Ligand binding of safrole to cytochrome P-450.  - Surrey Research Insight Open AccessLigand binding of safrole to cytochrome P-450. - Surrey Research Insight Open Access

Microsomes, Liver, Protein Binding, Rats, Safrole ... of the safrole reactive intermediate with microsomes from ...
more infohttp://epubs.surrey.ac.uk/823390/

Liver Microsomes, S9 Fractions and Cytosol | Thermo Fisher Scientific - USLiver Microsomes, S9 Fractions and Cytosol | Thermo Fisher Scientific - US

... microsomes & other liver subcellular fractionsLarge pooled lots for reproducible, long-term studiesFractions carefully isolated ... Table 1. Relevant applications for liver subcellular fractions.. Metabolic Enzymes. Liver Microsomes. Liver S9 Fractions. Liver ... Table 3. Kinetic parameters for the Gibco 50 donor human liver microsome pool.. Isoform. Metabolite. Km(μM). Vmax (nmol/min/mg) ... 11 specialty human liver microsome pools. Prepared with 5 to 20 donors each and pooled for your convenience according to age, ...
more infohttps://www.thermofisher.com/us/en/home/industrial/pharma-biopharma/drug-discovery-development/microsomes-s9-fractions-cytosol.html

Metabolic Interaction of the Active Constituents of Coptis chinensis in Human Liver MicrosomesMetabolic Interaction of the Active Constituents of Coptis chinensis in Human Liver Microsomes

... in human liver microsomes. After incubation of the four constituents of ,i,Coptis chinensis,/i, in HLMs, the metabolism of the ... Human Liver Microsomes. HLMs used in this study were provided by the Research Institute for Liver Diseases Co. Ltd. (Shanghai, ... However, metabolic interaction of the herbal constituents of Rhizoma Coptidis alkaloid in human liver microsomes has not been ... Metabolic Interaction of the Active Constituents of Coptis chinensis in Human Liver Microsomes. ...
more infohttps://www.hindawi.com/journals/ecam/2015/802903/

Liver Microsomes, S9 Fractions and Cytosol | Thermo Fisher Scientific - JPLiver Microsomes, S9 Fractions and Cytosol | Thermo Fisher Scientific - JP

... microsomes & other liver subcellular fractionsLarge pooled lots for reproducible, long-term studiesFractions carefully isolated ... Table 1 - Relevant applications for liver subcellular fractions Metabolic Enzymes Liver Microsomes Liver S9 Fractions Liver ... Table 3 - Kinetic parameters for the GIBCO® 50 donor human liver microsome pool Isoform Metabolite Km(μM) Vmax (nmol/min/mg) ... Human microsome pools and subcellular fractions Subcellular fractions, derived from the endoplasmic reticulum of liver, contain ...
more infohttps://www.thermofisher.com/jp/en/home/industrial/pharma-biopharma/drug-discovery-development/microsomes-s9-fractions-cytosol.html

Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes.  - PubMed - NCBIRoles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes. - PubMed - NCBI

Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes.. Yamazaki H1, Inoue K, Hashimoto M, Shimada T. ... In liver microsomes of 16 human samples, nicotine C-oxidation activities were correlated with CYP2A6 contents at 10 microM ... Nicotine C-oxidation by recombinant human cytochrome P450 (P450 or CYP) enzymes and by human liver microsomes was investigated ... on the nicotine C-oxidation activities by human liver microsomes at 500 microM nicotine. CYP2D6 was found to have minor roles ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/10350185

Metabolism of 4′-(9-Acridinylamino)methanesulfon-m-anisidide by Rat Liver Microsomes | Cancer ResearchMetabolism of 4′-(9-Acridinylamino)methanesulfon-m-anisidide by Rat Liver Microsomes | Cancer Research

Metabolism of 4′-(9-Acridinylamino)methanesulfon-m-anisidide by Rat Liver Microsomes. D. D. Shoemaker, R. L. Cysyk, P. E. ... Metabolism of 4′-(9-Acridinylamino)methanesulfon-m-anisidide by Rat Liver Microsomes ... Metabolism of 4′-(9-Acridinylamino)methanesulfon-m-anisidide by Rat Liver Microsomes ... Metabolism of 4′-(9-Acridinylamino)methanesulfon-m-anisidide by Rat Liver Microsomes ...
more infohttp://cancerres.aacrjournals.org/content/44/5/1939.short

JCI -
Markedly inhibited 7-dehydrocholesterol-delta 7-reductase activity in liver microsomes from Smith-Lemli-Opitz homozygotes.JCI - Markedly inhibited 7-dehydrocholesterol-delta 7-reductase activity in liver microsomes from Smith-Lemli-Opitz homozygotes.

Markedly inhibited 7-dehydrocholesterol-delta 7-reductase activity in liver microsomes from Smith-Lemli-Opitz homozygotes.. S ... Thus, lathosterol 5-dehydrogenase is equally active which indicates that homozygotes liver microsomes are viable. Accordingly, ... 7-dehydrocholesterol into cholesterol by liver microsomes from seven controls and four Smith-Lemli-Opitz homozygous subjects. ... that is catalyzed by lathosterol-5-dehydrogenase was equally rapid in controls and homozygotes liver microsomes (120 +/- 8 vs ...
more infohttps://www.jci.org/articles/view/118223

Gemfibrozil Inhibits CYP2C8-Mediated Cerivastatin Metabolism in Human Liver Microsomes | Drug Metabolism & DispositionGemfibrozil Inhibits CYP2C8-Mediated Cerivastatin Metabolism in Human Liver Microsomes | Drug Metabolism & Disposition

... in human liver microsomes. B, a double-reciprocal plot obtained from a 20-min incubation of human liver microsomes with NADPH ... before the reaction was initiated with human liver microsomes (0.1 mg/ml) or preincubated with human liver microsomes and NADPH ... Pooled human liver microsomes (prepared from five male, and five female human liver microsomal samples) were obtained from BD ... In human liver microsomes, gemfibrozil markedly inhibited M-23 formation, with aKi (IC50) value of 69 (95) μM, whereas ...
more infohttp://dmd.aspetjournals.org/content/30/12/1352?ijkey=e7bde4e2a51e586b0a5c2bb8e243a60bc4e7df4b&keytype2=tf_ipsecsha

Characterization of cytochrome P-450 2B6 in human liver microsomes. | Drug Metabolism & DispositionCharacterization of cytochrome P-450 2B6 in human liver microsomes. | Drug Metabolism & Disposition

Characterization of cytochrome P-450 2B6 in human liver microsomes.. M Mimura, T Baba, H Yamazaki, S Ohmori, Y Inui, F J ... Characterization of cytochrome P-450 2B6 in human liver microsomes.. M Mimura, T Baba, H Yamazaki, S Ohmori, Y Inui, F J ... Characterization of cytochrome P-450 2B6 in human liver microsomes.. M Mimura, T Baba, H Yamazaki, S Ohmori, Y Inui, F J ... Characterization of cytochrome P-450 2B6 in human liver microsomes. Message Subject (Your Name) has forwarded a page to you ...
more infohttp://dmd.aspetjournals.org/content/21/6/1048?ijkey=273b18243ec3100e3ea2a87939846f27b364ea1d&keytype2=tf_ipsecsha

Response of Phospholipid Metabolism to Thiram in Rat Liver Microsomes | Springer for Research & DevelopmentResponse of Phospholipid Metabolism to Thiram in Rat Liver Microsomes | Springer for Research & Development

Incorporation of 14C into the phospholipid components of the liver microsomes isolated by a conventional method was determined ... Leyck S., Freundt K.J. (1978) Response of Phospholipid Metabolism to Thiram in Rat Liver Microsomes. In: Deutsche ... strongly with an inhibition of MFO as shown by a decrease in the O-demethylation of p-nitroanisol in prepared liver microsomes ...
more infohttps://rd.springer.com/chapter/10.1007/978-3-662-39532-5_76

Determination of the inhibitory potential of 6 fluoroquinolones on CYP1A2 and CYP2C9 in human liver microsomes - ZHANG - 2008 -...Determination of the inhibitory potential of 6 fluoroquinolones on CYP1A2 and CYP2C9 in human liver microsomes - ZHANG - 2008 -...

If you are a society or association member and require assistance with obtaining online access instructions please contact our Journal Customer Services team ...
more infohttp://onlinelibrary.wiley.com/doi/10.1111/j.1745-7254.2008.00908.x/pdf

Midazolam hydroxylation by human liver microsomes in vitro: inhibition by fluoxetine, norfluoxetine, and by azole antifungal...Midazolam hydroxylation by human liver microsomes in vitro: inhibition by fluoxetine, norfluoxetine, and by azole antifungal...

Midazolam hydroxylation by human liver microsomes in vitro: inhibition by fluoxetine, norfluoxetine, and by azole antifungal ... of the imidazobenzodiazepine midazolam to its alpha-hydroxy and 4-hydroxy metabolites was studied in vitro using human liver ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/8889898?dopt=Abstract

6 alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes6 alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes

... Araya, Z Uppsala ... Fourteen recombinant expressed cytochrome P450 (CYP) enzymes, human liver microsomes from different donors, and selective ... bile acid; 6 alpha-hydroxylation; CYP3A4; human liver; BILE-ACIDS; PIG-LIVER; METABOLISM; URINE; CYTOCHROME-P-450; ... The aim of the present study was to identify the enzymes in human liver catalyzing hydroxylations of bile acids. ...
more infohttp://uu.diva-portal.org/smash/record.jsf?pid=diva2:112787

AID 31223 - Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome - PubChemAID 31223 - Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome - PubChem

BioAssay record AID 31223 submitted by ChEMBL: Inhibition of acyl coenzyme A:cholesterol acyltransferase (ACAT) activity in rat liver microsome.
more infohttps://pubchem.ncbi.nlm.nih.gov/bioassay/31223

Metabolism of Carfentanil, an Ultra-Potent Opioid, in Human Liver Microsomes and Human Hepatocytes by High-Resolution Mass...Metabolism of Carfentanil, an Ultra-Potent Opioid, in Human Liver Microsomes and Human Hepatocytes by High-Resolution Mass...

Metabolism of fentanyl, a synthetic opioid analgesic, by human liver microsomes. Role of CYP3A4. Drug Metab Dispos. 1996;24(9): ... Metabolism of Carfentanil, an Ultra-Potent Opioid, in Human Liver Microsomes and Human Hepatocytes by High-Resolution Mass ... Metabolism of nicotine by human liver microsomes: stereoselective formation of trans-nicotine N-oxide. Chem Res Toxicol. 1992; ... Metabolism and bioactivation of clozapine by human liver in vitro. J Pharmacol Exp Ther. 1995;272(3):984-90.PubMedGoogle ...
more infohttps://link.springer.com/article/10.1208/s12248-016-9963-5

Identification of Cytochrome P450 Isoforms Involved in CitalopramN-Demethylation by Human Liver Microsomes | Journal of...Identification of Cytochrome P450 Isoforms Involved in CitalopramN-Demethylation by Human Liver Microsomes | Journal of...

Human liver microsomes.. Human liver samples (n = 14) were obtained, as excess material removed during surgery on the liver, ... Assay with human liver microsomes.. The basic incubation medium contained 0.1 or 0.2 mg/ml microsomes, 0.5 mM NADP+, 2.0 mM ... in human liver microsomes.. The immunoinhibition of CIT N-demethylation was examined by preincubating human liver microsomal ... Kinetic profile of CIT N-demethylation in human liver microsomes.. Eadie-Hofstee plots for the N-demethylation of CIT (2.5-500 ...
more infohttp://jpet.aspetjournals.org/content/280/2/927

Identification of di-(2-ethylhexyl) phthalate-induced carboxylesterase 1 in C57BL/6 mouse liver microsomes: purification, cDNA...Identification of di-(2-ethylhexyl) phthalate-induced carboxylesterase 1 in C57BL/6 mouse liver microsomes: purification, cDNA...

Identification of di-(2-ethylhexyl) phthalate-induced carboxylesterase 1 in C57BL/6 mouse liver microsomes: purification, cDNA ... and it was found to contribute significantly to temocapril hydrolase activity in mouse liver microsomes. To identify the ...
more infohttps://www.sigmaaldrich.com/catalog/papers/15269189

Evaluation of metabolism dependent inhibition of CYP2B6 mediated bupropion hydroxylation in human liver microsomes by monoamine...Evaluation of metabolism dependent inhibition of CYP2B6 mediated bupropion hydroxylation in human liver microsomes by monoamine...

Evaluation of metabolism dependent inhibition of CYP2B6 mediated bupropion hydroxylation in human liver microsomes by monoamine ... Human liver microsomal CYP2B6 activities were investigated using bupropion hydroxylation as probe substrate marker. The results ... In conclusion, the results from this study demonstrated that MAO inhibitors can inactivate human liver microsomal CYP2B6. The ... study was to evaluate the metabolism dependent inhibition of CYP2B6 catalyzed bupropion hydroxylation in human liver microsomes ...
more infohttp://www.sigmaaldrich.com/catalog/papers/25656918

Biotransformation of tirilazad in human: 1. Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver...Biotransformation of tirilazad in human: 1. Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver...

Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes.. L C Wienkers, R C Steenwyk, P E ... Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes.. L C Wienkers, R C Steenwyk, P E ... Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes.. L C Wienkers, R C Steenwyk, P E ... Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes. ...
more infohttp://jpet.aspetjournals.org/content/277/2/982

Glucuronidation of Buprenorphine and Norbuprenorphine by Human Liver Microsomes and UDP-Glucuronosyltransferases | Bentham...Glucuronidation of Buprenorphine and Norbuprenorphine by Human Liver Microsomes and UDP-Glucuronosyltransferases | Bentham...

Glucuronidation of Buprenorphine and Norbuprenorphine by Human Liver Microsomes and UDP-Glucuronosyltransferases. Author(s): ... Yan Chang and David E. Moody, " Glucuronidation of Buprenorphine and Norbuprenorphine by Human Liver Microsomes and UDP- ... We investigated the enzyme kinetics of buprenorphine and norbuprenorphine glucuronidation in human liver microsomes and UDP- ... Abstract: We investigated the enzyme kinetics of buprenorphine and norbuprenorphine glucuronidation in human liver microsomes ...
more infohttp://www.eurekaselect.com/93402

Benzene Metabolism by Ethanol-, Acetone-, and Benzene-inducible Cytochrome P-450 (IIE1) in Rat and Rabbit Liver Microsomes |...Benzene Metabolism by Ethanol-, Acetone-, and Benzene-inducible Cytochrome P-450 (IIE1) in Rat and Rabbit Liver Microsomes |...

In the present investigation it was found that benzene was metabolized at a rate 20-65-fold higher in liver microsomes from ... The data indicate that benzene is metabolized mainly by the ethanol-inducible P-450 form in liver microsomes and that the ... Benzene Metabolism by Ethanol-, Acetone-, and Benzene-inducible Cytochrome P-450 (IIE1) in Rat and Rabbit Liver Microsomes. ... Benzene Metabolism by Ethanol-, Acetone-, and Benzene-inducible Cytochrome P-450 (IIE1) in Rat and Rabbit Liver Microsomes ...
more infohttp://cancerres.aacrjournals.org/content/48/19/5387

Isoniazid is a mechanism-based inhibitor of cytochrome P450 1A2, 2A6, 2C19 and 3A4 isoforms in human liver microsomes.Isoniazid is a mechanism-based inhibitor of cytochrome P450 1A2, 2A6, 2C19 and 3A4 isoforms in human liver microsomes.

... ... METHODS: Using pooled human liver microsomes, the in vitro inhibitory effects of isoniazid on CYP1A2 (phenacetin O-deethylation ... CYP2C19 and CYP3A4 in human liver microsomes. Co-administration of isoniazid and drugs that are primarily metabolised by these ...
more infohttps://www.omicsonline.org/references/isoniazid-is-a-mechanismbased-inhibitor-of-cytochrome-p450-1a2-2a6-2c19-and-3a4-isoforms-in-human-liver-microsomes-1363160.html

Triptolide Induces hepatotoxicity via inhibition of CYP450s in Rat liver microsomes | BMC Complementary and Alternative...Triptolide Induces hepatotoxicity via inhibition of CYP450s in Rat liver microsomes | BMC Complementary and Alternative...

We monitored the body weight, survival proportions, liver index, changes in pathology, and biochemical index upon TP ... we then carried out in vitro enzymatic studies in liver microsomal incubation systems via ultra-high performance liquid ... Preparation and appraisal of rat liver microsomes. Rat liver microsomes were obtained via differential centrifugation [22] (L- ... Liver lysates were made from livers of rats. b Protein lysates were made from microsomes of rats liver and subjected to ...
more infohttps://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-016-1504-3

Tentative Identification of Benzo[a]pyrene Metabolite-Nucleoside Complexes Produced in Vitro by Mouse Liver Microsomes |...Tentative Identification of Benzo[a]pyrene Metabolite-Nucleoside Complexes Produced in Vitro by Mouse Liver Microsomes |...

Tentative Identification of Benzo[a]pyrene Metabolite-Nucleoside Complexes Produced in Vitro by Mouse Liver Microsomes. OLAVI ... Tentative Identification of Benzo[a]pyrene Metabolite-Nucleoside Complexes Produced in Vitro by Mouse Liver Microsomes. OLAVI ... Tentative Identification of Benzo[a]pyrene Metabolite-Nucleoside Complexes Produced in Vitro by Mouse Liver Microsomes. OLAVI ... When [3H]benzo[a]pyrene is incubated in vitro together with deproteinized salmon sperm DNA, NADPH, and mouse liver microsomes, ...
more infohttp://molpharm.aspetjournals.org/content/14/2/306