Angiotensin Receptor Blocker Prevented β-Amyloid-Induced Cognitive Impairment Associated With Recovery of Neurovascular...
Isolation of Brain Microvessels and Immunocytochemical Staining. Mouse brain microvessels were isolated and characterized as ... Figure 2. ROS production in brain microvessels assessed by DHE staining. A, Isolated cerebral microvessels were stained for ... B and C, The increased ROS signal in brain microvessels of young APP23 mice was attenuated by treatment with olmesartan (1.0 mg ... Olmesartan Improved Neurovascular Dysfunction and Decreased ROS in Brain Microvessels in Young APP23 Mice. With the view of ...http://hyper.ahajournals.org/content/54/6/1345.long
Properties of angiotensin-converting enzyme in intact cerebral microvessels. | Hypertension
Properties of angiotensin-converting enzyme in intact cerebral microvessels.. P Brecher, A Tercyak, A V Chobanian ... Angiotensin I was rapidly degraded by the intact microvessels, even in the presence of 10(-6)M captopril. An advantage of the ... The ability to measure ACE activity of the microvessels in vitro provides a unique opportunity to study the properties of the ... Activity was determined by measuring the degradation of hippuryl-histidyl-leucine (Hip-His-Leu) by the intact microvessels in a ...http://hyper.ahajournals.org/content/3/2/198
The endothelium partially obscures enhanced microvessel reactivity in DOCA hypertensive rats. | Hypertension
The endothelium partially obscures enhanced microvessel reactivity in DOCA hypertensive rats.. C M King, R C Webb ...http://hyper.ahajournals.org/content/12/4/420
Clinical Implications | Hypertension
... a structural decrease in microvessels. In addition to impairing angiogenesis, VSP inhibitors also impair formation of lymph ...http://hyper.ahajournals.org/content/69/5/739
Ryanodine Receptor Type 2 Is Required for the Development of Pressure Overload-Induced Cardiac Hypertrophy | Hypertension
Coronary microvessel density and vascular endothelial growth factor (VEGF) expression in the heart. A, Coronary microvessel ...http://hyper.ahajournals.org/content/58/6/1099
Pulmonary Hypertension | Hypertension
Microvessel Mechanobiology in Pulmonary Arterial HypertensionCause and Effect Nathaniel C. Bloodworth, James D. West and W. ...http://hyper.ahajournals.org/collection/pulmonary-hypertension
Contribution of Central Nervous System Endothelial Nitric Oxide Synthase to Neurohumoral Activation in Heart Failure Rats |...
Arrows point to typical examples of staining in rounded, coronally cut microvessels. E, Summary data showing a diminished ... microvessels, and oxytocin neurons. Confocal images were obtained and a densitometry analysis was used to compare eNOS ... it did not overlap with endothelial cells but rather with processes in contact with the abluminal side of the microvessels. ... ensues that eNOS-derived NO from either astrocytes or microvessels contributes to NO availability and actions in nearby neurons ...http://hyper.ahajournals.org/content/58/3/454
Low Concentrations of Sphingosylphosphorylcholine Enhance Pulmonary Artery Vasoreactivity | Hypertension
Sphingosine-1-phosphate and sphingosylphosphorylcholine constrict renal and mesenteric microvessels in vitro. Br J Pharmacol. ...http://hyper.ahajournals.org/content/51/2/239
Fate of Renin Cells During Development and Disease | Hypertension
Renin release and gene expression in intact rat kidney microvessels and single cells. J Clin Invest. 1990;86:169-175. doi: ...http://hyper.ahajournals.org/content/69/3/387
Nifedipine Increases Endothelial Nitric Oxide Bioavailability by Antioxidative Mechanisms | Hypertension
Amlodipine promotes kinin-mediated nitric oxide production in coronary microvessels of failing human hearts. Am J Cardiol. 1999 ... Amlodipine releases nitric oxide from canine coronary microvessels: an unexpected mechanism of action of a calcium channel- ... This may be explained by species differences or the different preparation, especially of the microvessels (sequential- ... production in microvessels and macrovessels of dog hearts (acute addition of the DHP). This increase could be abolished with ...http://hyper.ahajournals.org/content/37/2/240
Impaired Prostaglandin E2/Prostaglandin I2 Receptor-Gs Protein Interactions in Isolated Renal Resistance Arterioles of...
Multiple aliquots of microvessels (40 μg of protein) were incubated at room temperature in a final volume of 0.25 mL of buffer ... G protein mRNA expression in renal microvessels from spontaneously hypertensive and Wistar-Kyoto rats. Am J Physiol. 1997;273: ... Western blots demonstrated the presence of 3 classes of G-protein families in preglomerular microvessels. Figure 2⇓ (top) shows ... E2 revealed 1 receptor class in renal microvessels; PGE2 receptor density was similar in SHR and WKY (106 versus 115 fmol/mg; P ...http://hyper.ahajournals.org/content/34/5/1134
Oxidative Stress Contributes to Sex Differences in Blood Pressure in Adult Growth-Restricted OffspringNovelty and Significance ...
Gender differences in superoxide generation in microvessels of hypertensive rats: role of NAD(P)H-oxidase. Cardiovasc Res. 2004 ... male spontaneously hypertensive rats exhibit higher levels of oxidative stress in microvessels as compared with female ...http://hyper.ahajournals.org/content/60/1/114
Heme Oxygenase Attenuates Angiotensin II-Mediated Increase in Cyclooxygenase-2 Activity in Human Femoral Endothelial Cells |...
Regulation of cyclooxygenase by the heme-heme oxygenase system in microvessel endothelial cells. J Pharmacol Exp Ther. 2002; ... A previous study in rabbit coronary microvessel endothelial cells demonstrated that upregulation of HO-1 leading to reduction ... Arachidonic acid and prostaglandin endoperoxide metabolism in isolated rabbit and coronary microvessels and isolated and ... cultivated coronary microvessel endothelial cells. J Clin Invest. 1983; 72: 1658-1671. ...http://hyper.ahajournals.org/content/41/3/715
Deletion of G Protein-Coupled Estrogen Receptor Increases Endothelial Vasoconstriction | Hypertension
Influence of female sex hormones on endothelium-derived vasoconstrictor prostanoid generation in microvessels of spontaneously ...http://hyper.ahajournals.org/content/59/2/507
Continuous Activation of Renin-Angiotensin System Impairs Cognitive Function in Renin/Angiotensinogen Transgenic Mice |...
AT1 receptor blockade regulates the local angiotensin II system in cerebral microvessels from spontaneously hypertensive rats. ... Angiotensin II AT1 blockade reverses pathological hypertrophy and inflammation in brain microvessels of spontaneously ...http://hyper.ahajournals.org/content/53/2/356
Metformin Reverses Development of Pulmonary Hypertension via Aromatase InhibitionNovelty and Significance | Hypertension
Aryl hydrocarbon receptor-dependent upregulation of Cyp1b1 by TCDD and diesel exhaust particles in rat brain microvessels. ...http://hyper.ahajournals.org/content/68/2/446
Effects of Human Renin in the Vasculature of Rats Transgenic for Human Angiotensinogen | Hypertension
Absence of renin-like activity in rat aorta and microvessels. Hypertension. 1983;5:635-641. ...http://hyper.ahajournals.org/content/26/2/272
Indigo Carmine Inhibits Endothelium-Dependent and -Independent Vasodilation | Hypertension
In vivo effect of methylene blue on endothelium-dependent and endothelium-independent dilations of brain microvessels in mice. ...http://hyper.ahajournals.org/content/27/2/228
Hypertension Correlates With Lenticulostriate Arteries Visualized by 7T Magnetic Resonance Angiography | Hypertension
... in vivo imaging of cerebral microvessels, like the LSAs, using ultrahigh-field MRI, such as 7T.9,10 However, in our previous ... resulting in high vascular resistance and reduced blood flow through the microvessels.2 Given the relatively high blood flow ... visualize angiographically because of a decrease in signal intensity attributed to reduced blood flow through the microvessels ...http://hyper.ahajournals.org/content/54/5/1050
Upregulation of Vascular Arginase in Hypertension Decreases Nitric Oxide-Mediated Dilation of Coronary Arterioles | Hypertension
30-32 including human coronary microvessels.33 Collectively, these results suggest that l-arginine can be a limiting factor for ... and the heart was fibrillated and excised for coronary microvessel isolation. ... agonist-stimulated NO synthesis in coronary microvessels and that arginase expressed in the endothelium can compete with NOS ...http://hyper.ahajournals.org/content/44/6/935
Association of Maternal Antiangiogenic Profile at Birth With Early Postnatal Loss of Microvascular Density in Offspring of...
Degree of microvessel loss was predicted by the vasculogenic capacity of their endothelial cells at birth, which, in turn, ... Degree of postnatal microvessel reduction is proportional to levels of antiangiogenic factors in the maternal circulation at ... Maternal and fetal characteristics of the samples used for microvessel tube Matrigel measures are presented in Tables 1 and 2. ... There was a graded relationship between maternal sFlt-1 level and offspring microvessel loss between birth and 3 months (Figure ...http://hyper.ahajournals.org/content/68/3/749
Contribution of 20-HETE to Augmented Myogenic Constriction in Coronary Arteries of Endothelial NO Synthase Knockout Mice |...
Regulation of coronary diameter by myogenic mechanisms in arterial microvessels ,100 microns in diameter. Am J Physiol. 1995; ... Smooth muscle-specific expression of CYP4A1 induces endothelial sprouting in renal arterial microvessels. Circ Res. 2004; 94: ...http://hyper.ahajournals.org/content/46/3/607
Differential Regulation of Elevated Renal Angiotensin II in Chronic Renal Ischemia | Hypertension
Hayashi K, Epstein M, Loutzenhiser R. Pressure-induced vasoconstriction of renal microvessels in normotensive and hypertensive ... renal microvessels tended to dilate in response to CS866 (afferent: from 16.0±0.3 to 16.9±0.5 μm, P=0.15, n=4; efferent: from ... 17 Sequential images of renal microvessels were captured with a computer with a freeze-frame modality, and the density in the ...http://hyper.ahajournals.org/content/40/1/34
Hypertension Accelerates the Progression of Alzheimer-Like Pathology in a Mouse Model of the DiseaseNovelty and Significance |...
Cortical microvessels of AD&HT mice were less abundant and less branched than those of animals of the 3 other groups (Figure 2A ... Microvessel density quantification using an Archimed software demonstrates a significant decrease in the area occupied by ... Quantification of amyloid deposits colocalized with microvessels reveals a significantly higher CAA in the cortex and ... At the early stage of the disease, Alzheimer pathology stimulates cerebral angiogenesis and increases cortical microvessel ...http://hyper.ahajournals.org/content/65/1/218
Inactivation of Nitric Oxide Synthesis Exacerbates the Development of Alzheimer Disease Pathology in APPPS1 Mice (Amyloid...
Thioflavin S-positive deposits colocalized with cortical microvessels were significantly more numerous in AD-l-NAME mice than ... the percentage of amyloid plaques associated with collagen IV-positive microvessels was quantified in the cortex, medial ...http://hyper.ahajournals.org/content/70/3/613