Microglia as therapeutic targets in retinal degeneration: role of translocator protein (18 κDa) (TSPO) and minocycline. -...  Microglia as therapeutic targets in retinal degeneration: role of translocator protein (18 κDa) (TSPO) and minocycline. -...
Microglia are the resident immune cells of the central nervous system (CNS) and play an important role in innate immune defense ... Microglia as therapeutic targets in retinal degeneration: role of translocator protein (18 κDa) (TSPO) and minocycline.. ... Therefore immunmodulation of microglia presents a possible therapeutic strategy for retinal degenerations. Notably, the ... A co-localization of TSPO and microglia was furthermore detectable in human retinal sections, indicating a potential role for ...
more infohttp://kups.ub.uni-koeln.de/7032/
Microglia: new roles for the synaptic stripper  - MDC Repository  Microglia: new roles for the synaptic stripper - MDC Repository
Activated microglia can remove damaged cells as well as dysfunctional synapses, a process termed "synaptic stripping." Here we ... Any pathologic event in the brain leads to the activation of microglia, the immunocompetent cells of the central nervous system ... In the normal brain microglia were considered "resting," but it has recently become evident that they constantly scan the brain ... Microglial dysfunction results in behavioral deficits, indicating that microglia are essential for proper brain function. This ...
more infohttp://edoc.mdc-berlin.de/12776/
北京大学医学部机构知识库(IR@PKUHSC): AGEs mediated expression and secretion of TNF alpha in rail retinal microglia  北京大学医学部机构知识库([email protected]): AGEs mediated expression and secretion of TNF alpha in rail retinal microglia
... we attempted to confirm that AGEs induce the release of TNF alpha from rat retinal microglia using an in vitro microglia ... The degree of microglia activation may influence the extent of retina injury following retinal metabolic stress. We have ... AGEs increased the protein secretion and mRNA expression of TNF alpha in cultured rat retinal microglia. These effects of AGEs ... AGEs-activated microglia showed an increase of NFkB p65 nuclear translocation. These observations indicated that ...
more infohttp://ir.bjmu.edu.cn/handle/400002259/55593
NIOSHTIC-2  Publications Search - 20026467 - Identification of signaling pathways activating reactive gliosis in multiple...  NIOSHTIC-2 Publications Search - 20026467 - Identification of signaling pathways activating reactive gliosis in multiple...
This response is characterized by activation of microglia and astrocytes at sites of damage. Despite the regional- and cell- ... This response is characterized by activation of microglia and astrocytes at sites of damage. Despite the regional- and cell- ...
more infohttps://www.cdc.gov/niosh/nioshtic-2/20026467.html
Past Recipients 2011  Past Recipients 2011
However, in microglia, there is a range of possible responses, including activation into either a pro-inflammatory (M1) or an ... Specifically, we hypothesize that activation of microglia at a low power density will induce an M1 microglial phenotype, while ...
more infohttps://www.aslms.org/for-professionals/research-grants-awards/research-grants/aslms-research-grant/past-recipients-2011
Multiple Sclerosis Research: Minocycline as short term success or does it bite the dust?.  Multiple Sclerosis Research: Minocycline as short term success or does it bite the dust?.
Why was RRMS patients (CIS to clinically definitive MS) chosen when it works on inhibiting microglia. Progressive patients ... treats intracellular bacteria by inhibiting protein synthesis in bacteria and has a possible inhibitory effect on microglia? ...
more infohttp://multiple-sclerosis-research.blogspot.gr/2017/06/minocycline-as-short-term-success-or.html
C1q, the recognition subcomponent of the classical pathway of complement, drives microglial activation  - WRAP: Warwick...  C1q, the recognition subcomponent of the classical pathway of complement, drives microglial activation - WRAP: Warwick...
Microglia, central nervous system (CNS) resident phagocytic cells, persistently police the integrity of CNS tissue and respond ... nonramified microglia. In this study, we demonstrate that cultured microglial cells respond to extrinsic C1q with a marked ... that C1q synthesized and released by activated microglia is likely to contribute in an autocrine/paracrine way to maintain and ... an activation and differentiation process similar to the proinflammatory response of microglia to exposure to ...
more infohttp://wrap.warwick.ac.uk/28526/
November 1995 - Scientific American  November 1995 - Scientific American
It consists of cells called microglia that are normally protective but can be surprisingly destructive. The cells may ...
more infohttps://www.scientificamerican.com/magazine/sa/1995/11-01/
Microglia in Alzheimers Disease  Microglia in Alzheimer's Disease
Microglia in Alzheimers Disease. Ying Li,1,2 Meng-Shan Tan,3 Teng Jiang,4 and Lan Tan1,3,4 ... G. W. Kreutzberg, "Microglia: a sensor for pathological events in the CNS," Trends in Neurosciences, vol. 19, no. 8, pp. 312- ... M. Kitazawa, T. R. Yamasaki, and F. M. LaFerla, "Microglia as a potential bridge between the amyloid β-peptide and tau," Annals ... E. P. Azevedo, J. H. Ledo, G. Barbosa et al., "Activated microglia mediate synapse loss and short-term memory deficits in a ...
more infohttps://www.hindawi.com/journals/bmri/2014/437483/ref/
Microglia actions in Alzheimers disease | SpringerLink  Microglia actions in Alzheimer's disease | SpringerLink
... combined with studies in mouse models has highlighted microglia, the brains intrinsic myeloid cells,... ... The identification of microglia-associated, neurological disease-causing mutations in patients, ... Streit WJ (2004) Microglia and Alzheimers disease pathogenesis. J Neurosci Res 77:1-8. doi: 10.1002/jnr.20093 PubMedGoogle ... Kreutzberg GW (1996) Microglia: a sensor for pathological events in the CNS. Trends Neurosci 19:312-318PubMedGoogle Scholar ...
more infohttps://link.springer.com/article/10.1007%2Fs00401-013-1182-x
Traçando o microglia do cérebro  Traçando o microglia do cérebro
O Microglia é sabido para ser importante para a função do cérebro. As pilhas imunes foram encontradas para proteger o cérebro ... "Este o microglia é muito inflamatório comparado com o microglia normal," diz Hammond. "Poderia ser um subconjunto patológico ... Bisbilhotar no microglia ao longo do tempo. Começando com ratos, Hammond e seus colegas arranjaram em seqüência o RNA de um ... Traçando o microglia. Hammond foi então uma etapa mais. Cobriu as classificações em um mapa do cérebro, para ver como as ...
more infohttps://www.news-medical.net/news/20181206/19085/Portuguese.aspx
JCI -
Microglia in steady state  JCI - Microglia in steady state
In addition to their function as a resident immune cell in the CNS parenchyma, microglia display a variety of other functions ... Microglia modulate wiring and patterning in the developing CNS by regulating apoptosis of neuronal subpopulations, releasing ... In addition to this well-accepted function, recent findings point to major roles for microglia in instructing and regulating ... and how microglia help to maintain tissue homeostasis in the CNS. ... Homeostatic function of microglia in the developing and adult ...
more infohttps://www.jci.org/articles/view/90602/figure/1
JCI -
Microglia in prion diseases  JCI - Microglia in prion diseases
At an early stage of prion infection and PrPSc aggregation, microglia are activated by PrPSc. Microglia then acquire a ... Here, we argue that microglia play an overall neuroprotective role in prion pathogenesis. Several microglia-related molecules, ... This damage may trigger microglia to switch to a proinflammatory phenotype with secretion of TNF-α, IL-1β, and IL-6. Such ... Moreover, studies on the role of microglia in prion disease could deepen our understanding of neuroinflammation in a broad ...
more infohttps://www.jci.org/articles/view/90605/figure/1
Changing Face of Microglia | Science  Changing Face of Microglia | Science
Microglia in healthy CNS tissue do not qualify as macrophages, and their specific functions are beginning to be explored. ... Microglia are resident brain cells that sense pathological tissue alterations. They can develop into brain macrophages and ... Experimental studies support the idea that microglia have a role in the maintenance of synaptic integrity. Analogous to ... However, expression of immune proteins by microglia is not synonymous with inflammation, because these molecules can have ...
more infohttp://science.sciencemag.org/content/330/6005/783
A new role for microglia  A new role for microglia
... researchers at the UC Davis MIND Institute and their colleagues have found that microglia remove healthy neural progenitor ... Microglia are the immune component cell of the central nervous system. Similar to macrophages, microglia provide the brains ... which our data shows increases the activation of microglia, and as a result microglia may take out too many progenitor cells in ... "Microglia are generated in the yolk sack and quickly become attracted to the proliferative zones in the brain, colonize that ...
more infohttp://www.ucdmc.ucdavis.edu/publish/news/research/7443
A new role for microglia  A new role for microglia
... researchers at the UC Davis MIND Institute and their colleagues have found that microglia remove healthy neural progenitor ... Microglia are the immune component cell of the central nervous system. Similar to macrophages, microglia provide the brains ... which our data shows increases the activation of microglia, and as a result microglia may take out too many progenitor cells in ... "Microglia are generated in the yolk sack and quickly become attracted to the proliferative zones in the brain, colonize that ...
more infohttp://www.ucdmc.ucdavis.edu/publish/news/medicalcenter/7443
Death by microglia | JEM  Death by microglia | JEM
In keeping with the idea that activated microglia fuel neurodegeneration, the presence of CD68+ microglia was associated with ... However, the tau transgenic ApoE4 mice had more CD68+ microglia, suggesting that while their overall number of microglia ... Death by microglia. View ORCID ProfileShahrnaz Kemal, Robert Vassar Correspondence email ... The roles of microglia and ApoE in tauopathies, such as Alzheimers disease, remain elusive. In this issue, Shi et al. (https ...
more infohttp://jem.rupress.org/content/216/11/2451
WikiGenes - Microglia  WikiGenes - Microglia
Associations of Microglia with chemical compounds. *Peritoneal macrophages and neonatal microglia from Lewis and BN rats are ... Using primary cultures of microglia, we show that IFN-gamma enhanced clearance of Abeta, microglia, and T cell motility, and ... Analytical, diagnostic and therapeutic context of Microglia. *TGF-beta 1 expression increases in astrocytes and microglia in ... Because there is microglia activation in all stages of multiple sclerosis, we determined whether a microglia product, ...
more infohttps://www.wikigenes.org/e/mesh/e/13571.html
The Role of Microglia in Diabetic Retinopathy  The Role of Microglia in Diabetic Retinopathy
U. K. Hanisch, "Microglia as a source and target of cytokine activities in the brain," in Microglia in the Regenerating and ... J. Gehrmann, R. B. Banati, and G. W. Kreutzberg, "Microglia in the immune surveillance of the brain: human microglia ... The Role of Microglia in Diabetic Retinopathy. Jeffery G. Grigsby,1 Sandra M. Cardona,2 Cindy E. Pouw,3 Alberto Muniz,2 Andrew ... G. W. Kreutzberg, "Microglia: a sensor for pathological events in the CNS," Trends in Neurosciences, vol. 19, no. 8, pp. 312- ...
more infohttps://www.hindawi.com/journals/joph/2014/705783/ref/
Medical Xpress - microglia  Medical Xpress - microglia
Microglia. Microglia are a type of glial cell that are the resident macrophages of the brain and spinal cord, and thus act as ... Classifying brain microglia: Which are good and which are bad?. Microglia are known to be important to brain function. The ... Microglia (and astrocytes) are distributed in large non-overlapping regions throughout the brain and spinal cord. Microglia are ... Microglia transmit pain to the brain during stress. Research in male mice published in JNeurosci demonstrates activation of ...
more infohttps://medicalxpress.com/tags/microglia/