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*  Ablation of interleukin-12 exacerbates Lyme arthritis in SCID mice.
... antibodies to Borrelia burgdorferi-infected C3H/HeN-scid mice increased the severity of acute Lyme arthri ... These data suggest that downregulation of innate immunity in SCID mice in the absence of B- and T-cell responses leads to an ... The administration of interleukin-12 (IL-12) antibodies to Borrelia burgdorferi-infected C3H/HeN-scid mice increased the ...
http://www.prohealth.com/library/showarticle.cfm?libid=25871
*  Adoptive Transfer of Splenocytes in SCID Mice Implicates CD4+ T C...: Ingenta Connect
... mouse recipients of congenic splenocytes. The H. pylori-infected and uninfected C57BL/6J and recipient SCID mice were evaluated ... Adoptive Transfer of Splenocytes in SCID Mice Implicates CD4+ T Cells in Apoptosis and Epithelial Proliferation Associated with ... Recipient mice differed, however, according to the source of the transferred CD4+ cells. The CD4+ cell scores for recipients of ... In all H. pylori-infected mice, gastric CD4+ cell scores were increased, compared with scores for uninfected controls. ...
http://www.ingentaconnect.com/content/aalas/cm/2003/00000053/00000005/art00006
*  The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency. | PNAS
Thymomagenesis in the NOD-scid/scid mouse was associated with expression of an NOD mouse-unique endogenous ecotropic murine ... The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency.. M Prochazka, H R ... The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency. ... The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency. ...
https://www.pnas.org/content/89/8/3290?ijkey=0da62d46f1a6e576961c9362d1dd2ea155c4b76d&keytype2=tf_ipsecsha
*  Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4 | Science
Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4 ... Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4 ... Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4 ... Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4 ...
http://science.sciencemag.org/content/283/5403/845
*  Center for Humanized SCID Mouse Models | Microbiology and Immunology | SUNY Upstate Medical University
SUNY Upstate Medical University currently maintains a severe combined immunodeficiency (SCID) mouse facility which has been ...
http://upstate.edu/microb/research/scidcenter/
*  SCID Mouse Model for Lethal Q Fever | Infection and Immunity
Mice.SCID (C.B-17/Icr-scid/scid) mice and immunocompetent C.B-17 (C.B-17/Icr-+/+) mice were obtained from Japan CLEA Inc. ( ... As controls, SCID mice (n = 10), C.B-17 mice (n = 6), and A/J mice (n = 6) were mock inoculated with PBS. The mice were ... As controls, SCID mice (n = 6) and C.B-17 mice (n = 6) were mock inoculated with PBS. The SCID mice were observed for 60 days, ... The 50% lethal dose of C. burnetii in SCID mice was at least 108 times less than that in immunocompetent mice. The SCID mouse ...
https://iai.asm.org/content/71/8/4717?ijkey=d883d1aeb07ee01302474c4f9f0fd7bf94968656&keytype2=tf_ipsecsha
*  Apoptosis Induction in Primary Human Colorectal Cancer Cell Lines and Retarded Tumor Growth in SCID Mice by Sulforaphane
... Ming- ... "Apoptosis Induction in Primary Human Colorectal Cancer Cell Lines and Retarded Tumor Growth in SCID Mice by Sulforaphane," ...
https://www.hindawi.com/journals/ecam/2012/415231/cta/
*  Generation of Intestinal Mucosal Lymphocytes in SCID Mice Reconstituted with Mature, Thymus-Derived T Cells | The Journal of...
Mice. C.B-17(H-2d) SCID mice homozygous for the scid mutation were bred from stocks obtained from the SCID Mouse Core Facility ... BALB/c × C57BL/6 F1 (CB6F1) mice, which have the H-2d/H-2b haplotype, were used for transfer into C.B-17 SCID mice. When ... Mice in this colony, including the rederived C.B-17 SCID mice, are devoid of intestinal aerobes. They have been reassociated ... Lymph node lymphocytes prepared from CB6F1 mice were transferred to C.B-17 SCID mice. Eight to ten weeks post-transfer, SI-IEL ...
http://www.jimmunol.org/content/160/6/2608
*  CD134L Expression on Dendritic Cells in the Mesenteric Lymph Nodes Drives Colitis in T Cell-Restored SCID Mice | The Journal of...
Thus, the total cell number in colitic mice ranged from 2 to 11 × 106, whereas MLN from unrestored SCID mice or SCID mice ... Although these activated DC were present in significantly reduced number in SCID mice compared with SCID mice restored with ... protected SCID), normal BALB/c mice, and unreconstituted SCID mice (Fig. 5⇓A). In all cases, the CD134L+ cells were CD11c ... 106 per mouse from protected or unreconstituted SCID mice. Data represent the mean plus SEM of 5-11 mice per group. B, MLN from ...
https://www.jimmunol.org/content/166/11/6972?ijkey=3d1099b30c401952ff20300fbdeca34d427a822f&keytype2=tf_ipsecsha
*  Immunoglobulin-Like Transcript 3-Fc Suppresses T-Cell Responses to Allogeneic Human Islet Transplants in hu-NOD/SCID Mice |...
Human T-cell engraftment in Hu-NOD/SCID mice.. Human CD45+ PBMC engraftment in NOD/SCID mice recipients of allogeneic islet ... ILT3-Fc treatment prevents islet allograft rejection in hu-NOD/SCID mice. Diabetic NOD/SCID mice were transplanted under the ... hu-NOD/SCID mice).. RESEARCH DESIGN AND METHODS. NOD/SCID female mice purchased from Charles River Laboratories were used at 6- ... Ts cell assays in ILT3-Fc-treated (▵) and human IgG-treated (▪) hu-NOD/SCID mice recipients of allogeneic islet cells. Mice ...
http://diabetes.diabetesjournals.org/content/57/7/1878
*  Inhibition of MDM2 by a Rhein-Derived Compound AQ-101 Suppresses Cancer Development in SCID Mice | Molecular Cancer Therapeutics
Inhibition of MDM2 by a Rhein-Derived Compound AQ-101 Suppresses Cancer Development in SCID Mice. Lubing Gu, Hailong Zhang, Tao ... When given for a period of 2 weeks (20 mg/kg/day, 3×/week), AQ-101 inhibited development of ALL in nude or SCID mice with a ... Inhibition of MDM2 by a Rhein-Derived Compound AQ-101 Suppresses Cancer Development in SCID Mice ... Inhibition of MDM2 by a Rhein-Derived Compound AQ-101 Suppresses Cancer Development in SCID Mice ...
http://mct.aacrjournals.org/content/17/2/497
*  "Growth and metastasis of human melanoma in SCID mice: the effect of hu" by Laurie Lynn Hill
Hill, Laurie Lynn, "Growth and metastasis of human melanoma in SCID mice: the effect of human natural killer cells on tumor ... Growth and metastasis of human melanoma in SCID mice: the effect of human natural killer cells on tumor growth in vivo ...
http://jdc.jefferson.edu/theses/379/
*  Construction of Human‐SCID Chimeric Mice - Current Protocols
Until recently, testing of new therapeutic agents has relied extensively upon the use of mice and nonhuman primates for in vivo ... C.B‐17 scid/scid (SCID) or C.B‐17 scid/scid bg/bg (SCID.BG) mice, preferably male, 6 to 8 weeks old (Taconic Farms) ... SCID‐hu mice). The describes the surgical implantation of human fetal thymus and liver under the kidney capsules of SCID mice ( ... SCID‐hu Thy/Liv model). Subcutaneous transplantation of human fetal bone marrow and thymus (SCID‐hu Bm/Thy mice) is described ...
http://www.currentprotocols.com/WileyCDA/CPUnit/refId-im0408.html?quicktabs_cp=materials
*  siRNA-Mediated Down-Regulation of P-glycoprotein in a Xenograft Tumor Model in NOD-SCID Mice | Springer for Research &...
P-gp over-expressing MDA435/LCC6 MDR1 cells were used to establish xenografts in NOD-SCID mouse. Cationic polymers ... siRNA-Mediated Down-Regulation of P-glycoprotein in a Xenograft Tumor Model in NOD-SCID Mice. ...
https://rd.springer.com/article/10.1007/s11095-011-0480-z
*  HAdV-2-suppressed growth of SV40 T antigen-transformed mouse mammary epithelial cell-induced tumours in SCID mice
... Wu, Chengjun ... Injection of HAdV-2 into tumours established by NMuMG-T in SCID mice caused reduced tumour growth and signs of intratumoural ... Previously, we reported a highly efficient replication of HAdV-2 in a non-tumorigenic mouse mammary epithelial cell line, NMuMG ... animal models for productive HAdV infections has restricted the evaluation of systemic effects to mainly immunodeficient mice. ...
http://uu.diva-portal.org/smash/record.jsf?pid=diva2%3A917040&
*  Long-term Effects of Intravitreal Administration of GMP-grade Human Bone Marrow-derived CD34+ Cells in NOD-SCID Mice with Acute...
Methods: : Acute ischemia-reperfusion injury was induced in the right eye of adult NOD-SCID mice (n = 20) by elevating the ... Long-term Effects of Intravitreal Administration of GMP-grade Human Bone Marrow-derived CD34+ Cells in NOD-SCID Mice with Acute ... Long-term Effects of Intravitreal Administration of GMP-grade Human Bone Marrow-derived CD34+ Cells in NOD-SCID Mice with Acute ... grade human bone marrow-derived CD34+ cells in NOD-SCID mice with acute retinal ischemia-reperfusion injury in order to ...
https://iovs.arvojournals.org/article.aspx?articleid=2353918
*  Regulation of gamma interferon production by natural killer cells in scid mice: roles of tumor necrosis factor and bacterial...
CB-17 scid mice exhibit a T-cell-independent but gamma interferon (IFN-gamma)-dependent immunity to Listeria monocytogenes. In ... scid mouse-derived natural killer (NK) cells cultured with heat-killed (HK) L. monocytogenes and macrophages secreted IFN-gamma ... Regulation of gamma interferon production by natural killer cells in scid mice: roles of tumor necrosis factor and bacterial ... Regulation of gamma interferon production by natural killer cells in scid mice: roles of tumor necrosis factor and bacterial ...
https://iai.asm.org/content/59/5/1709
*  KAKEN - Research Projects | A transfer study of human tonsillar lymphocytes into NOD/LtSz-scid/scid mice (KAKENHI-PROJECT...
To challenge this issue, we have done a transfer study of human tonsillar lymphocytes into NOD/LtSz-scid/scid mice and obtained ... A transfer study of human tonsillar lymphocytes into NOD/LtSz-scid/scid mice. Research Project ... human helper/inducer and suppressor/cytotoxic T cells were detected in various degrees in spleens of NOD/LtSz-scid/scid mice at ... Publications] Hideyuki Kawauchi: 'A Transfer Study of Human Tonsillar Lymphocytes into NOD/LtSz-scid/scid Mice'Recent Advances ...
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14571619/
*  Regulation of human cell engraftment and development of EBV-related lymphoproliferative disorders in Hu-PBL-scid mice. -...
Hu-PBL-scid mice). Hu-PBL-NOD-scid mice generate 5- to 10-fold higher levels of human cells than do Hu-PBL-C.B-17-scid mice, ... and Hu-PBL-NOD-scid beta2-microglobulin-null (NOD-scid-B2mnull) mice support even higher levels of engraftment, particularly ... We now report that human cell proliferation in NOD-scid mice increased after in vivo depletion of NK cells. Human cell ... We further document that Hu-PBL-NOD-scid mice are resistant to development of human EBV-related lymphoproliferative disorders. ...
https://www.semanticscholar.org/paper/Regulation-of-human-cell-engraftment-and-of-in-Wagar-Cromwell/7337455855706abde865ace82ddd021cd25cf99f
*  T-cell dysfunctions in hu-PBL-SCID mice infected with human im...
T-cell dysfunctions in hu-PBL-SCID mice infected with human immunodeficiency virus (HIV) shortly after reconstitution: in vivo ... in the peritoneal cavity of SCID mice. At 2 to 24 h after the intraperitoneal injection into SCID mice, there was a clear-cut ... To explore this issue with a practical in vivo model, we developed a modified protocol of HIV infection in hu-PBL-SCID mice. ... Thus, the hu-PBL-SCID mouse model may be useful in exploring, in vivo, the relevance of hu-PBL activation and differentiation ...
https://www.mysciencework.com/publication/show/t-cell-dysfunctions-in-hu-pbl-scid-mice-infected-with-human-immunodeficiency-virus-hiv-shortly-after-reconstitution-in-vivo-effects-of-hiv-on-highly-activated-human-immune-cells
*  KAKEN - Research Projects | THE ESTABLISHING OF THE IMMUNE SYSTEM OF THE scid MOUSE BY THE TRANSPLANTATION OF THE XENOGENEIC...
Therefore, when transplanting the bone-barrow cells of nude (rnu/rnu) rat to the scid mouse (rat BMT scid mouse), the ... Then, this mouse falls into GVHD after several months of the rat thymus graft and dies. At the rat BMT scid mouse, neither GVHD ... scid/scid) mouse. However the thymus is equipped with the normal organization. ... The rat BMT scid mouse is the model which is extremely useful to study education effects to the T cell of the thymus. ...
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09670247/
*  Thymic selection of the human T cell receptor V beta repertoire in SCID-hu mice. | JEM
Thymic selection of the human T cell receptor V beta repertoire in SCID-hu mice.. B A Vandekerckhove, R Baccala, D Jones, D H ... Implantation of pieces of human fetal liver and thymus into SCID mice results in the development of a human thymus-like organ, ... Thymic selection of the human T cell receptor V beta repertoire in SCID-hu mice. ... Thymic selection in SCID-hu thymus induces changes in V beta usage by the single-positive CD4+ or CD8+ T cells comparable with ...
http://jem.rupress.org/content/176/6/1619
*  Recovery and Biodistribution of Ex Vivo Expanded Human Erythroblasts Injected into NOD/SCID/IL2R mice
EBs per mouse) into NOD/SCID/IL2R. mice that were bled (500 L) the day before (Supplemental Figure 3). Mice were sacrificed at ... NOD/SCID, and the improved NOD/SCID/IL2R. mice, lack cell mediated and immunoglobulin-mediated humoral responses (these mice do ... mice (4 mice per group) were used. NOD/SCID/IL2R. mice were anaesthetized with isoflurane (Baxter, Deerfield, USA) and ... Mice. 12-week-old female NOD/SCID/IL. mice were purchased from Jackson laboratory and housed in the animal facility of Memorial ...
https://www.hindawi.com/journals/sci/2011/673752/
*  Hepatitis C virus dynamics and cellular gene expression in uPA-SCID chimeric mice with humanized livers during intravenous...
Visualization of the human CD4{sup +} T-cell response in humanized HLA-DR4-expressing NOD/Shi-scid/γc{sup null} (NOG) mice by ... Title: Hepatitis C virus dynamics and cellular gene expression in uPA-SCID chimeric mice with humanized livers during ... Accepted Manuscript: Hepatitis C virus dynamics and cellular gene expression in uPA-SCID chimeric mice with humanized livers ... Hepatitis C virus dynamics and cellular gene expression in uPA-SCID chimeric mice with humanized livers during intravenous ...
https://www.osti.gov/pages/biblio/1325641-hepatitis-virus-dynamics-cellular-gene-expression-upa-scid-chimeric-mice-humanized-livers-during-intravenous-silibinin-monotherapy