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*  Gene Ontology Classifications
... is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone ...
http://www.informatics.jax.org/go/marker/MGI:88283
*  OriGene - SERPINH1 (NM 001235) Human ORF cDNA Clone
... is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone ... The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual ...
http://www.origene.com/Human_ORF_Clone/RG209847.aspx
*  Dokument bez názvu
Saito Y, Ihara Y, Leach MR et al.: Calreticulin functions in vitro as a molecular chaperone for both glycosylated and non- ... Nauseef WM, McCormick SJ, Clark RA: Calreticulin functions as a molecular chaperone in the biosynthesis of myeloperoxidase. J ... Gething MJ: Role and regulation of the ER chaperone BiP. Sem Cell Dev Biol 10:465-472, 1999.. Guo L, Nakamura K, Lynch J et al ... endoplasmic reticulum; calreticulin; calnexin; chaperones; lipid metabolism. REFERENCES. Arnaudeau S, Frieden M, Nakamura K et ...
http://jab.zsf.jcu.cz/3_4/michalak.htm
*  Anti-Calreticulin Antibody | 06-661
FUNCTION: SwissProt: P27797 # Molecular calcium binding chaperone promoting folding, oligomeric assembly and quality control in ...
http://www.merckmillipore.com/INTL/en/product/Anti-Calreticulin-Antibody,MM_NF-06-661
*  UW Biochemistry - Faculty - Rachel Klevit
sHSPs form an integral part of the cellular chaperone network by maintaining aggregation-prone proteins in a soluble state. Due ... Research in the Klevit group is directed towards an understanding of molecular recognition, with an emphasis on protein-protein ... We use a variety of structural, biochemical, molecular biological, and biophysical techniques, with a major emphasis on high ...
https://depts.washington.edu/biowww/pages/faculty-Klevit.shtml
*  Heat Shock and Molecular Chaperones
Heat Shock Proteins and Molecular Chaperones Most, but not all, heat shock proteins are molecular chaperones. Molecular ... List the major classes of molecular chaperones and identify their cellular roles. *Compare the mechanism of regulated binding ... All molecular chaperones recognize hydrophobic features of unfolded substrate polypeptides, thereby discriminating against ... Consider the involvement of molecular chaperones in disease, immunology and tissue repair. Characteristics of Protein-protein ...
http://www.tulane.edu/~biochem/med/hsp.htm
*  Phys.org - molecular chaperones
Biochemists trap a chaperone machine in action. Molecular chaperones have emerged as exciting new potential drug targets, ... Phys.org)-Heidelberg molecular biologists have gained new insights into the function of so-called molecular chaperones in ... The dance of the chaperones: Scientists identify key player of protein folding. Proteins are the molecular building blocks and ... Molecular assembly line brings muscles into shape. Scientists at the Research Institute of Molecular Pathology (IMP) in Vienna ...
https://phys.org/tags/molecular+chaperones/
*  The Hsp70 molecular chaperone machines | Frontiers Research Topic
As such, Hsp70s, acting in cooperation with their J-domain co-chaperones and nucleotide exchange factors, constitute a central ... Members of the Hsp70 family form a central hub of the molecular chaperone network, controlling protein homeostasis in ... Members of the Hsp70 family form a central hub of the molecular chaperone network, controlling protein homeostasis in ... Members of the Hsp70 family form a central hub of the molecular chaperone network, controlling protein homeostasis in ...
https://www.frontiersin.org/research-topics/3519/the-hsp70-molecular-chaperone-machines
*  BAG family molecular chaperone regulator 4 (O95429) | InterPro | EMBL-EBI
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
http://www.ebi.ac.uk/interpro/protein/O95429
*  Celastrol increases glucocerebrosidase activity in Gaucher disease by modulating molecular chaperones | PNAS
... and quantitative reduction of the enzyme is determined by molecular chaperones (19). Therefore, targeting molecular chaperones ... The gene expression of molecular chaperones was determined using heat shock proteins and chaperones RT2 profiler PCR array ( ... 2001) Molecular chaperone targeting and regulation by BAG family proteins. Nat Cell Biol 3(10):E237-E241. ... Furthermore, BAG family molecular chaperone regulator 3 assisted protein folding and maturation of mutant GCase. These findings ...
http://www.pnas.org/content/111/1/249
*  SACS sacsin molecular chaperone [Homo sapiens (human)] - Gene - NCBI
SACS sacsin molecular chaperone [Homo sapiens] SACS sacsin molecular chaperone [Homo sapiens]. Gene ID:26278 ... DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones] ... DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones] ... sacsin molecular chaperoneprovided by HGNC. Primary source. HGNC:HGNC:10519 See related. Ensembl:ENSG00000151835 MIM:604490 ...
https://www.ncbi.nlm.nih.gov/gene/26278
*  Molecular Chaperone Dysfunction in Neurodegenerative Diseases and Effects of Curcumin
... Panchanan Maiti,1 Jayeeta Manna,2 Shobi ... Panchanan Maiti, Jayeeta Manna, Shobi Veleri, and Sally Frautschy, "Molecular Chaperone Dysfunction in Neurodegenerative ...
https://www.hindawi.com/journals/bmri/2014/495091/cta/
*  The Biology of Extracellular Molecular Chaperones | Cell & Molecular Biology | Life Sciences | Subjects | Wiley
The Biology of Extracellular Molecular Chaperones is of particular interest to immunologists, cell and molecular biologists, ... Symposium on The biology of extracellular molecular chaperones, held at the Novartis Foundation, London, 5-7 June 2007. Editors ... and it has been recognized that not all molecular chaperones are stress proteins and vice versa. The discovery of molecular ... Péter Csermely, Tamás Korcsmáros, István A. Kovács, Máté S. Szalay and Csaba Soti Systems biology of molecular chaperone ...
https://www.wiley.com/en-us/The+Biology+of+Extracellular+Molecular+Chaperones-p-9780470723333
*  RCSB PDB - Protein Feature View - Molecular chaperone DnaK - I6Y7L1 (I6Y7L1 MYCTU)
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
http://www.rcsb.org/pdb/protein/I6Y7L1
*  Biology of Extracellular Molecular Chaperones, The (Novartis Foundation Symposium 291)
... cell and molecular biologists, microbiologists and virologists, as well as clinical researchers working in cardiology, diabetes ... The Biology of Extracellular Molecular Chaperones is of particular interest to immunologists, ... The Biology of Extracellular Molecular Chaperones is of particular interest to immunologists, cell and molecular biologists, ... and it has been recognized that not all molecular chaperones are stress proteins and vice versa. The discovery of molecular ...
http://www.silverplatter.com/site/catalog/books/9361.jsp
*  Characterization of the molecular chaperone ClpB from the pathogenic spirochaete Leptospira interrogans
Our results indicate that ClpB's importance during infection might be due to its role as a molecular chaperone involved in ... The molecular mechanisms of the Leptospira virulence remain mostly unknown. Recently, it has been demonstrated that an AAA+ ... This result underscores the species-specificity of the ClpB cooperation with the co-chaperones and is most likely due to a loss ... but not AMP-PNP induces the formation of ClpBLi hexamers and stabilizes the associated form of the chaperone. ADP also induces ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0181118
*  Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101
The journal provides a multidisciplinary forum for translational and clinical oncology research in the areas of molecular ... pathology, genomics, diagnosis and therapy, with a specific focus on molecular targeted agents and novel immune therapies. ... C. Jolly and R. I. Morimoto, "Role of the heat shock response and molecular chaperones in oncogenesis and cell death," Journal ... Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101. Marc J. Braunstein,1 Sadeaqua S. Scott ...
https://www.hindawi.com/journals/jo/2011/232037/ref/
*  Molecular chaperones in the pathogenesis of amyotrophic lateral sclerosis: the role of HSPB1.
... Capponi S., Geuens T., Geroldi A ... In this study, we evaluated the role of the candidate gene HSPB1, a molecular chaperone involved in several proteome- ... Genetic discoveries in amyotrophic lateral sclerosis (ALS) have a significant impact on deciphering molecular mechanisms of ... sequestering the wild-type protein in a stable dimer and resulting in a loss of chaperone-like activity. Our results underline ...
https://www.uniprot.org/citations/27492805
*  Evolution of molecular chaperones - Wikipedia
Chaperones, also called molecular chaperones, are proteins that assist other proteins in assuming their three-dimensional fold ... Heat shock proteins (HSPs) are a diverse class of molecular chaperones that assist in folding under stress. While originally ... Since chaperones are mediators of this transition by assisting in the fold of the client protein, chaperone activity is thought ... Feder, ME; Hofmann, GE (1999). "Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological ...
https://en.wikipedia.org/wiki/Evolution_of_molecular_chaperones
*  Protein Expression via the Molecular Chaperone ClpL | Open Access Journals
ClpL functions as a molecular chaperone without a cooperative chaperone system. Pneumococcal ClpL and ClpP are highly induced ... For instance, pneumococcal ClpL is a very promising chaperone system that does not require co-chaperones, but the chaperone ... Protein Expression via the Molecular Chaperone ClpL Hyog Young Kwon1, Sang-Sang Park2, Mohammad Farid Zia1and Dong-Kwon Rhee2* ... the addition of individual chaperones or chaperone sets may boost the availability of chaperones and help solubilize target ...
https://www.omicsonline.org/open-access/protein-expression-via-the-molecular-chaperone-clpl-1948-5948-1000266.php?aid=72812
*  Molecular chaperone therapy - Wikipedia
Molecular chaperone therapy is one of the latest pharmacological approaches to lysosomal storage diseases. It fixes defective ... These chaperones are minute molecules that can enter the central nervous system ( via Blood Brain Barrier). Once in the CNS, ...
https://en.wikipedia.org/wiki/Molecular_chaperone_therapy
*  RCSB PDB - Protein Feature View - BAG family molecular chaperone regulator 1 - Q99933 (BAG1 HUMAN)
Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP ... Forms a heteromeric complex with HSP70/HSC70 (PubMed:9305631). Binds to the ATPase domain of HSP/HSC70 chaperones. Isoform 1, ...
http://www.rcsb.org/pdb/protein/Q9Y2V4
*  The collagen-specific molecular chaperone HSP47: is there a role in fibrosis? - PubMed - NCBI
Heat shock protein 47 (HSP47) is a collagen-specific molecular chaperone that is required for molecular maturation of various ... The collagen-specific molecular chaperone HSP47: is there a role in fibrosis?. Taguchi T1, Razzaque MS. ... Because HSP47 is a specific chaperone for collagen synthesis, it provides a selective target to manipulate collagen production ...
https://www.ncbi.nlm.nih.gov/pubmed/17169614?dopt=Abstract
*  Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis.
... Yoshida S., ... this mitochondrial molecular chaperone may act as a tumor suppressor.. Proc. Natl. Acad. Sci. U.S.A. 110:E1604-E1612(2013) [ ... TRAP1 (TNF receptor-associated protein), a member of the HSP90 chaperone family, is found predominantly in mitochondria. TRAP1 ... is broadly considered to be an anticancer molecular target. However, current inhibitors cannot distinguish between HSP90 and ...
http://www.uniprot.org/citations/23564345
*  UMass Amherst Study Demonstrates 'Tunability' of a Molecular Chaperone | Office of News & Media Relations | UMass Amherst
... molecular biologists studying a class of molecular chaperones known as heat shock proteins (Hsp70s) have relied on the Hsp70s ... For decades, molecular biologists studying a class of molecular chaperones known as heat shock proteins (Hsp70s) have relied on ... UMass Amherst Study Demonstrates 'Tunability' of a Molecular Chaperone November 9, 2018 ... Molecular chaperones help cells to maintain healthy proteins by assisting newly synthesized proteins to fold to their ...
https://www.umass.edu/newsoffice/article/umass-amherst-study-demonstrates-