Mice, SCIDPoint MutationMutation, MissenseMutationFrameshift MutationGerm-Line MutationPedigreeMutation RateBase SequenceSevere Combined ImmunodeficiencyExonsHeterozygoteAmino Acid SubstitutionPolymerase Chain ReactionMolecular Sequence DataDNA Mutational AnalysisAllelesPolymorphism, Single-Stranded ConformationalMutagenesis, Site-DirectedAmino Acid SequenceGenotypeHomozygoteCodon, NonsenseMutagenesisSequence Analysis, DNAGenes, RecessiveSequence DeletionDNA PrimersPhenotypeGenes, DominantGenetic TestingProtein Structure, TertiaryCell LineMice, Inbred NODEscherichia coliDNA-Binding ProteinsSuppression, GeneticChromosome MappingModels, MolecularCodonBinding SitesTransplantation, HeterologousSequence Homology, Amino AcidGenetic Complementation TestGene DeletionTranscription FactorsGenes, p53DNACloning, MolecularFounder EffectProtein BindingSyndromeGenetic LinkageMembrane ProteinsSequence AlignmentConsanguinityMutant ProteinsTransfectionPlasmidsGenetic Predisposition to DiseaseSaccharomyces cerevisiaeNuclear ProteinsBacterial ProteinsModels, GeneticImmunologic Deficiency SyndromesRecombination, GeneticMice, Mutant StrainsGenes, LethalMutagenesis, InsertionalRNA, MessengerTranscription, GeneticPolymorphism, GeneticDisease Models, AnimalHeterozygote DetectionExomeDNA, MitochondrialProto-Oncogene Proteins B-rafGenes, BRCA1Family HealthPromoter Regions, GeneticDNA, NeoplasmCarrier ProteinsRecombinant ProteinsIntronsGene FrequencyGenetic VariationSignal TransductionGenes, BacterialProtein ConformationCells, CulturedCrosses, GeneticKineticsMicrosatellite RepeatsStructure-Activity RelationshipDrug Resistance, ViralGenesJewsAge of OnsetGenes, SuppressorProto-Oncogene Proteins