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*  Liver Microsomes, S9 Fractions and Cytosol | Thermo Fisher Scientific - US
... microsomes & other liver subcellular fractionsLarge pooled lots for reproducible, long-term studiesFractions carefully isolated ... Table 1. Relevant applications for liver subcellular fractions.. Metabolic Enzymes. Liver Microsomes. Liver S9 Fractions. Liver ... Table 3. Kinetic parameters for the Gibco 50 donor human liver microsome pool.. Isoform. Metabolite. Km(μM). Vmax (nmol/min/mg) ... 11 specialty human liver microsome pools. Prepared with 5 to 20 donors each and pooled for your convenience according to age, ...
https://www.thermofisher.com/us/en/home/industrial/pharma-biopharma/drug-discovery-development/microsomes-s9-fractions-cytosol.html
*  Liver Microsomes, S9 Fractions and Cytosol | Thermo Fisher Scientific - JP
... microsomes & other liver subcellular fractionsLarge pooled lots for reproducible, long-term studiesFractions carefully isolated ... Table 1 - Relevant applications for liver subcellular fractions Metabolic Enzymes Liver Microsomes Liver S9 Fractions Liver ... Table 3 - Kinetic parameters for the GIBCO® 50 donor human liver microsome pool Isoform Metabolite Km(μM) Vmax (nmol/min/mg) ... Human microsome pools and subcellular fractions Subcellular fractions, derived from the endoplasmic reticulum of liver, contain ...
https://www.thermofisher.com/jp/en/home/industrial/pharma-biopharma/drug-discovery-development/microsomes-s9-fractions-cytosol.html
*  Metabolism of 4′-(9-Acridinylamino)methanesulfon-m-anisidide by Rat Liver Microsomes | Cancer Research
Metabolism of 4′-(9-Acridinylamino)methanesulfon-m-anisidide by Rat Liver Microsomes. D. D. Shoemaker, R. L. Cysyk, P. E. ... Metabolism of 4′-(9-Acridinylamino)methanesulfon-m-anisidide by Rat Liver Microsomes ... Metabolism of 4′-(9-Acridinylamino)methanesulfon-m-anisidide by Rat Liver Microsomes ... Metabolism of 4′-(9-Acridinylamino)methanesulfon-m-anisidide by Rat Liver Microsomes ...
http://cancerres.aacrjournals.org/content/44/5/1939.short
*  JCI - Markedly inhibited 7-dehydrocholesterol-delta 7-reductase activity in liver microsomes from Smith-Lemli-Opitz homozygotes.
Markedly inhibited 7-dehydrocholesterol-delta 7-reductase activity in liver microsomes from Smith-Lemli-Opitz homozygotes.. S ... Thus, lathosterol 5-dehydrogenase is equally active which indicates that homozygotes liver microsomes are viable. Accordingly, ... 7-dehydrocholesterol into cholesterol by liver microsomes from seven controls and four Smith-Lemli-Opitz homozygous subjects. ... that is catalyzed by lathosterol-5-dehydrogenase was equally rapid in controls and homozygotes liver microsomes (120 +/- 8 vs ...
https://www.jci.org/articles/view/118223
*  Gemfibrozil Inhibits CYP2C8-Mediated Cerivastatin Metabolism in Human Liver Microsomes | Drug Metabolism & Disposition
... in human liver microsomes. B, a double-reciprocal plot obtained from a 20-min incubation of human liver microsomes with NADPH ... before the reaction was initiated with human liver microsomes (0.1 mg/ml) or preincubated with human liver microsomes and NADPH ... Pooled human liver microsomes (prepared from five male, and five female human liver microsomal samples) were obtained from BD ... In human liver microsomes, gemfibrozil markedly inhibited M-23 formation, with aKi (IC50) value of 69 (95) μM, whereas ...
http://dmd.aspetjournals.org/content/30/12/1352?ijkey=e7bde4e2a51e586b0a5c2bb8e243a60bc4e7df4b&keytype2=tf_ipsecsha
*  Response of Phospholipid Metabolism to Thiram in Rat Liver Microsomes | Springer for Research & Development
Incorporation of 14C into the phospholipid components of the liver microsomes isolated by a conventional method was determined ... Leyck S., Freundt K.J. (1978) Response of Phospholipid Metabolism to Thiram in Rat Liver Microsomes. In: Deutsche ... strongly with an inhibition of MFO as shown by a decrease in the O-demethylation of p-nitroanisol in prepared liver microsomes ... After 16 h the livers were subjected to extracorporeal perfusion for 1 h, the perfusate containing ca. 10 μCi u 14C glucose/100 ...
https://rd.springer.com/chapter/10.1007/978-3-662-39532-5_76
*  Metabolism of thioacetamide and thioacetamide S-oxide by rat liver microsomes. | Drug Metabolism & Disposition
Metabolism of thioacetamide and thioacetamide S-oxide by rat liver microsomes.. W R Porter and R A Neal ... Metabolism of thioacetamide and thioacetamide S-oxide by rat liver microsomes.. W R Porter and R A Neal ... Metabolism of thioacetamide and thioacetamide S-oxide by rat liver microsomes.. W R Porter and R A Neal ... Metabolism of thioacetamide and thioacetamide S-oxide by rat liver microsomes. Message Subject (Your Name) has forwarded a page ...
http://dmd.aspetjournals.org/content/6/4/379
*  Determination of the inhibitory potential of 6 fluoroquinolones on CYP1A2 and CYP2C9 in human liver microsomes - ZHANG - 2008 -...
If you are a society or association member and require assistance with obtaining online access instructions please contact our Journal Customer Services team ...
http://onlinelibrary.wiley.com/doi/10.1111/j.1745-7254.2008.00908.x/pdf
*  Propofol Hydroxylation by Dog Liver Microsomes: Assay Development and Dog Breed Differences | Drug Metabolism & Disposition
Liver Microsomes.. The liver tissue used in this study was obtained from mature male greyhound, beagle, and mixed-breed dogs ( ... Liver microsomes were diluted with phosphate buffer and 50 μl was added to each tube. Next, 100 μl of an NADPH-regenerating ... Propofol Hydroxylation by Dog Liver Microsomes: Assay Development and Dog Breed Differences. Michael H. Court, Bonnie L. Hay- ... Propofol Hydroxylation by Dog Liver Microsomes: Assay Development and Dog Breed Differences. Michael H. Court, Bonnie L. Hay- ...
http://dmd.aspetjournals.org/content/27/11/1293
*  In Vitro Metabolism of 17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin in Human Liver Microsomes | Drug Metabolism &...
human liver microsome. HPLC. high-performance liquid chromatography. LC-MS/MS. liquid chromatography-tandem mass spectrometry. ... In Vitro Metabolism of 17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin in Human Liver Microsomes. Nan Zheng, Peng Zou, ... In Vitro Metabolism of 17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin in Human Liver Microsomes. Nan Zheng, Peng Zou, ... In Vitro Metabolism of 17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin in Human Liver Microsomes. Nan Zheng, Peng Zou, ...
http://dmd.aspetjournals.org/content/39/4/627.short
*  6 alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes
... Araya, Z Uppsala ... Fourteen recombinant expressed cytochrome P450 (CYP) enzymes, human liver microsomes from different donors, and selective ... bile acid; 6 alpha-hydroxylation; CYP3A4; human liver; BILE-ACIDS; PIG-LIVER; METABOLISM; URINE; CYTOCHROME-P-450; ... The aim of the present study was to identify the enzymes in human liver catalyzing hydroxylations of bile acids. ...
http://uu.diva-portal.org/smash/record.jsf?pid=diva2:112787
*  AID 31223 - Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome - PubChem
BioAssay record AID 31223 submitted by ChEMBL: Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome.
https://pubchem.ncbi.nlm.nih.gov/bioassay/31223
*  Metabolism of Carfentanil, an Ultra-Potent Opioid, in Human Liver Microsomes and Human Hepatocytes by High-Resolution Mass...
Metabolism of fentanyl, a synthetic opioid analgesic, by human liver microsomes. Role of CYP3A4. Drug Metab Dispos. 1996;24(9): ... Metabolism of Carfentanil, an Ultra-Potent Opioid, in Human Liver Microsomes and Human Hepatocytes by High-Resolution Mass ... Metabolism of nicotine by human liver microsomes: stereoselective formation of trans-nicotine N'-oxide. Chem Res Toxicol. 1992; ... Metabolism and bioactivation of clozapine by human liver in vitro. J Pharmacol Exp Ther. 1995;272(3):984-90.PubMedGoogle ...
https://link.springer.com/article/10.1208/s12248-016-9963-5
*  Identification of Cytochrome P450 Isoforms Involved in CitalopramN-Demethylation by Human Liver Microsomes | Journal of...
Human liver microsomes.. Human liver samples (n = 14) were obtained, as excess material removed during surgery on the liver, ... Assay with human liver microsomes.. The basic incubation medium contained 0.1 or 0.2 mg/ml microsomes, 0.5 mM NADP+, 2.0 mM ... in human liver microsomes.. The immunoinhibition of CIT N-demethylation was examined by preincubating human liver microsomal ... Kinetic profile of CIT N-demethylation in human liver microsomes.. Eadie-Hofstee plots for the N-demethylation of CIT (2.5-500 ...
http://jpet.aspetjournals.org/content/280/2/927
*  Evaluation of metabolism dependent inhibition of CYP2B6 mediated bupropion hydroxylation in human liver microsomes by monoamine...
Evaluation of metabolism dependent inhibition of CYP2B6 mediated bupropion hydroxylation in human liver microsomes by monoamine ... Human liver microsomal CYP2B6 activities were investigated using bupropion hydroxylation as probe substrate marker. The results ... In conclusion, the results from this study demonstrated that MAO inhibitors can inactivate human liver microsomal CYP2B6. The ... study was to evaluate the metabolism dependent inhibition of CYP2B6 catalyzed bupropion hydroxylation in human liver microsomes ...
http://www.sigmaaldrich.com/catalog/papers/25656918
*  Biotransformation of tirilazad in human: 1. Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver...
Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes.. L C Wienkers, R C Steenwyk, P E ... Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes.. L C Wienkers, R C Steenwyk, P E ... Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes.. L C Wienkers, R C Steenwyk, P E ... Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes. ...
http://jpet.aspetjournals.org/content/277/2/982
*  Glucuronidation of Buprenorphine and Norbuprenorphine by Human Liver Microsomes and UDP-Glucuronosyltransferases | Bentham...
Glucuronidation of Buprenorphine and Norbuprenorphine by Human Liver Microsomes and UDP-Glucuronosyltransferases. Author(s): ... Yan Chang and David E. Moody, " Glucuronidation of Buprenorphine and Norbuprenorphine by Human Liver Microsomes and UDP- ... We investigated the enzyme kinetics of buprenorphine and norbuprenorphine glucuronidation in human liver microsomes and UDP- ... Abstract: We investigated the enzyme kinetics of buprenorphine and norbuprenorphine glucuronidation in human liver microsomes ...
http://www.eurekaselect.com/93402
*  Benzene Metabolism by Ethanol-, Acetone-, and Benzene-inducible Cytochrome P-450 (IIE1) in Rat and Rabbit Liver Microsomes |...
In the present investigation it was found that benzene was metabolized at a rate 20-65-fold higher in liver microsomes from ... The data indicate that benzene is metabolized mainly by the ethanol-inducible P-450 form in liver microsomes and that the ... Benzene Metabolism by Ethanol-, Acetone-, and Benzene-inducible Cytochrome P-450 (IIE1) in Rat and Rabbit Liver Microsomes. ... Benzene Metabolism by Ethanol-, Acetone-, and Benzene-inducible Cytochrome P-450 (IIE1) in Rat and Rabbit Liver Microsomes ...
http://cancerres.aacrjournals.org/content/48/19/5387
*  Isoniazid is a mechanism-based inhibitor of cytochrome P450 1A2, 2A6, 2C19 and 3A4 isoforms in human liver microsomes.
... ... METHODS: Using pooled human liver microsomes, the in vitro inhibitory effects of isoniazid on CYP1A2 (phenacetin O-deethylation ... CYP2C19 and CYP3A4 in human liver microsomes. Co-administration of isoniazid and drugs that are primarily metabolised by these ...
https://www.omicsonline.org/references/isoniazid-is-a-mechanismbased-inhibitor-of-cytochrome-p450-1a2-2a6-2c19-and-3a4-isoforms-in-human-liver-microsomes-1363160.html
*  Triptolide Induces hepatotoxicity via inhibition of CYP450s in Rat liver microsomes | BMC Complementary and Alternative...
We monitored the body weight, survival proportions, liver index, changes in pathology, and biochemical index upon TP ... we then carried out in vitro enzymatic studies in liver microsomal incubation systems via ultra-high performance liquid ... Liver lysates were made from livers of rats. b Protein lysates were made from microsomes of rats' liver and subjected to ... Preparation and appraisal of rat liver microsomes. Rat liver microsomes were obtained via differential centrifugation [22] (L- ...
https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-016-1504-3
*  AID 706454 - Metabolic stability in human liver microsomes assessed as compound remaining at 1 uM after 60 mins by HPLC-MS...
Metabolic stability in human liver microsomes assessed as compound remaining at 1 uM after 60 mins by HPLC-MS analysis. ...
https://pubchem.ncbi.nlm.nih.gov/bioassay/706454
*  In Vitro Glucuronidation of Thyroxine and Triiodothyronine by Liver Microsomes and Recombinant Human UDP...
In liver microsomes, phenolic glucuronidation was the highest in mice for T4 and in rats for T3 and lowest in monkeys for both ... In human liver microsomes, phenolic glucuronide was formed in higher amounts than acyl glucuronide for T4; in contrast, the ... Alamethicin (50 μg/mg protein) was mixed with liver microsomes for use in incubations. T4 or T3 in 5 μl of methanol was added ... To evaluate the effect of pH on the formation of T4 glucuronides, T4 was incubated with human liver microsomes at pH 6.8 and ...
http://dmd.aspetjournals.org/content/35/12/2203
*  Amlodipine Metabolism in Human Liver Microsomes and Roles of CYP3A4/5 in the Dihydropyridine Dehydrogenation | Drug Metabolism ...
human liver microsomes. LC. liquid chromatography. MH+. protonated molecular ions. MS. mass spectrometry. MSn. multiple stage ... Amlodipine Metabolism in Human Liver Microsomes and Roles of CYP3A4/5 in the Dihydropyridine Dehydrogenation. Yanlin Zhu, Fen ... Amlodipine Metabolism in Human Liver Microsomes and Roles of CYP3A4/5 in the Dihydropyridine Dehydrogenation ... in human liver microsomes (HLM), and to identify the cytochrome P450 (P450) enzyme(s) involved in the M9 formation. Liquid ...
http://dmd.aspetjournals.org/content/42/2/245
*  Tentative Identification of Benzo[a]pyrene Metabolite-Nucleoside Complexes Produced in Vitro by Mouse Liver Microsomes |...
Tentative Identification of Benzo[a]pyrene Metabolite-Nucleoside Complexes Produced in Vitro by Mouse Liver Microsomes. OLAVI ... Tentative Identification of Benzo[a]pyrene Metabolite-Nucleoside Complexes Produced in Vitro by Mouse Liver Microsomes. OLAVI ... Tentative Identification of Benzo[a]pyrene Metabolite-Nucleoside Complexes Produced in Vitro by Mouse Liver Microsomes. OLAVI ... When [3H]benzo[a]pyrene is incubated in vitro together with deproteinized salmon sperm DNA, NADPH, and mouse liver microsomes, ...
http://molpharm.aspetjournals.org/content/14/2/306