"The mitochondrial elongation factors MIEF1 and MIEF2 exert partially distinct functions in mitochondrial dynamics". Exp. Cell ... 3. Fenton, Adam R.; Jongens, Thomas A.; Holzbaur, Erika L. F. (2021-02-01). "Mitochondrial dynamics: Shaping and remodeling an ... Fenton, Adam R.; Jongens, Thomas A.; Holzbaur, Erika L. F. (2021-02-01). "Mitochondrial dynamics: Shaping and remodeling an ... This gene encodes an outer mitochondrial membrane protein that functions in the regulation of mitochondrial morphology. It can ...

On the other hand, regulation of mitochondrial dynamics is essential for CNS health maintenance and leading to the induction of ... Here, we discuss the importance of these mitochondrial dynamics during neuroinflammation, and how they correlate either with ... Here, we discuss the importance of these mitochondrial dynamics during neuroinflammation, and how they correlate either with ... regulation of mitochondrial dynamics is essential for CNS health maintenance and leading to the induction of IL-10 and ...

MSC co-culture of skin fibroblasts from mitochondrial disease patients rescued aberrant mitochondrial morphology from a fission ... MSC co-culture with skin fibroblasts from mitochondrial disease patients rescued aberrant mitochondrial morphology from a ... In vivo experiments confirmed mitochondrial abundance and mitochondrial oxygen consumption rates were elevated in host tissues ... In vivo experiments confirmed mitochondrial abundance and mitochondrial oxygen consumption rates were elevated in host tissues ...

Understanding the molecular mechanisms controlling mitochondrial dynamics is crucial to decipher how mitochondrial shape meets ... apoptosis and mitochondrial quality control. Mutations in the core machinery components and defects in mitochondrial dynamics ... Mitochondrial fusion is driven by a two-step process with the outer mitochondrial membrane fusion mediated by mitofusins 1 and ... mitochondrial dynamics, in order to maintain their shape, distribution and size. Their transient and rapid morphological ...

... subclones that can evolve over time along with changes in accessible chromatin and gene expression profiles to capture dynamics ... Longitudinal Single-Cell Dynamics of Chromatin Accessibility and Mitochondrial Mutations in Chronic Lymphocytic Leukemia Mirror ... We employ mitochondrial single-cell assay for transposase-accessible chromatin with sequencing to profile 163,279 cells from 9 ... While cancers evolve during disease progression and in response to therapy, temporal dynamics remain difficult to study in ...

We conclude that E2 regulates mitochondrial dynamics to maintain the mitochondrial network promoting mitochondrial fusion and ... Oestrogenic Regulation of Mitochondrial Dynamics. International Journal of Molecular Sciences , 23 (3) , Article 1118. 10.3390/ ... More recently, it has become apparent that E2 also regulates mitochondrial fusion-fission dynamics, thereby affecting cellular ... is to discuss the regulatory pathways by which E2 orchestrates the activity of several components of mitochondrial dynamics in ...

Monitoring calcium and mitochondrial dynamics in primary rodent neurons grown over two weeks in the multi-curvature patterns, ... Multi-curvature micropatterns unveil distinct calcium and mitochondrial dynamics in neuronal networks H. Khan, C. Beck and A. ... Multi-curvature micropatterns unveil distinct calcium and mitochondrial dynamics in neuronal networks† ...

The mitochondrial cascade hypothesis of dementia assumes mitochondrial dysfunction leading to reduced energy supply, impaired ... These effects go parallel with improvement of impaired mitochondrial dynamics shifting back fission and fusion balance to the ... Enhanced Neuroplasticity by the Metabolic Enhancer Piracetam Associated with Improved Mitochondrial Dynamics and Altered ... The mitochondrial cascade hypothesis of dementia assumes mitochondrial dysfunction leading to reduced energy supply, impaired ...

These mitochondrial defects can be widely rescued by Cdk5 inhibition with roscovitine or Cdk5 knockdown with siRNA transfection ... Altogether, our findings support the hypothesis that Cdk5 plays a crucial role in mitochondrial defects involved in the ... Cyclin-dependent kinase 5 is an upstream regulator of mitochondrial fission during neuronal apoptosis. Cell Death Differ 2007; ... whether this aberrant Cdk5 signalling contributes to the striatal neurodegeneration by altering mitochondrial dynamics ...

Utilizing a small molecule mitochondrial fission inhibitor, mitochondrial division inhibitor-1, the results so far have ... non-invasive intervention strategy to mitigate a primary cause of loud-sound induced hearing loss mitochondrial dysfunction and ... demonstrated that inhibition of the mitochondrial fission process significantly attenuates NIHL and reduces damage to the ... Utilizing a small molecule mitochondrial fission inhibitor, mitochondrial division inhibitor-1, the results so far have ...

... mediated by mitochondrial respiration in Brown Adipose Tissue (BAT), is important for defense against cold and maintenance of ... 1959-P: Sel1l-Hrd1 ER-Associated Degradation (ERAD) Controls Mitochondrial Dynamics, ER-Mitochondrial Dynamics, and ER- ... Controls Mitochondrial Dynamics, ER-Mitochondrial Dynamics, and ER-Mitochondria Contacts in Brown Adipocytes. Diabetes 1 June ... we show that the Sel1L-Hrd1 ERAD complex is essential for cold-induced thermogenesis in part by managing mitochondrial dynamics ...

Mitochondrial dynamics are particularly critical to neurons, and the vulnerable neurons in PD may be especially dependent on ... Thus, there is a critical need to understand neuron-specific regulation of mitochondrial dynamics and how this is altered in PD ... In addition, we found early alterations in mitochondrial dynamics in neurons in a chronic neurotoxic PD-relevant model, and we ... We and others have found differences in regulation of mitochondrial dynamics in neurons and have found that differences in ...

Fuel oxidation under the control of mitochondrial shape and dynamics.. Erin L Seifert, György Hajnóczky. EMBO Journal 2023 May ... How mitochondrial shape and substrate-specific metabolism are related has been a difficult question to address. Here, new work ... supporting a novel role for mitochondrial fission products as β-oxidation hubs. ... by Ngo et al (2023) reports that mitochondrial shape-long versus fragmented-determines the activity of β-oxidation of long- ...

Moreover, viral proteins can bind to mitochondrial complexes, disrupting mitochondrial function and causing the immune cells to ... It is important to note that the roles of mitochondrial damage and inflammatory responses caused by SARS-CoV-2 in the ... Targeting mitochondrial function may provide promising new clinical approaches for long-COVID patients; however, further ... One of the underlying mechanisms of long COVID may be mitochondrial dysfunction. Severe acute respiratory syndrome coronavirus ...

To address this issue, we used a mouse model that enabled direct measurement of cytosolic and mitochondrial ATP levels. ... The SGLT2 inhibitor, Empagliflozin, is shown to exert cardioprotective effects by increasing mitochondrial ATP in a mouse model ... Empagliflozin treatment significantly increased cytosolic and mitochondrial ATP levels in the hearts of db/db mice. ... findings suggest that empagliflozin enters cardiac mitochondria and directly causes these effects by increasing mitochondrial ...

Biphasic effect of sulforaphane on angiogenesis in hypoxia via modulation of both Nrf2 and mitochondrial dynamics. In: Food & ... Biphasic effect of sulforaphane on angiogenesis in hypoxia via modulation of both Nrf2 and mitochondrial dynamics. Food & ... Biphasic effect of sulforaphane on angiogenesis in hypoxia via modulation of both Nrf2 and mitochondrial dynamics. Yaqian Wang ... Biphasic effect of sulforaphane on angiogenesis in hypoxia via modulation of both Nrf2 and mitochondrial dynamics. / Wang, ...

MITOchondrial DYNamics variation portal. The ACO2 gene homepage - Variation OPA1 mutation database. ...

Mitochondrial dynamics. Mitochondria divide and fuse dynamically, and our aim is to unravel the physical and physiological ... We are fascinated by mitochondrial fission, fusion, growth, transport, and network topology, and how they contribute to energy ... By quantifying the dynamic geometry of mitochondrial constrictions, we extract the energies and forces required for division ... Furthermore, we are investigating the metabolic and bioenergetic changes associated with mitochondrial division on a single- ...

To address this shortcoming, we developed tools to study mitochondrial dynamics in vivo in optically accessible zebrafish. We ... While in vitro studies have greatly expanded our knowledge of mitochondrial dynamics, our understanding in vivo remains limited ... In Vivo Imaging of Disease-Related Mitochondrial Dynamics in a Vertebrate Model System. ... of mitochondria and allows identifying pharmacological and genetic modulators of mitochondrial dynamics. Furthermore we ...

Opa1(enu/+) mice show a slow progressive loss of RGCs, activation of astroglia and microglia, and pronounced mitochondrial ... Optic atrophy gene 1 (OPA1) is an inner membrane protein important for mitochondrial fusion. Autosomal dominant optic atrophy ( ... Our results conclusively demonstrate that not only glutamate excitotoxicity and/or oxidative stress alters mitochondrial ... fission/fusion, but that an imbalance in mitochondrial fission/fusion in turn leads to NMDA receptor upregulation and oxidative ...

... PubMed, SCI ... This protein is crucial for mitochondrial dynamics and is involved mainly in the processes of mitochondrial fusion and ... The continuous process of fusion and fission, underlying mitochondrial dynamics, is crucial for the maintenance of the shape, ... Mitochondrial dynamics: Shaping and remodeling an organelle Curr Opin Cell Biol 68 (2021): 28-36. ...

Imaging Reversible Mitochondrial Membrane Potential Dynamics with a Masked Rhodamine Voltage Reporter.. Klier, Pavel E Z; ... Once within mitochondria, esterases remove the AM ester, trapping RhoVR inside of the mitochondrial matrix, where it can ... This negative membrane potential across the inner mitochondrial membrane (ΔΨm) represents a fundamental biophysical parameter ... artifacts and the requirement to maintain dye in the extracellular solution to visualize reversible ΔΨm dynamics. Here, we ...

Among the putative mRNA targets of CAR-1, we characterized the roles of micu-1, a regulator of the mitochondrial calcium ... Our data uncover a novel pathway that controls axon regrowth through axonal mitochondrial calcium uptake. ... the axonal mitochondrial calcium influx is more sustained, which likely underlies enhanced axon regrowth. ... The mRNA Decay Factor CAR-1/LSM14 Regulates Axon Regeneration via Mitochondrial Calcium Dynamics. .avatar img { max-width: 100 ...

Mitochondria dynamics and metabolism regulate species-specific features of human brain development. ... MRC Mitochondrial Biology Unit Seminars. Add to your list(s) Send you e-mail reminders Further detail Subscribe using ical/vcal ...

... neurons from patients with Lewy-body pathology revealed a deficiency in nuclear-encoded genes for mitochondrial respiration, ... it caused reductions in genes involved in synaptic and mitochondrial function and autophagy. Altogether, these experiments ... Many studies implicate mitochondrial dysfunction as a key contributor to cell loss in Parkinson disease (PD). Previous analyses ... DAergic neurons in adult mice was sufficient to cause a levodopa-responsive PD-like phenotype with reductions in mitochondrial ...

Decreased mitochondrial dynamics (Lenaz et al. 2006).. *Increased mitochondrial morphology/ abnormal distribution (Wang et al. ... Mitochondrial/bioenergetics. Mitochondria are a primary source of cellular energy that supports the formation of lipids, ... Decreased mitochondrial nuclear-coded proteins (Liang et al. 2008).. *Increased oxidative stress - increased protein oxidation ... Numerous drugs have been developed in oncology targeting inhibition of mitochondria to force the cell to use non-mitochondrial ...

The role of alterations in mitochondrial dynamics and PGC-1α over-expression in fast muscle atrophy following hindlimb ... Mitochondrial fusion and fission have emerged as important processes that govern mitochondrial function and PGC-1α may regulate ... Mitochondrial fusion and fission have emerged as important processes that govern mitochondrial function and PGC-1α may regulate ... it is also becoming evident that mitochondrial dysfunction may play a causative role in determining muscle atrophy. ...

p53 regulates mitochondrial dynamics by inhibiting Drp1 translocation into mitochondria during cellular senescence. ...

Analysis of mitochondrial dynamics and function in the retinal pigment epithelium by high-speed high-resolution live imaging. ... Video1_Analysis of mitochondrial dynamics and function in the retinal pigment epithelium by high-speed high-resolution live ... Video1_Analysis of mitochondrial dynamics and function in the retinal pigment epithelium by high-speed high-resolution live ... Here, we demonstrate the advantages of live imaging to investigate RPE mitochondrial dynamics in cell-based and mouse models. ...

Left-Ventricular Dysfunction in Male Obese Insulin-Resistant Rats via Impairing Cardiac Mitochondrial Function and Dynamics ... Left-Ventricular Dysfunction in Male Obese Insulin-Resistant Rats via Impairing Cardiac Mitochondrial Function and Dynamics ... aggravates LV dysfunction and cardiac autonomic imbalance via the impairment of cardiac mitochondrial function and dynamics ...