Thymomagenesis in the NOD-scid/scid mouse was associated with expression of an NOD mouse-unique endogenous ecotropic murine ... The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency.. M Prochazka, H R ... The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency. ... The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency. ...
... including immunodeficient mice such as the Fox Chase SCID Beige mouse, for use in basic research and nonclinical drug discovery ... This mouse was developed by Croy, et al. at the University of Guelph by an intercross of C.B-17 SCID/SCID to C57BL/6 bg/bg mice ... This mouse was developed by Croy, et al. at the University of Guelph by an intercross of C.B-17 SCID/SCID to C57BL/6 bg/bg mice ... This mouse was developed by Croy, et al. at the University of Guelph by an intercross of C.B-17 SCID/SCID to C57BL/6 bg/bg mice ...
Biological context of Mice, SCID. *These results suggest that the SCID-hu mouse provides a useful small animal model to assess ... High impact information on Mice, SCID. *The SCID-hu mouse is a heterochimeric small animal model designed to support ... scid mice [21].. *Significantly more of the HIV-1-infected SCID-hu mice expressed mRNA for human tumor necrosis factors alpha ... Because mice are not able to metabolize thalidomide efficiently, SCID-hu mice received implants of fetal human liver fragments ...
... mouse recipients of congenic splenocytes. The H. pylori-infected and uninfected C57BL/6J and recipient SCID mice were evaluated ... Adoptive Transfer of Splenocytes in SCID Mice Implicates CD4+ T Cells in Apoptosis and Epithelial Proliferation Associated with ... Recipient mice differed, however, according to the source of the transferred CD4+ cells. The CD4+ cell scores for recipients of ... In all H. pylori-infected mice, gastric CD4+ cell scores were increased, compared with scores for uninfected controls. ...
... antibodies to Borrelia burgdorferi-infected C3H/HeN-scid mice increased the severity of acute Lyme arthri ... These data suggest that downregulation of innate immunity in SCID mice in the absence of B- and T-cell responses leads to an ... The administration of interleukin-12 (IL-12) antibodies to Borrelia burgdorferi-infected C3H/HeN-scid mice increased the ...
EBs per mouse) into NOD/SCID/IL2R. mice that were bled (500 L) the day before (Supplemental Figure 3). Mice were sacrificed at ... NOD/SCID, and the improved NOD/SCID/IL2R. mice, lack cell mediated and immunoglobulin-mediated humoral responses (these mice do ... mice (4 mice per group) were used. NOD/SCID/IL2R. mice were anaesthetized with isoflurane (Baxter, Deerfield, USA) and ... Mice. 12-week-old female NOD/SCID/IL. mice were purchased from Jackson laboratory and housed in the animal facility of Memorial ...
SUNY Upstate Medical University currently maintains a severe combined immunodeficiency (SCID) mouse facility which has been ...
C.B-17 severe combined immunodeficient (scid) mice carry the scid mutation and are severely deficient in both T cell- and B ... scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair.. K A ... scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair. ... scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair. ...
... infected NOD/SCID mice (hu-SCID) and nonreconstituted, infected NOD/SCID mice (SCID) on day 8. Virus positive-strand RNA was ... Signs of dengue virus infection in humanized NOD/SCID mice. (a) Thrombocytopenia and erythema in infected mice by day 8 (means ... Dengue Fever in Humanized NOD/SCID Mice. Dennis A. Bente, Michael W. Melkus, J. Victor Garcia, Rebeca Rico-Hesse ... The nonreconstituted, infected mouse is on the left, and the reconstituted, infected mouse is on the right (both day 7 ...
Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4 ... Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4 ... Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4 ... Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4 ...
Until recently, testing of new therapeutic agents has relied extensively upon the use of mice and nonhuman primates for in vivo ... C.B‐17 scid/scid (SCID) or C.B‐17 scid/scid bg/bg (SCID.BG) mice, preferably male, 6 to 8 weeks old (Taconic Farms) ... SCID‐hu mice). The describes the surgical implantation of human fetal thymus and liver under the kidney capsules of SCID mice ( ... SCID‐hu Thy/Liv model). Subcutaneous transplantation of human fetal bone marrow and thymus (SCID‐hu Bm/Thy mice) is described ...
Single human B cells were sorted from bone marrow and periphery of humanized NOD/SCID γc(null) (hNSG) mice at 8-10 months post ... Human B-cell ontogeny in humanized NOD/SCID γc(null) mice generates a diverse yet auto/poly- and HIV-1-reactive antibody ... Sorting criteria of human B cell subsets from humanized NOD/SCID γcnull (hNSG) mice. (a) Single cell suspension was prepared ... Human B-cell ontogeny in humanized NOD/SCID γcnull mice generates a diverse yet auto/poly- and HIV-1 reactive antibody ...
... in the humanized SCID mouse (hu-PBL-SCID).. METHODS: Two models of hu-PBL-SCID were used for these studies. In one model, human ... The allogeneic response to cultured human skin equivalent in the hu-PBL-SCID mouse model of skin rejection.. Briscoe DM1, ... Both human foreskin and HSE successfully engrafted onto naive SCID mice and remained stable for more than 6 months. In contrast ... HSE also engrafted onto hu-PBL-SCID mice that were exposed to alloantigen by prior injection with interferon-gamma-treated ...
... Ming- ... "Apoptosis Induction in Primary Human Colorectal Cancer Cell Lines and Retarded Tumor Growth in SCID Mice by Sulforaphane," ...
Mice.SCID (C.B-17/Icr-scid/scid) mice and immunocompetent C.B-17 (C.B-17/Icr-+/+) mice were obtained from Japan CLEA Inc. ( ... As controls, SCID mice (n = 10), C.B-17 mice (n = 6), and A/J mice (n = 6) were mock inoculated with PBS. The mice were ... As controls, SCID mice (n = 6) and C.B-17 mice (n = 6) were mock inoculated with PBS. The SCID mice were observed for 60 days, ... The 50% lethal dose of C. burnetii in SCID mice was at least 108 times less than that in immunocompetent mice. The SCID mouse ...
Visualization of the human CD4{sup +} T-cell response in humanized HLA-DR4-expressing NOD/Shi-scid/γc{sup null} (NOG) mice by ... Title: Hepatitis C virus dynamics and cellular gene expression in uPA-SCID chimeric mice with humanized livers during ... Accepted Manuscript: Hepatitis C virus dynamics and cellular gene expression in uPA-SCID chimeric mice with humanized livers ... Hepatitis C virus dynamics and cellular gene expression in uPA-SCID chimeric mice with humanized livers during intravenous ...
Thymic selection of the human T cell receptor V beta repertoire in SCID-hu mice.. B A Vandekerckhove, R Baccala, D Jones, D H ... Implantation of pieces of human fetal liver and thymus into SCID mice results in the development of a human thymus-like organ, ... Thymic selection of the human T cell receptor V beta repertoire in SCID-hu mice. ... Thymic selection in SCID-hu thymus induces changes in V beta usage by the single-positive CD4+ or CD8+ T cells comparable with ...
Mice. C.B-17(H-2d) SCID mice homozygous for the scid mutation were bred from stocks obtained from the SCID Mouse Core Facility ... BALB/c × C57BL/6 F1 (CB6F1) mice, which have the H-2d/H-2b haplotype, were used for transfer into C.B-17 SCID mice. When ... Mice in this colony, including the rederived C.B-17 SCID mice, are devoid of intestinal aerobes. They have been reassociated ... Lymph node lymphocytes prepared from CB6F1 mice were transferred to C.B-17 SCID mice. Eight to ten weeks post-transfer, SI-IEL ...
Human T-cell engraftment in Hu-NOD/SCID mice.. Human CD45+ PBMC engraftment in NOD/SCID mice recipients of allogeneic islet ... ILT3-Fc treatment prevents islet allograft rejection in hu-NOD/SCID mice. Diabetic NOD/SCID mice were transplanted under the ... hu-NOD/SCID mice).. RESEARCH DESIGN AND METHODS. NOD/SCID female mice purchased from Charles River Laboratories were used at 6- ... Ts cell assays in ILT3-Fc-treated (▵) and human IgG-treated (▪) hu-NOD/SCID mice recipients of allogeneic islet cells. Mice ...
Thus, the total cell number in colitic mice ranged from 2 to 11 × 106, whereas MLN from unrestored SCID mice or SCID mice ... Although these activated DC were present in significantly reduced number in SCID mice compared with SCID mice restored with ... protected SCID), normal BALB/c mice, and unreconstituted SCID mice (Fig. 5⇓A). In all cases, the CD134L+ cells were CD11c ... 106 per mouse from protected or unreconstituted SCID mice. Data represent the mean plus SEM of 5-11 mice per group. B, MLN from ...
Inhibition of MDM2 by a Rhein-Derived Compound AQ-101 Suppresses Cancer Development in SCID Mice. Lubing Gu, Hailong Zhang, Tao ... When given for a period of 2 weeks (20 mg/kg/day, 3×/week), AQ-101 inhibited development of ALL in nude or SCID mice with a ... Inhibition of MDM2 by a Rhein-Derived Compound AQ-101 Suppresses Cancer Development in SCID Mice ... Inhibition of MDM2 by a Rhein-Derived Compound AQ-101 Suppresses Cancer Development in SCID Mice ...
We have produced mice homozygous for both the scid and beige mutations. By contrast with C.B-17 scid mice, BALB/c scid.beige ... Homozygous scid/scid;beige/beige mice have low levels of spontaneous or neonatal T cell-induced B cell generation.. D E Mosier ... The scid mutation occurred in the allotype congenic C.B-17 line, and up to 25% of C.B-17 scid mice spontaneously produce both T ... Homozygous scid/scid;beige/beige mice have low levels of spontaneous or neonatal T cell-induced B cell generation. ...
Helicobacter bilis has been isolated from aged inbred mice with multifocal chronic hepatitis and from scid mice with diarrhea, ... bilis causes IBD in scid mice with defined flora. This result both confirms a pathogenic role for H. bilis in mice and provides ... Helicobacter bilis-induced inflammatory bowel disease in scid mice with defined flora.. N H Shomer, C A Dangler, M D Schrenzel ... Helicobacter bilis-induced inflammatory bowel disease in scid mice with defined flora. ...
Hill, Laurie Lynn, "Growth and metastasis of human melanoma in SCID mice: the effect of human natural killer cells on tumor ... Growth and metastasis of human melanoma in SCID mice: the effect of human natural killer cells on tumor growth in vivo ...