RCSB PDB - 4GS6: Irreversible Inhibition of TAK1 Kinase by 5Z-7-Oxozeaenol
Irreversible Inhibition of TAK1 Kinase by 5Z-7-Oxozeaenol ... a member of the mitogen-activated protein kinase kinase kinase ... Transforming growth factor-β activated kinase-1 (TAK1) is ... Tak1-Tab1 fusion protein. A. 315. Homo sapiens. Mutation(s): 0 ... Here, we show that, in addition to its kinase activity, TAK1 has intrinsic ATPase activity, that (5Z)-7-Oxozeaenol irreversibly ... Detailed biochemical characterization revealed that (5Z)-7-Oxozeaenol inhibited both the kinase and the ATPase activity of TAK1 ...
RCSB PDB - 3MW1: p38 kinase Crystal structure in complex with small molecule inhibitor
p38 kinase Crystal structure in complex with small molecule inhibitor ... Mitogen-activated protein kinase 14. A. 359. Homo sapiens. Mutation(s): 0 Gene Names: MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2, ... 1,7-Naphthyridine 1-Oxides as Novel Potent and Selective Inhibitors of p38 Mitogen Activated Protein Kinase. Lumeras, W., Vidal ... The design, synthesis, and ability to inhibit p38α MAP kinase by a novel series of naphthyridine N-oxides will be described. ...
RCSB PDB - 3G9N: JNK3 bound to (Z)-1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)-4-phenylindolin-2-one
Mitogen-activated protein kinase 10. A. 365. Homo sapiens. Mutation(s): 0 Gene Names: JNK3, JNK3A, MAPK10, PRKM10, SAPK1B. EC: ... A series of N-benzylated isatin oximes were developed as inhibitors of the mitogen-activated kinase, JNK3. X-ray ... Structure-based design and parallel synthesis of N-benzyl isatin oximes as JNK3 MAP kinase inhibitors.. Cao, J., Gao, H., Bemis ... but not p38 MAP kinase and provided key insights into understanding the behavior of gatekeeper residue methionine-146 in ...
data 4DLJ
MAX-interacting protein 2, Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Stress-activated protein kinase 2a ... Mitogen-activated protein kinase 14 41269.055 1 2.7.11.24 ? ? ? 2 non-polymer syn 2-phenyl-N~4~-(2-phenylethyl)quinazoline-4, ... MAP kinase 14, MAPK 14, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAP kinase ... Fluorophore labeled kinase detects ligands that bind within the MAPK insert of p38alpha kinase. _citation.journal_abbrev Plos ...
data 3BV2
Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Cytokine suppressive anti-inflammatory drug-binding protein, ... Mitogen-activated protein kinase 14 (E.C.2.7.11.24) _struct.pdbx_model_details ? _struct.pdbx_CASP_flag ? _struct.pdbx_model_ ... Mitogen-activated protein kinase 14 42105.004 1 2.7.11.24 ? ? ? 2 non-polymer syn ;5-methyl-4-[(2-methyl-5-{[(2-morpholin-4- ... SERINE/THREONINE-PROTEIN KINASE, KINASE, TRANSFERASE, P38 MAP KINASE, Alternative splicing, ATP-binding, Cytoplasm, Nucleotide- ...