... the mucin secreting cell; enteroendocrine cells, the hormone-producing population; and in the cecum-and very rarely in the ... Figure 2. Colorectal cancer (CRC) has better survival odds than metastatic CRC (mCRC) or young-adult CRC (YA-CRC). The ... Figure 2. Colorectal cancer (CRC) has better survival odds than metastatic CRC (mCRC) or young-adult CRC (YA-CRC). The ... 2. Intestinal Structure and the Stem Cell Niche. The primary function of the gastrointestinal tract is to facilitate nutrient ...

Lee, J.; Lee, J.; Yun, J.H.; Jeong, D.G.; Kim, J.H. DUSP28 links regulation of Mucin 5B and Mucin 16 to migration and survival ... Mucin 5B (MUC5B), a little-characterized secretory type of mucin previously found in human bile and overexpressed in PDAC ... 2,3,4,*,‡. add Show full author list remove Hide full author list ... 2. Results. 2.1. UHPLC-MS Lipidomic Analysis of Bile. Bile samples obtained from patients described in Table 1 were processed ...

Mucin 1 oncoprotein and a bacterial antigen neomycin phosphotransferase [83]. However to date, EBNA1 is the only viral antigen ... Gangappa, S.; van Dyk, L.F.; Jewett, T.J.; Speck, S.H.; Virgin, H.W.t. Identification of the in vivo role of a viral bcl-2. J. ... 2.2.2. Human Herpesvirus (HHV-6). HHV-6, which belongs to the Roseolovirus genus of the β-Herpesvirus subfamily, is related to ... 2.1.2. Bovine Herpes Simplex Virus Type 1 (BHV-1). Recent findings suggest that BHV-1 may have developed a strategy to evade ...

Ishida, A.; Ohta, M.; Toda, M.; Murata, T.; Usui, T.; Akita, K.; Inoue, M.; Nakada, H. Mucin-induced apoptosis of monocyte- ... mucin 2 (MUC2) [149], and high-mobility group protein B1 (HMGB1) [150], have been shown to trigger apoptosis of TADCs. This ... Ther. 2000, 2, 324-329. [Google Scholar] [CrossRef] [PubMed]. *Kim, J.H.; Oh, J.Y.; Park, B.H.; Lee, D.E.; Kim, J.S.; Park, H.E ... Immunol. 2001, 2, 1144-1150. [Google Scholar] [CrossRef] [PubMed]. *Moseman, E.A.; Liang, X.; Dawson, A.J.; Panoskaltsis- ...

... intraductal mucin producing neoplasm, chronic pancreatitis, hereditary pancreatitis, or life habit) should be understood. ... Cancers, Volume 10, Issue 2 (February 2018) - 31 articles Cover Story (view full-size image): Pancreatic ductal adenocarcinoma ... Stable disease (SD) was seen in 21 patients for at least 2 months. One subject with prior gemcitabine and docetaxel had PR, and ... We evaluated the efficacy and toxicity of respiratory-gated PBT without fiducial markers for HCC located within 2 cm of the ...

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... tissue accompanied by a decrease in the mRNA levels of macrophage marker genes including EGF-like module-containing mucin-like ... Nrf-2, SOD, CAT. ↓ Snail-1. Shim SG, 2013 [32]. Caffeine 1, 5, 10 mmol. -HSC treated with caffeine -Sprague-Dawley rats treated ... Figure 2. The bioactive components of coffee, caffeine and chlorogenic acids, inhibit de novo lipogenesis, promotes lipid ... Figure 2. The bioactive components of coffee, caffeine and chlorogenic acids, inhibit de novo lipogenesis, promotes lipid ...

... shown to fortify tight junction formation between epithelial cells by inducing expressions of claudins and by stimulating mucin ... 5.3.2. Immunomodulation of TGF-β, IL-1β and IL-6 Cytokines. TGF-β regulates Th17 differentiation by actiβating transcription ... 2. Role of Th17 Cells in the Gut Immune Homeostasis. Roles of Th17 cells in intestinal pathology and homeostasis still remain ... 2. School of Nutrition and Health Sciences, College of Public Health and Nutrition, Taipei Medical University, 250 Wu-Xing ...

The Mucus and Mucins of the Goblet Cells and Enterocytes Provide the First Defense Line of the Gastrointestinal Tract and ... Bergstrom, K.S.B.; Xia, L. Mucin-Type O-Glycans and Their Roles in Intestinal Homeostasis. Glycobiology 2013, 23, 1026-1037. [ ... The gastro-intestinal tract is lined with a mucosal layer consisting of secreted mucin glycoproteins produced by goblet cells, ... which encodes the most abundant secreted mucin in the colon, was greatly reduced in FFD mice (t-test, p = 0.002; Figure 1H). ...

... mucin expression and microbiota integrity. Avicenna J. Phytomed. 2022, 12, 241-256. [Google Scholar] [CrossRef] [PubMed] ... TQ can reduce mucin glycoprotein 4 (MUC4) expression in pancreatic cancer cells, contributing to the regulation of ... TQ was also found to increase NO production and gastric mucin secretion. TQ exhibits inhibitory effects on factors that may be ... Effects of thymoquinone in the expression of mucin 4 in pancreatic cancer cells: Implications for the development of novel ...

In patients diet, it is crucial to ensure an adequate intake of micronutrients, such as omega-3 fatty acids (at 2-4 g/d), ... selenium (300-450 μg/d) and zinc (30-50 mg/d), and vitamins A (900-700 µg/d), E (135 mg/d), D (20,000-50,000 IU), C (1-2 g/d), ... and the outcome of patients with SARS-CoV-2 is strongly associated with their nutritional status. The purpose of this study was ... useful information about the possible elements of nutritional and probiotic therapy in patients infected with the SARS-CoV-2 ...

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Special Issue in Cancers: Mucins and Cancers. Special Issue in Cancers: Checkpoint Markers and Cancer Microenvironment: What Do ... Special Issue in Biologics: Anti-SARS-CoV-2/COVID-19 Drugs and Vaccines - Part II. Special Issue in Viruses: SARS-CoV-2: ... Special Issue in Vaccines: Therapeutic Approaches for Type 1 and Type 2 Diabetes. Special Issue in Brain Sciences: Advances in ... Special Issue in Biologics: Anti-SARS-CoV-2/COVID-19 Drugs and Vaccines. Special Issue in Vaccines: Multiple Sclerosis, ...

... and type 2 diabetes (T2D). Intake of gluten, a major component of wheat, rye, and barley, affects the microbiota and increases ... The mucin-degrading Akkermansia is of special interest in T1D. For example, NOD mice treated with vancomycin from an early age ... Figure 2).. 3.4. GF Diet, the Beta Cell and Adipose Tissue. Signalling through the pattern-recognition receptor TLR4, which is ... Figure 2. Gluten-free (GF) diet and the development of type 2 diabetes (T2D)-a hypothesis. A GF diet decreases intestinal ...

Wang, G.; Li, G.; Zhang, S.; Jiang, C.; Qin, J.; Xu, J.R. Activation of the signalling mucin MoMsb2 and its functional ... Table 2. Predicted PPIs in T. aestivum-T. laevis interactome.. Interaction Database. Number of Interactions. Number of Host ... 2.1.2. Degree. On an average, the degree of T. aestivum and Tilletia proteins (orthologs) was found to be 64 and 11999, ... 2.5.2. Functional Analysis of Unique T. laevis Proteins in the Predicted PPIs. The GO enrichment analysis of unique T. laevis ...

Sabatolimab is a T-cell immunoglobulin and mucin domain-containing protein 3 (TIM3) inhibitor. TIM3 is a member of the TIM ... 2 years NRM: 15%. [68]. TP53 mut MDS. 289. RIC/MAC. Not available. 3 years OS: 20%. Median OS: 8 months. 2 years NRM: 35%. [69] ... 2. Landscape of TP53 Mutations. An analysis of the TP53 whole coding sequence found that about 85% of mutations were clustered ... The US phase 2 trial enrolled fifty-five patients (40 MDS/11 AML) with a median age of 66 years. The Overall Response Rate (ORR ...

Modulation of Mucin (MUC2, MUC5AC and MUC5B) mRNA Expression and Protein Production and Secretion in Caco-2/HT29-MTX Co- ... Mucin is a major component of the intestinal mucus layer, which plays an important role in maintaining intestinal mucosal ... Mucin is a major component of the intestinal mucus layer, which plays an important role in maintaining intestinal mucosal ... However, the effect of mycotoxins AFM1 and OTA on intestinal mucin production is still not clear. This study aimed to ...

T cell immunoglobulin and mucin-domain containing-3 (TIM3), lymphocyte-activation gene 3 (LAG3) and CTLA-4, for which CD4+ and ... 2. Crosstalk of DCs and T Cells. 2.1. DCs in the Liver. Since the first morphological report of a cutaneous DC type of unknown ... Wynn, T.A. Fibrotic disease and the T(H)1/T(H)2 paradigm. Nat. Rev. Imm. 2004, 4, 583-594. [Google Scholar] [CrossRef][Green ... Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells. Nat. Immunol. 2011, 12, 870-878 ...

Mechanistic and Functional Shades of Mucins and Associated Glycans in Colon Cancer ... Figure 2. Structures of non-residualizing radioiodine labels provided by the labeling of affibody molecules using PIB (A), ... Figure 2. Structures of non-residualizing radioiodine labels provided by the labeling of affibody molecules using PIB (A), ... Index 2 in designations (ZHER2:4)2 and (ZHER2:477)2 shows that these affibody constructs contain two monomeric units fused head ...

According to the authors, PEG chains can promote hydrogen bonds between polymers and mucins on the ocular surface, which ... and concentration-dependent adhesive interaction between the DDS and mucin. The in vitro permeation assay demonstrated a ... In Table 2, we present a summary of the most-used polymers and DDS for the most commonly discussed diseases and/or tissues. We ... 3.4.2. The Cornea. The corneal endothelium is the most crucial part of the cornea and its damage can cause corneal edema, ...

Podoplanin (PDPN), a small transmembrane mucin-like glycoprotein, is ectopically expressed on tumor cells. PDPN is known to be ... Podoplanin (PDPN), a small transmembrane mucin-like glycoprotein, is ectopically expressed on tumor cells. PDPN is known to be ... Cited by 2 , Viewed by 1905 Abstract It has come to our attention that two images in Figure 2A (100%), and Figure 2C (GM) of ... Cited by 2 , Viewed by 1961 Abstract Mammarenaviruses are a diverse genus of emerging viruses that include several causative ...

Once the solution was made, it was boiled, 100 mg of sterile mucin from porcine stomach was added, degassed under oxygen-free ... 2. Materials and Methods. 2.1. Participants. This was an adult study which recruited to three groups: Crohns disease and UC in ... BMI, kg/m2. 25.4 (5.6). 26.0 (5.3). 26.4 (5.8). 25.3 (3.6). 24.7 (3.6). 26.3 (4.9). ... Reducing solution (50 mL) was made up of 2 mL of 1 M NaOH, 312.5 mg of cysteine hydrochloride and 312.5 mg of Na2S·9H2O. ...

Analysis of Epithelial Growth Factor-Receptor (EGFR) Phosphorylation in Uterine Smooth Muscle Tumors: Correlation to Mucin-1 ... Correlation analysis revealed an overall positive correlation between pEGFR Y845 and mucin 1 (MUC1). Further subgroup analysis ... Cited by 2 , Viewed by 5834 Abstract In the special issue "Signaling Molecules and Signal Transduction in Cells" authors were ... In in vitro experiments, mPGES-1 produces PGE2, which enhances astrocytic Ca2+ levels via the EP3 receptor and increases Ca2+- ...

Special Issue in Cancers: Mucins and Cancers. Special Issue in Cancers: Checkpoint Markers and Cancer Microenvironment: What Do ... Special Issue in Biologics: Anti-SARS-CoV-2/COVID-19 Drugs and Vaccines: Part II. Special Issue in Viruses: SARS-CoV-2: Vaccine ... Type 2 diabetes (T2D) is a progressive condition where beta cells in the pancreas still make insulin but not enough or the the ... Special Issue in Biologics: Anti-SARS-CoV-2/COVID-19 Drugs and Vaccines. Special Issue in Vaccines: Multiple Sclerosis, ...

... intraductal mucin producing neoplasm, chronic pancreatitis, hereditary pancreatitis, or life habit) should be understood. ... and TRAIL receptor 2 (TRAIL-R2) also death receptor 5 (DR5) thereby inducing the formation of the death-inducing signaling ...

Mack, D.R.; Ahrne, S.; Hyde, L.; Wei, S.; Hollingsworth, M.A. Extracellular MUC3 mucin secretion follows adherence of ... 2. Experimental Section. 2.1. Materials, Animals, and Experiment Design. L. plantarum TWK10 (LP10) was obtained from Dr. Tsung- ... Figure 2. Effects of LP10 supplementation on swimming exercise performance. Mice were pretreated with vehicle, LP10-1X, LP10-5X ... Figure 2. Effects of LP10 supplementation on swimming exercise performance. Mice were pretreated with vehicle, LP10-1X, LP10-5X ...

Discs were tested for surface roughness (Ra), hydrophobicity (contact angle), mucin adsorption (Bradford assay), and Candida ... These results were associated with mucin adsorption levels rather than surface roughness. Results suggest that 3D printing may ... Figure 2. ,p,The relationship of storage (,b,G,/b,) and loss (,b,G",/b,) modulus with angular frequency of oscillation for PVP ... To remove the SiO2 that forms on the surface of AHSS, 30 wt.% NH4HF2 was added to the pickling solution, resulting in a ...

In addition, the role that the viral mucin-like domains (MLD) of the HSV-1 glycoprotein C plays in facilitating the diffusion ... Cellular Chondroitin Sulfate and the Mucin-like Domain of Viral Glycoprotein C Promote Diffusion of Herpes Simplex Virus 1 ... Cited by 2 , Viewed by 1201 Abstract Hepatitis B and C (HBV/HCV) coinfected patients have a potential risk of hepatitis B ... Cited by 2 , Viewed by 1720 Abstract Epitopes are short amino acid sequences that define the antigen signature to which an ...

... has safely demonstrated the inhibition of mast cell activity and the depletion of eosinophils in several phase 1 and phase 2 ... Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis. J. Allergy Clin. Immunol. 2015, 135 ... 9-N-(2-naphthyl-sulfonyl)-Neu5Acα2-3-[6-O-sulfo]-Galβ1-4GlcNAc (6-O-sulfo (NSA)Neu5Ac). Yes. Yes. ... Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils. J. Allergy Clin. Immunol. 2000, ...