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*  Obese mice are more susceptible to liver abnormalities
A previous study of leptin-deficient obese mice noted depleted levels of NKT cells. However, since obese humans have increased ... Obese mice are more susceptible to liver abnormalities. By Wiley InterScience. Oct 4, 2005, 00:34. ... The mice on high fat diets gained significantly more weight than the mice on normal diets, and they also developed fatty livers ... When the researchers induced liver injury in mice on the varying diets, they found that high fat-diet mice experienced more ...
http://www.rxpgnews.com/printer_2548.shtml
*  Cutting Off Blood Supply to Fat Cells Slims Obese Mice - Scientific American
Obese mice treated with the compound lost 10 percent of their body weight each week over the course of a four-week study ... which is expressed on blood vessels that supply fat cells in obese mice. The team then paired a peptide that binds to ... Findings reported in the June issue of Nature Medicine indicate that the tactic is successful in mice. A team lead by Wadih ... "this work may lead to the development of targeted drugs for treatment of obese patients." ...
https://www.scientificamerican.com/article/cutting-off-blood-supply/
*  Macadamia Oil Supplementation Attenuates Inflammation and Adipocyte Hypertrophy in Obese Mice
... Edson A. Lima,1 Loreana S. ... In conclusion, macadamia oil supplementation attenuated inflammation and adipocyte hypertrophy in obese mice. ... "Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice," Diabetes, vol. 58, no. 11, pp. 2574 ... induced obesity in mice. C57BL/6 male mice (8 weeks) were divided into four groups: (a) control diet (CD), (b) HF, (c) CD ...
https://www.hindawi.com/journals/mi/2014/870634/
*  SRT1720 improves survival and healthspan of obese mice
... Author: Minor, Robin K.; Baur, Joseph A.; Gomes, Ana P.; Ward, Theresa ... SRT1720 improves survival and healthspan of obese mice. DSpace/Manakin Repository. * DASH Home ... "SRT1720 Improves Survival and Healthspan of Obese Mice." Scientific Reports 1 (August 18). doi:10.1038/srep00070.. ... Using a conditional SIRT1 knockout mouse and specific gene knockdowns we show SRT1720 affects mitochondrial respiration in a ...
https://dash.harvard.edu/handle/1/27364289
*  Bifidobacterium may prevent weight gain and glucose intolerance in obese mice
lactis 420 prevents weight gain and glucose intolerance in diet-induced obese mice"​. Authors: L.K. Stenman, A. Waget A, Garret ... lactis 420 may reduce fat levels and glucose intolerance in obese and diabetic mice, says a new study from DuPont Nutrition and ... Bifidobacterium may prevent weight gain and glucose intolerance in obese mice. By Stephen Daniells ... Lab mice fed a high fat diet to induce obesity and diabetes were found to have lower levels of fat mass when the diets were ...
https://www.nutraingredients-usa.com/Article/2014/10/06/Bifidobacterium-may-prevent-weight-gain-and-glucose-intolerance-in-obese-mice
*  Black elderberry extract attenuates inflammation and metabolic dysfunction in diet-induced obese mice. - PubMed - NCBI
... in a diet-induced obese C57BL/6J mouse model. Mice were fed either a low-fat diet (n 8), high-fat lard-based diet (HFD; n 16), ... Black elderberry extract attenuates inflammation and metabolic dysfunction in diet-induced obese mice.. Farrell NJ1, Norris GH1 ... Diet-induced obese mice; HFD high-fat diet; HOMA-IR homoeostasis model assessment of insulin resistance; Inflammation; Insulin ... These results suggest that BEE may have improved some metabolic disturbances present in this mouse model of obesity by lowering ...
https://www.ncbi.nlm.nih.gov/pubmed/26314315
*  Astaxanthin has a therapeutic effect in obese mice fed a high-fat
... diet. - GreenMedInfo Summary ... We investigated the effects of astaxanthin supplementation in obese mice fed a high-fat diet. Astaxanthin inhibited the ...
http://www.greenmedinfo.com/article/astaxanthin-has-therapeutic-effect-obese-mice-fed-high-fat-diet
*  Consumption of baru nuts (Dipteryx alata) in the treatment of obese mice
The inclusion of baru nut in the diet improved the control of weight gain and glucose and triglyceride levels in obese mice. ... After this period the obese mice were divided into 4 groups (7 animals per group) that received (8 weeks; ad libitum regimen) ... The results indicated that baru flour consumption by obese mice is beneficial, especially because it reduced EPI and RET ... amount of adipose tissue and blood levels in obese male Swiss mice. After inducing obesity by providing high-glucose diet (60 ...
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017000200405&lng=en&tlng=en
*  Vagotomy Reduces Insulin Clearance in Obese Mice Programmed by Low-Protein Diet in the Adolescence
... Camila Lubaczeuski,1 ... "Vagotomy Reduces Insulin Clearance in Obese Mice Programmed by Low-Protein Diet in the Adolescence," Neural Plasticity, vol. ...
https://www.hindawi.com/journals/np/2017/9652978/cta/
*  Marine Drugs | Free Full-Text | Leptolide Improves Insulin Resistance in Diet-Induced Obese Mice | HTML
Likewise, prolonged leptolide treatment (0.1 mg/kg) in diet-induced obese mice improved insulin sensitivity. These effects were ... We concluded that leptolide significantly improves insulin sensitivity in vitro and in obese mice, suggesting that leptolide ... promotes pancreatic beta-cell proliferation in mice. Considering the beneficial effects of leptolide in diabetic mice, in this ... phosphorylation of PKB in liver and skeletal muscle and reduced circulating pro-inflammatory cytokines in obese mice. ...
https://www.mdpi.com/1660-3397/15/9/289/htm
*  LEPTIN REPLACEMENT RESTORES SUPRASPINAL CHOLINERGIC ANTINOCEPTION IN LEPTIN DEFICIENT OBESE MICE
Microinjection sites for B6 mice (black dots, n=13), obese mice (green dots, n=8), and obese mice ... ... leptin replacement in obese mice attenuates differences in nociceptive responses between obese and B6 mice. Adult male mice (n= ... Studies of obese mice have provided insight into the roles of leptin. Obese mice have deficiencies in brain development1, ... Neostigmine, carbachol, and nicotine caused PWL to increase significantly in B6 but not obese mice. An additional 15 obese mice ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC2777714/
*  Differential Effects of Calorie Restriction and Exercise on the Adipose Transcriptome in Diet-Induced Obese Mice
... labeled lean mice), or DIO (labeled obese mice) for 8 weeks (. /diet group). Body composition on these mice was determined ... To test this hypothesis, we generated obese (DIO) and lean (CR) mice (relative to overweight control mice consuming AIN-76A ... body fat compared to DIO control mice. Achieving meaningful reductions in adiposity in obese mice via CR and EX was a goal of ... mice were euthanized. In the morning the mice were killed, all mice received their respective dietary or exercise treatment, ...
https://www.hindawi.com/journals/jobe/2011/265417/
*  The Antiobesity Effect of Polygonum aviculare L. Ethanol Extract in High-Fat Diet-Induced Obese Mice
... concentrations were decreased in PAE-treated HFD-induced obese mice relative to the same measurements in untreated obese mice. ... induced obese mice were investigated. The mice were fed an HFD or an HFD supplemented with PAE (400 mg/kg/day) for 6.5 weeks. ... Compared with normal mice, the HFD-induced obese mice exhibited increased mRNA levels of adipocyte markers such as sterol ... Figure 7: The effect of PAE on serum MDA levels in HFD-induced obese mice. Values are expressed as means ± SEM (. ). ...
https://www.hindawi.com/journals/ecam/2013/626397/
*  Differential Effects of Calorie Restriction and Exercise on the Adipose Transcriptome in Diet-Induced Obese Mice
... Karrie E. ... differentially modulates adipose gene expression using 48 female C57BL/6 mice administered a diet-induced obesity (DIO) regimen ...
https://www.hindawi.com/journals/jobe/2011/265417/abs/
*  IJMS | Free Full-Text | Global Transcriptome Analysis of Brown Adipose Tissue of Diet-Induced Obese Mice
RNA sequencing was used to generate global transcriptome profiles from BAT of lean mice fed with a low-fat diet (LFD) and obese ... mice fed with a HFD. Gene Ontology (GO) analysis identified increased expression of genes involved in biological processes (BP ... RNA sequencing was used to generate global transcriptome profiles from BAT of lean mice fed with a low-fat diet (LFD) and obese ... "Global Transcriptome Analysis of Brown Adipose Tissue of Diet-Induced Obese Mice." Int. J. Mol. Sci. 19, no. 4: 1095. ...
https://www.mdpi.com/1422-0067/19/4/1095
*  JCI - Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice
... mice homozygous for the floxed Ghr. allele; LLc, βGHRKO mice; WWc, RIP-Cre transgenic mice; I, islet; Exo, exocrine; P, ... Phosphorylation of STAT5 in liver upon intravenous injection of GH to obese control and βGHRKO mice, as assessed by Western ... Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice. ... Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice. ...
https://www.jci.org/articles/view/45027/figure/1
*  Dietary methionine restriction improves glucose metabolism in skeletal muscle of obese mice - Food & Function (RSC Publishing)
This study aimed to determine the effects of MR on insulin signalling and glucose utilisation in skeletal muscle of obese mice ... Dietary methionine restriction improves glucose metabolism in skeletal muscle of obese mice T. Luo, Y. Yang, Y. Xu, Q. Gao, G. ... This study aimed to determine the effects of MR on insulin signalling and glucose utilisation in skeletal muscle of obese mice ... Dietary methionine restriction improves glucose metabolism in skeletal muscle of obese mice ...
https://pubs.rsc.org/en/content/articlelanding/2019/fo/c8fo02571a
*  Adipocyte Long-Noncoding RNA Transcriptome Analysis of Obese Mice Identified Lnc-Leptin, Which Regulates Leptin | Diabetes
A microarray analysis of sexual dimorphism of adipose tissues in high-fat-diet-induced obese mice. Int J Obes 2010;34:989-1000 ... Male mice on the C57BL/6 background were kept at the Duke-NUS animal facilities. Mice were fed normal chow diet (ND) or high- ... Positional cloning of the mouse obese gene and its human homologue [published correction appears in Nature 1995;374:479]. ... Adipocyte Long-Noncoding RNA Transcriptome Analysis of Obese Mice Identified Lnc-Leptin, Which Regulates Leptin. ...
http://diabetes.diabetesjournals.org/content/67/6/1045
*  High and moderate intensity training normalizes ventricular function and mechanoenergetics in diet-induced obese mice | Diabetes
Diet-induced obese C57BL/6J (DIO) mice, displaying a cardiac phenotype with altered substrate utilization and impaired ... High and moderate intensity training normalizes ventricular function and mechanoenergetics in diet-induced obese mice ... High and moderate intensity training normalizes ventricular function and mechanoenergetics in diet-induced obese mice ... High and moderate intensity training normalizes ventricular function and mechanoenergetics in diet-induced obese mice ...
http://diabetes.diabetesjournals.org/content/early/2013/03/13/db12-1580
*  Epigallocatechin-3-gallate inhibits pancreatic lipase and reduces body weight gain in high fat-fed obese mice. - PubMed - NCBI
Epigallocatechin-3-gallate inhibits pancreatic lipase and reduces body weight gain in high fat-fed obese mice.. Grove KA1, Sae- ... In conclusion, EGCG supplementation reduced final BW and BW gain in obese mice, and some of these effects may be due to ... obese mice (P , 0.01) was observed compared to controls. EGCG treatment increased fecal lipid content by 29.4% (P , 0.05) ... could reverse metabolic syndrome in high fat-fed obese C57bl/6J mice, and that these effects were related to inhibition of ...
https://www.ncbi.nlm.nih.gov/pubmed/21633405
*  Antiobesity Activities of Methanolic Extracts of Amaranthus dubius, Cucurbita pepo, and Vigna unguiculata in Progesterone...
... and Vigna unguiculata in Progesterone-Induced Obese Mice. Kathryn Wanjiku Nderitu,1 Njagi Shadrack Mwenda,2 Ndegwa John ... and Artemisia capillaris in high-fat diet-induced obese mice," Journal of Ethnopharmacology, vol. 115, no. 2, pp. 263-270, 2008 ... α activity in HepG2 cells and decreases plasma and hepatic triglycerides in obese diabetic mice," Journal of Nutrition, vol. ... "Dietary capsaicin reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet," Obesity ...
https://www.hindawi.com/journals/ecam/2017/4317321/ref/
*  Increased Expression of Macrophage-Inducible C-type Lectin in Adipose Tissue of Obese Mice and Humans | Diabetes
the respective wild-type mice. B: Mincle mRNA expression in the adipose tissue of diet-induced obese mice. **P , 0.01 vs. SD. C ... we next examined the tissue distribution of Mincle mRNA in genetically obese ob/ob mice and wild-type mice (Fig. 3A). Real-time ... We also observed a significant upregulation of Mincle mRNA in the adipose tissue of diet-induced obese mice (P , 0.01) (Fig. 3B ... Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res 2005;46: ...
http://diabetes.diabetesjournals.org/content/60/3/819
*  Decaffeinated green and black tea polyphenols decrease weight gain and alter microbiome populations and function in diet...
... polyphenols inhibit weight gain in mice fed an obesogenic diet. Since the intestinal microflora is an important contributor to ... and black tea on gut microbiota in high-fat-induced obese mice. Food Funct 7(12):4869-4879. doi: 10.1039/c6fo01439a CrossRef ... C57BL/6J mice were fed a high-fat/high-sucrose diet (HF/HS, 32% energy from fat; 25% energy from sucrose) or the same diet ... green and black tea polyphenols decrease weight gain and alter microbiome populations and function in diet-induced obese mice. ...
https://link.springer.com/article/10.1007%2Fs00394-017-1542-8
*  Abstract 11402: Cardioprotective Effects Of mTOR Against Ex Vivo Ischemia-reperfusion Injury In Diet-induced Obese Mice |...
Abstract 11402: Cardioprotective Effects Of mTOR Against Ex Vivo Ischemia-reperfusion Injury In Diet-induced Obese Mice. ... Abstract 11402: Cardioprotective Effects Of mTOR Against Ex Vivo Ischemia-reperfusion Injury In Diet-induced Obese Mice ... Abstract 11402: Cardioprotective Effects Of mTOR Against Ex Vivo Ischemia-reperfusion Injury In Diet-induced Obese Mice ... Abstract 11402: Cardioprotective Effects Of mTOR Against Ex Vivo Ischemia-reperfusion Injury In Diet-induced Obese Mice ...
http://circ.ahajournals.org/content/126/Suppl_21/A11402