Loading...
*  Of inflammasomes and pathogens - sensing of microbes by the inflammasome | EMBO Molecular Medicine
Upon binding, the pyrin domain is liberated from an intramolecular autoinhibitory complex (PYD/HIN domain complex). This ... Activated NLRP3 presumably forms multiprotein aggregates with the adaptor protein ASC and recruits caspase‐1. Autocatalytically ... Inflammasome complexes can be formed by members of the Nod‐like receptor family or the PYHIN family member AIM2. Upon formation ... Here, we review the sensing mechanisms of the currently characterized inflammasome complexes and discuss how they are involved ...
http://embomolmed.embopress.org/content/5/6/814
*  Critical Roles of ASC Inflammasomes in Caspase-1 Activation and Host Innate Resistance to Streptococcus pneumoniae Infection |...
Recent studies have demonstrated that the inflammasome, a multiprotein complex that typically consists of a nucleotide-binding ... and each has been designated according to the receptor within the protein complex. Of these, the NLR family, pyrin domain ...
http://www.jimmunol.org/content/187/9/4890.full
*  The Inflammasome Mediates Hyperoxia-Induced Alveolar Cell Permeability | The Journal of Immunology
The NALP3 inflammasome is a multiprotein complex, which contains NALP3, the caspase recruitment domain-containing protein ... 4). The assembly of the NALP3 and ASC complex is thought to induce IL-1β processing by caspase-1. These results suggest that ... During the final stages of HALI, which occur after 72 h of hyperoxia exposure, the NALP3 complex is highly active and leads to ... The inflammasome protein complex activates caspase-1 to promote the processing and secretion of proinflammatory cytokines. We ...
http://www.jimmunol.org/content/184/10/5819.long
*  Lighting up multiprotein complexes: lessons from GPCR oligomerization
... or heterodimer complexes; however, a given protein can also be part of multiprotein complexes involving numerous interactions ... Lighting up multiprotein complexes: lessons from GPCR oligomerization. Francisco Ciruela,1 Jean-Pierre Vilardaga,2,3 and Víctor ... Visualization of AP-1 NF-κB ternary complexes in living cells by using a BiFC-based FRET. Proc Natl Acad Sci U S A. 2008;105: ... Three-chromophore FRET microscopy to analyze multiprotein interactions in living cells. Nat Methods. 2004;1:209-217. [PubMed] ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC3065825/?lang=en-ca
*  Thomas Höfer: "Specificity and efficiency of multiprotein complexes that control genome function"</span>
Specificity and efficiency of multiprotein complexes that control genome function. Multiprotein machineries in DNA repair and ... Thomas Höfer: "Specificity and efficiency of multiprotein complexes that control genome function" ... Quelle: Thomas Höfer: "Specificity and efficiency of multiprotein complexes that control genome function" - Freiburg Institute ... Thomas Höfer: "Specificity and efficiency of multiprotein complexes that control genome function" ...
http://www.frias.uni-freiburg.de/de/das-institut/archiv-frias/school-of-lifenet/veranstaltungen/thomas-hofer-stochasticity-and-fidelity-in-mammalian-dna-repair
*  Multiprotein complexes - Multi-source protein - Store, ranking, reviews
Multiprotein complexes are multi-ingredient preparations with at least 4 different protein fractions. Discover a wide variety ... Protein multi-complexes can be boldly called universal supplements, which are suitable for use at any time of the day; they ... Protein multi-complexes usually contain milk-derived proteins, i.e. an isolate, concentrate or whey hydrolyzate, and casein, as ... Protein multi-complexes have a high anabolic potential. In addition, they provide effective, many-hours' protection against ...
https://www.mz-store.com/protein-multicomplexes
*  The Ku-like protein from Saccharomyces cerevisiae is required in vitro for the assembly of a stable multiprotein complex at a...
Purified OBF2 not only binds DNA but also supports the formation of a protein complex at essential sequences within the ARS121 ... this is the first requirement for a Ku-like protein in the assembly of a protein complex at essential sequences within a ... are necessary for the ATP-dependent assembly of a specific and stable multiprotein complex at a yeast origin of replication. ... The Ku-like protein from Saccharomyces cerevisiae is required in vitro for the assembly of a stable multiprotein complex at a ...
https://www.semanticscholar.org/paper/The-Ku-like-protein-from-Saccharomyces-cerevisiae-a-Shakibai-Kumar/7a9325047503c3e3ea7c65101dac01ba1e740352
*  "Proteasomal selection of multiprotein complexes recruited by LIM homeo" by Cenap Gungor, Naoko Taniguchi-Ishigaki et al.
Here, we identify a cascade of specific protein interactions that protect LIM-HD multiprotein complexes from proteasomal ... Together, our results indicate a combinatorial code that selects specific multiprotein complexes via proteasomal degradation in ... However, our knowledge about the molecular mechanisms governing the assembly and dynamics of these complexes in cells remains ... cells with broad implications for the assembly and specificity of multiprotein complexes. ...
https://escholarship.umassmed.edu/oapubs/1355/
*  Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization.
... Stewart S., Sundaram M., Zhang ... Furthermore, we observe that murine KSR forms a multimolecular signaling complex in human embryonic kidney 293T cells composed ...
https://www.uniprot.org/citations/10409742
*  Genetic code expansion for multiprotein complex engineering - Berger Lab (2016) | 4DCellFate
Developing a global understanding of the PRC and NuRD complexes in stem cell differentiation and in disease. ... for structure-function studies of novel eukaryotic complexes using single-molecule Förster resonance energy transfer as well as ... protein engineering method that enables site-specific introduction of unique functionalities in a eukaryotic protein complex ...
http://4dcellfate.eu/article/genetic-code-expansion-multiprotein-complex-engineering-berger-lab-2016
*  A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with...
These results suggest that TANC protein may work as a postsynaptic scaffold component by forming a multiprotein complex with ... A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with ... forms a multiprotein complex with various postsynaptic density proteins.}, author={Tatsuo Suzuki and Weidong Li and Jingping ... Hypoxia-ischemia modifies postsynaptic GluN2B-containing NMDA receptor complexes in the neonatal mouse brain.. Fuxin Lu, Guo ...
https://www.semanticscholar.org/paper/A-novel-scaffold-protein%2C-TANC%2C-possibly-a-rat-of-a-Suzuki-Li/9d157c325b1064bd43044e1ae29de4976fb221b6
*  Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex...
Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex ... Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex ... Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex ... Multiprotein Complexes, Protein Binding, Proto-Oncogene Protein c-fli-1, Proto-Oncogene Proteins, Sequence Alignment, T-Cell ...
https://www.rdm.ox.ac.uk/publications/106370
*  The PAM domain, a multi-protein complex-associated module with an all-alpha-helix fold | BMC Bioinformatics | Full Text
... present in single subunits of well characterized multiprotein complexes, like the regulatory lid of the 26S proteasome, the COP ... The occurrence of the PAM domain in specific subunits of multimeric protein complexes, together with the role of other all- ... Multimeric protein complexes have a role in many cellular pathways and are highly interconnected with various other proteins. ... signalosome and the Sac3-Thp1 complex. This module is an around 200 residue long domain with a predicted TPR-like all-alpha- ...
https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-4-64
*  Purification to homogeneity and reconstitution of the individual components of the epoxide carboxylase multiprotein enzyme...
Phosphorylation of Sar1b protein releases liver fatty acid-binding protein from multiprotein complex in intestinal cytosol ... The three-dimensional structure of the biotin carboxylase-biotin carboxyl carrier protein complex of E. coli acetyl-CoA ... to homogeneity and reconstitution of the individual components of the epoxide carboxylase multiprotein enzyme complex from ... to homogeneity and reconstitution of the individual components of the epoxide carboxylase multiprotein enzyme complex from ...
https://www.semanticscholar.org/paper/Purification-to-homogeneity-and-reconstitution-of-Allen-Ensign/61f87e06d80256ea5c0a2eee7c77a880c2ba7e7f
*  Detecting coordinated regulation of multi-protein complexes using logic analysis of gene expression | BMC Systems Biology |...
... we may find that the transcription of complex C is increased only if the transcription of both complex A AND complex B is ... In order to focus on complexes, we associate the members of a gene triplet with the distinct protein complexes to which they ... we derive a large network involving this essential cellular complex. In this network we find that all multi-protein complexes ... By grouping gene triplets, we are able to decipher coordinated regulation among sets of three complexes. Moreover, using all ...
https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-3-115
*  Ph.D. Admissions - Cell Biology & Development - FSU College of Medicine
... design principles governing assembly of multiprotein complexes. Yuan Wang Ph.D.. Development and plasticity of neuronal ...
https://med.fsu.edu/?page=phdAdmissions.cellbiologyDevelopment
*  Watching cellular machinery in action, one molecule at a time | JCB
A single-molecule view of DNA replication: the dynamic nature of multi-protein complexes revealed. Curr. Opin. Struct. Biol. 23 ... Recently, the use of these approaches has expanded to the study of complex multiprotein systems and has enabled detailed ... We also discuss how single-molecule approaches have increased our understanding of the dynamic behavior of complex multiprotein ... Instead of deterministic pathways, multiprotein complexes seem to perform their tasks by choosing from a multitude of pathways ...
http://jcb.rupress.org/content/216/1/41
*  IJMS | Free Full-Text | Analysis of Cooperativity by Isothermal Titration Calorimetry
Keywords: isothermal titration calorimetry; stoichiometry; cooperativity; multiprotein complexes; thermodynamics; global ... analysis; NMR isothermal titration calorimetry; stoichiometry; cooperativity; multiprotein complexes; thermodynamics; global ...
http://www.mdpi.com/1422-0067/10/8/3457
*  MEDLINE Data Changes - 2015. NLM Technical Bulletin. 2014 Nov-Dec
Protein Aggregates with Multiprotein Complexes.. *Historically Controlled Study with Historical Article.. In addition to ...
https://www.nlm.nih.gov/pubs/techbull/nd14/nd14_medline_data_changes_2015.html
*  Caspase - Wikipedia
Multiprotein complexes often form during caspase activation.[12] Some activating multiprotein complexes includes:. *The death- ... This is done by the formation of a multiprotein Death Inducing Signalling Complex (DISC) that recruits and activates a pro- ... This cellular ion imbalance leads to oligomerisation of NLRP3 molecules to form a multiprotein complex called the NLRP3 ... These proteins allow caspase-1 activation by forming a multiprotein activating complex called Inflammasomes. For example, a NOD ...
https://en.wikipedia.org/wiki/Caspase
*  Booktopia - Advances in Systems Biology, Advances in Experimental Medicine and Biology by Lee K. Opresko, 9780306483141. Buy...
These topics include complex microbial systems, gene regulatory networks, molecular machines/ multiprotein complexes and ... Structure and function of multiprotein complexes involved in protein degradation, muscle function and protein kinase ... Molecular biological methods for the analysis of complex microbial communities and the use of specific bacterial species for ...
https://www.booktopia.com.au/advances-in-systems-biology-lee-k-opresko/prod9780306483141.html
*  The translational landscape of the mammalian cell cycle.
0/Multiprotein Complexes; 0/RNA, Messenger; 0/cohesins; 0/condensin complexes; EC 3.6.1.-/Adenosine Triphosphatases ... Multiprotein Complexes / genetics, metabolism. Protein Biosynthesis*. RNA, Messenger / genetics, metabolism. Transcriptome. ... Next Document: The Mre11 complex suppresses oncogene-driven breast tumorigenesis and metastasis.. ... This includes the majority of mRNAs comprising the cohesin and condensin complexes responsible for maintaining genome ...
http://www.biomedsearch.com/nih/Translational-Landscape-Mammalian-Cell-Cycle/24120665.html
*  mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis.
0/Multiprotein Complexes; 0/Rptor protein, mouse; 0/mechanistic target of rapamycin complex 1; EC 2.7.1.1/TOR Serine-Threonine ... Multiprotein Complexes / metabolism*. PTEN Phosphohydrolase / deficiency*, metabolism. Survival Analysis. TOR Serine-Threonine ... However, the roles of the unique mTOR complexes (mTORCs) in hematopoiesis and leukemogenesis have not been adequately ...
http://www.biomedsearch.com/nih/mTOR-Complex-1-Plays-Critical/22958934.html
*  Browsing Norges teknisk-naturvitenskapelige universitet by Title
X-ray repair cross-complementing protein 1 associated multiprotein complexes in base excision repair  Hanssen-Bauer, Audun ( ... In the work described in this report, we have looked at the use of EXtensible Stylesheet Language (XSL) for complex metadata ...
https://brage.bibsys.no/xmlui/handle/11250/223328/browse?rpp=20&order=ASC&sort_by=1&etal=-1&type=title&starts_with=X