... skeletal muscle fibers contract (actively generate force) as a result of repetitive power strokes of acto-myosin cross-bridges ... On the basis of bio-chemical kinetics, we present a model of muscle fiber exhaustion based on hydrolytic ATP-ADP-Pi dynamics, ... We discuss implications of our model approach for enhancing muscle models in general, as well as a few aspects regarding the ... the hydrolysis reaction products diminish the chemical potential of ATP and thus inhibit the muscles force generation as their ...

Accordingly, the volume of SR tubules localized around the myofibrils is strongly reduced in skeletal muscle fibers of 4- and ... cytosolic Ca2+ levels were analyzed in stimulated skeletal muscle fibers from 4- and 10-month-old sAnk1 KO mice. The SR Ca2+ ... on saponin-permeabilized muscle fibers indicated that the frequency of sparks was significantly lower in fibers from 4-month- ... Furthermore, both the amplitude and spatial spread of sparks were significantly smaller in muscle fibers from both 4- and 10- ...

Journal / Biochemistry / Quantification of Subcellular Glycogen Distribution in Skeletal Muscle Fibers using Transmission ... Quantification of Subcellular Glycogen Distribution in Skeletal Muscle Fibers using Transmission Electron Microscopy. ... Quantification of Subcellular Glycogen Distribution in Skeletal Muscle Fibers using Transmission Electron Microscopy ... methods to obtain unbiased and quantitative data on fiber type-specific subcellular glycogen distribution in skeletal muscle. ...

Results-The PKC α, β1, β2, δ, ξ, and ζ isoforms were localized within the fibers of equine skeletal muscle. In addition, PKC α ... Conclusions and Clinical Relevance-Results indicated that PKC isoforms are expressed in equine skeletal muscle in a fiber type- ... Therefore, the involvement of PKC isoforms in signal transduction in equine skeletal muscle might be dependent on fiber type ... In contrast, MHC-I negative fibers contained more PKC ζ than MHC-I-positive fibers. Distribution of PKC β1 was equal among the ...

Golgi complex, endoplasmic reticulum exit sites, and microtubules in skeletal muscle fibers are organized by patterned activity ...

"Nerve activity-dependent modulation of calcineurin signaling in adult fast and slow skeletal muscle fibers." J Biol Chem, vol. ... "Nerve activity-dependent modulation of calcineurin signaling in adult fast and slow skeletal muscle fibers." J Biol Chem 276, ... Nerve activity-dependent modulation of calcineurin signaling in adult fast and slow skeletal muscle fibers.. Publication , ... Nerve activity-dependent modulation of calcineurin signaling in adult fast and slow skeletal muscle fibers. J Biol Chem. 2001 ...

Comparison of Simulated and Measured Calcium Sparks in Intact Skeletal Muscle Fibers of the Frog (Reaction B). License and ... Comparison of Simulated and Measured Calcium Sparks in Intact Skeletal Muscle Fibers of the Frog (Reaction A) ... Comparison of Simulated and Measured Calcium Sparks in Intact Skeletal Muscle Fibers of the Frog (Reaction B) ... Comparison of Simulated and Measured Calcium Sparks in Intact Skeletal Muscle Fibers of the Frog (Reaction C) ...

Comparison of Simulated and Measured Calcium Sparks in Intact Skeletal Muscle Fibers of the Frog (Reaction A) ... Comparison of Simulated and Measured Calcium Sparks in Intact Skeletal Muscle Fibers of the Frog (Reaction B) ... Comparison of Simulated and Measured Calcium Sparks in Intact Skeletal Muscle Fibers of the Frog (Reaction C) ... Comparison of Simulated and Measured Calcium Sparks in Intact Skeletal Muscle Fibers of the Frog (Reaction D) ...

... diet on parameters of oxidative stress among muscles with distinct fiber type compositi ... High-fat diet induces skeletal muscle oxidative stress in a fiber type-dependent manner in rats. ... This study investigated the effects of high-fat (HF) diet on parameters of oxidative stress among muscles with distinct fiber ... This also suggests that the impact of potentially deleterious effects of ROS production on skeletal muscle metabolism/function ...

Mechanisms for fiber-type specificity of skeletal muscle atrophy. / Wang, Yichen; Pessin, Jeffrey E. In: Current Opinion in ... Mechanisms for fiber-type specificity of skeletal muscle atrophy. Current Opinion in Clinical Nutrition and Metabolic Care. ... Wang, Yichen ; Pessin, Jeffrey E. / Mechanisms for fiber-type specificity of skeletal muscle atrophy. In: Current Opinion in ... Wang, Y., & Pessin, J. E. (2013). Mechanisms for fiber-type specificity of skeletal muscle atrophy. Current Opinion in Clinical ...

Altered Ca2+ signaling in skeletal muscle fibers of the R6/2 mouse, a model of Huntingtons disease. ...

Mammalian skeletal muscle fiber type transitions.. Pette D, Staron RS., Int. Rev. Cytol. 170(), 1997 PMID: 9002237 ... The histochemical profiles of fast fiber types IIB, IID, and IIA in skeletal muscles of mouse, rat, and rabbit.. Hamalainen N, ... D. Vullhorst, et al., "Expression of the potassium channel KV3.4 in mouse skeletal muscle parallels fiber type maturation and ... Expression of the potassium channel KV3.4 in mouse skeletal muscle parallels fiber type maturation and depends on excitation ...

Computational model of cellular metabolic dynamics in skeletal muscle fibers during moderate intensity exercise. Li Y;Lai N; ... Human skeletal muscles have different fiber types with distinct metabolic functions and physiological properties. The ... Human skeletal muscles have different fiber types with distinct metabolic functions and physiological properties. The ... This model is validated by comparing model simulations with experimental data in single muscle fibers and in whole muscle. ...

This project aims at the development of a fiber-based modeling approach for the behavior of muscles within the musculoskeletal ... DYMARA - A dynamic manikin with fiber-based modeling of skeletal muscles. May 13, 2018. pinnau2015 ... The core idea is to describe the skeletal system as a rigid multibody system which is actuated by muscles. Each muscle is ... This project aims at the development of a fiber-based modeling approach for the behavior of muscles within the musculoskeletal ...

Start page /Publications /Desmin filaments influence myofilament spacing and lateral compliance of slow skeletal muscle fibers ... Desmin filaments influence myofilament spacing and lateral compliance of slow skeletal muscle fibers. ... Desmin filaments influence myofilament spacing and lateral compliance of slow skeletal muscle fibers}, journal = {Biophys J}, ... ArnerDesmin filaments influence myofilament spacing and lateral compliance of slow skeletal muscle fibersIn Biophys J, volume ...

... Front. Biosci. ( ... In this study, we identified a selective atrophy of fast-glycolytic myofibers in skeletal muscles of homozygous HIV-1 ... but not those rich in oxidative fibers such as the soleus, exhibited a reduced muscle size in homozygous HIV-1 transgenic mice ... fiber-type-specific inhibition of muscle growth in the presence of the HIV-1 transgene. ...

Skeletal Muscle Fiber Model. Approximately 10,000 times life size. Model displays microstructure of skeletal muscle fiber. ... Skeletal Muscle Histology Model. Approximately 10,000 times life size. Model displays a section of the skeletal muscle fiber in ... Muscled Arm. Superficial and deeper muscles including tendons, vessels, nerves, and bone components of the left arm and ... Deep and superficial muscles. 25 parts total: chest/abdominal wall, 2-part larynx, 2 lungs, diaphragm, 2-part stomach, liver ...

Calcium currents in skeletal muscle fibers of an insect, Carausius morosus, inactivate under depolarization. This inactivation ... Calcium currents in skeletal muscle fibers of an insect, Carausius morosus, inactivate under depolarization. This inactivation ... Calcium dependence of the inactivation of calcium currents in skeletal muscle fibers of an insect ... Calcium dependence of the inactivation of calcium currents in skeletal muscle fibers of an insect ...

Starring or supporting role? Satellite cells and skeletal muscle fiber size regulation. / Murach, Kevin A.; Fry, Christopher S. ... Starring or supporting role? Satellite cells and skeletal muscle fiber size regulation. In: Physiology. 2018 ; Vol. 33, No. 1. ... Starring or supporting role? Satellite cells and skeletal muscle fiber size regulation. Physiology. 2018 Jan;33(1):26-38. doi: ... Dive into the research topics of Starring or supporting role? Satellite cells and skeletal muscle fiber size regulation. ...

... the vitamin C transporter SVCT2 is preferentially expressed in slow muscle fibers. To gain insights into the possible ... In vertebrate skeletal muscle, the vitamin C transporter SVCT2 is preferentially expressed in slow muscle fibers. To gain ... These findings suggest that SVCT2-mediated uptake of vitamin C could play diverse roles on skeletal muscle development and ... SVCT2 expression increases in cultures of both, slow and fast muscle-derived myoblasts, as they fuse to form mainly fast ...

The Maves Lab investigates skeletal muscle and heart development, with the goal of making discoveries that lead to new ... Skeletal muscle fiber type: using insights from muscle developmental biology to dissect targets for susceptibility and ... fast muscle fibers are more susceptible to damage than slow fibers. It is not clear how fiber-type identity confers ... Understanding skeletal muscle fiber-type differentiation. One focus of our lab is understanding the mechanisms behind how ...

Phospholipases can induce necrosis of skeletal muscle fibers. While the defibrinating action results in anticoagulant blood, ...

Skeletal Muscle Fibers: Type I vs. Type II. Skeletal muscles contain a mix of different fibers, and the exact ratio depends on ... Muscle Types. There are three kinds of muscle tissue in the human body:. *Skeletal muscle gets the lions share of attention ... For a muscle to move, the central nervous system sends an electrical impulse to the muscle fibers and causes the actin and ... Type II muscle fibers are also called "fast-twitch" because they contract quickly and produce bursts of power. These fibers are ...

Comparison of simulated and measured calcium sparks in intact skeletal muscle fibers of the frog, S.M. Baylor, S. Hollingworth ... Comparison of Simulated and Measured Calcium Sparks in Intact Skeletal Muscle Fibers of the Frog (Reaction C) ... ABSTRACT: Calcium sparks in frog intact skeletal muscle fibers were modeled as stereotypical events that arise from a constant ... Comparison of Simulated and Measured Calcium Sparks in Intact Skeletal Muscle Fibers of the Frog (Reaction A) ...

In summary, sustained MEK1-ERK1/2 activity in skeletal muscle produces a fast-to-slow fiber-type switch that protects from ... MEK1-ERK2 signaling was shown to underlie this fast-to-slow fiber type switching in adult skeletal muscle as well as during ... Here we investigated ERK1/2 signaling in skeletal muscle homeostasis and disease. Using mouse genetics, we observed that the ... muscle-specific expression of a constitutively active MEK1 mutant promotes greater ERK1/2 signaling that mediates fiber-type ...

Histology of Skeletal Muscle Tissue. Skeletal muscle consists of fibers (cells). [1, 2, 3] These cells are up to 100 µm in ... Through contraction, muscle provides motion of the body (skeletal muscle), motion of blood (cardiac muscle), and motion of ... it supplies 10 muscle fibers. Small motor units are for fine control of muscles; large motor units are for muscles that do not ... Each contains sarcoplasm (cytoplasm) and multiple peripheral nuclei per fiber. Skeletal muscle is actually formed by the fusion ...

Muscle Fibers, Skeletal; Muscle, Skeletal; Smoking; Vitamin D Deficiency; 06 Biological Sciences; 11 Medical and Health ... Muscle, Skeletal; Animals; Mice, Inbred C57BL; Humans; Mice; Vitamin D Deficiency; Hypertrophy; Smoking; Male; Muscle Fibers, ... The combination of smoking with vitamin D deficiency impairs skeletal muscle fiber hypertrophy in response to overload in mice ... The combination of smoking with vitamin D deficiency impairs skeletal muscle fiber hypertrophy in response to overload in mice. ...

involved_in skeletal muscle fiber development IEA Inferred from Electronic Annotation. more info ... involved_in skeletal muscle tissue regeneration IEA Inferred from Electronic Annotation. more info ... involved_in positive regulation of supramolecular fiber organization ISS Inferred from Sequence or Structural Similarity. more ...

Skeletal muscle fiber type‐specific expressions of mechanosensors integrin‐linked kinase, talin, and vinculin and their ... Skeletal muscle fiber type‐specific expressions of mechanosensors integrin‐linked kinase, talin, and vinculin and their ...