Mice, Neurologic Mutants PubMed MeSh Term *Overview. Overview. subject area of * A novel mode of tangential migration of ... Genetic dissection of quantitative trait locus for ethanol sensitivity in long- and short-sleep mice Journal Article ...

Mice, Neurologic Mutants * Multiple Sclerosis / pathology * Myelin Sheath / ultrastructure* Grants and funding * MOP-43871/ ...

The shape of OKN in the homozygotic Weaver mouse was cle … ... speed around the animal was investigated in wildtype mice and ... Weaver mutants (cerebellar impairment) by means of chronically implanted EOG-electrodes. ... The shape of OKN in the homozygotic Weaver mouse was clearly different from that in normal mice. The OKN in the mutant showed ... Horizontal optokinetic ocular nystagmus in wildtype (B6CBA+/+) and weaver mutant mice Exp Brain Res. 1988;72(1):29-36. doi: ...

Mice, Neurologic Mutants. Trumbull KA, McAllister D, Gandelman MM, Fung WY, Lew T, Brennan L, Lopez N, Morré J, Kalyanaraman B ... Mice. Trumbull KA, McAllister D, Gandelman MM, Fung WY, Lew T, Brennan L, Lopez N, Morré J, Kalyanaraman B, Beckman JS. 2012. ... Diapocynin and apocynin administration fails to significantly extend survival in G93A SOD1 ALS mice.. Neurobiol Dis. 45(1):137- ... Diapocynin and apocynin administration fails to significantly extend survival in G93A SOD1 ALS mice.. Neurobiol Dis. 45(1):137- ...

The protocol has been used to test several mutant mice, including dystrophin-deficient mutants, transgenic models of ... Jacquelin C, Strazielle C, Lalonde R (September 2011). "Neurologic function during developmental and adult stages in Dab1(scm ... This protocol became known as the "modified SHIRPA" and has been used to screen for dominant phenotypes in mice. Sanger Mouse ... mutant mice". Behav. Brain Res. 226 (1): 265-273. doi:10.1016/j.bbr.2011.09.020. PMID 21945093. S2CID 140205214. Masuya H, ...

Spontaneous neurologic disease developed in 113LBoPrP-Tg037 mice expressing mutant 113LBoPrP. These mice had reduced lifespans ... Neurologic signs did not develop in any of the inoculated mice (Table 2). These mice were euthanized at 650 dpi and did not ... In this instance, neurologic signs developed in only 1 of 5 (attack rate 20%) inoculated Tg110 mice. This mouse died at 333 dpi ... Spontaneous Neurologic Disease in Transgenic Mice Expressing Mutant 113LBoPrP. ...

The neurologic mutant mouse, oscillator, is characterized by a fine motor tremor and muscle spasms that begin at 2 weeks of age ... We then demonstrate how crosses of TGF-beta1 mutant mice with mouse models of Alzheimers disease (AD) produced important new ... We then demonstrate how crosses of TGF-beta1 mutant mice with mouse models of Alzheimers disease (AD) produced important new ... a recessive neurologic mouse mutant, resembles hyperekplexia phenotypically, and the two disease loci map to homologous ...

Despite the limited number of animals used in the study, our bioinformatic analysis indicates the En2 -/- mouse is a valuable ... Cerebellar and hippocampal tissue samples from three En2 -/- and wild type (WT) littermate mice were assessed for differential ... To unravel recurrent ASD-related neuropathological mechanisms, we took advantage of the En2 -/- mouse model and performed ... gene ontology enrichment and mouse phenotype ontology analysis. Furthermore, we performed direct enrichment analysis of ASD- ...

Neurologic Mutant Mice 60% * Axon Guidance 53% * Extracellular Matrix Proteins 46% * Psychology Recognition 36% ...

Loss of murine Samd9l can lead to a MDS-like disease in mice49. Recently, germline variants in these genes have been associated ... Suzuki, J., Kaziro, Y. & Koide, H. An activated mutant of R-Ras inhibits cell death caused by cytokine deprivation in BaF3 ... with multisystem disorders with a range of systemic abnormalities, including neurologic, endocrine, gastrointestinal, immune, ... Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with ...

Mice, Mutant Strains - Mice, Knockout PubMed MeSh Term * Mice, Neurologic Mutants PubMed MeSh Term ... Mice, Mutant Strains PubMed MeSh Term *Overview. Overview. subject area of * Abnormal hypothalamic oxytocin system in ... Mice, Mutant Strains - Mice, Inbred mdx PubMed MeSh Term * ... Mice PubMed MeSh Term narrower concept * Mice, Mutant Strains ... Oral nitrite therapy improves vascular function in diabetic mice Journal Article * Patterned expression of BDNF and NT-3 in the ...

In mice, although no knockout models have been established for the gene, knockout lines were generated for the Sac3 [19] and ... In C. elegans [17] and Drosophila [18], several mutant lines were generated for the PIKFYVE gene with the ethyl ... In both knockout lines, neurologic defects and juvenile or perinatal death was seen. Thus, complete loss of function of the ... In both organisms, mutant lines harboring loss-of-function mutations of the gene displayed numerous vacuoles in their cells and ...

Neurologic Mutant Mice Medicine & Life Sciences 100% * Neurokinin-1 Receptors Medicine & Life Sciences 93% ... Localisation and activation of the neurokinin 1 receptor in the enteric nervous system of the mouse distal colon. In: Cell and ... Information regarding the distribution of NK1R in subtypes of mouse enteric neurons is lacking and is the focus of the present ... Localisation and activation of the neurokinin 1 receptor in the enteric nervous system of the mouse distal colon. Cell and ...

Mice, Hairless. *Mice, Inbred mdx. *Mice, Jimpy. *Mice, Knockout. *Mice, Neurologic Mutants ... Mice homozygous for the mutant autosomal recessive gene, quaking (qk), associated with disorder in myelin formation and ... Size changes of protamine 1 mRNA provide a molecular marker to monitor spermatogenesis in wild-type and mutant mice. ... Proton magnetic resonance in myelin deficient brains of mutant mice. J Neurol Sci. 1989 Jun; 91(1-2):85-96. ...

Here these mice are used to examine the impact of an extracellular proteolytic imbalance on long-term neuronal function. These ... These mice can serve to study early stages of in vivo neuronal dysfunction not yet associated with cell loss. ... In an earlier study we showed that transgenic mice with ectopic or increased expression of PN-1 in postnatal neurons have ... mice develop disturbances in motor behavior from 12 weeks on, with some of the histopathological changes described in early ...

The purpose of the present study was to evaluate extensively the effect of light on Fos-LI in the mouse SCN. Brief pulses of ... roles of Fos in the circadian system and add to our understanding of light regulation of circadian physiology in the mouse. ... Animals, Circadian Rhythm, Immunohistochemistry, Male, Mice, Mice, Inbred Strains, Mice, Neurologic Mutants, Muridae, Oncogene ... The purpose of the present study was to evaluate extensively the effect of light on Fos-LI in the mouse SCN. Brief pulses of ...

... we generated CRLF3L389P-mutant hiPSC lines and Crlf3L389P-mutant genetically engineered mice. While this variant does not ... suggesting that this gene might be important for neurologic function. To explore the functional consequences of this variant, ... In addition, Crlf3L389P-mutant mouse neurons have reduced dendrite lengths and branching, without any axonal deficits. Moreover ... impair protein expression, brain structure, or mouse behavior, CRLF3L389P-mutant human cerebral organoids and mouse brains ...

A transgenic mouse model for HGPS has been created by introducing a splicing defect into intron 9 of the mouse LMNA gene. [18] ... After translation, the mutant preprogerin protein undergoes normal farnesylation of a CAAX tetrapeptide motif located at the ... Neurologic features of Hutchinson-Gilford progeria syndrome after lonafarnib treatment. Neurology. 2013 Jul 30. 81 (5):427-30. ... A progeroid syndrome in mice is caused by defects in A-type lamins. Nature. 2003 May 15. 423(6937):298-301. [QxMD MEDLINE Link] ...

Researchers eBioMedicine track down potential vaccine targets with transposon sequencing on mutant bacteria causing neonatal ... the researchers searched for fitness contributors in the mutant K1 strain Escherichia coli in a mouse model of neonatal ... "If further testing is successful, it could support human testing of this potential means to prevent serious neurologic ... meningitis in mouse models of the disease. ...

Here these mice are used to examine the impact of an extracellular proteolytic imbalance on long-term neuronal function. These ... These mice can serve to study early stages of in vivo neuronal dysfunction not yet associated with cell loss. ... In an earlier study we showed that transgenic mice with ectopic or increased expression of PN-1 in postnatal neurons have ... mice develop disturbances in motor behavior from 12 weeks on, with some of the histopathological changes described in early ...

... tumors implemented in mouse cranium and grown until first appearance of neurologic signals before collection of the brains and ... Investigation of IDH-mutant Gliomas Metabolism by Mass Spectrometry Imaging (Application Note #MSI-16) June 25, 2018 By: * ... This work was performed on collected PDX (Patient-derived xenografts) with IDH wild type (IDHwt) and mutant (IDHm) ... MALDI Mass Spectrometry Imaging correlated the expression of the IDH1 mutant or wild type versions through major molecular ...

PHENOTYPE: Mice homozygous for a gene trap allele develop a progressive neurologic disease typified by urinary incontinence, ... Mutant males are sterile while females are subfertile. [provided by MGI curators] ... FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] ... MutationsIncidental MutationsEngineered MutationsCandidate ExplorerProtocolsMutation StatisticsAboutContactLinksRequest Mice ...

These new findings will extend the utility of the hph-1 mouse in studies of GTP-CH I deficiency. ... hph-1 and heterozygote mice, and found that heterozygote animals have partial tetrahydrobiopterin deficiency. ... The hph-1 ENU-mutant mouse provides a model of tetrahydrobiopterin deficiency for studying hyperphenylalaninaemia, dopa- ... Mice, Mice, Inbred C57BL, Mice, Inbred CBA, Mice, Neurologic Mutants, Phenylketonurias, Polymerase Chain Reaction ...

Mice, Neurologic Mutants, Reproduction:physiology,. Citation OBJECTIVE: One of the common, but less studied deficiencies in ... Maternal infanticide and low maternal ability in cerebellar mutants Lurcher.. Tuma J, Cendelin J, Vozeh F. ... Tuma J, Cendelin J, Vozeh F. Maternal infanticide and low maternal ability in cerebellar mutants Lurcher. Neuro Endocrinol Lett ...

... using mutant strains of Salmonella typhimurium or Escherichia coli; a forward mutation assay in L5178Y TK +/- mouse lymphoma ... A PND 4 rat is generally comparable to a 3rd trimester human fetus with regards to neurologic development/myelination. At ≥15 ... In addition, there was no evidence of mutagenicity in either a dominant lethal test in mice or a micronucleus test in mice. ... In another 2-year study in mice with doses up to 100 mg/kg/day (producing drug exposures approximately 2 times the HD of 80 mg ...

... using mutant strains of Salmonella typhimurium or Escherichia coli; a forward mutation assay in L5178Y TK +/− mouse lymphoma ... A PND 4 rat is generally comparable to a 3rd trimester human fetus with regards to neurologic development/myelination. At ≥ 15 ... In addition, there was no evidence of mutagenicity in either a dominant lethal test in mice or a micronucleus test in mice. ... In another 2-year study in mice with doses up to 100 mg/kg/day (producing drug exposures approximately 2 times the HD of 80 mg ...

Mice, Hairless. *Mice, Inbred mdx. *Mice, Jimpy. *Mice, Knockout. *Mice, Neurologic Mutants ... Mutant Strains" by people in this website by year, and whether "Mice, Mutant Strains" was a major or minor topic of these ... "Mice, Mutant Strains" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Mice, Mutant Strains" by people in Profiles. ...

Many mutant and gene-targeted mouse models can develop cranial and spinal neural tube defects. Some studies appear to indicate ... Certain neurologic anomalies, such as hydrocephalus and Chiari II malformation (discussed below), accompany myelomeningocele. ... Studies on mice embryos have provided some unifying theories for explaining the associated anomalies seen with neural tube ... Once the patient experiences a significant neurologic deficit, such as a neurogenic bladder or leg weakness, from these occult ...

1 is mice with early hunched back; 2 is mice presenting slight social isolation, weight loss and abnormal gait; 3 is mice ... Severe neurologic syndrome associated with Middle East respiratory syndrome corona virus (MERS-CoV). Infection 2015, 43, 495- ... based on previous data using different mutant recombinant viruses harboring mutation in the S protein [266,268,269] and making ... 1 is mice with early hunched back; 2 is mice presenting slight social isolation, weight loss and abnormal gait; 3 is mice ...

As many mouse models of prion diseases have recently been developed and the knowledge about the proteases responsible for the ... For example, expression of non-cleavable PrPC mutants in transgenic mice generates neurotoxicity, even in the absence of ... Thus, the introduction of PrPC rescues the phenotypes of these mice. In these mice, the exogenous artificial PrP mutants are ... spontaneous neurologic illness accompanied by amyloid plaques. In addition, the disease was transmissible. Thus, Tg(PrP,ΔGPI) ...