid protein(PLP1) expressed in in vitro E.coli expression system ... Description: A sandwich ELISA kit for detection of Proteolipid Protein 1, Myelin from Human in samples from blood, serum, ... Description: A sandwich quantitative ELISA assay kit for detection of Rat Proteolipid Protein 1, Myelin (PLP1) in samples from ...

... a 74-base deletion in the mRNA for myelin proteolipid protein and evidence for a primary defect in RNA splicing. ... Jimpy mutant mouse: a 74-base deletion in the mRNA for myelin proteolipid protein and evidence for a primary defect in RNA ... a 74-base deletion in the mRNA for myelin proteolipid protein and evidence for a primary defect in RNA splicing. Proceedings of ... we have examined the expression of mRNAs encoding myelin proteolipid protein (PLP). PLP mRNAs were detectable in jimpy brain ...

coiled-coil domain-containing protein 177. Names. myelin proteolipid protein-like protein. ... mRNA and Protein(s) * NM_001271507.2 → NP_001258436.1 coiled-coil domain-containing protein 177 ... General protein information Go to the top of the page Help Preferred Names. ... Model RNAs and proteins are also reported here.. Reference GRCh38.p14 Primary Assembly. Genomic * NC_000014.9 Reference GRCh38. ...

Myelin and Lymphocyte-Associated Proteolipid Proteins * NPHP1 protein, human Supplementary concepts * Nephronophthisis, ...

Induction of the myelin proteolipid protein (PLP) gene in C6 glioblastoma cells: functional analysis of the PLP promotor KA ... Induction of the myelin proteolipid protein (PLP) gene in C6 glioblastoma cells: functional analysis of the PLP promotor KA ... Molecular cloning and sequencing of general odorant-binding proteins GOBP1 and GOBP2 from the tobacco hawk moth Manduca sexta: ... Molecular cloning and sequencing of general odorant-binding proteins GOBP1 and GOBP2 from the tobacco hawk moth Manduca sexta: ...

... stained for myelin by immunohistochemistry for proteolipid protein. Magnification bar: 1 mm. (B) The classical active lesions ... immunocytochemistry for proteolipid protein) shows patchy areas of active demyelination, which is associated with dense ... Subpial myelin is completely lost in an area with meningeal inflammation (C); CD8+ T-cells are present in the meningeal ... The CSF protein profiles most significantly associated with progressive MS were related to the formation of tertiary lymph ...

The major proteins of central nervous system myelin include: MYELIN PROTEOLIPID PROTEIN; MYELIN BASIC PROTEINS; and MYELIN- ... MYELIN BASIC PROTEINS (myelin P1 protein and MYELIN P2 PROTEIN); MYELIN P0 PROTEIN; and MYELIN-ASSOCIATED GLYCOPROTEIN. ... "Myelin Proteins" by people in Harvard Catalyst Profiles by year, and whether "Myelin Proteins" was a major or minor topic of ... Protein citrullination marks myelin protein aggregation and disease progression in mouse ALS models. Acta Neuropathol Commun. ...

Cysteine-108 is an acylation site in myelin proteolipid protein. Bizzozero, O.A., Good, L.K., Evans, J.E. Biochem. Biophys. Res ... Amino acid sequence of human myelin basic protein peptide 45-89 as determined by mass spectrometry. Gibson, B.W., Gilliom, R.D ... Verification of protein sequence by fast atom bombardment mass spectrometry. Amino acid sequence of protein S, a development- ... In order to resolve the uncertainties about the primary structure of human myelin basic protein at residues 45-89, the sequence ...

... an epitope on proteolipid protein, to an epitope on myelin basic protein, such as MBP84-104. ... myelin basic protein and myelin oligodendrocyte glycoprotein is ameliorated by administration of a single myelin basic protein ... High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of ... Myelin basic protein-specific T helper 2 (TH2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts ...

1989) Mutation of the proteolipid protein (PLP) gene in a human X-linked myelin disorder. Proc Natl Acad Sci USA 86:8128-8131. ... an X-linked neurologic disorder of myelin metabolism with a novel mutation in the gene encoding proteolipid protein. Am J Hum ... The myelin pallor was neither accompanied by infiltration of inflammatory cells (including macrophages) nor by a remarkable ... 1998) Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation. Nature 392:923-926. ...

... axons are enwrapped by myelin, an insulating membrane produced by oligodendrocytes. Neuron-derived signaling molecules are ... the myelin basic protein, and the proteolipid proteins (PLPs/DM20) are low molecular weight proteins found in compact myelin ... Overexpression of the myelin proteolipid protein leads to accumulation of cholesterol and proteolipid protein in endosomes/ ... Overexpression of the myelin proteolipid protein leads to accumulation of cholesterol and proteolipid protein in endosomes/ ...

This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play ... a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and ...

We have completed the optimization of two models for induction of EAE MS using Proteolipid Protein and Myelin-oligodendrocyte ...

... raised against selected peptides from myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG) and proteolipid ... This process triggers a potent immune response against specific subsets of autoreactive T-cells known to attack myelin. ... generation of an autologous pool of myelin-reactive T-cells (MRTCs) ... protein (PLP), and the return of these expanded, irradiated T-cells back to the patient. These attenuated T-cells are ...

In animal models, several studies have investigated HBOTs influence on myelin basic protein (Mbp) and remyelination. Baratz- ... upregulation of proteolipid protein (Plp), and increased remyelination processes.. Although these and other studies show the ... which is a production-limiting protein of NAD+, and upregulation of Sirt1 expression, which is an upstream protein of p53 and ... Myelin is the outer layer that envelopes neurons [55]. It is comprised mostly of lipids and is produced by OLs in the CNS [56 ...

Here, we sought to evaluate the therapeutic efficacy of 1H10 against myelin oligodendrocyte glycoprotein 35-55-induced EAE. ... although protective functions are well documented for AMP-activated protein kinase (AMPK), paradoxically, disease-promoting ... or proteolipid protein-as peptide fragments presented by major histocompatibility complex (MHC) molecules, become activated, ... Demyelination was monitored using an antibody against the myelin-specific marker myelin basic protein (MBP), and microglia/ ...

... or by immunohistochemistry using antibodies against myelin basic-protein (MBP) or proteolipid-protein (PLP), as well as, ... or myelin-associated protein (MAG), whereas macrophages in the latter demonstrate merely the presence of the major myelin ... The former is defined by the presence in macrophages of major and small molecular weight myelin proteins, such as cyclic ... For this classification of MS lesions, identification of myelin with histological stains [such as luxol fast blue-PAS] ...

... myelin basic protein (MBP) and proteolipid protein (PLP), that can mimic some of the complexities of human autoimmune diseases ... A Fusion Protein Consisting of IL-16 and the Encephalitogenic Peptide of Myelin Basic Protein Constitutes an Antigen-Specific ... Enhancement of Experimental Allergic Encephalomyelitis (EAE) by DNA Immunization with Myelin Proteolipid Protein (PLP) Plasmid ... Oral Administration of Myelin Basic Protein Is Superior to Myelin in Suppressing Established Relapsing Experimental Autoimmune ...

... proteolipid protein (PLP). The PLP gene is located on chromosome Xq22.. Genetic locations have also been identified in ... of HSP that has been identified is believed to be caused by mutations in a gene that regulates production of a myelin protein ... The evidence is suggestive that the SPG4 gene regulates production of a protein referred to as, spastin. In members of ... SPG7 has been associated with mutations of a gene which regulates the production of a protein referred to as, paraplegin. ...

... for in situ detection of antigen-specific CD4 T cells using brain sections obtained from SJL mice immunized with myelin ... proteolipid protein (PLP) 139-151; the sections were costained with IAs/PLP 139-151 (specific) or Theilers murine ... detection of antigen-specific CD4 T cells using brain sections obtained from SJL mice immunized with myelin proteolipid protein ...

Antibodies for target: Myelin Proteolipid Protein. Mouse PLP mAb Millipore MAB388. Primary oligodendrocytes from rat brain that ...

Antibody titers to myelin basic protein (MBP), proteolipid protein, and several non-specific proteins were determined. Among 58 ... Antibody titers to myelin basic protein (MBP), proteolipid protein, and several non-specific proteins were determined. Among 58 ... At the individual protein level, no single protein or set of proteins predicts mood. But by using univariate analyses of the ... Antibodies to myelin basic protein are associated with cognitive decline after stroke. Journal of neuroimmunology Becker, K. J ...

Some proteins known to contain a CCHHC-type zinc finger are listed below: *Animal myelin transcription factor 1 (MyT1), or ... It binds to sites in the proteolipid protein promoter.. *Vertebrate MyT1-like (MyT1L/NZF1), appears to be involved in neural ... Vertebrate L3MBTL, a member of the Polycomb group of proteins, which function as transcriptional repressors in large protein ... Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem ...

Some proteins known to contain a CCHHC-type zinc finger are listed below: *Animal myelin transcription factor 1 (MyT1), or ... It binds to sites in the proteolipid protein promoter.. *Vertebrate MyT1-like (MyT1L/NZF1), appears to be involved in neural ... Vertebrate L3MBTL, a member of the Polycomb group of proteins, which function as transcriptional repressors in large protein ... Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem ...

Proteomic analysis of nuclear factors binding to an intronic enhancer in the myelin proteolipid protein gene. J Neurochem 2008; ... A 39-kD DNA-binding protein from mouse brain stimulates transcription of myelin basic protein gene in oligodendrocytic cells. J ... A developmentally regulated DNA-binding protein from mouse brain stimulates myelin basic protein gene expression. Mol Cell Biol ... may have an important regulatory role in control of the gene expression of myelin proteolipid protein (Plp1), which is the most ...