Gene Discovery by MMTV Mediated Insertional Mutagenesis | SpringerLinkGene Discovery by MMTV Mediated Insertional Mutagenesis | SpringerLink

Gene Discovery by MMTV Mediated Insertional Mutagenesis. In: Dupuy A., Largaespada D. (eds) Insertional Mutagenesis Strategies ... Retroviral insertional mutagenesis (IM) screens provide one of the most efficient tools to identify genes involved in ... 2007). MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer. Nature of Genetics ... Lee, F. S., Lane, T. F., Kuo, A., Shackleford, G. M., & Leder, P. (1995). Insertional mutagenesis identifies a member of the ...
more infohttps://link.springer.com/chapter/10.1007/978-1-4419-7656-7_3

Insertional Mutagenesis - Definitive Vector Study 11042Insertional Mutagenesis - Definitive Vector Study 11042

... Testing Status of Insertional Mutagenesis - Definitive Vector Study ... Insertional mutagenesis studies using various vector exposures (LTR; uORF LTR, SIN, EFS LTR, and P(-) SIN vectors. ...
more infohttps://ntp.niehs.nih.gov/testing/status/agents/ts-11042.html

Genome-Wide Insertional Mutagenesis of Arabidopsis thaliana | ScienceGenome-Wide Insertional Mutagenesis of Arabidopsis thaliana | Science

Genome-Wide Insertional Mutagenesis of Arabidopsis thaliana. By José M. Alonso, Anna N. Stepanova, Thomas J. Leisse, ... Genome-Wide Insertional Mutagenesis of Arabidopsis thaliana. By José M. Alonso, Anna N. Stepanova, Thomas J. Leisse, ... Genome-Wide Insertional Mutagenesis of Arabidopsis thaliana Message Subject. (Your Name) has forwarded a page to you from ...
more infohttp://science.sciencemag.org/content/301/5633/653?ijkey=7b4bc0f9b25c76f76024e79795b6771e9a08bf11&keytype2=tf_ipsecsha

Genome-Wide Insertional Mutagenesis of Arabidopsis thaliana | ScienceGenome-Wide Insertional Mutagenesis of Arabidopsis thaliana | Science

Genome-Wide Insertional Mutagenesis of Arabidopsis thaliana. By José M. Alonso, Anna N. Stepanova, Thomas J. Leisse, ... Genome-Wide Insertional Mutagenesis of Arabidopsis thaliana. By José M. Alonso, Anna N. Stepanova, Thomas J. Leisse, ... Genome-Wide Insertional Mutagenesis of Arabidopsis thaliana Message Subject. (Your Name) has forwarded a page to you from ...
more infohttps://science.sciencemag.org/content/301/5633/653?ijkey=5a4ced797dcc26009802c33f4951459428e9f66d&keytype2=tf_ipsecsha

Insertional mutagenesis - WikipediaInsertional mutagenesis - Wikipedia

Insertional mutagenesis is mutagenesis of DNA by the insertion of one or more bases. Insertional mutations can occur naturally ... Directed mutagenesis Insertion (genetics) PCR mutagenesis Site-directed mutagenesis Transposon mutagenesis Biology-online Biffi ... Recombinant DNA Insertional inactivation Carlson CM, Largaespada DA (July 2005). "Insertional mutagenesis in mice: new ... mutagenesis caused by viral infections is a fairly common occurrence. Not all integrating viruses cause insertional mutagenesis ...
more infohttps://en.wikipedia.org/wiki/Insertional_mutagenesis

Random insertional mutagenesis in fungal genomes to identify virulence factorsRandom insertional mutagenesis in fungal genomes to identify virulence factors

ATMT-based approaches such as random insertional mutagenesis and targeted knockout are widely used for gene functional analysis ... Here, we describe a protocol for the identification of pathogenicity and virulence genes through random insertional mutagenesis ...
more infohttp://library.wur.nl/WebQuery/wurpubs/425890

European Medicines Agency - Multidisciplinary  - Management of clinical risks deriving from insertional mutagenesisEuropean Medicines Agency - Multidisciplinary - Management of clinical risks deriving from insertional mutagenesis

Gene therapy medicinal products, insertional mutagenesis, integration. Description. This document discusses the factors ... the strategies to reduce the risk associated to insertional mutagenesis and the assays to evaluate vector oncogenesis at the ...
more infohttp://www.ema.europa.eu/ema/index.jsp?curl=pages/regulation/general/general_content_001370.jsp&mid=WC0b01ac058002958d

Cloning by insertional mutagenesis of a cDNA encoding Caenorhabditis elegans kinesin heavy chain | PNASCloning by insertional mutagenesis of a cDNA encoding Caenorhabditis elegans kinesin heavy chain | PNAS

Cloning by insertional mutagenesis of a cDNA encoding Caenorhabditis elegans kinesin heavy chain. N Patel, D Thierry-Mieg, and ... Cloning by insertional mutagenesis of a cDNA encoding Caenorhabditis elegans kinesin heavy chain ... Cloning by insertional mutagenesis of a cDNA encoding Caenorhabditis elegans kinesin heavy chain ... Cloning by insertional mutagenesis of a cDNA encoding Caenorhabditis elegans kinesin heavy chain ...
more infohttps://www.pnas.org/content/90/19/9181?ijkey=68f23e79acd58a48d14f6935392cf77e21206eba&keytype2=tf_ipsecsha

INSERTIONAL MUTAGENESIS IN THE DIPLOID STRAWBERRY (FRAGARIA VESCA)INSERTIONAL MUTAGENESIS IN THE DIPLOID STRAWBERRY (FRAGARIA VESCA)

Challenges and Opportunities for Horticulture in the World INSERTIONAL MUTAGENESIS IN THE DIPLOID STRAWBERRY (FRAGARIA VESCA) ... INSERTIONAL MUTAGENESIS IN THE DIPLOID STRAWBERRY (FRAGARIA VESCA). Authors: R.E. Veilleux, T. Oosumi, P.A. Wadl, A.J. Baxter, ... Insertional mutant collections are essential tools in plant genomic research and functional genomics. Extensive collections in ... We have therefore undertaken a program to develop an insertional mutant collection of the diploid strawberry, Fragaria vesca, ...
more infohttp://www.actahort.org/books/941/941_3.htm

Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFκB | PNASValidation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFκB | PNAS

Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFκB. Tao Lu, Mark W. ... While MLV-based insertional mutagenesis has a long history in gene discovery, we understand HIV-based insertion less well. ... Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFκB ... Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFκB ...
more infohttps://www.pnas.org/content/106/38/16339

Candida albicans Mds3p, a Conserved Regulator of pH Responses and Virulence Identified Through Insertional Mutagenesis |...Candida albicans Mds3p, a Conserved Regulator of pH Responses and Virulence Identified Through Insertional Mutagenesis |...

Candida albicans Mds3p, a Conserved Regulator of pH Responses and Virulence Identified Through Insertional Mutagenesis. *Dana A ... We have developed an insertional mutagenesis strategy that is based on the UAU1 cassette, a gene disruption marker that permits ... Mutagenesis was performed using the GPS-M mutagenesis system (New England Biolabs) according to the manufacturers instructions ... which we sought to identify here through insertional mutagenesis.. Mds3p is required for normal responses to alkaline pH, on ...
more infohttps://www.genetics.org/node/330968.full.print

Candida albicans Mds3p, a Conserved Regulator of pH Responses and Virulence Identified Through Insertional Mutagenesis |...Candida albicans Mds3p, a Conserved Regulator of pH Responses and Virulence Identified Through Insertional Mutagenesis |...

We have developed an insertional mutagenesis strategy that is based on the UAU1 cassette, a gene disruption marker that permits ... Candida albicans Mds3p, a Conserved Regulator of pH Responses and Virulence Identified Through Insertional Mutagenesis. Dana A ... Candida albicans Mds3p, a Conserved Regulator of pH Responses and Virulence Identified Through Insertional Mutagenesis. Dana A ... Candida albicans Mds3p, a Conserved Regulator of pH Responses and Virulence Identified Through Insertional Mutagenesis. Dana A ...
more infohttps://www.genetics.org/content/162/4/1573

Identification of Pathogenicity Mutants of the Rice Blast Fungus Magnaporthe grisea by Insertional MutagenesisIdentification of Pathogenicity Mutants of the Rice Blast Fungus Magnaporthe grisea by Insertional Mutagenesis

... mutagenesis was used to identify mutants of Magnaporthe grisea impaired in pathogenicity. Three REMI protocols were evaluated ... Restriction enzyme-mediated DNA integration (REMI) mutagenesis was used to identify mutants of Magnaporthe grisea impaired in ...
more infohttps://www.apsnet.org/publications/mpmi/1999/February/Pages/12_2_129.aspx

Mouse genetic corneal disease resulting from transgenic insertional mutagenesis | British Journal of OphthalmologyMouse genetic corneal disease resulting from transgenic insertional mutagenesis | British Journal of Ophthalmology

Another possibility is that the transgenic insertional mutagenesis affected a regulatory gene, such as Pax6 or a similar gene. ... Rijkers T, Peetz A, Ruther U. Insertional mutagenesis in transgenic mice. Transgenic Res 1994;3:203-15. ... Conclusion: Eye abnormality in T27aT15 mice results from random insertional mutagenesis of the transgene as it was only ... Insertional mutation of classical and novel genes in transgenic mice. Trends Genet 1992;8:341-4. ...
more infohttp://bjo.bmj.com/content/88/3/428

Mouse genetic corneal disease resulting from transgenic insertional mutagenesis | British Journal of OphthalmologyMouse genetic corneal disease resulting from transgenic insertional mutagenesis | British Journal of Ophthalmology

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Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation.Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation.

... Wu J, Keng VW, Patmore DM ... Home , Research and Education , Find a Scientific Publication , Insertional Mutagenesis Identifies A Stat3arid1b Catenin ... we used unbiased insertional mutagenesis screening, mouse models, and molecular analyses. We mapped an Nf1-Stat3-Arid1b/β- ... we used unbiased insertional mutagenesis screening, mouse ...
more infohttps://cancer.osu.edu/research-and-education/find-a-scientific-publication/insertional-mutagenesis-identifies-a-stat3arid1b-catenin-pathway-driving-neurofibroma-initiation

An Insertional Mutagenesis and Immunochemical Analysis of Visual Arrestin Interaction with Rhodopsin  | IOVS | ARVO JournalsAn Insertional Mutagenesis and Immunochemical Analysis of Visual Arrestin Interaction with Rhodopsin | IOVS | ARVO Journals

A Dinculescu, JH McDowell, S Amici, D Dugger, N Richards, PA Hargrave, WC Smith; An Insertional Mutagenesis and Immunochemical ... An Insertional Mutagenesis and Immunochemical Analysis of Visual Arrestin Interaction with Rhodopsin ... An Insertional Mutagenesis and Immunochemical Analysis of Visual Arrestin Interaction with Rhodopsin ... Our goal was to further probe the structural determinants of arrestin function by using a combined insertional mutagenesis and ...
more infohttps://iovs.arvojournals.org/article.aspx?articleid=2418664

Interposon mutagenesis of soil and water bacteria: a family of DNA fragments designed for in vitro insertional mutagenesis of...Interposon mutagenesis of soil and water bacteria: a family of DNA fragments designed for in vitro insertional mutagenesis of...

Interposon mutagenesis of soil and water bacteria: a family of DNA fragments designed for in vitro insertional mutagenesis of ... that can be used for in vitro insertional mutagenesis. Each of these DNA fragments carries a different antibiotic or Hg2+ ... Thus, the selection and/or characterization of omega insertional mutations can be carried out in these bacterial species. ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/3038679?dopt=Abstract

Genetic analysis of the pAD1 hemolysin/bacteriocin determinant in Enterococcus faecalis: Tn917 insertional mutagenesis and...Genetic analysis of the pAD1 hemolysin/bacteriocin determinant in Enterococcus faecalis: Tn917 insertional mutagenesis and...

Genetic analysis of the pAD1 hemolysin/bacteriocin determinant in Enterococcus faecalis: Tn917 insertional mutagenesis and ... Genetic analysis of the pAD1 hemolysin/bacteriocin determinant in Enterococcus faecalis: Tn917 insertional mutagenesis and ... Genetic analysis of the pAD1 hemolysin/bacteriocin determinant in Enterococcus faecalis: Tn917 insertional mutagenesis and ... Genetic analysis of the pAD1 hemolysin/bacteriocin determinant in Enterococcus faecalis: Tn917 insertional mutagenesis and ...
more infohttps://jb.asm.org/content/172/1/155

Winning Abstracts from the 2010 Medical Student Abstract Competition: Assessing Potential Toxicities Of Gene Therapy:...Winning Abstracts from the 2010 Medical Student Abstract Competition: Assessing Potential Toxicities Of Gene Therapy:...

Insertional Mutagenesis Risk Following Aav Vector-mediated Gene Transfer Author: Hojun Li, University of Pennsylvania School of ... Insertional Mutagenesis Risk Following Aav Vector-mediated Gene Transfer. Winning Abstracts from the 2010 Medical Student ... Insertional Mutagenesis Risk Following Aav Vector-mediated Gene Transfer. Author: Hojun Li, University of Pennsylvania School ... Insertional Mutagenesis Risk Following Aav Vector-mediated Gene Transfer. Winning Abstracts from the 2010 Medical Student ...
more infohttps://www.acponline.org/membership/medical-students/acp-impact/archive/september-2010/winning-abstracts-from-the-2010-medical-student-abstract-competition-assessing-potential-toxicities

Molecular mechanisms of insertional mutagenesis in yeasts and mycelium fungi, Russian Journal of Genetics | 10.1134...Molecular mechanisms of insertional mutagenesis in yeasts and mycelium fungi, Russian Journal of Genetics | 10.1134...

"Molecular mechanisms of insertional mutagenesis in yeasts and mycelium fungi, Russian Journal of Genetics" on DeepDyve, the ... Molecular mechanisms of insertional mutagenesis in yeasts and mycelium fungi. Molecular mechanisms of insertional mutagenesis ... Molecular mechanisms of insertional mutagenesis in yeasts and mycelium fungi. Dmytruk, K.; Sibirny, A. ... "Molecular mechanisms of insertional mutagenesis in yeasts and mycelium fungi." Russian Journal of Genetics 43.8 (2007): 835-845 ...
more infohttps://www.deepdyve.com/lp/springer-journals/molecular-mechanisms-of-insertional-mutagenesis-in-yeasts-and-mycelium-9dOox8gEGT

Analysis of HIV-2 Vpx by Modeling and Insertional Mutagenesis by Lisa A. Mahnke, Michael Belshan et al."Analysis of HIV-2 Vpx by Modeling and Insertional Mutagenesis" by Lisa A. Mahnke, Michael Belshan et al.

1 Vpr in a central helical domain and probed regions of Vpx by insertional mutagenesis. A predicted loop between helices two ... Other insertional mutants in the predicted loop and in a linker region between the central domain and the C-terminus may be ... 1 Vpr in a central helical domain and probed regions of Vpx by insertional mutagenesis. A predicted loop between helices two ... Other insertional mutants in the predicted loop and in a linker region between the central domain and the C-terminus may be ...
more infohttp://digitalcommons.unl.edu/virologypub/83/

Retroviral insertional mutagenesis in murine mammary cancer. | The Nusse Lab @ Stanford UniversityRetroviral insertional mutagenesis in murine mammary cancer. | The Nusse Lab @ Stanford University

... as an insertional mutagen. MMTV, a retrovirus lacking a host cell-derived viral oncogene, induces adenocarcinomas of the ...
more infohttp://web.stanford.edu/group/nusselab/cgi-bin/lab/node/293

Characterization of a Chinese Hamster Ovary Cell Line Developed by Retroviral Insertional Mutagenesis That Is Resistant to...Characterization of a Chinese Hamster Ovary Cell Line Developed by Retroviral Insertional Mutagenesis That Is Resistant to...

1995) Retroviral insertional mutagenesis of a target allele in a heterozygous murine cell line. Proc. Natl. Acad. Sci. USA 82: ... 1994) Generation of Chinese hamster ovary cell glycosylation mutants by retroviral insertional mutagenesis. J. Biol. Chem. 269: ... Generation of SV-resistant CHO mutant cells by retroviral insertional mutagenesis.CHO-22 cells were infected with U3Neo Mo-MuLV ... We have shown that cells resistant to SV infection can be developed by retroviral insertional mutagenesis. The mutant cells ...
more infohttps://jvi.asm.org/content/73/6/4919?ijkey=4444df8cbd30e53d22e8fafeae960d11b6fe2899&keytype2=tf_ipsecsha

Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice - Universiteit LeidenUsing insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice - Universiteit Leiden

Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice. In this thesis, we used ... Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice ... Secondly, we employed a Sleeping Beauty (SB)-based insertional mutagenesis screen in conditional Cdh1 knockout mice to identify ... We show that active transposon mutagenesis drives ILC formation and analysis of common insertion sites in SB-induced tumors ...
more infohttps://www.universiteitleiden.nl/onderzoek/onderzoeksoutput/wiskunde-en-natuurwetenschappen/using-insertional-mutagenesis-to-identify-breast-cancer-drivers-and-therapy-resistance-genes-in-mice