Neuraminidase - Wikipedia
"Characterization of temperature sensitive influenza virus mutants defective in neuraminidase". Virology. 61 (2): 397-410. doi: ... Liu C, Eichelberger MC, Compans RW, Air GM (February 1995). "Influenza type A virus neuraminidase does not play a role in viral ... The enzymatic mechanism of influenza virus sialidase has been studied by Taylor et al., shown in Figure 1. The enzyme catalysis ... Article includes a good clear line drawing of a neuraminidase on an influenza virus. Portal: Biology (CS1: long volume value, ...
Academic Unit: Biochemistry and Molecular Biophysics / Language: English | Search Results | Academic Commons
2. A transformation-defective mutant of Abelson murine leukemia virus lacks protein kinase activity Witte, Owen N.; Goff, ... RetrovirusesAntiviral agentsMouse leukemia virusesRetroviruses--GeneticsBiochemistry 4. Construction of mutants of Moloney ... Interactions of Host Proteins with the Murine Leukemia Virus Integrase Studamire, Barbara; Goff, Stephen P. 2010 Articles ... 1. Synthesis of a 600-nucleotide-long plus-strand DNA by virions of Moloney murine leukemia virus Mitra, Sudha W.; Goff, ...
Characterization of Sendai virus M protein mutants that can partially interfere with virus particle production | Microbiology...
One of the M mutants (HA-M30 , an M protein carrying Thr112Met and Val113 Glu substitutions tagged with an influenza virus ... characterized by their exclusion from virus particles and by their ability to interfere with virus particle production. These ... Such mutants constitute potential tools for the identification of critical steps in paramyxovirus assembly and budding. ... Substitution of Val113 in Sendai virus (SeV) M protein generates non-functional polypeptides, ...
Cytological analysis of Saccharomyces cerevisiae cells supporting cymbidium ringspot virus defective interfering RNA...
... were found to support the replication of defective interfering (DI) RNA in Saccharomyces cerevisiae cells. Two yeast strains ... The replicase proteins p33 and p92 of Cymbidium ringspot virus (CymRSV) ... Mutants of the yeast Yarrowia lipolytica defective in protein exit from the endoplasmic reticulum are also defective in ... Pantaleo V., Rubino L., Russo M. 2003; Replication of Carnation Italian ringspot virus defective interfering RNA in ...
Herpes Simplex Virus (HSV) Keratitis: Practice Essentials, Pathophysiology, Etiology
Infection occurs by direct contact of skin or mucous membrane with virus-laden lesions or secretions. ... HSV is a DNA virus that commonly affects humans. ... with a replication-defective herpes simplex virus 2 mutant ... HSV is a DNA virus that commonly affects humans. Infection occurs by direct contact of skin or mucous membrane with virus-laden ... encoded search term (Herpes Simplex Virus (HSV) Keratitis) and Herpes Simplex Virus (HSV) Keratitis What to Read Next on ...
Vaccines | Free Full-Text | Role of the DNA-Binding Protein pA104R in ASFV Genome Packaging and as a Novel Target for Vaccine...
Genome condensation and packaging are essential processes in the life cycle of viruses. The involvement of viral DNA-binding ... there is no vaccine or treatment available for preventing and controlling the ASF virus (ASFV) infection, and there is an ... A pA104R replication defective DISC mutant (Ba71∆pA104R) has already been generated but not successfully isolated. Efforts are ... Generation of Replication-Defective Virus-Based Vaccines That Confer Full Protection in Sheep against Virulent Bluetongue Virus ...
Viruses | Free Full-Text | Herpesviruses and Autophagy: Catch Me If You Can!
reported that the growth of an ICP34.5 deletion mutant virus was defective in normal cells, whereas in PKR-/- MEFs, replication ... This mutant virus, which does not express ICP34.5, is able to inhibit virus-induced and PKR-mediated autophagy (our unpublished ... Immediate early kinetic expression of the Us11 protein in an ICP34.5 deletion mutant virus restores the ability of the virus to ... hepatitis C virus (HCV), Dengue virus and Coxsackie B virus [53-55]. It has also been suggested that autophagy may help ...
Oncogenes and their perception to cancer.
Transformation-defective mutants of feline sarcoma virus which express a product of the viral Src gene. J Virol 1980; 35:129- ... Second, both strongly transforming retroviruses and non-virus induced malignancies, including human cancers, contain comparable ... of oncogenes into retroviral genomes as well as some proto-oncogene and tumour suppressor gene alterations in non-virus induced ...
Novel Virus Related to Kaposi's Sarcoma-Associated Herpesvirus from Colobus Monkey - Volume 25, Number 8-August 2019 - Emerging...
... represents a replication-defective deletion mutant generated in the animal investigated. Of note, CbGHV1 has also been ... herpes B virus, simian T-cell leukemia virus, measles virus, rhesus macaque rhadinovirus, human cytomegalovirus, or simian ... and closely related viruses of other Old World primates (2,5). The RV2 lineage contains macaque viruses more distantly related ... using Epstein-Barr virus (a lymphocryptovirus) as the outgroup, confirmed that the novel virus clusters in the RV1 lineage with ...
Publications - Professor Michael A. ('Mike') Skinner
Laidlaw SM, Skinner MA, 2014, Construction of Deletion-knockout Mutant Fowlpox Virus (FWPV)., Bio Protoc, Vol: 4, ISSN: 2331- ... FWPV defective in fpv012 replicate well in culture and barely induce ChIFN2 during infection, suggesting other factors are ... fowlpox virus (FWPV) FP9, canarypox virus (CNPV), and modified vaccinia virus Ankara (MVA)) and a birnavirus (infectious bursal ... Fowlpox virus is the type species of an extensive and poorly-defined group of viruses isolated from more than 200 species of ...
"Role of Glycosylation of Envelope (E) and Non-structural Protein 1 (NS" by Arun Saravanakumar Annamalai
All mutant viruses grew to titers similar to the rMR virus in cell culture except the m5MR virus (triple glycosylation ... defective), which grew to lower titers. Mice inoculated with m5MR virus did not exhibit morbidity and survived. Interestingly, ... The mutant viruses replicated poorly in the brain of infected mice when inoculated subcutaneously but replicated well following ... virus recovered from the full-length cDNA clone mimicked growth and pathogenic properties of the parental virus both in vitro ...
Frontiers | A New Mechanistic Model for Viral Cross Protection and Superinfection Exclusion
... for RNA viruses like TCV, SIE manifests a viral function that denies progeny viruses the chance of re-replicating their genomes ... for RNA viruses like TCV, SIE manifests a viral function that denies progeny viruses the chance of re-replicating their genomes ... Recent investigations in our labs, by analyzing the whole-plant dynamics of a turnip crinkle virus (TCV) population, coupled ... Recent investigations in our labs, by analyzing the whole-plant dynamics of a turnip crinkle virus (TCV) population, coupled ...
Tamiflu Resistant Flu More Common - Parker Waichman LLP
The Centers for Disease Control and Prevention (CDC) estimate that a small sampling of flu viruses nationwide carry the ... Some current influenza viruses are carrying a mutation-A/H1N1-H274Y-that makes them resistant to Tamiflu. ... The CDC estimate that a small sampling of flu viruses nationwide carry the mutation. The Tamiflu resistant mutation has ... The percentage of mutant viruses is low-about 3.8 percent in a sampling of 237 specimens. The percentage of mutant viruses is ...
Protein Processing, Post-Translational - McMaster Experts
Role of glycosylation in transport of vesicular stomatitis virus envelope glycoprotein. A new class of mutant defective in ... Defective insulin maturation in patients with type 2 diabetes Journal Articles * Development of a 2‐D apoB peptide profile to ... Herpes Simplex Virus Type 2 Glycoprotein Biogenesis: Effect of Monensin on Glycoprotein Maturation, Intracellular Transport and ... Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice ...
Viruses as Quasispecies: Biological Implications | SpringerLink
... play a key role in the adaptability of viruses to changing environments and the fate of the population as a whole. Mutant ... Holland JJ (1990) Defective viral genomes. In Fields BM, Knipe DM (eds) Virology. Raven, New York, pp 151-165 ... Also, mutant spectra are the target on which selection and random drift act to shape the long-term evolution of viruses. The ... De la Torre JC, Holland JJ (1990) RNA virus quasispecies populations can suppress vastly superior mutant progeny. J Virol 64: ...
In remembrance of Larry Rohrschneider, cell biologist | Fred Hutchinson Cancer Center
The isolation of temperature-sensitive transformation-defective mutants of Rous sarcoma virus led to the hypothesis that the ... just one year after the avian erythroblastosis virus oncogene was found to be a mutant EGF receptor. ... He found that adhesion plaques also contained the oncoproteins of Abelson leukemia virus (Abl, now best known at the cause of ... The transforming protein of Rous sarcoma virus, Src, had just been identified by Dr. Ray Eriksons group using antibodies from ...
US Patent Application for Chimeric Vectors Patent Application (Application #20080269149 issued October 30, 2008) - Justia...
... as only adenovirus early gene expression is required to mediate packaging of AAV virus. Adenovirus mutants defective for late ... A "donor" virus or virus capsid as used herein is a parent virus or virus capsid from which the modification is taken and ... As used herein, a "recipient" virus or virus capsid is the parent virus or virus capsid into which the modification is ... Adeno-associated virus 4 NC_001829 Adeno-associated virus 5 Y18065, AF085716 Adeno-associated virus 6 NC_001862 Avian AAV ATCC ...
Mutational analysis of Human Immunodeficiency Virus type-1 nucleocapsid protein to evaluate its nucleic acid chaperone activity
All mutants retained wt levels of the condensation/aggregation activity of NC. Unlike I24Q and others, N27D was defective in ... and NC proteins from Simian Immunodeficiency Virus and Murine Leukemia Virus are also reported. ... Double and triple mutants F16W/I24Q, F16W/N27D, and F16W/I24Q/N27D all showed defects in DNA binding, strand transfer, and ... Each mutant was analyzed in annealing assays with unstructured and structured substrates. Three groupings emerged: (1) those ...
A "traffic control" role for TGFβ3: orchestrating dermal and epidermal cell motility during wound healing | Journal of Cell...
lanes 1 and 3). The kinase-defective TβRII mutant (TβRII-KD) was included as the control for specificity. As shown in Fig. 5 D ... of the virus stock (Fig. 7 B, lane 4 vs. lane 1). The dilutions of the virus stocks did not cause any significantly compromised ... lanes 3 and 4 and lanes 1 and 2). To study TβRIII, we infected HKs with pRRLsinhCMV-TβRIII virus. As shown in Fig. 5 E, the T ... 7 A, infection of DFs (a) with 50% of the original virus stock (lane 3) reduced the TβRII expression in DFs (lane 6) to the ...
RNase-Resistant Virus-Like Particles - Politicalespionage
Formation of defective bacteriophage particles by fr amber mutants. J. Mol. Biol.17:136-144. PubMed. ... avian influenza virus 5 (4), and West Nile virus (6) using reverse transcription-PCR (RT-PCR), real-time RT-PCR, and branched ... avian influenza virus matrix gene (M300), and H5N1 avian influenza virus (HA300)-was successfully expressed by the two-plasmid ... or calibrators for the detection of hepatitis C virus (HCV) (11, 12, 28), human immune-deficiency virus (11, 15), severe acute ...
The effect of multiple infection, recombination, and synaptic transmission on the evolution of human immunodeficiency virus...
... as well as a substantial fitness disadvantage of the mutant, most likely corresponding to defective virus particles. ... For neutral mutants, both production and spread of double mutants are important, and hence an optimal mixture of free virus and ... For advantageous mutants, double mutant spread is the most important force, and hence free virus transmission leads to fastest ... ii) The mode of virus spread also directly influences the evolutionary fate of double mutants. For disadvantageous mutants, ...
Changes in amino-terminal sequences of pp60src lead to decreased membrane association and decreased in vivo tumorigenicity -...
The protein encoded by the transforming gene of avian sarcoma virus (pp60src) and a homologous protein in normal cells ( ... Transformation by Rous sarcoma virus: effects of src gene expression on the synthesis and phosphorylation of cellular ... Viral and cellular src genes contribute to the structure of recovered avian sarcoma virus transforming protein ... Differences in intracellular location of pp60src in rat and chicken cells transformed by Rous sarcoma virus ...
Innate immune pathways act synergistically to constrain RNA virus evolution in <i>Drosophila melanogaster<...
Wild-type or mutant flies were then orally infected with DCV and the virus was serially passaged ten times via reinfection in ... We isogenized eight fly genotypes generating animals defective for RNAi, Imd and Toll innate immune pathways as well as ... Wild-type or mutant flies were then orally infected with DCV and the virus was serially passaged ten times via reinfection in ... Wild-type or mutant flies were then orally infected with DCV and the virus was serially passaged ten times via reinfection in ...
JZUS - Journal of Zhejiang University SCIENCE
Hepatitis B virus mutants associated with 3TC and famcicloviir administration are replication defective. Hepatology, 27(2):628- ... Emergence and takeover of YMDD motif mutant hepatitis B virus during long-term lamivudine therapy and re-takeover by wild-type ... 1. Character of HBV (hepatitis B virus)..... 2. Clinical and angiographic features..... 3. Association between serum vitamin D ... Hepatitis B virus infection−natural history and clinical consequences. N. Engl. J. Med., 350(11):1118-1129. ...
DAVID G JOHNSON | Profiles RNS
Pseudorabies Virus Mutants Lacking US9 Are Defective in Cytoplasmic Assembly and Sorting of Virus Particles into Axons and Not ... Herpes Simplex Virus gE/gI and US9 Promote both Envelopment and Sorting of Virus Particles in the Cytoplasm of Neurons, Two ... Erratum for DuRaine et al., "Herpes Simplex Virus gE/gI and US9 Promote both Envelopment and Sorting of Virus Particles in the ... Herpes simplex virus gE/gI must accumulate in the trans-Golgi network at early times and then redistribute to cell junctions to ...
Targeting of pseudorabies virus structural proteins to axons requires association of the viral Us9 protein with lipid rafts<...
As a result, Us9 null mutants are defective in anterograde transmission of infection in vivo. However, it is unclear how Us9 ... As a result, Us9 null mutants are defective in anterograde transmission of infection in vivo. However, it is unclear how Us9 ... As a result, Us9 null mutants are defective in anterograde transmission of infection in vivo. However, it is unclear how Us9 ... As a result, Us9 null mutants are defective in anterograde transmission of infection in vivo. However, it is unclear how Us9 ...
Theodore Friedmann | UCSD Profiles
Cytotoxicity of a replication-defective mutant of herpes simplex virus type 1. J Virol. 1992 May; 66(5):2952-65. Johnson PA, ... Replication-defective recombinant herpes simplex virus vectors. Methods Cell Biol. 1994; 43 Pt A:211-30. Johnson PA, Friedmann ... cell survival by the reduction of immediate-early gene expression in replication-defective mutants of herpes simplex virus type ... Effects of gene transfer into cultured CNS neurons with a replication-defective herpes simplex virus type 1 vector. Brain Res ...
Jean-Vianney BARNIER - Institut des Neurosciences Paris‑Saclay
Small deletion in v-src SH3 domain of a transformation defective mutant of rous sarcoma virus restores wild type transforming ... Jean-Vianney Barnier, Maria Marx, Philippe Dezélée, Danielle Laugier, Miroslav Hill, et al.. Transformation-defective mutants ... Nucleotide sequence of the src gene of the Schmidt - Ruppin strain of Rous Sarcoma virus type E. Nucleic Acids Research, 1989, ... the generation of virus PR2257.. Folia Biologica -Krakow-, 1994, 40 (5), pp.211-23. ⟨hal-02525381⟩. Accès au bibtex. 1993 ...
Complete Genome Sequence of Tomato Spotted Wilt Virus from Paprika in Korea | Kim | International Journal of Phytopathology
Complete Genome Sequence of Tomato Spotted Wilt Virus from Paprika in Korea ... Generation of enveloped and defective interfering RNA mutants of tomato spotted wilt virus by mechanical passage. J. Gen. Virol ... Defective isolates of tomato spotted wilt virus. In: Virus-thrips plant interactions of tomato spotted wilt virus. Hsu, H.T. ... A sap-transmissible, defective form of tomato spotted wilt virus. J. G. Virol. 59:387-391. ...
Innate Immunity: natural cellular mechanisms that battle HIV
Oddly, a Vif mutant that could not be phosphorylated at Ser 144 was defective in HIV replication but not in APOBEC3G ... When Vif is present in sufficient quantity in virus-producing cells, APOBEC3G is no longer incorporated into virus particles. ... Thus, the packaging of APOBEC3G into progeny virions renders the virions defective, targeting them for a mutational death.. HIV ... Although these proteins are likely to have multiple functions, blocking the growth of incoming viruses appears to be among them ...